Re: Amoxicillin and Probenecid

[Guest guest]

I don't have experience with it and children, but I did run across some

Finnish studies where they used it. I don't think it was with kids, but I

can doublecheck for you if you'd like. I asked my doctor about putting my

son on it, and he said he only uses it with amoxycillin (and my son's not on

amox.). So if that's any comfort, my doctor uses it in the same way.

I'll have a look at the abstracts (I printed them out) and if they are

pediatric I'll post the link.

On Thu, Feb 3, 2011 at 1:16 PM, throughgrace97 <TriciaSod@...>wrote:

>

>

> Hi Everyone,

>

> My daughters 10 & 13 had their Lyme checks yesterday. Our doctor wanted to

> start them on Amoxicillin and Probenecid. She explained that Probenecid is

> used in adults for gout but using it with amoxicillin would increase the

> blood levels of amoxicillin without causing the side effects that would come

> by only using high doses of amoxicillin.

>

> I wasn't comfortable with this because she has never used this drug on

> children and doesn't know of anyone who has but she has had success using it

> in adults.

>

> I'm just wondering by any chance if any of your children have had this duo

> of meds?

>

> Thanks

>

>

>

[Guest guest]

Thank you so much . Anything you come across will be most helpful.

* ´¨) ¸.• ´¸.•* ´¨)¸. •*¨)

(¸.•´ (¸ ;. •´ Tricia

________________________________

From: Farhangi <lesliefarhangi@...>

Sent: Thu, February 3, 2011 4:27:23 PM

Subject: Re: [ ] Amoxicillin and Probenecid

I don't have experience with it and children, but I did run across some

Finnish studies where they used it. I don't think it was with kids, but I

can doublecheck for you if you'd like. I asked my doctor about putting my

son on it, and he said he only uses it with amoxycillin (and my son's not on

amox.). So if that's any comfort, my doctor uses it in the same way.

I'll have a look at the abstracts (I printed them out) and if they are

pediatric I'll post the link.

On Thu, Feb 3, 2011 at 1:16 PM, throughgrace97 <TriciaSod@...>wrote:

>

>

> Hi Everyone,

>

> My daughters 10 & 13 had their Lyme checks yesterday. Our doctor wanted to

> start them on Amoxicillin and Probenecid. She explained that Probenecid is

> used in adults for gout but using it with amoxicillin would increase the

> blood levels of amoxicillin without causing the side effects that would come

> by only using high doses of amoxicillin.

>

> I wasn't comfortable with this because she has never used this drug on

> children and doesn't know of anyone who has but she has had success using it

> in adults.

>

> I'm just wondering by any chance if any of your children have had this duo

> of meds?

>

> Thanks

>

>

>

[Guest guest]

OK, as I suspected the studies did not involve children. The name of the

first article is " Comparison of oral cefixime and intravenous ceftriaxone

followed by oral amoxicillin in disseminated Lyme borreliosis " published in

*Eur J Clin Microbiol Infect Dis* in 1998. I found it on:

www.ncbi.nlm.nih.gov/pubmed/9865985?dopt=Citation

The second article is titled " Treatment of Late Lyme Borreliosis " in *J

Infect* 1994 Nov 29(3)255-61.

www.ncbi.nlm.nig.gov/pubmed/7884218?dopt=Citation.

In the studies they used and compared several different kinds of

antibiotics, but in both studies, they combined the amoxycillin with the

probenecid.

My two cents (which I realize you haven't asked for) is that you have to

weigh the risks of taking the amox. and the probenicid vs. the risks of

taking a much higher dose of amox w/o the probenicid. I suspect there are

risks to both courses of action. Have you done a search for pediatric use

of probenicid?

If you trust your doctor, I would follow her advice. I had my 11 year old

put on actigall for the short time he was on rocephin. That is also a med

that is not indicated/studied with children, but I felt the risks of

developing gall bladder complications without it outweighed the risk of the

actigall, which is routinely used in adults on rocephin. The visiting nurse

who changes my son's dressing is also a paramedic and he said the rule for

paramedics in deciding if it was OK to give adult drugs to kids was: are

they over 10? over 5' tall? If the answer is yes, you can treat them like

an adult.

