Re: Arimidex as to sides and study's.

[Guest guest]

Sorry to butt in on this thread, but after reading the post below, I had

a question:

Why would Arimidex do anything to a woman's E2 levels? It's an aromatase

inhibitor and women's E2 is not produced through aromatase. It's

produced in the same way men produce T, by the " gonads " , which, in

women, of course, are the ovaries.

On 3/14/2010 10:16 AM, pmgamer18 wrote:

>

> This was a reply by Chillin a Mod. at Dr. 's forum and I feel this

> says it all.

> =======================================================================

> Originally Posted by jcfitzge

> I recently read a post that mentioned that Arimidex had side effects.

> My doctor just started me Arimidex and I am curious what side effects

> I should be aware of. All input is appreciated.

>

> Thanks in advance.

>

> My previous discussions were false starts because I tried to take a

> high level approach, but people decided to get caught up in a

> philosophical discussion of whether an effect is a primary effect or a

> side effect.

>

> That discussion is actually a major distraction because your real

> question is:

>

> " When I take arimidex, what are all of the biological processes which

> will happen inside my body ? " .

>

> The concept of a primary effect or a side effect is meaningless if you

> ask this question.

> So I'm going to answer this question and cut straight to the chase.

>

> The answer to that question is that arimidex will:

> a) inhibit the action of the aromatase enzymes throughout your body,

> and

> gradually be metabolized by your liver.

> and

> c) do nothing else <--- CRITICAL !

>

> Everything else which occurs in your body is a downstream result of

> either:

> a) the inhibition of the aromatase enzymes in your body

> and

> the metabolization of the arimidex by your liver.

>

> The effects of inhibiting the aromatase enzymes in your body will be a

> reduction in the amount of conversion of your T (testosterone) into E2

> (estradiol) - the most powerful estrogen.

>

> Which will initially result in a reduction in your E2, and a

> corresponding increase in your T, and these two hormone level changes

> will feedback on many of your remaining hormones, using several

> different feedback loops.

>

> As a result, the effects of supplementing with armidex will be the

> modulation of several hormone levels, even though arimidex only

> directly affects the amount of T (testosterone) being converted into E2.

>

> ###

>

> The effects of metabolizing the arimidex in your liver will tax your

> liver by an amount proporitional to the dose of arimidex. Since you're

> only taking " male " dosage levels of arimidex, this effect is trivial.

>

> If you were taking female-on-anti-cancer-therapy doses of arimidex (1

> tab per day) then your liver will suffer over a decade or two, but

> then arimidex was never assumed to be taken for such long durations at

> such high dosages, because female cancer sufferers are never expected

> to live for decades after contracting cancer, and having to kill off

> close to 100% of their estradiol.

>

> ###

>

> There are no " decades-long " studies of arimidex, using male dosages

> (approx 0.1 mg per day) so you're not going to find any papers proving

> that arimidex is safe over decades of use at male dosages (approx 0.1

> mg per day).

>

> We know arimidex is safe because males (mostly body builders) have

> been using arimidex since soon after 1994 when Astra Zeneca developed

> it. These males have been taking arimidex longer than you have (and

> most likely ever will) and if they ever experience any long term

> effects, then we will broadcast that info here, and you can abandon

> arimidex long before it will ever become a problem for you.

>

> The development of arimidex was a refinement of several previous

> not-sufficiently-specific aromatase inhibitors. Those earlier

> generation aromatase inhibitors suppressed more than just P450

> aromatase enzymes, hence a more specific aromatase inhibitor had to be

> developed.

>

> Astra Zeneca developed arimidex with the specific intention of

> ensuring that the drug acted only on P450 aromatase enzymes, and

> that's exactly what they achieved.

>

> As far as anyone has ever been able to ascertain, that's all there is.

> That's what makes arimidex such a relatively safe drug. It's extremely

> specific to the aromatase enzyme.

>

> ###

>

> It's up to your medical professional adviser to predict how the

> remaining hormones in your body will move (change levels) after the

> reduction in E2, but we can help you with that.

>

>

[Guest guest]

I think Arimidex only works this way in women.

===================================================

An aromatase inhibitor cannot lower estrogen levels made by the ovaries. That is

why an aromatase inhibitor only works after menopause, when a woman's ovaries

have stopped making estrogen and other hormones.1

===================================================

How women make Aromatase I think it is made from there Adreals after menopause.

