colon cancer recurrence

March 3, 2010

Carl,

The high content of cysteine and cystine in the cottage cheese

in the FSO/CC protocol encourages the growth of colon cancer. See

below. This isn't all bad, but it is a poorly thought-out

protocol. It is probably smarter to conjugate the FSO and perhaps

chemically complex with selenium much the same way Klaus Tilly

processed FSO with sulphur some 400 years ago. I had been asked to

review a Russian patent application on this updated process and the

numbers looked good.

You can safely kick up an IPT protocol that is specific for colon

cancer. You would use full dose dipyridamole along with low dose AZT

and antimetabolites 5FU or MTX. Another strategy is Mit C, valproic

acid, and parthenolide. The strategies can be made completely devoid

of side effects. Another strategy is IL-2 with ranitadine.

You can immediately start on cimetidine (Tagamet) to prevent further

mets while making decisions.

I would not trust surgery. You have many surgical adhesions from

before so it will be very difficult to locate and identify diseased

tissue. The recovery period seems to encourage the growth of cancer

cells left behind.

There are many alternative protocols that you can use but I can't go

into them here. It would take days to sort them out and come to a

treatment decision.

(see below)

Cell Prolif 2002 Apr;35(2):117-29

<http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://www.blackwell-synergy\

..com/openurl?genre=article & sid=nlm:pubmed & issn=0960-7722 & date=2002 & volume=35 & iss\

ue=2 & spage=117>

Click here to read

Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells.

Noda T, Iwakiri R, Fujimoto K, Rhoads CA, Aw TY.

Department of Molecular and Cellular Physiology, Louisiana State

University Health Sciences Center, Shreveport, LA 71130-3932, USA.

Previous studies have shown that intracellular glutathione, a

ubiquitous intracellular thiol, is related to cell proliferation and

that cysteine or its disulphide form, cystine, also induces cell

proliferation. Cysteine is a thiol containing amino acid and a

rate-limiting precursor of glutathione. Therefore, it is still

unresolved as to whether the proliferative effect of cysteine or

cystine is entirely mediated by a change in the intracellular

glutathione status. The objective of this study was to delineate the

relationship among cysteine/cystine (thereafter referred to as

cyst(e)ine), intracellular glutathione and cell proliferation in the

human colon cancer CaCo-2 cell line. CaCo-2 cells were cultured in

cyst(e)ine-free Dulbecco's Modified Eagle Medium without serum, and

treated with 200 microm cysteine and/or 200-400 microm cystine for 24

h. In the presence of DL-buthionine-[s, R]-sulfoximine (BSO), a

glutathione synthesis inhibitor, exogenously administered cyst(e)ine

did not change the intracellular glutathione content, but increased

the intracellular cysteine as well as cystine level. Addition of

exogenous cyst(e)ine following 5 mm BSO treatment significantly

increased cell proliferation as measured by 3H-thymidine

incorporation and protein content. Cell cycle analyses revealed that

cyst(e)ine promoted cell progression from the G1 phase to the S

phase. Correspondingly, cyst(e)ine treatment induced expression of

cyclin D1 and phosphorylation of retinoblastoma protein (Rb). In

conclusion, these data indicate that both cysteine and cystine have

proliferative effects in CaCo-2 cells independent of an increase in

intracellular glutathione. Induction of cyclin D1, phosphorylation of

Rb, and subsequent facilitation of G1-to-S phase transition were

involved in the proliferative effect of exogenous cyst(e)ine.

At 04:40 PM 3/3/2010, you wrote:

>,

>I'm glad to hear that your are progressing positively in your

>fight. I posted the following on the list but

>haven't gotten ant responses. If you have a moment to read this post

>and respond with your take on my current situation I'd be honored.

>Thanks so much

>

>Carl in Monroe

>

>Hello everyone. I've been a " lurker " for several months. I'm a 55

>year old male. I was diagnosed with stage 4 rectal cancer with mets

>to my liver in May of '08. Tumor was large enough to prevent a

>colonoscopy from being performed. I established a relationship with

>a gastroenterologist and oncologist at this time. On 6/18/08 I was

>fitted with a mediport and colostomy bag. I underwent chemo and

>radiation which ended approx Thanksgiving weekend of '08. On 2/18/09

>I underwent major surgery for removal of the main rectal tumor and

>piece of my liver. Surgery took over 10 hours. Since surgery, I make

>visits to my oncologist for a port flush and blood test. My CAS

>level has been going up (approx 35 now). Doctor sent me for PET scan

>which showed activity at the original rectal site. Thank God, the

>rest of my body is " clean " . My doctor feels that during the surgery,

>the tumor was not completely removed. He believes that this is a

> " local " problem and advises me to have surgery for removal. I have

>faith in the doctor but I am looking for additional input from

>people that may have gone down this road in the past. I have been

>doing the FOCC for a few months. Other than this issue, I am in very

>good health. Thanks for the responses.

>

>Carl in Monroe

>

March 4, 2010

:

Thank you very for taking the time to respond to my letter. I was told that

mixing the flax oil with cottage cheese was necessary so that the flax oil

becomes water soluble for better cell absorption. How would I substitute

selenium? How do I go about taking Tagamet? What type of dosage? How

could I find the many alternative protocols that you mention?

Again, thank you very much for taking the time to respond.

Carl

From: [mailto: ] On

Behalf Of VGammill

Sent: Thursday, March 04, 2010 1:35 AM