Guest guest Posted March 13, 2011 Report Share Posted March 13, 2011 What can I be looking for if pregnenolone is working for me? I just received my order in a pump bottle. The instructions say use it 25 days and then take a 5 day break and start again. I just finished my 2nd day of usage. Thanks, Dan Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2011 Report Share Posted March 14, 2011 Most of what I know about this I read a Sticky at Dr. 's by the Mod. chilln " Hormones 101 " . Men don't need to use Preg 25 days on 5 days off this is for women. Here is a cut and past on how to find your best dose. From this link. http://www.musclechatroom.com/forum/content.php?118-cortisol-boost-101 It all starts with this link read down to " Part 1 " then click on that link. http://www.musclechatroom.com/forum/showthread.php?15290-Hormones-101 I don't follow this I just do my Preg. cream once in the morning. ================================================ BOOSTING THE CORTISOL-PRODUCTION-LINE, TREAT VIA PREGNENOLONE OR PROGESTERONE 2 Dosing Strategies A small percentage of us have two oral pregnenolone and progesterone dosing sweet spots, but only one of them will be optimal. (see above discussion re oral versus transdermal) The vast majority of us have two transdermal pregnenolone and progesterone dosing sweet spots, but only one of them will be optimal. A very very small minority of people should not use pregnenolone or progesterone to boost their cortisol because one of their adrenal enzymes is permanenly downregulated which severly limits either: a) pregnenolone <--> progesterone or: progesterone -> 17 hydroxyprogesterone or: c) 17 hydroxyprogesterone -> cortisol ### So the vast majority of us can find two pregnenolone, and two progesterone dosing sweet spots, and only one of them will be optimal. The two pregnenolone and progesterone dosing sweet spots are: 1) Our pregnenolone and progesterone " top up " sweet spot, for those whose cortisol-production-line operates at slow to normal rate. 2) Our pregnenolone and progesterone " replacement " sweet spot, for those whose cortisol-production-line operates at a high / fast rate. Initially we don't know what rate our cortisol-production-line operates at, and we can't determine it from labs (we don't yet know which genes are responsible for this rate) so we first find our pregnenolone " top-up " sweet spot since it uses a minimalist approach. If we discover that we must dose pregnenolone or progesterone more than 3 times per day, sticking to our " top up " sweet spot dose, then we can switch to the pregnenolone or progesterone " replacement " sweet spot dosing strategy. BOOST THE CORTISOL-PRODUCTION-LINE, TREAT VIA PREGNENOLONE OR PROGESTERONE Finding the pregnenolone and progesterone " top up " sweet spots This dosing strategy is to supplement with small doses of pregnenolone or progesterone which only " tops up " our pregnenolone or progesterone levels, and which only " tops up " cortisol too, and keeps cortisol just under the level which would cause mild ACTH suppression. The way we find the " top up " sweet spot is to; A) Find the minimum useful " top up " dose: ......a) Start out on a very small dose, which must not cause any increase in alertness and / or energy within 4 hours, or does not cause an improvement in your sleep quality overnight. ............Eg: oral=50mg, transdermal=5mg. ...... Increase the dose, each day, until you first notice an increase in alertness and / or energy within 4 hours, or causes an improvement in your sleep quality overnight. ............Eg: oral 50mg -> 100mg -> 150mg etc... ............Eg: transdermal 5mg -> 10mg -> 15mg -> 20mg -> 30mg -> 40mg etc... ......c) The dose which causes you to first notice an increase in alertness and / or energy within 4 hours, or causes an improvement in your sleep quality overnight, is your minimum useful " top up " dose. ......d) If you're using oral formulation, and you get to 500mg and you never notice an increase in alertness and / or energy within 4 hours, or your sleep quality never increases, then start over with a transdermal formulation. ......e) If you're using a transdermal formulation, and you get to 200mg and you never notice either spacey feelings, or an increase in alertness and / or energy within 4 hours, or you notice no improvement in sleep quality overnight, then either: ...........(i) You're not absorbing the base used by your compounding pharmacist (you should try switching bases to lipoderm) ...........(ii) Your adrenals are not synthesizing cortisol from your pregnenolone or progesterone (you should purchase a 24hr urinary test, eg: Rheins has markers for preg, prog and cortisol. Genova has markers for prog, 17 hydroxyprog. Meridian has markers for prog, cortisol) Now find the " top up " dose sweet spot ......a) Increase the dose each day, and monitor the intensity and duration of the improvement of alertness and / or energy ...........Eg: increase your oral dose by 50mg each day ...........Eg: increase your transdermal dose by 10mg each day ...... The intensity and duration of the improvement of alertness and / or energy should initially increase (with increasing dose) and then decrease (with continued increases in dosage. ......c) Too high a dose brings on the yawns (due to ACTH suppression) this is normal, reduce your dose. ......d) Too high a dose brings on spacey feelings and / or a tingly face without the yawns, then your adrenal enzymes aren't synthesizing preg all the way to cortisol, and your adrenal enzymes need to be upregulated by a boost to your thyroid hormones - see the Thyroid Boost 101 primer. ......e) Adjust the dose around the sweet spot to confirm that you've found your " top up " sweet spot. C) Now find how many times per day you need to " top up " your pregnenolone or progesterone ......a) As each dose wears off, if you still experience symptoms of too low cortisol, or a downregulated cortisol-production-line, then re-apply the same " sweet spot " dose. ...... If your body requires repeated applications of " top up " doses, it can become annoying, in which case discuss