Guest guest Posted November 28, 2010 Report Share Posted November 28, 2010 http://hrt-rx.com/2010/11/26/new-testosterone-med-axiron/ While there are many seemingly positive attributes to Axiron that might make it a strong contender on the U.S. hormone market, this new preparation may also have some notable disadvantages. In particular, the more limited surface area of the axillae may cause the solution to hit saturation limits very quickly. The skin will only absorb a certain amount of hormone; you cannot keep escalating the dosage of a topical product without running into diminishing absorption at some point. In the case of Axiron, the product is applied to a very small area of skin. This seems to cause absorption limits to be reached at much lower thresholds compared to Androgel/Testim. The problem with delivery limits seems to be apparent in the prescribing information. The product delivers 30 mg per pump; so 1-4 pumps are used per day. The data shows an average testosterone concentration of 300-350 ng/dL after 7 days of using 1 pump per day. With two pumps, the level hovers somewhere between 350-450 ng/dL. When the individual needs 3-4 pumps, the armpit(s) must be used twice. The resulting testosterone level at 3 pumps is only marginally higher than 2 (400-475 ng/nL). The 7-day values for 4 pumps are not provided, however, data is given that shows the average testosterone concentration after 120 days of use to be 493, 506, 415, and 390 ng/dL for the 30, 60, 90, and 120 mg doses, respectively. The double applications on the armpit(s) are not yielding higher levels. The literature adopts the range of 300-1050 ng/dL as " normal " (many researchers, myself included, extend the normal range to 1200 ng/dL). Even with this scale, Axiron produces an average testosterone level that failed to reach the mid-point of 675 ng/dL. Regardless of the dose applied, the average testosterone level remained within the lower half of the normal range (around 400-500 ng/dL). In comparison, a 100 mg dose of Androgel results in average levels of around 800 ng/dL. This may be a very important distinction. We know from other studies that higher blood levels of testosterone are often necessary to correct certain symptoms of androgen deficiency. The highest quartile of normal is also a common objective of HRT/anti-aging medicine. Many patients will likely be unable to achieve this with the recommended use of Axiron. Summary Axiron appears to have both strong positives and negatives. For patients that are asymptomatic on low doses of other topical testosterone medications (for example, 50 mg/5 g per day of Androgel or Testim), this product may be an easier and " less messy " alternative. For those that require higher blood levels of testosterone, however, Axiron may not be a sufficient product. With average blood levels falling in the lower half or quartile of normal, it is unlikely to become a primary item of choice with physicians that strive to " optimize " testosterone levels at the higher end of the normal range. While some patients may achieve such levels with this product, its inconsistency to do so will likely leave Androgel and Testim as the primary topical testosterone products of choice for this type of application. > > Saw this on drudgereport: > > Australian Firm To Sell World's First Armpit Testosterone Lotion In US > Updated: Friday, 26 Nov 2010, 11:30 AM EST > Published : Friday, 26 Nov 2010, 8:43 AM EST > > By Jane Lee / news.com.au > > An Australian company will sell the world's first armpit testosterone lotion in American stores next year after receiving approval from the US Food and Drug Administration, news.com.au reported Friday. > > The lotion, created by Melbourne-based drug delivery firm Acrux, treats men with hypogonadism, a disease which produces low testosterone levels and includes symptoms such as erectile dysfunction, low sexual desire and performance. > > Axiron -- an anagram for " iron ax " -- is the first testosterone replacement therapy to be applied in the armpit, with current treatments including a gel for the upper body and regular injections. > > Only available by prescription, Axiron will be sold for the first time next year in the US, which has the world’s largest market for testosterone replacement, worth about $1 billion a year. > > Acrux CEO Treagus said: " What we’ve found is the population is aging in the US, Australia and around the world, and with [that comes] greater awareness around men’s health issues; more are now receiving treatment for them. " > > Read more: http://www.news.com.au/business/business-owner/aussie-hypogonadism-lotion-to-deb\ ut-in-us-in-2011/story-e6frfm5i-1225961457290 > > Arkansas > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 29, 2010 Report Share Posted November 29, 2010 Good points for me this is no good just like the gels I could never get good levels. Co-Moderator Phil > From: cvictorg <cvgrashow@...