Result of PMTCT Program in Namakkal district

[Guest guest]

Parameshwari S, MS, Vijayakumari JJ, Shalini D, Sushi MK, Sivakumar MR.

A program on prevention of mother to child transmission of HIV at government

hospital, Tiruchengode taluk, Namakkal district.

Indian J Community Med [serial online] 2009 [cited 2009 Aug 30];34:261-3.

Available from: http://www.ijcm.org.in/text.asp?2009/34/3/261/55298

Introduction

UNAIDS states that mother to child transmission (MTCT) is the largest source of

HIV infection in children below the age of 15 years. [1] According to National

AIDS Control Organization (NACO), it is estimated that about 30,000 infants

acquire HIV infection each year. [2] Tamil Nadu Sentinel surveillance for 2004,

showed that the median positivity rate of HIV infection among the antenatal

women was 0.65% (range 0-3.7%) [3] and in 2005 it was 0.50%.

Prevention of mother to child transmission (PMTCT) program has been established

at the Tiruchengode government hospital (Tiruchengode taluk, Namakkal district)

in November 2002 by the Department of Experimental Medicine of the Tamilnadu Dr.

MGR Medical University.

This was the first PMTCT program in India that has been established at a taluk

hospital. The objective of the program was to establish a PMTCT center and offer

antiretroviral prophylaxis to all HIV positive pregnant women and their infants.

Materials and Methods

Group counseling and education in Tamil (local language) on health and hygiene

during pregnancy, importance of regular antenatal visits, nutrition, importance

of HIV testing, HIV prevention and infant feeding issues were stressed to all

pregnant women visiting the antenatal clinic. After obtaining written informed

consent, HIV testing was performed followed with individual post test

counseling. HIV seronegative women are counseled on HIV prevention and risk

reduction behaviors. For HIV seropositive pregnant women, individual post test

counseling included psychological support, ARV prophylaxis, infant feeding

options, disclosure issues, couple-counseling sessions, postpartum follow up,

nutrition, and prevention of pregnancy.

Blood was collected by finger-stick and rapid test was performed using CombAIDS.

If the test was reactive, blood was collected by venipuncture and two other

rapid tests were performed (EIA Comb and Tridot).

Tablet nevirapine (single dose of 200 mg at the onset of labor) was provided to

pregnant women to take home in the 3 rd trimester. Nevirapine syrup (2 mg/kg

body weight) was offered to the infants within 72 hours after birth. HIV DNA PCR

was performed for the infants at six months of age and HIV rapid test was done

at 18 months.

Results

Over a period of five years, 7866 pregnant women accessed the PMTCT services.

Group counseling was provided in batches of 2-8 women with an average of 3 women

and the time taken was 20-40 minutes. Fifty six antenatal women (0.77%) tested

positive [Table 1]. Forty seven of them (83%) received nevirapine. Nine did not

receive nevirapine because three gave false addresses, two shifted out of the

locality and one patient expired. Three antenatal women were yet to deliver.

All of the seropositive pregnant women were married and were below 30 years.

None had any opportunistic infections (O.I.). 75% (35/47) had vaginal delivery

while 12 (25%) underwent caesarian section.

Forty six infants were born and one was stillbirth. The mean birth weight of the

infants was 2.6 kg. There were no congenital abnormalities. Two infants survived

for a day and then died of pneumonitis and acute gastroenteritis, respectively.

One infant was diagnosed with protein energy malnutrition at the age of 5 months

and expired.

Forty four (44/46) infants received nevirapine syrup. Thirty two of them

received nevirapine in the government hospital, 8 during the home visit and 4

infants received nevirapine in private hospital. Twenty infants who completed 6

months of age tested negative using HIV DNA PCR. HIV rapid test was performed

for 14 of the infants at 18 months and two were found to be HIV positive.

Discussion

The Department of Experimental Medicine of the Tamilnadu Dr. MGR Medical

University initiated PMTCT program at the Government Hospital, Thiruchengode

taluk, Namakkal District in Oct 2002. This program is unique that it offers

services to those women who are able to visit the government hospital at taluk

level.

Rouzioux et al . observed that perinatal transmission could occur during

antepartum, intrapartum and after delivery through breast milk. [4] Therefore,

strategies for PMTCT would involve HIV education, voluntary counseling and

testing (VCT) for pregnant women and providing antiretroviral prophylaxis to

them and their infants.

In this study, the acceptability of HIV education and VCT is 100%.

The factors leading to high rates of acceptance for HIV testing are cultural;

where the rural women regard the health care workers with high respect and feel

obligated to get tested in spite of testing not being mandatory, Group dynamics

may also play a role, since if one person gets tested, the rest in the group

also get tested.

Rapid HIV testing is beneficial to pregnant women. The test is simple and easy

to use at the rural settings. Moreover, the test results are provided to the

pregnant women on the same day. In a study done among women in northern

Thailand, Liu et al. observed that 56% of the women preferred blood collection

by finger-stick and 79% of women favored rapid test method to venepuncture. [5]

Single-dose nevirapine prophylaxis to mother and infant is widely used in

resource-constrained settings for PMTCT programs. The simplicity and low cost of

nevirapine's single dose regimen suggest that this highly efficacious drug might

be very useful in rural settings. As the tablet does not require refrigeration,

it can be offered to the mother in the last week of trimester. In this study,

83% of the pregnant women received nevirapine prophylaxis while 96% (44/46)

infants received nevirapine syrup.

HIV DNA PCR was performed at 6 months of age for the infants. Dunn et al.

reported a meta-analysis of published data from 271 infected children indicated

that HIV DNA PCR was sensitive for the diagnosis of HIV infection during the

neonatal period. Thirty-eight percent (90% confidence interval [CI] = 29%-46%)

of infected children had positive HIV DNA PCR tests by age 48 hours. No

substantial change in sensitivity during the first week of life was observed,

but sensitivity increased rapidly during the second week, with 93% of infected

children (90% CI = 76-97%) testing positive by PCR by age 14 days. By age 28

days, HIV DNA PCR has 96% sensitivity and 99% specificity to identify HIV

proviral DNA in peripheral blood mononuclear cells (PBMCs). [6]

In this study, 20 infants born to the seropositive women were HIV negative at 6

months of age when tested with in house qualitative HIV DNA PCR. WHO

recommendation is that a diagnosis of HIV-1 infection can be made on the basis

of two positive HIV-1 DNA or RNA assay results. However, in this study, 14 of

the above infants were tested at 18 months of age and two (14%) tested positive

by HIV rapid tests.

Both these infants were male infants. Both the infants and their mothers

received Nevirapine prophylaxis. One was born through vaginal delivery and the

other was by caesarian section. One infant received exclusive breast-feeding for

the first four months and the other has received mixed feeds. The diagnosis of

HIV-1 infection among infants and young children with a history of breastfeeding

is more difficult because of continuing exposure to the virus postnatally. [7]

The HIV positive infants in this study may have been infected through breast

feeding.

Conclusions

PMTCT programs are feasible in government hospitals where resources are limited.

Rural pregnant women are receptive to voluntary counseling and testing. Through

this program, rural pregnant women were educated on HIV/AIDS and PMTCT. Simple

intervention strategies for PMTCT will reduce the incidence of pediatric HIV

infection in India.

Acknowledgements

PMTCT program at Government Hospital, Thiruchengode was supported by grants

received from Glaser Pediatric AIDS Foundation, USA. The authors are

grateful to all the HIV seropositive women and their infants participated in

this program.

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