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Re: E2 too low???

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Your E2 looks good- between 15 -30 pg/mL is a good place to be. When

everything else is optimized, an E2 of 20 pg/mL is excellent.

One would expect TRT to reduce SHBG as well. DHT is generally higher

with the gel than with injections as the skin has lots of 5 alpha

reductase receptors that make DHT. This could cause prostatic

problems (note changes in your PSA over time) but if your E2 is in

check, it might make very little impact.

Injections have greater likelihood in converting to E2 than Androgel,

but this can be minimized by dosage & frequency. Sounds like you have

a good solution, so why change it?

Tiredness might be from intense training or could simply be due to too

many carbohydrates in a meal.

~Xian

>

>

> I am a 59 years old, primary, have been taking Androgel (7.5

> grams/day) for several years. Outside of my testicles shrinking

> bigtime, I have absolutely no complaints. My libido is great,

> erections are hard and frequent and ejaculates are large and

> satisfying. I take nothing but androgel/daily. I got my

> testosterone, etc. tested last week.

>

> my estradiol-2 was <20 pg/ml (via a Beckman Imunoassay)

>

> is this good?

>

> can't it be too low??

>

> any help would be most appreciated.

>

>

>

> Other labs are below

>

> Most recent lab results reference range in parantheses)

>

> Test total = 663 ng/dl (250-1100)

> test, free = 105 pg/ml (46-224)

> test (bioavailable) = 214 ng/dl (110-575)

> SHGB = 22 nmol/L (18-47)

> Albumin, serum = 4.4 (3.6-5.1)

>

> DHT = 85 ng/dL (25-75)

> PSA = 1.0 ng/ml (0.0-3.5)

>

> Estradiol-2 < 20 pg/ml (<20-47)

>

> several questions

>

> 1. my DHT is higher than normal range-- implication?

> 2. E2 was simply given as < 20, no number given, can it be too low? I

> take nothing but Androgel daily (nothing to control E2). Is there a

> way to increase E2 some, but not too much?

> 3. do these numbers look reasonable?

>

>

> I most feel good although I get tired in the afternoons and usualy

> take a 40 min nap about 4 days/week. My libido is mostly great

> (almost too good at times but does seem to vary over the course of a

> month). I usually have morning wood and erections are strong and

> frequent (I never use viagra or any similar ED drug). I am retired

> and have the luxury to workout 2 hours/day, 5 days/week consisting of

> cardio and weight training).

>

> This chronic tiredness could be a result of training hard but could

> it be related to other endocrine issues? What tests would be a good

> follow up? I have had thyroid panels done but never cortisol.

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