Re: immune system enhancement

November 29, 2008

Right. This should be in the FAQ somewhere, it's definitely the biggest one

However, LDN doesn't blindly enhance your immune system. It helps your body Orchestrate your immune system. Restore your body to as close to homeostasis as it can. Since LDN also helps those diseases with an overly active immune system, and all sides of the spectrum, we must assume the body is smart enough to Orchestrate more properly once on LDN.DX

-- LarryGC/LarryLDN LDN Info rrms DX 07/31/02 LDN since 04/17/03

^mystory

Good luck to ya

[low dose naltrexone] immune system enhancement

This has probably been discussed among board members, but I haven't kept up with all posts. Sorry. MS is thought to be an attack on myelin by the immune system. The immune system is not weak, just mis-directed. LDN enhances the immune system, i.e., it makes the immune system stronger.It seems to me that we would want to avoid strenghtening something that is causing us problems.Dan------------------------------------

November 29, 2008

Apparently the thought may be misguided. The treatments for MS along these

lines is not very successful in the long term for many. A few get good disease

moderation for awhile, but many continue down the same old path, in spite of the

powerful CRABS and Tysabri.

Many on LDN report no exacerbations since starting, some for many years. While

this is not a long expensive study, there seems to be enough evidence that it

shows as much promise as anything else out there for MANY.

You will find most on this list wishing they had started it sooner, and not

wasted time on dangerous and worthless other modalities.

> From: banker6991 <madden@...>

> Subject: [low dose naltrexone] immune system enhancement

> low dose naltrexone

> Date: Saturday, November 29, 2008, 4:24 PM

> This has probably been discussed among board members, but I

> haven't

> kept up with all posts. Sorry.

>

> MS is thought to be an attack on myelin by the immune

> system. The

> immune system is not weak, just mis-directed. LDN enhances

> the immune

> system, i.e., it makes the immune system stronger.

> It seems to me that we would want to avoid strenghtening

> something that

> is causing us problems.

>

> Dan

November 29, 2008

I have had MS for 19 years and have been using LDN since March 2005.

Previously, I used the expensive, dangerous, ineffective, FDA

approved, doctor recommended, immune system suppressants Avonex,

Copaxone and Novantrone.

Whatever the mechanism is, I plan on staying on LDN. It works.

Art

My MS/LDN Story:

http://tinyurl.com/3lzoo2

--

>

> This has probably been discussed among board members, but I haven't

> kept up with all posts. Sorry.

>

> MS is thought to be an attack on myelin by the immune system. The

> immune system is not weak, just mis-directed. LDN enhances the

immune

> system, i.e., it makes the immune system stronger.

> It seems to me that we would want to avoid strenghtening something

that

> is causing us problems.

>

> Dan

>

November 30, 2008

LDN does not help to strengthen the immune system, but instead modulate. This is an important distinction. An example being the T cells that cross the blood brain barrier. This should not happen, and strengthening the BBB against this can help to reduce damage done by MS. Also, research is being done on using the bodies own cells to remodulate/train the immune system for the self recognition process. An example of this type of research can be seen in the xing trials. So it is not the strength/assertiveness/number of Tcells that do the damage, but instead it is their regulation that is the problem.

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December 1, 2008

>

> LDN does not help to strengthen the immune system, but instead

modulate. This is an important distinction. An example being the T

cells that cross the blood brain barrier. This should not happen, and

strengthening the BBB against this can help to reduce damage done by

MS. Also, research is being done on using the bodies own cells to

remodulate/train the immune system for the self recognition process.

An example of this type of research can be seen in the xing

trials. So it is not the strength/assertiveness/

901

number of Tcells that do the damage, but instead it is their

regulation that is the problem.

>

==============

From the official LDN website on how LDN works.

How does LDN work?

LDN boosts the immune system, activating the body's own natural

defenses.

