Re: More info about SHBG and now Zinc.

[Guest guest]

Can you explain this in lay man terms

>

> I feel the men on T3 only meds for RT3 need to keep an eye on there SHBG

levels.

> http://tinyurl.com/36nxzdq

>

> Structure/function analyses of human sex hormone-binding globulin: effects of

zinc on steroid-binding specificity

>

> In humans, sex hormone-binding globulin (SHBG) binds and transports the

biologically most important androgens and estrogens in the blood, and regulates

the access of these steroids to their targets tissues. In addition to binding

sex steroids, SHBG has specific binding sites for divalent cations including

calcium and zinc. Zinc binding to a site at the entrance of the steroid-binding

pocket in human SHBG has been shown to reduce its affinity for estrogens, while

having no impact on the binding of C19 steroids. Crystallographic studies

indicate that C18 and C19 steroids are bound in opposite orientations within the

SHBG steroid-binding site, and we have obtained new information that supports a

molecular model explaining the mechanism by which zinc alters the affinity of

human SHBG for estrogens, by studying directly the estradiol-binding properties

SHBG variants created by site-directed mutagenesis. In this model, the

coordination of a zinc ion by the side chains of residues Asp65 and His136

eliminates a critical hydrogen bond between Asp65 and the hydroxyl at C3 of

estrogens, such as estradiol and 2-methoxyestradiol, and causes disorder in a

polypeptide loop segment that covers the steroid-binding site. The combination

of these structural changes explains the specific decrease in the affinity of

human SHBG for C18 steroids in the presence of a zinc ion.

>

[Guest guest]

A lot of info has been on the forums about RT3 being to high and people are

going on T3 only meds to get this down. I keep telling people this is a bandaid

you need to fix the problems making RT3 go to high. I have higher levels of RT3

from having Heart Bypass Surgery and now form Statin Drug damage causing me pain

in my lower back, hips and upper legs so bad I can't stand or walk. So this is

the kind of stress that will make RT3 levels go to high.

Now I can accross this link about SHBG binding up Zinc I know it binds up

Testosterone. Men doing T3 only meds that them higher doses are driving up

there SHBG and higher levels of SHBG are now not only binding up Testosterone

but Zinc too.

Here is a link to what started all this with taking T3 to lower RT3 and men

don't under stand why there Free Testosterone levels are below the normal

levels. It's the T3 only meds making there SHBG go to high. And most of them

men did not feel any better getting there RT3 levels down doing this.

People are reading this link and messing up there Testosterone levels trying to

get there RT3 down just because it's high and RT3 has a very short half life.

http://thyroid-rt3.com/

Co-Moderator

Phil

> From: gasper.patrico <gasper.patrico@...>

> Subject: Re: More info about SHBG and now Zinc.

>

> Date: Tuesday, October 26, 2010, 4:29 PM

> Can you explain this in lay man

> terms

>

>

> >

> > I feel the men on T3 only meds for RT3 need to keep an

> eye on there SHBG levels.

> > http://tinyurl.com/36nxzdq

> >

> > Structure/function analyses of human sex

> hormone-binding globulin: effects of zinc on steroid-binding

> specificity

> >

> > In humans, sex hormone-binding globulin (SHBG) binds

> and transports the biologically most important androgens and

> estrogens in the blood, and regulates the access of these

> steroids to their targets tissues. In addition to binding

> sex steroids, SHBG has specific binding sites for divalent

> cations including calcium and zinc. Zinc binding to a site

> at the entrance of the steroid-binding pocket in human SHBG

> has been shown to reduce its affinity for estrogens, while

> having no impact on the binding of C19 steroids.

> Crystallographic studies indicate that C18 and C19 steroids

> are bound in opposite orientations within the SHBG

> steroid-binding site, and we have obtained new information

> that supports a molecular model explaining the mechanism by

> which zinc alters the affinity of human SHBG for estrogens,

> by studying directly the estradiol-binding properties SHBG

> variants created by site-directed mutagenesis. In this

> model, the coordination of a zinc ion by the side chains of

> residues Asp65 and His136 eliminates a critical hydrogen

> bond between Asp65 and the hydroxyl at C3 of estrogens, such

> as estradiol and 2-methoxyestradiol, and causes disorder in

> a polypeptide loop segment that covers the steroid-binding

> site. The combination of these structural changes explains

> the specific decrease in the affinity of human SHBG for C18

> steroids in the presence of a zinc ion.

> >

>

>

>

>

> ------------------------------------

>

>

[Guest guest]

So my testosterone got low due to T3-only treatment? Maybe I am not

hypopituitary afterall?

Sendt fra min iPhone

Den 26. okt. 2010 kl. 23.22 skrev philip georgian <pmgamer18@...>:

A lot of info has been on the forums about RT3 being to high and people are

going on T3 only meds to get this down. I keep telling people this is a bandaid

you need to fix the problems making RT3 go to high. I have higher levels of RT3

from having Heart Bypass Surgery and now form Statin Drug damage causing me pain

in my lower back, hips and upper legs so bad I can't stand or walk. So this is

the kind of stress that will make RT3 levels go to high.

