Guest guest Posted March 23, 2011 Report Share Posted March 23, 2011 Your dose may not be high enough http://www.ncbi.nlm.nih.gov/pubmed/6594001 Serum levels of sex hormone binding globulin (SHBG) were measured by radioelectro-immunoassay before and during administration of danazol in daily doses varying between 200 and 800 mg for a period of 1-6 months. After approximately one month of treatment, the SHBG concentrations began to approach a new steady state at a level of approximately 20-30% of the original concentration, depending on the dose of danazol. The proportional suppression of SHBG was significantly greater following 600 or 800 mg of danazol daily than following 200 or 400 mg. However, with all doses the SHBG levels after one month of treatment were well below the levels normally found in healthy males. The findings of the present investigation suggest that danazol exerts a direct inhibitory effect on the hepatic synthesis of SHBG, which is dependent of the dose of danazol, independent of estrogen concentration, but possibly accentuated by endogenous androgens. http://www.ncbi.nlm.nih.gov/pubmed/4040541 During treatment with danazol, levels of % free T were increased about three fold, but in contrast the SHBG concentration were significantly decreased. Similar changes in % free T were observed by computer simulation. These data suggest that the androgenic effects of danazol were the results of increased free T levels by the T-displacing ability of danazol from SHBG. The concentration of SHBG might be reduced as a consequence of increased levels of free T. On the other hand, danazol binding to androgen receptor might partially inhibit the action of excess amounts of free T, because the androgenization during therapy was too weak to compare the levels of free T > > With shbg close to 60. I started 25 mgs of danazol looking to slash it down to low 20's. There is a theory that using danazol may actual reset my bodys natural level. I have seen this happen with a few patients I have been working with in the past. I felt best with shbg 20 TT 900 at trough and when I was the most muscular, strongest and vascular. Right now I am using as temporary stop gap untill I resolve other issues to altering shbg levels (gut, and liver) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2011 Report Share Posted March 23, 2011 How do you think your level got from 20s to nearly 60? Could you elaborate on what liver and gut issues you're working on? I brought up grape seed extract on the thyroid board and Phil said you take it. Not sure if you knew that it raises SHBG (I Googled " grape seed raise shbg " ). I feel it doing this to me as it seems to blunt free androgens based on how I feel. But, I like the lighter skin it gives me and its surprisingly effective aromatase inhibiting properties. I'm doing nettle root and have been taking more lately and like the increased free testosterone feeling very much so. : ) -Nigel On 23 March 2011 14:55, hardasnails1973 <hardasnails1973@...> wrote: > > > With shbg close to 60. I started 25 mgs of danazol looking to slash it down > to low 20's. There is a theory that using danazol may actual reset my bodys > natural level. I have seen this happen with a few patients I have been > working with in the past. I felt best with shbg 20 TT 900 at trough and when > I was the most muscular, strongest and vascular. Right now I am using as > temporary stop gap untill I resolve other issues to altering shbg levels > (gut, and liver) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2011 Report Share Posted March 23, 2011 thats for women I found studys for men 25 mgs to 50 mgs was the dosage with dropping about 60%. I Start at 25 then check 3 weeks later. > > > > With shbg close to 60. I started 25 mgs of danazol looking to slash it down to low 20's. There is a theory that using danazol may actual reset my bodys natural level. I have seen this happen with a few patients I have been working with in the past. I felt best with shbg 20 TT 900 at trough and when I was the most muscular, strongest and vascular. Right now I am using as temporary stop gap untill I resolve other issues to altering shbg levels (gut, and liver) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2011 Report Share Posted March 23, 2011 GSE is for candida and antiseptive. I have not used it for years. Reservatrol may raise it, but unlikely at 250 mgs a day. It helps rejevenate my skin keeping gleeming. Was prolong time on t-3 can cause it increase. This is highly medically documented. From this response it indicated we do not have thyroid resistance where as people with thyroid resistance remained the same shbg. MY low AA urine also indictated low methylation, malabsorption, and other factors. So possible protein malnutritoi due to GI tract compromised. Nettle will not move shbg just free things up at the prostate receptor. Nettle will also drive e2 in to the ground in some people. I use a certain combinatoin of nutraceuticals to control e2 with patients with out AI. These pepole are usually in the 35-40 range e2 range. > > > > > > > With shbg close to 60. I started 25 mgs of danazol looking to slash it down > > to low 20's. There is a theory that using danazol may actual reset my bodys > > natural level. I have seen this happen with a few patients I have been > > working with in the past. I felt best with shbg 20 TT 900 at trough and when > > I was the most muscular, strongest and vascular. Right now I am using as > > temporary stop gap untill I resolve other issues to altering shbg levels > > (gut, and liver) > > > > > Quote Link to comment Share on other sites More sharing options...
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