with your medical professional adviser to consider switching from pregnenolone top-up dosing during the day, to pregnenolone replacement dosing during the day - for a few weeks. Once you can keep your pregnenolone levels relatively high all day (let them lower at night to get to sleep) with only a " convenient " number of doses (you define this) then it's time to introduce thyroid hormones to get your cells to start absorbing the extra cortisol you're creating with all that extra pregnenolone. If you've found your " top up " sweet spot, and either: a) your sleep hasn't improved adequately, or your energy hasn't improved adequately, or: c) your E2 hasn't been lowered sufficiently, then: your pregnenolone or progesterone are most likely getting backed up, so now you need to introduce the boost to your thyroid hormones to invigorate your adrenal enzymes to synthesize all of your preg and prog into cortisol, without backing up Boosting thyroid hormones is the second step in the overall step-by-step hormone modulation therapy explained in the Hormone Modulation Therapy 101 primer. BOOST THE CORTISOL-PRODUCTION-LINE, TREAT VIA PREGNENOLONE OR PROGESTERONE Why increasing our " top up " dose past the sweet spot (by a small amount), results in no more improvement Increasing the dose of pregnenolone or progesterone past the sweet spot by a small amount, causes a too large increase in cortisol, which causes mild ACTH suppression, which results in downregulation of self-made pregnenolone greater than the amount of supplementary pregnenolone taken, which results in overall lower pregnenolone, causing a downregulation of neurotransmitters, which increases drowsiness. In those whose cortisol-production-line operates at a slow to intermediate rate, this " top up " dosing strategy only requires once-per-day dosing, or twice-per-day dosing or some may elect to use this dosing strategy with 3-times-per-day dosing. For these people, this dosing strategy is also their optimal dosing strategy. In those whose cortisol-production-line operates at a high / fast rate (like chilln), this requires 6 to 10 times per day dosing. For these people the " top up " sweet spot is not optimal. In those whose cortisol-production-line operates at a high / fast rate (like chilln), gradually increasing the dose past the " top up " sweet spot by a large amount, eventually causes complete ACTH suppression. At this point the dose is sufficient to replace all of our requirements for pregnenolone or progesterone (as appropriate) for several hours. The large reservoir of supplementary hormone is used up more slowly than the much smaller " top up " doses. This type of dosing is called " replacement " dosing. BOOST THE CORTISOL-PRODUCTION-LINE, TREAT VIA PREGNENOLONE Finding the pregnenolone " replacement " sweet spot A) First find your " top up " dose sweet spot (see above) Find your minimum " replacement " dose ......a) Starting with twice the dose of pregnenolone which was your " top up " dose sweet spot, confirm that this dose results in only minimal alertness (sometimes none) but definitely causes drowsiness within an hour. This is not yet your minimum " replacement " dose of pregnenolone. ...... Increase the dose of pegnenolone until the dose is enough to restore alertness ...........Eg: increase oral pregnenolone by 100mg each day ...........Eg: increase transdermal pregnenolone by 50mg each day ......c) The dose of pregnenolone which is at least double your " top up " dose, and which causes you to first notice an increase in alertness and / or energy within 4 hours, is your minimum useful " replacement " dose. At this point you will have replaced all of your naturally produced pregnenolone with exogenous pregnenolone. ......d) If you're using oral pregnenolone, and you get to 1000mg and you never notice an increase in alertness and / or energy within 4 hours, then start over with transdermal pregnenolone. ......e) If you're using transdermal pregnenolone, and you get to 500mg and you never notice an increase in alertness and / or energy within 4 hours, then either: ...........(i) You're not absorbing the base used by your compounding pharmacist (you should try switching bases to lipoderm) ...........(ii) Your adrenals are not synthesizing enough cortisol from your pregnenolone (you should purchase a 24hr urinary test which measures many of the adrenal hormones, eg: Genova, or get doctors prescription for Rheins) C) Now find the " replacement " dose sweet spot ......a) Increase the dose of pregnenolone, each day, and monitor the intensity and duration of the improvement of alertness and / or energy ...........Eg: increase oral pregnenolone by 100mg each day ...........Eg: increase transdermal pregnenolone by 50mg each day ...... The intensity and duration of the improvement of alertness and / or energy should initially increase (with increasing pregnenolone) and then decrease with continued increases in pregnenolone. ......c) Adjust the dose of pregnenolone around the sweet spot to confirm that you've found your " replacement " sweet spot. D) Now find how many times per day you need to " replace " your pregnenolone ......a) As each dose of pregnenolone wears off, if you still experience symptoms of too low cortisol, or a downregulated cortisol-production-line, then re-apply the same " sweet spot " dose of pregnenolone. ...... If your body requires repeated applications of " replacement " pregnenolone doses, the solution is to supplement with transdermal progesterone, which has a much longer half life than pregnenolone in the human body - but this is currently experimental. Co-Moderator Phil > From: Dan Lee <nvestnyuth@...> > Subject: pregnenolone working? > > Date: Monday, March 14, 2011, 12:06 AM > What can I be looking for > if pregnenolone is working for me? I just received my > order in a pump bottle. The instructions say use it 25 > days and then take a 5 day break and start again. I just > finished my 2nd day of usage. Thanks, > > Dan > > > > > Quote Link to comment Share on other sites More sharing options...
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