Re: Testosterone release rate and duration of action of testosterone pellet impl

February 2, 2008

Hi,

The dosage of only 800 mg is a common problem according to my

endocrinologist with decades of experience.

Dr. Gambrell, now deceased, used this formula.

Subtract 30 pounds from the total weight of the patient and for every

remaining 10 pounds he should receive a 75 mg pellet. For me at 240

pounds he gave me his max amount of 20 pellets or 1500 mg total.

This dosage allows the patient to have a better than 800 T level which

in essence was what he experienced in his teens. It is this high level

that lets the patient feel the benefit of TRT.

" The duration of the pellet was determined by the patient who felt the

return of the symptoms. " For continuing TRT therapy this should not

happen according to Dr. Gambrell. There is nothing to be gained for

the patient to have his T level drop out of the enjoyable range and

then have to swing back up again.

It was pointed out to me by the doctor that too much T even over 1000

is not harmful as teens frequently run that high and some blood

conditions can be treated with high T as well. I forget the other

conditions where high T dosages are in order.

Yes an annual PSA test is essential to avoid possibly feeding a

prostate cancer.

The use of a trocar to insert the pellets well away from the incision

still seems the best.

I have received another set of pellets every 4 months and feel great

at 76.

ernestnolan

>

> What wandering the internet, I ran into this study that could be of

> interest and a second study noted below and also a FAQ on pellets.

>

> Testosterone release rate and duration of action of testosterone pellet

> implants

>

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2265.2004.01994.x?cookie\

Set=1 & journalCode=cen

>

> " CONCLUSION: Testosterone pellet implants release testosterone at a

> steady rate of 1·3 mg/200 mg implant/day (95% CI). The duration of

> action is about 6 months in an uncomplicated cycle with timing of

return

> shortened by extrusions only in the 3·6% of procedures followed by

> multiple extrusions. No other patient or procedural features influenced

> duration of action. Among men with an intact hypothalamo-pituitary

unit,

> plasma gonadotropins are more sensitive than blood total or free

> testosterone to reduced testosterone delivery following an extrusion. "

>

> An analysis of testosterone implants for androgen replacement therapy

>

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2265.1997.2521050.x

>

> " CONCLUSIONS: This study demonstrates the very satisfactory clinical

> acceptability of testosterone pellet implants for androgen replacement

> therapy within a single unit with experienced operators. The only

> regular adverse effect is extrusion, which may be related to mechanical

> factors such as habitual work activity but also possibly procedural

> factors. Other adverse effects such as bleeding, infection and fibrosis

> were rare. An improved method of implant delivery would enhance this

old

> but durable technology. "

>

> Pellets - Hormone Implant FAQ (doc includes image of trocar)

> http://www.hormonebalance.org/files/Web%20Pellets%20Handout.doc

>

> If you don't or cannot download the doc format, google has an HTML

> cached version.

>

> There was also a slide show:

>

http://www.hormonebalance.org/files/Pellets/Pellets%20WEB%201%20audio1.swf

>

> --

>

> Steve - dudescholar4@...

>

> Take World's Smallest Political Quiz at

> http://www.theadvocates.org/quiz.html

>

> " If a thousand old beliefs were ruined on our march

> to truth we must still march on. " --Stopford

>

February 2, 2008

Great slide show. Very informative for those looking for information.

I felt there was an error. It was mentioned that only those women that

are pre-menopausal should take progesterone monthly.

The wife had to take progesterone until she had her hysterectomy. Many

women want to stop their periods but Dr. Gambrell felt it was

unhealthy not to continue the periods as long as there was a uterus

involved.