Now I can accross this link about SHBG binding up Zinc I know it binds up

Testosterone. Men doing T3 only meds that them higher doses are driving up there

SHBG and higher levels of SHBG are now not only binding up Testosterone but Zinc

too.

Here is a link to what started all this with taking T3 to lower RT3 and men

don't under stand why there Free Testosterone levels are below the normal

levels. It's the T3 only meds making there SHBG go to high. And most of them men

did not feel any better getting there RT3 levels down doing this.

People are reading this link and messing up there Testosterone levels trying to

get there RT3 down just because it's high and RT3 has a very short half life.

http://thyroid-rt3.com/

Co-Moderator

Phil

> From: gasper.patrico <gasper.patrico@...>

> Subject: Re: More info about SHBG and now Zinc.

>

> Date: Tuesday, October 26, 2010, 4:29 PM

> Can you explain this in lay man

> terms

>

>

> >

> > I feel the men on T3 only meds for RT3 need to keep an

> eye on there SHBG levels.

> > http://tinyurl.com/36nxzdq

> >

> > Structure/function analyses of human sex

> hormone-binding globulin: effects of zinc on steroid-binding

> specificity

> >

> > In humans, sex hormone-binding globulin (SHBG) binds

> and transports the biologically most important androgens and

> estrogens in the blood, and regulates the access of these

> steroids to their targets tissues. In addition to binding

> sex steroids, SHBG has specific binding sites for divalent

> cations including calcium and zinc. Zinc binding to a site

> at the entrance of the steroid-binding pocket in human SHBG

> has been shown to reduce its affinity for estrogens, while

> having no impact on the binding of C19 steroids.

> Crystallographic studies indicate that C18 and C19 steroids

> are bound in opposite orientations within the SHBG

> steroid-binding site, and we have obtained new information

> that supports a molecular model explaining the mechanism by

> which zinc alters the affinity of human SHBG for estrogens,

> by studying directly the estradiol-binding properties SHBG

> variants created by site-directed mutagenesis. In this

> model, the coordination of a zinc ion by the side chains of

> residues Asp65 and His136 eliminates a critical hydrogen

> bond between Asp65 and the hydroxyl at C3 of estrogens, such

> as estradiol and 2-methoxyestradiol, and causes disorder in

> a polypeptide loop segment that covers the steroid-binding

> site. The combination of these structural changes explains

> the specific decrease in the affinity of human SHBG for C18

> steroids in the presence of a zinc ion.

> >

>

>

>

>

> ------------------------------------

>

>

[Guest guest]

I need to be sure you under stand what I am saying. Doing T3 only meds

can drive up a mans SHBG levels over time it will not lower your Total

Testosterone or in your country S Testosterone levels but it will bind them up

so they are not working you can still have high levels.

But your Free Testosterone and Bio. Testosterone levels will become low and this

is what is working in your body.

Co-Moderator

Phil

>

> > From: gasper.patrico <gasper.patrico@...>

> > Subject: Re: More info about SHBG and

> now Zinc.

> >

> > Date: Tuesday, October 26, 2010, 4:29 PM

> > Can you explain this in lay man

> > terms

> >

> >

> > >

> > > I feel the men on T3 only meds for RT3 need to

> keep an

> > eye on there SHBG levels.

> > > http://tinyurl.com/36nxzdq

> > >

> > > Structure/function analyses of human sex

> > hormone-binding globulin: effects of zinc on

> steroid-binding

> > specificity

> > >

> > > In humans, sex hormone-binding globulin (SHBG)

> binds

> > and transports the biologically most important

> androgens and

> > estrogens in the blood, and regulates the access of

> these

> > steroids to their targets tissues. In addition to

> binding

> > sex steroids, SHBG has specific binding sites for

> divalent

> > cations including calcium and zinc. Zinc binding to a

> site

> > at the entrance of the steroid-binding pocket in human

> SHBG

> > has been shown to reduce its affinity for estrogens,

> while

> > having no impact on the binding of C19 steroids.

> > Crystallographic studies indicate that C18 and C19

> steroids

> > are bound in opposite orientations within the SHBG

> > steroid-binding site, and we have obtained new

> information

> > that supports a molecular model explaining the

> mechanism by

> > which zinc alters the affinity of human SHBG for

> estrogens,

> > by studying directly the estradiol-binding properties

> SHBG

> > variants created by site-directed mutagenesis. In

> this

> > model, the coordination of a zinc ion by the side

> chains of

> > residues Asp65 and His136 eliminates a critical

> hydrogen

> > bond between Asp65 and the hydroxyl at C3 of

> estrogens, such

> > as estradiol and 2-methoxyestradiol, and causes

> disorder in

> > a polypeptide loop segment that covers the

> steroid-binding

> > site. The combination of these structural changes

> explains

> > the specific decrease in the affinity of human SHBG

> for C18

> > steroids in the presence of a zinc ion.

> > >

> >

> >

> >

> >

> > ------------------------------------

> >

> >