Co-Moderator

Phil

> >

> > This was a reply by Chillin a Mod. at Dr. 's forum

> and I feel this

> > says it all.

> >

> =======================================================================

> > Originally Posted by jcfitzge

> > I recently read a post that mentioned that Arimidex

> had side effects.

> > My doctor just started me Arimidex and I am curious

> what side effects

> > I should be aware of. All input is appreciated.

> >

> > Thanks in advance.

> >

> > My previous discussions were false starts because I

> tried to take a

> > high level approach, but people decided to get caught

> up in a

> > philosophical discussion of whether an effect is a

> primary effect or a

> > side effect.

> >

> > That discussion is actually a major distraction

> because your real

> > question is:

> >

> > " When I take arimidex, what are all of the biological

> processes which

> > will happen inside my body ? " .

> >

> > The concept of a primary effect or a side effect is

> meaningless if you

> > ask this question.

> > So I'm going to answer this question and cut straight

> to the chase.

> >

> > The answer to that question is that arimidex will:

> > a) inhibit the action of the aromatase enzymes

> throughout your body,

> > and

> > gradually be metabolized by your liver.

> > and

> > c) do nothing else <--- CRITICAL !

> >

> > Everything else which occurs in your body is a

> downstream result of

> > either:

> > a) the inhibition of the aromatase enzymes in your

> body

> > and

> > the metabolization of the arimidex by your liver.

> >

> > The effects of inhibiting the aromatase enzymes in

> your body will be a

> > reduction in the amount of conversion of your T

> (testosterone) into E2

> > (estradiol) - the most powerful estrogen.

> >

> > Which will initially result in a reduction in your E2,

> and a

> > corresponding increase in your T, and these two

> hormone level changes

> > will feedback on many of your remaining hormones,

> using several

> > different feedback loops.

> >

> > As a result, the effects of supplementing with armidex

> will be the

> > modulation of several hormone levels, even though

> arimidex only

> > directly affects the amount of T (testosterone) being

> converted into E2.

> >

> > ###

> >

> > The effects of metabolizing the arimidex in your liver

> will tax your

> > liver by an amount proporitional to the dose of

> arimidex. Since you're

> > only taking " male " dosage levels of arimidex, this

> effect is trivial.

> >

> > If you were taking female-on-anti-cancer-therapy doses

> of arimidex (1

> > tab per day) then your liver will suffer over a decade

> or two, but

> > then arimidex was never assumed to be taken for such

> long durations at

> > such high dosages, because female cancer sufferers are

> never expected

> > to live for decades after contracting cancer, and

> having to kill off

> > close to 100% of their estradiol.

> >

> > ###

> >

> > There are no " decades-long " studies of arimidex, using

> male dosages

> > (approx 0.1 mg per day) so you're not going to find

> any papers proving

> > that arimidex is safe over decades of use at male

> dosages (approx 0.1

> > mg per day).

> >

> > We know arimidex is safe because males (mostly body

> builders) have

> > been using arimidex since soon after 1994 when Astra

> Zeneca developed

> > it. These males have been taking arimidex longer than

> you have (and

> > most likely ever will) and if they ever experience any

> long term

> > effects, then we will broadcast that info here, and

> you can abandon

> > arimidex long before it will ever become a problem for

> you.

> >

> > The development of arimidex was a refinement of

> several previous

> > not-sufficiently-specific aromatase inhibitors. Those

> earlier

> > generation aromatase inhibitors suppressed more than

> just P450

> > aromatase enzymes, hence a more specific aromatase

> inhibitor had to be

> > developed.

> >

> > Astra Zeneca developed arimidex with the specific

> intention of

> > ensuring that the drug acted only on P450 aromatase

> enzymes, and

> > that's exactly what they achieved.

> >

> > As far as anyone has ever been able to ascertain,

> that's all there is.

> > That's what makes arimidex such a relatively safe

> drug. It's extremely

> > specific to the aromatase enzyme.

> >

> > ###

> >

> > It's up to your medical professional adviser to

> predict how the

> > remaining hormones in your body will move (change

> levels) after the

> > reduction in E2, but we can help you with that.

> >

> >

>

>

>

> ------------------------------------

>

>

[Guest guest]

Estradiol is produced by the aromatization of androstenedione. It can also be

produced by the aromatization of testosterone. As such, aromatase inhibitors

block the synthesis of estradiol in both men and women. The testes and ovaries

use the same biochemical pathway.

