Guest guest Posted January 9, 2008 Report Share Posted January 9, 2008 Hello Everyone, I've been reading through posts discussing MTX and related mouth ulcers and still have some questions. 8]:-) I've been on MTX about 18 months -- on Enbrel injections about 15 months and just recently began developing ulcers that did not heal by themselves. I've been instructed to stop the MTX until all ulcers are healed. My rheumy decreased the MTX dose from 5 to 4 tablets per week and increased the folic acid from one to two mg tablets per day due to the MCV imbalance but to take any more than that. Her nurse said that ulcers usually show up in the first weeks of MTX therapy rather than a year later. She prescribed Kenalog dental paste and my PCP suggested oral benzocaine for the discomfort. Some of my most uncomfortable ulcers are where mouth and throat join -- where I can barely reach with the paste (which helped, BTW). She tells me that the folic acid is increased only to get the MCV values back within normal limits and does NOT have anything to do with healing ulcers. Now I'm confused big time because. Would someone explain to me the mechanics of how MTX causes these ulcers, please? What's to say they don't form on other mucosal tissue elsewhere in the body? Although I've been off MTX for 3 weeks, I can still feel a strange tenderness in my mouth just before the tissue erupts; sometimes the ridges in the roof of my mouth just swell for several hours after this 'feeling' and then recedes. Are there other suggestions for easing the discomfort or reducing symptoms? Many thanks to everyone on the list for your helpfulness over the years, Patty in an unusually mild winter in the Pineywoods of East Texas Quote Link to comment Share on other sites More sharing options...
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