Arava and liver function

[Guest guest]

I've been on MTX plus Arava for >1.5 years now. All was OK with blood tests,

until my ALT started increasing slowly. When ALT rose to about 1 1/2 times the

upper normal value, we decreased MTX and increased Arava to 20 mg. Unfortunately

ALT then rose to >2 times upper normal value.

 

Now I am on 10 mg Arava and still low MTX, ALT back to 1 1/2 times. Now feeling

effects of low MTX.

 

Has anyone else had Liver problems like this? Also the latest FDA statements are

that if ALT becomes >2 times upper normal, you should stop it (whereas

previously they said if it went between 2-3 times you should lower Arava to 10

mg).

 

Thanks for your thoughts

max