OT: Re: MS, spasm and 4.5mg ldn

[Guest guest]

Yeah, it's a bird poison, not an insecticide. I stand corrected on

that. Corrected but not comforted.

> >

> > Colleen,

> >

> > Glad 4AP is working for you. I've been on the 4AP clinical trial

> for

> > about a year now and it has done nothing for me (good or bad). Just

> > so everyone knows.. 4AP = fampridine, but in a slow release

> > formulation. Fampridine itself is dirt cheap and can be purchase

> from

> > a compounding pharmacy. However, 4AP is a patented formula not yet

> > approved by the FDA. You can only get 4AP via a clinical study as

> far

> > as I know. And I believe the clinical studies are closed to new

> > entrants at the moment.

> >

> > Its worth noting that fampridine is actually an insecticide. The

> > reason it's so cheap is that it is still used in bulk as an

> > insecticide. 4AP is a low dose of fampridine (so it doesn't kill

> you)

> > and has the special patented slow release mechanism. A compounding

> > pharmacy might say that they can make a slow release formulation of

> > fampridine, but it's not as effective as 4AP -- at least according

> to

> > the big pharma folks who are paying for the 4AP clinical studies.

> >

> > The primary success measure of the 4AP study is a timed 25 foot

> walk.

> > My times have not improved after a year of 4AP, but I guess a lot

> of

> > people have shown improvement. The pharma company is hoping that

> the

> > FDA will fast track approval of 4AP in the next few months even.

> >

> > I posted earlier about going from LDN 3.0 to 4.5. I said that for

> the

> > first two days I felt noticeable reduction in spasticity (I'm sure

> my

> > 25 foot walk times would have been 50% better -- had I actually

> taken

> > the test). However, from day 3 until now (day 8), my spasticity has

> > gotten worse every day. I'm to the point that I can hardly lift one

> > of my feet off the floor at all. So as of today I'm going to fall

> > back to 3.0. I may try sprinkling in an occasional 4.5 dose as

> > another poster suggested to see what happens. Honestly, the first

> two

> > days of 4.5 were so encouraging that there just has to be a way to

> get

> > that improvement back.

> >

> > I'll let everyone know how it goes.

> >

> > Wayne

> >

>