Re: Re: Reliable Source for Bremelanotide (PT-141)?

[Guest guest]

does anyone know if there is a pill for PT-141 now that works; I don't want to

have to inject anything. Thanks.

Bill

From: edhill_2006@...

Date: Mon, 30 Aug 2010 15:38:43 +0000

Subject: Re: Reliable Source for Bremelanotide (PT-141)?

http://www.melanotanus.com/

>

> Does anyone here use Bremelanotide (formerly called PT-141)?

> Do you have a high-purity (>99%)source that doesn't have mannitol or other

fillers in it?

> If you don't know what bremelanotide is, google it!

>

[Guest guest]

Hi Kris and you can post here anything thats on your mind.

Here is what Romeo B. no, MD, physician, psychiatrist

says about this here is a link and a cut and paste in case your not a member

there.

http://www.definitivemind.com/forums/showthread.php?t=436 & highlight=Bremelanotid\

e

As for your DH doing shots every 2 weeks is very old kind of TRT many good Dr.'s

have found doing this puts the poor guy on a roller coaster ride up after the

shot only to fall to low by the next one. After all we feel good when levels go

up but bad when they fall to low.

Even in the AACE Guildelines and this is dated on page 11 it states to start

shots at 100 mgs every 2 to 10 days.

http://www.aace.com/pub/pdf/guidelines/hypogonadism.pdf

Today Dr.'s up on this will do shots 2x's per week some every 3 days this is

what I do. And Dr.'s add in HCG doing 250 IU's of HCG the day before there shot

to keep there Testis working going on TRT shuts down the brain from sending LH

the message that tell his Testis to make T and in time his testis will get

smaller from not working. Go to Dr. 's site www.allthingsmale.com and read

TRT: A Recipe for Success and His HCG update.

====================================================

Re: Melantan II - Dr. M any thoughts?

--------------------------------------------------------------------------------

Quote:

Originally Posted by wondering

I saw the post below over at the AM forum. I haven't heard of melanotan and

doing a search see that it hasn't been discussed here before. Anyone with info.

or an opinion?

" Longish post concerning problems with low libido (most likely due to low

dopamine levels) even after testosterone is fixed.

Quick history on me. I'm taking medication for hypothyroidism and low

testosterone levels. My thyroid numbers have been good for a couple of years

now. After a year or so of trying Androgel, then HCG alone, then testosterone

cypionate alone, then testosterone cyptionate + HCG, I think at least my

testosterone and estrogen numbers are balanced. Yet another blood test in less

than a week will confirm whether this is the case.

One thing that hasn't really changed is seemingly low or mediocre libido, sex

drive, etc. It's better than it was when my testosterone levels were below

range, but probably still low for a healthy, fit 40 year old, and I've had

associated ED problems off and on for a couple of years. These issues haven't

been great for relationships. I've tried Viagra and similar drugs, but they only

affect the vascular system to increase blood flow to the penis, and then

seemingly only if testosterone and estrogen levels are okay. They don't do

anything to increase libido, which is centered in the brain and nervous system.

Consequently, results were not always great with the blue pill and equivalents.

About a year or so ago I had a blood test that measured various catecholamines:

norepenephrine: 345 pg/mL [range 0-399]

epinephrine: 44 pg/mL [range 0-99]

dopamine: <10 pg/mL [range 0-142]

catecholamine: <399 pg/mL [range 0-642]

Clearly dopamine is quite low. My doc had me try cabergoline for awhile, but I

didn't see much (if any) effect, so we stopped that to focus on straightening

out testosterone levels. My understanding is that low dopamine levels adversely

affect sex drive.

I recently became curious about whether Melanotan II or Bremelanotide (PT-141)

might be of benefit, so I ordered some Melanotan II and started injecting at 0.5

mg/day at bedtime (I'm 6'2 " and weight about 190lbs). I experienced greatly

enhanced sex drive within a few hours, in addition to much firmer and consistent

morning erections. I was actually concerned about the duration of the erection

when I woke up at 2:30am the first morning, so I stuck a flexible cold pack in

my shorts to ensure blood had a chance to circulate.

