FYI : aromasin info - phil

[Guest guest]

(aromasin) Exemestane is rapidly and extensively absorbed after

oral administration, although animal data suggest that

oral bioavailability might be incomplete due to first-

pass hepatic metabolism. Food enhances absorption,

resulting in plasma levels 40% higher than those

observed under fasting conditions. Exemestane is

extensively metabolised, viaoxidation (CYP3A4) and

reduction (aldoketoreductase), to form many secondary

metabolites, all of which are inactive or less active than

the parent compound. It has a terminal elimination half-

life of approximately 24 hours [3]. Both moderate and

severe hepatic and renal impairment affect the

pharmacokinetics of exemestane, but dose adjustments

do not appear to be necessary [3].