Up to the present time, the question of " What controls the immune

system? " has not been present in the curricula of medical colleges and

the issue has not formed a part of the received wisdom of practicing

physicians. Nonetheless, a body of research over the past two decades

has pointed repeatedly to one's own endorphin secretions (our internal

opioids) as playing the central role in the beneficial orchestration

of the immune system, and recognition of the facts is growing.

The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that

is caused by taking LDN at bedtime each night is believed to produce a

prolonged up-regulation of vital elements of the immune system by

causing an increase in endorphin and enkephalin production. Normal

volunteers who have taken LDN in this fashion have been found to have

much higher levels of beta-endorphins circulating in their blood in

the following days.

December 2, 2008

>

> LDN does not help to strengthen the immune system, but instead

modulate. This is an important distinction. An example being the T

cells that cross the blood brain barrier. This should not happen...

To the group: Sorry for my 'long absense' here - been busy with

Candida and other stuff (

To P:

I will partially give you some credit for this, I think, IMPORTANT

observation - I see this much as a matter of point of wiew - but

there IS some specific issues to explain: to MODULATE include (but is

not limited to) at least one or more of the folloving actions: to

set, inflect, adjust, vary, alter, change, induce, regulate, correct,

align...

This could be expressed such as 'to align, set or regulate so as to

achieve accuracy or conform to a given standard' (in this case a

balanced immune-system, including preset terms for correct function)

or

'to alter, adjust or change in order to become different in some

particular 'wanted' way, without permanently losing its basic

characteristics' (in this case, induce changes, but do not alter the

immune-system to the extend of 'no return')

Other combinations are possible..

LDN ENHANCES the endorphine production by MODULATING the µ-receptors

to produce more endorphine - in this particular case this will in

turn STRENGTHEN the overall immune-response by MODULATING the

behaviour of specific immune-cells - those are i other words set,

adjusted, varyed, altered, changed, corrected, aligned, MODULATED in

a particular way to perform better (or even correct?)...

As you?, I think it is 'problematic' to see this whole LDN-thing just

as a 'black or white-thing' - in other words - it is NOT just

a 'enhance/deplete-strengthen/suppression-thing' - Personally I see

LDN as a immunomodulator just like the CRAB's and similar BIG PHARME

drugs, including The One I get - don't forget: Naltrexone IS a BIG

PHARMA chemical too, AND it is not a CURE - it just happen's

(fortunately) to pull in the right direction when 'modulated

correct', i.e. used in correct dose and at a specific time (by the

protocol) -and I will have to add this: other immunomodulators MIGHT

or MIGHT NOT do the same (pull in the right direction) by other means

(i.e. modulations) concurrent with LDN.

This 'point of wiew' is the major reason why I dare to do Remicade

concurrent with LDN.

Sincerely yours

Crohn's, Arthritis and Pustular Psoriasis. On LDN since april 14.

2008 - just now taking a short, unfortunate 'LDN break' due to severe

Candida issues - will return soon with more on that (OT??)... but

thing's ARE getting better ))

December 2, 2008

Hi "The Norwegian",

I hope you get better soon, because you still owe and I a trip out to California!!!

Your friend

Aletha

December 2, 2008

>

> Hi " The Norwegian " ,

>

> I hope you get better soon, because you still owe and I a trip

out to California!!!

>

> Your friend

> Aletha

..............................................>

Thank you very much, Aletha - I highly appreciate your way of

conduct, your curiousity, your open mind, your firm belivement in LDN

and it's possibilities to be of great help in any autoimmune disease

and your kind way to spread such information - and last, but not

least - your friendship! Please accept my love and greetings to you,

Aletha, and also forward those to , and Josh, whom I've

had the immense pleasure to meet in person here in Oslo - I thus

experienced a very nice, happy and solid family with good inner

relations and high integrity - a family you can be very proud of -

all just the way it is supposed to be!!

Getting better and the option to travel to California is VERY HIGH on

the " things to do " list - making a trip to the US would be a dream

come true for us, though I've traveled the US in '93 - a two week

business trip to several states - then having no personal frinds over

there ( - now I DO have such friend(s), and that is of course a BIG

difference!!