The increase in sex drive was sufficiently distracting to lower my Melanotan II

dosage level to 0.35 mg/day. Around the same time I had to start taking

Prednisone (steroid based anti-inflamatory) for a minor nerve impingement

problem, and Prednisone's myriad side effects seemed to counteract the Melanotan

II benefits. However, after tapering off of the Prednisone over the past few

days, my sex drive seems to be back in high gear - - - sufficiently so that I

might lower my Melanotan II dosage level again.

I seem to have a very dramatic response to the Melanotan II at a very low dosage

level, at least compared to other people. I'm wondering if that has anything to

do with my low dopamine levels? I have a technical background, but it's not in

chemistry or biology, so I don't really know what mechanisms are at work here. "

It is an interesting compound that has not yet been approved by the FDA.

Looks like the studies for using it to improve sex drive have ended - for some

reason - perhaps due to adverse effects.

A good starting point is to read information on the website:

http://melanotan.org/

Here is an abstract from Medline:

Quote:

Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9.

Melanocortin receptor agonists, penile erection, and sexual motivation: human

studies with Melanotan II.

Wessells H, Levine N, Hadley ME, Dorr R, Hruby V.

Section of Urology, The University of Arizona College of Medicine, Tucson,

85724, USA. hwessels@...

We review our experience with Melanotan II, a non-selective melanocortin

receptor agonist, in human subjects with erectile dysfunction (ED). Melanotan II

was administered to 20 men with psychogenic and organic ED using a double-blind

placebo-controlled crossover design. Penile rigidity was monitored for 6 h using

RigiScan. Level of sexual desire and side effects were reported with a

questionnaire. In the absence of sexual stimulation, Melanotan II led to penile

erection in 17 of 20 men. Subjects experienced a mean of 41 min Rigiscan tip

rigidity>80%. Increased sexual desire was reported after 13/19 (68%) doses of

Melanotan II vs 4/21 (19%) of placebo (P<0.01). Nausea and yawning were

frequently reported side effects due to Melanotan II; at a dose of 0.025 mg/kg,

12.9% of subjects had severe nausea. We conclude that Melanotan II is a potent

initiator of penile erection in men with erectile dysfunction. Our findings

warrant further investigation of

melanocortin agonists and antagonists on penile erection. International Journal

of Impotence Research (2000) 12, Suppl 4, S74-S79.

PMID: 11035391 [PubMed - indexed for MEDLINE]

Here is another description from a peptide website:

Quote:

elanotan II is an analog of the peptide hormone alpha-melanocyte stimulating

hormone (a-MSH) that induces skin tanning. Melanotan II has the additional

effect of increasing libido and has also exhibited the potential to decrease

body fat mass and reduce food intake.

This formulation was developed at the University of Arizona. Researchers there

knew that one of the best defenses against skin cancer was a natural tan which

has been slowly developed over weeks. They hypothesized that an effective way to

reduce skin cancer rates in people would be to induce the body's natural tanning

system to produce a protective tan prior to UV exposure.

After synthesizing and screening hundreds of molecules, the researchers headed

by Dr. Victor Hruby, found a peptide that after trials and testing seemed to not

only be safe but also approximately 1,000 times more potent than natural a-MSH.

They dubbed this new peptide Melanotan. Since their discovery, numerous studies

dating back to the mid-1980s have shown no obvious toxic effects of Melanotan.

Melanotan II is a cyclic heptapeptide analog of the alpha-melanocyte stimulating

hormone.

And here is another abstract of a broad review of Melanocortins from Medline:

Quote:

Curr Drug Targets. 2003 Oct;4(7):586-97.

Melanocortins and their receptors and antagonists.

Voisey J, Carroll L, van Daal A.

