Guest guest Posted January 9, 2008 Report Share Posted January 9, 2008 I would bet that the edema and bruising came from the prednisone or the edema from the prednisone and bruising from the Lodine. My main problem with the MTX is the fatigue. Each time we increase the dose, the fatigue becomes more and more brutal. My doc has offered Provigil for the fatigue but it just seems futile to take one drug which causes you to need a second drug to fight off the side effects. Kinda like taking MTX to prevent your body from forming antibpdies to the TNFs. My Rheumy says that you initially only needed to take MTX to avoid antibody formation to Remicade but now it's for all TNFs. It seems hopeless. My 2 cents. Rae Quote Link to comment Share on other sites More sharing options...
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