________________________________

From: LostOne0069 <lostone0069@...>

Sent: Sun, March 14, 2010 10:49:40 AM

Subject: Re: Arimidex as to sides and study's.

Sorry to butt in on this thread, but after reading the post below, I had

a question:

Why would Arimidex do anything to a woman's E2 levels? It's an aromatase

inhibitor and women's E2 is not produced through aromatase. It's

produced in the same way men produce T, by the " gonads " , which, in

women, of course, are the ovaries.

On 3/14/2010 10:16 AM, pmgamer18 wrote:

>

> This was a reply by Chillin a Mod. at Dr. 's forum and I feel this

> says it all.

> =======================================================================

> Originally Posted by jcfitzge

> I recently read a post that mentioned that Arimidex had side effects.

> My doctor just started me Arimidex and I am curious what side effects

> I should be aware of. All input is appreciated.

>

> Thanks in advance.

>

> My previous discussions were false starts because I tried to take a

> high level approach, but people decided to get caught up in a

> philosophical discussion of whether an effect is a primary effect or a

> side effect.

>

> That discussion is actually a major distraction because your real

> question is:

>

> " When I take arimidex, what are all of the biological processes which

> will happen inside my body ? " .

>

> The concept of a primary effect or a side effect is meaningless if you

> ask this question.

> So I'm going to answer this question and cut straight to the chase.

>

> The answer to that question is that arimidex will:

> a) inhibit the action of the aromatase enzymes throughout your body,

> and

> gradually be metabolized by your liver.

> and

> c) do nothing else <--- CRITICAL !

>

> Everything else which occurs in your body is a downstream result of

> either:

> a) the inhibition of the aromatase enzymes in your body

> and

> the metabolization of the arimidex by your liver.

>

> The effects of inhibiting the aromatase enzymes in your body will be a

> reduction in the amount of conversion of your T (testosterone) into E2

> (estradiol) - the most powerful estrogen.

>

> Which will initially result in a reduction in your E2, and a

> corresponding increase in your T, and these two hormone level changes

> will feedback on many of your remaining hormones, using several

> different feedback loops.

>

> As a result, the effects of supplementing with armidex will be the

> modulation of several hormone levels, even though arimidex only

> directly affects the amount of T (testosterone) being converted into E2.

>

> ###

>

> The effects of metabolizing the arimidex in your liver will tax your

> liver by an amount proporitional to the dose of arimidex. Since you're

> only taking " male " dosage levels of arimidex, this effect is trivial.

>

> If you were taking female-on-anti-cancer-therapy doses of arimidex (1

> tab per day) then your liver will suffer over a decade or two, but

> then arimidex was never assumed to be taken for such long durations at

> such high dosages, because female cancer sufferers are never expected

> to live for decades after contracting cancer, and having to kill off

> close to 100% of their estradiol.

>

> ###

>

> There are no " decades-long " studies of arimidex, using male dosages

> (approx 0.1 mg per day) so you're not going to find any papers proving

> that arimidex is safe over decades of use at male dosages (approx 0.1

> mg per day).

>

> We know arimidex is safe because males (mostly body builders) have

> been using arimidex since soon after 1994 when Astra Zeneca developed

> it. These males have been taking arimidex longer than you have (and

> most likely ever will) and if they ever experience any long term

> effects, then we will broadcast that info here, and you can abandon

> arimidex long before it will ever become a problem for you.

>

> The development of arimidex was a refinement of several previous

> not-sufficiently-specific aromatase inhibitors. Those earlier

> generation aromatase inhibitors suppressed more than just P450

> aromatase enzymes, hence a more specific aromatase inhibitor had to be

> developed.

>

> Astra Zeneca developed arimidex with the specific intention of

> ensuring that the drug acted only on P450 aromatase enzymes, and

> that's exactly what they achieved.

>

> As far as anyone has ever been able to ascertain, that's all there is.

> That's what makes arimidex such a relatively safe drug. It's extremely

> specific to the aromatase enzyme.

>

> ###

>

> It's up to your medical professional adviser to predict how the

> remaining hormones in your body will move (change levels) after the

> reduction in E2, but we can help you with that.