The melanocortins are a group of small protein hormones derived by

post-translational cleavage of the proopiomelanocortin (POMC) gene product. The

known melanocortin hormones include alpha-melanocyte stimulating hormone (MSH),

beta-MSH, gamma-MSH and adrenocorticotropic hormone (ACTH). Five melanocortin

receptors (MCIR through to MC5R) have been identified and most of these show

tissue-specific expression patterns, as well as different binding affinities for

each of the melanocortin hormones. The central melanocortin system consists of

alpha-MSH, agouti-related protein (AGRP), MC3R and MC4R. AGRP and alpha-MSH are

believed to be the natural antagonist and agonist respectively of MC3R and MC4R.

This central melanocortin system is thought to play a fundamental role in the

control of feeding and body weight. Knock-out mice models and genetic studies

have pointed to the importance of the melanocortins in complex human pathways

such as pigmentation,

lipolysis, food intake, thermogenesis, sexual behaviour, memory and

inflammatory response. Recently the melanocortins and their receptors have been

the target for drug-based treatment of human physiological processes. MC3R and

MC4R are likely targets for controlling body weight; MCIR may be used in the

treatment of inflammation and MC2R for the treatment of glucocortical

deficiency. A role for MCSR still remains unclear, but the evidence suggests an

exocrine gland function.

PMID: 14535656 [PubMed - indexed for MEDLINE]

The melanocortins are a fairly new set of peptide hormones with their receptors,

which are new to research, which control multiple physiologic processes which

are desirable targets for treatment including: sexual function, skin tanning,

diabetes, weight loss, inflammation, memory, etc.

We'll have to see where this road heads. It is interesting.

There is a caveat: http://www.bmj.com/cgi/eletters/338/feb17_2/b566#209418.

It was noted in the British Medical Journal that some people who used Melanotan

had changes in their moles. Some developed malignant melanoma - a serious skin

cancer. Thus they warn against the use of drugs which haven't been fully studied

and approved.

In regard to dopamine tests, it is difficult to determine brain dopamine levels

from a lab test. With the plasma catecholamines, the dopamine is mostly leakage

from the norepinephrine secreting cells. It doesn't reflect nervous system

dopamine signaling.

__________________

-

Romeo B. no, MD, physician, psychiatrist

Any information provided on www.definitivemind.com is for informational purposes

only, is not medical advice, does not create a doctor/patient relationship or

liability, is not exhaustive, does not cover all conditions or their treatment,

and will change as knowledge progresses. Always seek the advice of your

physician or other qualified health provider before undertaking any diet,

exercise, supplement, medical, or other health program.

--------------------------------------------------------------------------------

Last edited by Drno; 08-01-2010 at 07:25 PM.

Co-Moderator

Phil

> From: Kris <magiclea@...>

> Subject: Re: Reliable Source for Bremelanotide (PT-141)?

>

> Date: Tuesday, December 28, 2010, 7:04 AM

> Hi, I just stumbled across

> Bremelanotide this morning in my never ending quest for

> helping my FSD!  I have no problems with the aspect of

> giving myself an subq injection with a tiny needle if it

> means 'waking up' my libido again! My T levels were high to

> begin with and with large doses of additional T with zero

> change other than lack of aversion (who wants to admit that

> they have gone from a 5 star sex drive to thinking all that

> poking and grunting is a bit nasty, I look at myself and

> wonder who I was and where did I go?) All T therapy had very

> very minimal side effects no matter how high the dose. The

> possibility of Bremelanotide is exciting. and like the

> poster am looking for a reliable source if my doctor will

> not/cannot prescribe. Is this drug approved for use in the

> U.S. for other reasons?

> ....On a side note:

> Posted a few times under " Kays hubby " with regard to dh and

> his journey with T gels, implants etc. He just did his first

> at home inject with Test Cyp, and it went wonderfully. His

> urolog has him doing every other week. My question is, would

> he 'feel' a roller coaster effect that would make him want

> every week, and if not, and his labs are ok do you see any

> problem with staying on that sched.

> .....I am amazed at the number of posts this forum has

> generated and its really very difficult to read/track down

> info in the group due to the vast numbers of them...but very

> glad this group is here as a long established source of info

> and community.

> ...thanks...

> Kay

> P.S. If any gals want to chat/share about their journey, I

> would love it.

>

> ---

>

>

>

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>

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