melatonin aloe myrrha

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Biotherapy with the pineal hormone melatonin plus aloe and myrrh tincture in

untreatable metastatic cancer patients as an essence therapy of cancer

Research Article

P. Lissoni1*, F. Rovelli1,G. Messina2, F. Brivio3, B. Boniardi1, G. Porro1,

L.Vigore4, G. Di Fede1, P. Marchiori1, G. Brera5

1Institute of Biological Medicine, Milan;

2Psychiatric Division, Policlinico Hospital, Milan;

3Division of Surgery, Bassini Hospital, Cinisello,Milan;

4Laboratory of Immunomicrobiology,San Gerardo Hospital, Monza, Milan;

5Ambrosian University, Milan, Italy.

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*Correspondence: Dr. Paolo Lissoni, Divisione di Radioterapia Oncologica,

Ospedale S. Gerardo, 20052 Monza, Milano, Italia. Fax: +390392332284, e-mail:

p.lissoni@...

Key words: Aloe Vera, Melatonin, Mirrh, and Anticancer Immunity

Abbreviations: Melatonin (MLT), complete response (CR), partial response (PR),

stable disease (SD), disease control (DC), progressive disease (PD), T helper

lymphocytes (TH, CD4+), T regulatory lymphocytes (T reg, CD4+ CD25+)

Received: 30 July 2009; Revised: 18 October 2009

Accepted: 20 October 2009; electronically published: December 2009

Summary

Background: The recent advances in understanding the immunobiological

interactions responsible for cancer progression have allowed us to define the

mechanisms of action of some plants, whose antitumor properties were already

known by the popular Medicine, in particular Aloe and Myrrha, whose mixture was

already therapeutically utilized more than 2000 years ago by the Essence

medicine. Moreover, some endogenous natural substances, namely the main hormone

produced by the pineal gland melatonin (MLT) may also play anticancer activity.

On this basis, a study was performed with a biological regimen consisting of

MLT, Aloe and Myrrha in untreatable metastatic cancer patients with life

expectancy lower than 1 year. Methods: The study included 35 patients. MLT was

given orally at 20 mg/day in the evening and a mixed Aloe and Myrrha tincture

was administered at a dose of 5 ml/thrice daily. Results: The clinical response

consisted of complete response (CR) in 1, partial response (PR) in 2, stable

disease (SD) in 19 patients, whereas the remaining 13 patients had a progressive

disease (PD). Thus, a disease control (CR + PR + SD) was achieved in 22/35

(63%)patients. Moreover, a survival longer than 1 year was achieved in 17/35

(49%) patients. Finally, DC was associated with an evident improvement in the

immune status, namely consisting of a decrease in the number of T regulatory

lymphocytes, which are the main cells responsible for the suppression of the

anticancer immunity. Conclusion: This preliminary study shows that a biological

anticancer regimen consisting of the pineal hormone MLT in association with Aloe

and Myrrha mixture, already known at the times of the Essence medical tradition,

may induce a control of the neoplastic disease by stimulating the anticancer

immunity, in a relevant percentage metastatic cancer patients, who did not

respond to the conventional anticancer treatments and for whom no other standard

therapy was available.