Biologics not working

[Guest guest]

Hi, hoping to get some response from the PSA community. In 2009 I started using

Remicade and it lost its effect within 5 infusions. I was then switched to

Simponi and within 5 shots I am not getting any effect. By effect I mean

reduction in inflammation, and pain.

Have others had the same kind of response? How many times have you had to

switch until the right one is found?

I am also taking meloxicam and sulfasalzine. I cannot tolerate MTX.

[Guest guest]

Hi, i just want to let you know that you are not alone when it comes to

biologics not working. So far I have tried and 'failed' Humira and Enbrel. I

have also tried Celebrex, sulfasalazine, MTX and all unfortunately haven't

helped :-( I am now going to try Simponi and instead of thinking...oh here we go

again... I'm trying to talk myself into being positive and believing that this

IS going to be the drug for me. Not sure if this is going to work but I'm going

with it!!

Good luck, fingers crossed Simponi works for us both :-D

Tina

[Guest guest]

Tina,

I also just changed over to Simponi...here's hoping! :-)

Sue in Oregon

On 2/9/11, ageandtina <tinaltv@...> wrote:

:-( I am now going to try Simponi and instead of thinking...oh here

we go again... I'm trying to talk myself into being positive and believing

[Guest guest]

Tina,

I am a firm believer in positive thinking and prayer. However, positive

thinking usually doesn't have the results we often think it will. Prayer,of

course, depends on the answer we get. I have had one problem after another. I

believe God will help us get through things and, of course, can heal us but we

all know that healing does not come to all who ask. Everything I've found

points to a healthy life style of eating a good diet full of vegetables, fruits,

whole grains and low fat meat. And, trying the medications the Doc prescribes.

Medicine is " practice " and it is certainly not perfected. I do believe that the

doctors should address our pain and help us deal with it without so much

discomfort. Since there are so many drug seekers, it makes it more difficult

for those who really are in pain to get the proper medications. I've found that

if I can get a good night's sleep, the pain is less. However, if you are

hurting, a good night's sleep is hard to come by. I looked forward to spending

some quality time with my children and grandchildren when I was able to slow

down and near retirement age. I'm there now, and frankly, I don't feel like

doing much of anything. I am going to try yoga and see if that will help. I

have a rheumatologist who does not believe in any kind of pain medication

stronger than Darvocet and since they pulled that from the market, I am left

with Relafen and Baclofen and both are pretty much useless. I am still on

Methotrexate and Enbrel and had pretty good results until about 3 months ago.

I've gotten very little relief lately and may consider something else. The

medication is too expensive to use if it is not of much benefit. ly, it is

a very perplexing illness and I don't think anyone truly understands the depth

of it or the effect it has on our entire body and also our emotional health.

Maybe sometime in the future those who suffer will be helped by all our

" trials " . Good luck and I hope everyone has a less painful day. Good luck with

your next medication. Perhaps it will be just what you needed.