Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 Hi and Welcome, First let me say men with a level for Total Testosterone at 400 and a low level of Free Testosterone need to do more labs to figure out whats wrong that there levels are so low. Yes the patch is old and for someone to use it they need HC cream to heal the red rash it leaves. Your going on Androgel at this low starting dose 5 grams I feel took your 400 levels down lower. At the end of this reply I will cut and paste a copy of a file I made about starting on gels. You said your LH and FSH was normal can you get a copy of your labs and post them. Men need to run labs a lot of them before going on TRT because it's for life you can't start on it be on it for a time then stop. Your brain sees the Testosterone meds in your blood and shuts down your HPTA - hypothalamic-pituitary-testicular axis. And stopping TRT it just dose not start back up again. Did your Dr. test your Estradiol levels if they were high above 40 this can lower your TT levels to 400 it makes your SHBG go up and this binds up your Testosteorne and you end up with low Free T. Getting Estraidol down you can add 200 to 300 Points to your 400 TT levels and your SHBG will go down and your Free T will go up near the top of the range. In this link it talks about this the link is about older men but I see this in younger men. http://jcem.endojournals.org/cgi/content/full/89/3/1174 Taking arimidex lowering Estraidol levels will bring up Testosteone. http://www.medibolics.com/ArimidexBoostsTestosterone.htm I am hoping you have not been on TRT long enough to shut down your HPTA and doing more labs to figure out why your feeling like this and if you find it and fix it your levels will go back up. TRT is the last thing you want to try. With high levels of Estraidol E2 your brain can't tell the difference between T and E2 so when E2 is high your brain thinks it is T and slows down sending the LH and FSH messages to your testis and they make less T. Here are some links read them learn about this so when you see a Dr. you know what your taking about and you will know if he knows. http://answers.google.com/answers/threadview?id=450553 ==================================================== According to the Great Smokies Diagnostic Lab, these are the causes of hypogonadism: chronic/systemic illness surgery chemotherapy infections premature aging testicular trauma stress Kleinfelter's syndrome autoimmune damage tobacco and alcohol sleep apnea excessive heat obesity hypercortisolism medications hyperthyroidism malnutrition ?Subtle clinical signs of hypogonadism may include slight gynecomastia and soft small testes. However, researchers have noted that " the findings of physical examination in men with adult-onset hypogonadism are often normal.? Secondary hypogonadism can develop as a result of hypothalamic or pituitary disease, obesity, hypothyroidism or other causes. Some conditions, such as hypercortisolemia, AIDS and severe systemic illnesses, can trigger hypogonadism through a combination of both primary and secondary mechanisms.? --------------------------------------------------- http://www.griffinmedical.com/male_hormone_modulation_therapy.html Get this book Testosterone: A Man's Guide By by Vergel it's a dam good book or buy the Kindle from Amazon.com Here is the cut and paste on what can happen starting on gels. =================================================== Starting on Androgel or Testim. Yes this happens a lot you start on a low starting dose 5 grams when your brain sees the testosterone in your blood even just a little it slows down even stops sending the LH and FSH message to your testis to make the Testosterone you were making. So lets say your labs for Total T were 350 you add this dose of gel your brain sees this and you lose the base level you had before the gel. Now lets say you need more then 5 grams most do so now all your left with is what the gel is doing so lets say it's doing 200 so you lost 150. The reason you feel good is your levels go up that 200 the gel is doing in the first 2 weeks so your levels go up to 550 in theory. The brain sees this and you fall back. Why can this happen it might be how your putting on the gel with Androgel you need to spread it over your upper arms and shoulders and down your back as far as you can reach this is half of your dose then do the other side. Just spread it over the area but don't rub it in. The other thing is it's not getting through your skin good so you need more. If you have a thyroid problem your skin will become thicker and gels and creams don't get through the skin and you need to switch to shots. I tell men when they go on Gels to retest in 2 weeks because you can end up feeling worse. Most men just need more gel. Dr.'s that tell men to go on 5 grams of gel and come back in 8 to 12 weeks for labs don't know much about the use of gels. Dr.'s that treat a lot of men for low T on gels see this happen and test them again in 2 weeks. When you go to do labs get up and shower that morning go do your labs and then put in the gel after your blood test so you don’t spike up your labs. If you can’t do labs in the morning shower put on the gel but don’t get any gel on the spot they take the blood from. Do your labs about 6 hrs later. Call your Dr. and tell him this and that your not feeling good you were but fell back. Co-Moderator Phil > From: jscottsmithunc <jscottsmithunc@...