Cervical cancer among HIV infected female population in West Bengal India

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Oncogenic HPV among HIV infected female population in West Bengal India

Prevalence of both cervical cancer and Human Immunodeficiency Virus (HIV)

infection are very high in India. Natural history of Human Papilloma Virus (HPV)

infection is known to be altered in HIV positive women and there is an increased

possibility of persistence of HPV infections in this population.

Therefore, this study was conducted to understand the epidemiology and

circulating genotypes of oncogenic HPV among HIV positive and negative female

population in West Bengal, India.

Methods: In this hospital-based cross-sectional study, 93 known HIV positive

females attending a pre-ART registration clinic and 1106 HIV negative females

attending a Reproductive and Child Health Care Clinic were subjected to study.

Cervical cell samples collected from the study population were tested for the

presence of HPV 16, 18 using specific primers.

Roche PCR assay was used to detect other specific HPV genotypes in the cervical

cells specimens of HIV positive cases only.

Results: Prevalence of HPV 16, 18 among HIV positive females (32.2%; n= 30) was

higher than HIV negative females (9.1%; n=101). About 53% (23/43) of cases with

oncogenic HPV were infected with genotypes other than 16, 18 either as

single/multiple infections.

HPV 18 and HPV 16 were the predominant genotypes among HIV positive and HIV

negative subjects respectively. Oncogenic HPV was not found to be associated

with age and duration of sexual exposure.

But the presence of HIV was found to a statistically significant predictor

oncogenic HPV.

Conclusion: The currently available HPV vaccines offer protection only against

HPV 16 and 18 and some cross- protection to few associated genotypes. These

vaccines are therefore less likely to offer protection against cervical cancer

in HIV positive women a high percentage of who were infected with non-16 and

non-18 oncogenic HPV genotypes.

Additionally, there is a lack of sufficient evidence of immunogenicity in HIV

infected individuals. Therefore, prevention of cervical cancer in HIV positive

women must be focused towards early detection of oncogenic HPV & cervical

cytological abnormality followed by an appropriate treatment.

Author: Kamalesh SarkarReshmi PalBaishali BalBibhuti SahaSubhasish

BhattacharyaSharmila SenguptaPartha Pratim MazumdarShekhar Chakraborti

Credits/Source: BMC Infectious Diseases 2011, 11:72

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