>

>

------------------------------------

[Guest guest]

Thank you ED I am not feeling well today hurt my back yesterday and took a pain

pill that made me sick. My back is getting better think GOD I just pulled a

muscle. But that dam pain pill kicked my butt.

Co-Moderator

Phil

> >

> > This was a reply by Chillin a Mod. at Dr. 's forum

> and I feel this

> > says it all.

> >

> =======================================================================

> > Originally Posted by jcfitzge

> > I recently read a post that mentioned that Arimidex

> had side effects.

> > My doctor just started me Arimidex and I am curious

> what side effects

> > I should be aware of. All input is appreciated.

> >

> > Thanks in advance.

> >

> > My previous discussions were false starts because I

> tried to take a

> > high level approach, but people decided to get caught

> up in a

> > philosophical discussion of whether an effect is a

> primary effect or a

> > side effect.

> >

> > That discussion is actually a major distraction

> because your real

> > question is:

> >

> > " When I take arimidex, what are all of the biological

> processes which

> > will happen inside my body ? " .

> >

> > The concept of a primary effect or a side effect is

> meaningless if you

> > ask this question.

> > So I'm going to answer this question and cut straight

> to the chase.

> >

> > The answer to that question is that arimidex will:

> > a) inhibit the action of the aromatase enzymes

> throughout your body,

> > and

> > gradually be metabolized by your liver.

> > and

> > c) do nothing else <--- CRITICAL !

> >

> > Everything else which occurs in your body is a

> downstream result of

> > either:

> > a) the inhibition of the aromatase enzymes in your

> body

> > and

> > the metabolization of the arimidex by your liver.

> >

> > The effects of inhibiting the aromatase enzymes in

> your body will be a

> > reduction in the amount of conversion of your T

> (testosterone) into E2

> > (estradiol) - the most powerful estrogen.

> >

> > Which will initially result in a reduction in your E2,

> and a

> > corresponding increase in your T, and these two

> hormone level changes

> > will feedback on many of your remaining hormones,

> using several

> > different feedback loops.

> >

> > As a result, the effects of supplementing with armidex

> will be the

> > modulation of several hormone levels, even though

> arimidex only

> > directly affects the amount of T (testosterone) being

> converted into E2.

> >

> > ###

> >

> > The effects of metabolizing the arimidex in your liver

> will tax your

> > liver by an amount proporitional to the dose of

> arimidex. Since you're

> > only taking " male " dosage levels of arimidex, this

> effect is trivial.

> >

> > If you were taking female-on-anti-cancer-therapy doses

> of arimidex (1

> > tab per day) then your liver will suffer over a decade

> or two, but

> > then arimidex was never assumed to be taken for such

> long durations at

> > such high dosages, because female cancer sufferers are

> never expected

> > to live for decades after contracting cancer, and

> having to kill off

> > close to 100% of their estradiol.

> >

> > ###

> >

> > There are no " decades-long " studies of arimidex, using

> male dosages

> > (approx 0.1 mg per day) so you're not going to find

> any papers proving

> > that arimidex is safe over decades of use at male

> dosages (approx 0.1

> > mg per day).

> >

> > We know arimidex is safe because males (mostly body

> builders) have

> > been using arimidex since soon after 1994 when Astra

> Zeneca developed

> > it. These males have been taking arimidex longer than

> you have (and

> > most likely ever will) and if they ever experience any

> long term

> > effects, then we will broadcast that info here, and

> you can abandon

> > arimidex long before it will ever become a problem for

> you.

> >

> > The development of arimidex was a refinement of

> several previous

> > not-sufficiently-specific aromatase inhibitors. Those

> earlier

> > generation aromatase inhibitors suppressed more than

> just P450

> > aromatase enzymes, hence a more specific aromatase

> inhibitor had to be

> > developed.

> >

> > Astra Zeneca developed arimidex with the specific

> intention of

> > ensuring that the drug acted only on P450 aromatase

> enzymes, and

> > that's exactly what they achieved.

> >

> > As far as anyone has ever been able to ascertain,

> that's all there is.

> > That's what makes arimidex such a relatively safe

> drug. It's extremely

> > specific to the aromatase enzyme.

> >

> > ###

> >

> > It's up to your medical professional adviser to

> predict how the

> > remaining hormones in your body will move (change

> levels) after the

> > reduction in E2, but we can help you with that.

> >

> >

>

>

>

> ------------------------------------

>

>