Testosterone release rate and duration of action of testosterone pellet implants

[Guest guest]

What wandering the internet, I ran into this study that could be of

interest and a second study noted below and also a FAQ on pellets.

Testosterone release rate and duration of action of testosterone pellet

implants

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2265.2004.01994.x?cookie\

Set=1 & journalCode=cen

" CONCLUSION: Testosterone pellet implants release testosterone at a

steady rate of 1·3 mg/200 mg implant/day (95% CI). The duration of

action is about 6 months in an uncomplicated cycle with timing of return

shortened by extrusions only in the 3·6% of procedures followed by

multiple extrusions. No other patient or procedural features influenced

duration of action. Among men with an intact hypothalamo-pituitary unit,

plasma gonadotropins are more sensitive than blood total or free

testosterone to reduced testosterone delivery following an extrusion. "

An analysis of testosterone implants for androgen replacement therapy

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2265.1997.2521050.x

" CONCLUSIONS: This study demonstrates the very satisfactory clinical

acceptability of testosterone pellet implants for androgen replacement

therapy within a single unit with experienced operators. The only

regular adverse effect is extrusion, which may be related to mechanical

factors such as habitual work activity but also possibly procedural

factors. Other adverse effects such as bleeding, infection and fibrosis

were rare. An improved method of implant delivery would enhance this old

but durable technology. "

Pellets - Hormone Implant FAQ (doc includes image of trocar)

http://www.hormonebalance.org/files/Web%20Pellets%20Handout.doc

If you don't or cannot download the doc format, google has an HTML

cached version.

There was also a slide show:

http://www.hormonebalance.org/files/Pellets/Pellets%20WEB%201%20audio1.swf

--

Steve - dudescholar4@...

Take World's Smallest Political Quiz at

http://www.theadvocates.org/quiz.html

" If a thousand old beliefs were ruined on our march

to truth we must still march on. " --Stopford

[Guest guest]

Thanks Steve that was a good find.

Steve <dudescholar4@...> wrote: What wandering the internet,

I ran into this study that could be of

interest and a second study noted below and also a FAQ on pellets.

Testosterone release rate and duration of action of testosterone pellet

implants

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2265.2004.01994.x?cookie\

Set=1 & journalCode=cen

" CONCLUSION: Testosterone pellet implants release testosterone at a

steady rate of 1·3 mg/200 mg implant/day (95% CI). The duration of

action is about 6 months in an uncomplicated cycle with timing of return

shortened by extrusions only in the 3·6% of procedures followed by

multiple extrusions. No other patient or procedural features influenced

duration of action. Among men with an intact hypothalamo-pituitary unit,

plasma gonadotropins are more sensitive than blood total or free

testosterone to reduced testosterone delivery following an extrusion. "

An analysis of testosterone implants for androgen replacement therapy

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2265.1997.2521050.x

" CONCLUSIONS: This study demonstrates the very satisfactory clinical

acceptability of testosterone pellet implants for androgen replacement

therapy within a single unit with experienced operators. The only

regular adverse effect is extrusion, which may be related to mechanical

factors such as habitual work activity but also possibly procedural

factors. Other adverse effects such as bleeding, infection and fibrosis

were rare. An improved method of implant delivery would enhance this old

but durable technology. "

Pellets - Hormone Implant FAQ (doc includes image of trocar)

http://www.hormonebalance.org/files/Web%20Pellets%20Handout.doc

If you don't or cannot download the doc format, google has an HTML

cached version.

There was also a slide show:

http://www.hormonebalance.org/files/Pellets/Pellets%20WEB%201%20audio1.swf

--

Steve - dudescholar4@...

Take World's Smallest Political Quiz at

http://www.theadvocates.org/quiz.html

" If a thousand old beliefs were ruined on our march

to truth we must still march on. " --Stopford

Co-Moderator " Don't believe anything you hear and only half of what you see. "

Phil

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