Article on HCG

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Interesting article in PubMed on HCG - Article is based on secondary hypo guys

but discusses the volume increase in testicle volume while on HGC. Basically the

average went from 5 ml to 10.8 ml. Also discusses how it greatly increases sperm

production. I put the link at the bottom - here is the abstract:

Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the

response to human chorionic gonadotropin is predicted by initial testicular

size.

Burris AS, Rodbard HW, Winters SJ, Sherins RJ.

Developmental Endocrinology Branch, National Institute of Child Health and Human

Development, Bethesda, land 20892.

This study was designed to determine whether exogenous hCG alone can complete

spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was

administered to 22 men with IHH until maximal testicular growth was achieved.

Their mean testicular volume increased from 5.5 +/- 1.1 (+/- SE) mL

(pretreatment) to 10.8 +/- 1.6 mL (maximum) during treatment (P less than

10(-6)). The maximum mean testicular volume was highly positively correlated

with initial volume (r = 0.84; P less than 10(-6)). All men attained normal

serum testosterone levels, and 7 of 22 men achieved supraphysiological serum

estradiol levels. During hCG treatment, 14 of the 22 men had sperm appear in

their semen. Six of 11 men with complete gonadotropin deficiency, defined as an

initial mean testicular volume less than 4 mL, became sperm positive during hCG

treatment. In contrast, 9 of 11 men with partial gonadotropin deficiency

(initial mean testicular volume of 4 mL or more)

produced sperm during treatment (P less than 0.001). Sperm concentration was

highly positively correlated with both pretreatment (r = 0.65; P less than 0.01)

and final testicular volume (r = 0.73; P less than 0.0001). Of 13 men attempting

to impregnate their partners, 7 were successful in initiating conception; a

total of 8 pregnancies ensued. The sperm concentration at the time of conception

was less than 10 million/mL in all but 1 man. Our study demonstrates that hCG,

in the absence of exogenous FSH, can complete spermiogenesis in men with partial

gonadotropin deficiency. The response to hCG in men with IHH is predicted by the

initial testicular volume.

Arkansas

http://www.ncbi.nlm.nih.gov/pubmed/3372679