Best of luck with your daughters --

On Thu, Feb 3, 2011 at 6:36 PM, Tricia Soderstrom <TriciaSod@...>wrote:

>

>

> Thank you so much . Anything you come across will be most helpful.

>

> * ´¨) ¸.• ´¸.•* ´¨)¸. •*¨)

> (¸.•´ (¸ ;. •´ Tricia

>

> ________________________________

> From: Farhangi <lesliefarhangi@...<lesliefarhangi%40gmail.com>

> >

> < %40>

> Sent: Thu, February 3, 2011 4:27:23 PM

> Subject: Re: [ ] Amoxicillin and Probenecid

>

>

> I don't have experience with it and children, but I did run across some

> Finnish studies where they used it. I don't think it was with kids, but I

> can doublecheck for you if you'd like. I asked my doctor about putting my

> son on it, and he said he only uses it with amoxycillin (and my son's not

> on

> amox.). So if that's any comfort, my doctor uses it in the same way.

>

> I'll have a look at the abstracts (I printed them out) and if they are

> pediatric I'll post the link.

>

>

>

> On Thu, Feb 3, 2011 at 1:16 PM, throughgrace97

<TriciaSod@...<TriciaSod%40verizon.net>

> >wrote:

>

> >

> >

> > Hi Everyone,

> >

> > My daughters 10 & 13 had their Lyme checks yesterday. Our doctor wanted

> to

> > start them on Amoxicillin and Probenecid. She explained that Probenecid

> is

> > used in adults for gout but using it with amoxicillin would increase the

> > blood levels of amoxicillin without causing the side effects that would

> come

> > by only using high doses of amoxicillin.

> >

> > I wasn't comfortable with this because she has never used this drug on

> > children and doesn't know of anyone who has but she has had success using

> it

> > in adults.

> >

> > I'm just wondering by any chance if any of your children have had this

> duo

> > of meds?

> >

> > Thanks

> >

> >

> >

>

>

[Guest guest]

Thank you so much . I agree with you! I like my doctor but I haven't

been able to trust any doctor 100% especially when it comes to my children.

I'm going to do some research online. I just wondered if anyone on this

wonderful forum had any experience with it. You guys are so supportive and

helpful!!

* ´¨) ¸.• ´¸.•* ´¨)¸. •*¨)

(¸.•´ (¸ ;. •´ Tricia

________________________________

From: Farhangi <lesliefarhangi@...>

Sent: Thu, February 3, 2011 7:35:17 PM

Subject: Re: [ ] Amoxicillin and Probenecid

OK, as I suspected the studies did not involve children. The name of the

first article is " Comparison of oral cefixime and intravenous ceftriaxone

followed by oral amoxicillin in disseminated Lyme borreliosis " published in

*Eur J Clin Microbiol Infect Dis* in 1998. I found it on:

www.ncbi.nlm.nih.gov/pubmed/9865985?dopt=Citation

The second article is titled " Treatment of Late Lyme Borreliosis " in *J

Infect* 1994 Nov 29(3)255-61.

www.ncbi.nlm.nig.gov/pubmed/7884218?dopt=Citation.

In the studies they used and compared several different kinds of

antibiotics, but in both studies, they combined the amoxycillin with the

probenecid.

My two cents (which I realize you haven't asked for) is that you have to

weigh the risks of taking the amox. and the probenicid vs. the risks of

taking a much higher dose of amox w/o the probenicid. I suspect there are

risks to both courses of action. Have you done a search for pediatric use

of probenicid?

If you trust your doctor, I would follow her advice. I had my 11 year old

put on actigall for the short time he was on rocephin. That is also a med

that is not indicated/studied with children, but I felt the risks of

developing gall bladder complications without it outweighed the risk of the

actigall, which is routinely used in adults on rocephin. The visiting nurse

who changes my son's dressing is also a paramedic and he said the rule for

paramedics in deciding if it was OK to give adult drugs to kids was: are

they over 10? over 5' tall? If the answer is yes, you can treat them like

an adult.

Best of luck with your daughters --