Guest guest Posted December 1, 2008 Report Share Posted December 1, 2008 What is GABA ? How does it help? Thanks, Maya > > Just got some GABA...how much do I give? What other supp. will > compliment GABA > > Magnesium?, l carnitine? folic? b12? vit c? > > thx, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2008 Report Share Posted December 1, 2008 from a previouse post from andy: /message/240434 From: mywonderbaby <mywonderbaby@...> Subject: [ ] Re: GABA for non verbal Date: Monday, December 1, 2008, 10:11 AM What is GABA ? How does it help? Thanks, Maya > > Just got some GABA...how much do I give? What other supp. will > compliment GABA > > Magnesium?, l carnitine? folic? b12? vit c? > > thx, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2008 Report Share Posted December 1, 2008 GABA is an inhibitory neurotransmitter that often helps our kids remain calm. Glutamate is like the opposite, an excitatory neurotransmitter which encourages neurons to fire - so there is a constant balancing act between GABA and Glutamate, the needs of which vary from time to time and for different situations/tasks. To put GABA in perspective so you can relate to in in your everyday life, remember the times you drank too much coffee and you felt really wired and hyped up? Caffeine inhibits the release of GABA. So you have less GABA doing its job, so more nerve transmissions are allowed to occur and Glutamate can run wild. Now lets not forget good old taurine, one of my favourite supplements for its assistance with bile salts formation and fatty acid metabolism. Taurine has been used to suppress seizures due to its ability to increase GABA utilisation in the brain. Some studies........ Fatemi SH, Folsom TD, Reutiman TJ, Thuras PD (2008) Expression of GABA( Receptors Is Altered in Brains of Subjects with Autism. Cerebellum. (), . PMID: 19002745 Autism is a neurodevelopmental disorder that is often comorbid with seizures. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain. GABA( receptors play an important role in maintaining excitatory-inhibitory balance in brain and alterations may lead to seizures. We compared levels of GABA( receptor subunits GABA( receptor 1 (GABBR1) and GABA( receptor 2 (GABBR2) in cerebellum, Brodmann's area 9 (BA9), and BA40 of subjects with autism and matched controls. Levels of GABBR1 were significantly decreased in BA9, BA40, and cerebellum, while GABBR2 was significantly reduced in the cerebellum. The presence of seizure disorder did not have a significant impact on the observed reductions in GABA( receptor subunit expression. Decreases in GABA( receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism. Fatemi SH, Reutiman TJ, Folsom TD, Thuras PD (2008) GABA(A) Receptor Downregulation in Brains of Subjects with Autism. J Autism Dev Disord. (), . PMID: 18821008 Gamma-aminobutyric acid A (GABA(A)) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABA(A) receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann's Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABA(A) receptor subunit expression in the three brain areas. Our results demonstrate that GABA(A) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. Muñoz-Yunta JA, Palau-Baduell M, Salvadó-Salvadó B, Valls-Santasusana A, Rosendo-Moreno N, Clofent-Torrentó M, Manchado F (2008) [Autism, epilepsy and genetics] Rev Neurol. 46 Suppl 1 (), S71-7. PMID: 18302128 INTRODUCTION: The rate of epilepsy in autism is higher than in other developmental disorders and estimates point to a frequency range of between 7% and 42%. Between 40% and 47% of autistic children suffer from clinical epilepsy. Onset of epilepsy may occur at any age. DEVELOPMENT: During the ontogenesis of the nervous system, if the maturing process is upset by some epileptogenic phenomenon, the consequences on the consolidation of the emerging cognitive functions can be severe. Epileptiform discharges can occur although clinical seizures are absent, but nevertheless they still have an effect on the maturing process. Between 10% and 50% of autistic children undergo a regression of acquired behaviour following a period of normal development. The absence of clinical seizures during regression does not rule out the epileptogenic origin of the regressive process. CONCLUSIONS: The relation between pervasive developmental disorders and epilepsy, epileptiform activity and subclinical seizures can be explained from a neurobiological point of view, on the one hand, by an imbalance between the excitatory system -glutamate- and the inhibitory system -gamma-aminobutyric acid (GABA)- in key points in the cerebral cortex and, on the other, by means of molecular genetic studies and studies of candidate genes (FOXP2, WNT2, subunits of GABA receptors, neuroligins, ARX, SCN1A, SCN2A, MECP2, CDKL5 and DLX5). mywonderbaby wrote: > > What is GABA ? How does it help? > > Thanks, > Maya > > > > > > Just got some GABA...how much do I give? What other supp. will > > compliment GABA > > > > Magnesium?, l carnitine? folic? b12? vit c? > > > > thx, > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2008 Report Share Posted December 1, 2008 GABA calms my son in about 15 minutes (one capsule only)and lessens stimming and hyperactivity. Our nurse practitioner gives it to her teen son with ADHD, and has stopped his prescription meds because she said it works so well. However, we notice the effects wear off for our son after a couple of hours. I read on some internet sites that metals can create a need for more GABA dosage, and I plan to ask our biomedical doctor about this. Our son is still high for 7 metals, so it may be that he needs a higher dosage of GABA. We can give up to 4 capsules per day. Here is another article I found: http://naturalmedicine.suite101.com/article.cfm/natural_anxiety_relie f_ltheanine_vs_gaba - > > > > Just got some GABA...how much do I give? What other supp. will > > compliment GABA > > > > Magnesium?, l carnitine? folic? b12? vit c? > > > > thx, > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2008 Report Share Posted December 2, 2008 Gaba made my son " feel funny " and did not help him sleep. Taurine was something that helped him though. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2008 Report Share Posted December 2, 2008 FYI, Gaba did not work for our son. Our guy is floppy and too relaxed, but has anxiety, so we tried it. It made him cry. Maggie d. > > GABA calms my son in about 15 minutes (one capsule only)and lessens > stimming and hyperactivity. Our nurse practitioner gives it to her > teen son with ADHD, and has stopped his prescription meds because > she said it works so well. > > However, we notice the effects wear off for our son after a couple > of hours. > I read on some internet sites that metals can create a need for more > GABA dosage, and I plan to ask our biomedical doctor about this. > Our son is still high for 7 metals, so it may be that he needs a > higher dosage of GABA. We can give up to 4 capsules per day. > > Here is another article I found: > http://naturalmedicine.suite101.com/article.cfm/natural_anxiety_relie > f_ltheanine_vs_gaba > > - > > Quote Link to comment Share on other sites More sharing options...
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