Looking forward to meet you and your family " some sunny day " ...

Your friend

" The Norwegian "

December 2, 2008

Hi ,

Further up the track, when you're ready to investigate gentler options that

can aid reduction of inflammation, and hence reduction of pain, please

check with your doctor about increasing your Omega 3 essential fatty acid

(EFA) intake - through diet or supplementation. To increase Omega 3

intake - a mix of cod liver oil, fish oil, flax seed oil, evening primrose

oil, and for Omega 9 (oleic acid), emu oil (anti-fungal properties).

Some supplements recommend very high intakes of Omega 3 but I'm not

convinced this is sustainable. Better to find the lowest level that works

for you.

For me ... that was initially taking a mix of three, 3000mg (including emu

oil) which delivered benefits for my Psoriasis. When I increased my daily

intake by just 2000mg the additional benefits in pain reduction were

dramatic.

I mix it up (I don't just take fish oil) because I believe too much of any

one thing is not good for the body.

It took around 3 months to notice a range of noticeable benefits, some

dramatic, such as relief of joint pain and stiffness, absence of throbbing

arm nerve on retiring, etc, etc. The benefits were slow and subtle, and

very similar to how others report the early benefits of LDN, eg; one night

the nerve throb was not there, then a week of throb every night, then it

was absent every third night or so, then only noticeable every other night,

then one glorious morning I realised the pain had been gone for a week and

I hadn't even noticed.

It was a glorious morning because I'd been sleeping comfortably, without

pain, for a week.

I also believe there would be few who would not benefit from a good

quality, non-dairy, refrigerated probiotic. (I tried a non-refrigerated,

and it was a waste of time and money.) Anyone who has taken medications -

antibiotics in particular - or has had a prolonged poor diet - is likely to

benefit from a course of probiotics.

Caution: Nothing is 100% safe. For example, Omega 3s can thin the blood.

Even though they're a dietary supplement, intake should be monitored by

health professional.

Kind regards,

Cris

Heres my present EFA mix:

I take 5000mg daily, and I take them all at night (after dinner & before

bed):

(1) 1000mg Cod Liver Oil = Vit A 1000iu, Colecalciferol 2.5mcg equiv to Vit

D3 100iu

(2) 1000mg Evening Primrose Oil = Omega 6 gamma-Linolenic Acid 100mg

(3) 750mg Emu Oil = Omega 3 Linolenic acid 7.5mg, Omega 6 Linoleic acid

81.0mg, Omega 9 Oleic acid 387.0mg

(4) 1000mg Fish Oil = Omega 3 marine triglycerides 300mg AS

Eicosapentaenoic Acid (EPA) 180mg, and

Docosahexaenoic Acid (DHA) 120mg

(5) 1000mg Flaxseed Oil = Omega 3 Linolenic Acid 175mg, Omega 6 Linoleic

acid 175mg, Omega 9 Oleic acid 175mg

Extracts from Wikipedia follow:

Botanical sources of n?3 fatty acids

Table 1. n?3 content as the percentage of ALA in the seed oil.[81]

Common name % n?3

Chia 64

Kiwifruit 62

Perilla 58

Flax (linseed) 55

Lingonberry 49

Camelina 36

Purslane 35

Black Raspberry 33

Table 2. n?3 content as the percentage of ALA in the whole food.[82][83]

Common name % n?3

Flaxseed 18.1

Butternuts 8.7

Walnuts 6.3

Pecan nuts 0.6

Hazel nuts 0.1

http://en.wikipedia.org/wiki/Omega-3_fatty_acid

Emu Oil

http://en.wikipedia.org/wiki/Emu_oil

8a. Re: immune system enhancement

Posted by: " Vagn Jensen " pvj@... peter.jensen215

Date: Mon Dec 1, 2008 5:14 pm ((PST))