Guest guest Posted November 23, 2010 Report Share Posted November 23, 2010 I have just begun taking Simponi. I found after the first injection the effect lasted about a week. The 2nd injection lasted about 10 days. I just had my 3rd. My question is does Simponi end up taking away all of the inflammation and pain for a whole month at a time. Do you still have to continue with the oral medications like sulfasalzine and meloxicam? Quote Link to comment Share on other sites More sharing options...
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