> > Subject: Re: Axiron > > Date: Sunday, November 28, 2010, 9:20 PM > http://hrt-rx.com/2010/11/26/new-testosterone-med-axiron/ > > While there are many seemingly positive attributes to > Axiron that might make it a strong contender on the U.S. > hormone market, this new preparation may also have some > notable disadvantages. In particular, the more limited > surface area of the axillae may cause the solution to hit > saturation limits very quickly. The skin will only absorb a > certain amount of hormone; you cannot keep escalating the > dosage of a topical product without running into diminishing > absorption at some point. In the case of Axiron, the product > is applied to a very small area of skin. This seems to cause > absorption limits to be reached at much lower thresholds > compared to Androgel/Testim. > > The problem with delivery limits seems to be apparent in > the prescribing information. The product delivers 30 mg per > pump; so 1-4 pumps are used per day. The data shows an > average testosterone concentration of 300-350 ng/dL after 7 > days of using 1 pump per day. With two pumps, the level > hovers somewhere between 350-450 ng/dL. When the individual > needs 3-4 pumps, the armpit(s) must be used twice. The > resulting testosterone level at 3 pumps is only marginally > higher than 2 (400-475 ng/nL). The 7-day values for 4 pumps > are not provided, however, data is given that shows the > average testosterone concentration after 120 days of use to > be 493, 506, 415, and 390 ng/dL for the 30, 60, 90, and 120 > mg doses, respectively. The double applications on the > armpit(s) are not yielding higher levels. > > The literature adopts the range of 300-1050 ng/dL as > " normal " (many researchers, myself included, extend the > normal range to 1200 ng/dL). Even with this scale, Axiron > produces an average testosterone level that failed to reach > the mid-point of 675 ng/dL. Regardless of the dose applied, > the average testosterone level remained within the lower > half of the normal range (around 400-500 ng/dL). In > comparison, a 100 mg dose of Androgel results in average > levels of around 800 ng/dL. This may be a very important > distinction. We know from other studies that higher blood > levels of testosterone are often necessary to correct > certain symptoms of androgen deficiency. The highest > quartile of normal is also a common objective of > HRT/anti-aging medicine. Many patients will likely be unable > to achieve this with the recommended use of Axiron. > > Summary > > Axiron appears to have both strong positives and negatives. > For patients that are asymptomatic on low doses of other > topical testosterone medications (for example, 50 mg/5 g per > day of Androgel or Testim), this product may be an easier > and " less messy " alternative. For those that require higher > blood levels of testosterone, however, Axiron may not be a > sufficient product. With average blood levels falling in the > lower half or quartile of normal, it is unlikely to become a > primary item of choice with physicians that strive to > " optimize " testosterone levels at the higher end of the > normal range. While some patients may achieve such levels > with this product, its inconsistency to do so will likely > leave Androgel and Testim as the primary topical > testosterone products of choice for this type of > application. > > > > > > > > > > > Saw this on drudgereport: > > > > Australian Firm To Sell World's First Armpit > Testosterone Lotion In US > > Updated: Friday, 26 Nov 2010, 11:30 AM EST > > Published : Friday, 26 Nov 2010, 8:43 AM EST > > > > By Jane Lee / news.com.au > > > > An Australian company will sell the world's first > armpit testosterone lotion in American stores next year > after receiving approval from the US Food and Drug > Administration, news.com.au reported Friday. > > > > The lotion, created by Melbourne-based drug delivery > firm Acrux, treats men with hypogonadism, a disease which > produces low testosterone levels and includes symptoms such > as erectile dysfunction, low sexual desire and performance. > > > > Axiron -- an anagram for " iron ax " -- is the first > testosterone replacement therapy to be applied in the > armpit, with current treatments including a gel for the > upper body and regular injections. > > > > Only available by prescription, Axiron will be sold > for the first time next year in the US, which has the > world’s largest market for testosterone replacement, > worth about $1 billion a year. > > > > Acrux CEO Treagus said: " What we’ve > found is the population is aging in the US, Australia and > around the world, and with [that comes] greater awareness > around men’s health issues; more are now receiving > treatment for them. " > > > > Read more: http://www.news.com.au/business/business-owner/aussie-hypogonadism-lotion-to-deb\ ut-in-us-in-2011/story-e6frfm5i-1225961457290 > > > > > Arkansas > > > > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
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