> > Subject: Guys...I need your help!! > > Date: Tuesday, January 25, 2011, 6:31 PM > New guy here. I am a 41 yo with > recent extreme fatigue, weight gain and reduced exercise > tolerance as well as lack of a morning woody. Found my > total testosterone to be around 400. My free was > 8.5 On my scale the low end of normal was 7.5. This > was an am test and I would imagine it drops considerably > during the day. Anyway, I was prescribed Androderm > patch which caused a horrific itchy rash on day 2. > Felt amazing however. Much more energy and sex went > through the roof. My doc then prescribed > Androgel. I used 5mg (4 pumps) and within 2 hours as > it peaked I had a terrific anxiety attack...felt some > shortness of breath and a heaviness in my breathing. > Went to the emergency room and was told it was an allergic > reaction and to never take any testosterone again! > I am really down in the dumps now. Something that helped me > so much now to not be able to take it. I do tend to be > a very stressed guy and have had anxiety for many > years...panic attacks about 10 years ago. Have done > well with no meds etc...just cut out caffeine. > This reaction today seemed more like a panic attack and > anxiety than an allergic reaction. > I have checked my thyroid and cortisol and they are > fine. My LH and FSH were normal as well. I will > try to check estradiol and progesterone, though I am > skeptical that they are the culprit. > HELP! Have any of you heard about this > happening? None of my friends have ever had any > reactions to this stuff. Do I truly stay off of it or > should I be brave (stupid) and try again at a lower dose and > then titrate up to 5mg. Any help is so appreciated. > > Thanks Guys!--- > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 Hi , Definitely have your Estradiol levels checked. For men, your levels should usually be around 20-25, even though the reference range usually gives a top number of about 56. If your estradiol levels are high, that could explain your lower testosterone levels. The brain cannot tell the difference between testosterone and estradiol, so if your estradiol levels are high, the brain thinks that you have enough testosterone and sends fewer signals to the testicles to produce testosterone. For me, when my estradiol levels get too high, I sometimes experience a number of symptoms including anxiety and labored breathing and shortness of breath (I will use my albuterol inhaler just like I was having an asthma attack). For years, I was diagnosed with asthma. However, once I figured out how I felt with high estradiol levels, I realized that most of my asthma was actually just high estradiols. Phil Georgian explains that he experiences anxiety and panic attacks when his estradiol levels get too high, too. Do you have any other common symptoms of high estradiols? Like breast tissue, increased fat around the abdomen, being overweight (high estradiol levels cause the body to want to retain fat, and fat cells contain aromatase which converts testosterone into estradiol, so it becomes a vicious cycle), insulin resistance (pre-diabetes, diabetes, getting tired after eating, etc.), prostate problems, depression, anxiety, mood swings, becoming emotional (like crying at movies), water retention (which can sometimes result in high blood pressure and this is also what causes labored breathing), erectile dysfunction, loss of libido, dizziness (when my estradiols get too high, I get water retention in my ears), etc. With your history of being a " stressed guy " and having anxiety and panic attacks in the past, I would venture to guess that you have probably had high estradiol levels for a while. When you took the androgel, your estradiol levels just got pushed a little higher and that is why you experienced those symptoms. If this is actually the case that your estradiol levels are high, you may be able to take a drug called " Arimidex " (generic is " anastrozole " ). Arimidex is an Aromatase Inhibitor that prevents testosterone from converting into estradiol. The drug is FDA approved for treating women with breast cancer, but it is extremely common for men to take this drug, too. As you lower your estradiol levels, your SHBG (Sex Hormone Binding Globulin) levels will most likely decrease, too (unless you have a case of insulin resistance, but taking Arimidex can help this, too). SHBG binds to Testosterone and basically makes it useless to the body. As SHBG levels go down, you will have more " usable " testosterone available to the body. There is a chance that you may be able to just take Arimidex and maybe even avoid TRT completely. There is also something called " DIM " that is sold over the counter that you can take. DIM works in a different way that Arimidex - it converts estradiols into other forms of estrogen that the liver can eliminate easier. Phil Georgian can give you more information about this. Post the lab results that you have. Maybe there is something else going on; many of the people here are very good at interpreting lab results. Of course, I am not a doctor. Best of luck! From: [mailto: ] On Behalf Of jscottsmithunc Sent: Tuesday, January 25, 2011 5:32 PM Subject: Guys...I need your help!! New guy here. I am a 41 yo with recent extreme fatigue, weight gain and reduced exercise tolerance as well as lack of a morning woody. Found my total testosterone to be around 400. My free was 8.5 On my scale the low end of normal was 7.5. This was an am test and I would imagine it drops considerably during the day. Anyway, I was prescribed Androderm patch which caused a horrific itchy rash on day 2. Felt amazing however. Much more energy and sex went through the roof. My doc then prescribed Androgel. I used 5mg (4 pumps) and within 2 hours as it peaked I had a terrific anxiety attack...felt some shortness of breath and a heaviness in my breathing. Went to the emergency room and was told it was an allergic reaction and to never take any testosterone again! I am really down in the dumps now. Something that helped me so much now to not be able to take it. I do tend to be a very stressed guy and have had anxiety for many years...panic attacks about 10 years ago. Have done well with no meds etc...just cut out caffeine. This reaction today seemed more like a panic attack and anxiety than an allergic reaction. I have checked my thyroid and cortisol and they are fine. My LH and FSH were normal as well. I will try to check estradiol and progesterone, though I am skeptical that they are the culprit. HELP! Have any of you heard about this happening? None of my friends have ever had any reactions to this stuff. Do I truly stay off of it or should I be brave (stupid) and try again at a lower dose and then titrate up to 5mg. Any help is so appreciated. Thanks Guys!--- Quote Link to comment Share on other sites More sharing options...
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