The role of clomophine in treating male infertility

[Guest guest]

Underlying GU disorders are treated. For men with sperm counts of 10 to 20

million/mL

and no endocrine disorder, clomiphene citrate (25 to 50 mg po once/day taken 25

days/

mo for 3 to 4 mo) can be tried. Clomiphene, an antiestrogen, may stimulate sperm

production and increase sperm counts. However, whether it improves sperm

motility or

morphology is unclear, and increased fertility has not been confirmed.

If sperm count is < 10 million/mL or clomiphene is unsuccessful in men with

normal

sperm motility, the most effective treatment is usually in vitro fertilization

with injections

of single sperm into single eggs (ie, intracytoplasmic sperm injection).

Alternatively,

intrauterine insemination using washed semen samples and timed to coincide with

ovulation is sometimes tried. Pregnancy is usually achieved by the 6th treatment

cycle if it

will occur at all.

http://www.merck.com/mmpe/sec18/ch256/ch256b.html?qt=clomid & alt=sh