If you have primary why would you take hcg? Read more from the MESO-Rx Steroid

[Guest guest]

Question - Can HcG be used to treat hypergonadotropic hypogonadism (primary

hypogonadism), and if so, how and at what dosage?

Answer - Primary hypogonadism or HYPERgonadotropic hypogonadism is testicular

failure. So the answer in general is no.

If this is correct why then id hcg used??

Crisler says this

Any physician who administers TRT will, within the first few months of doing so,

field complaints from their patients because they are now experiencing troubling

testicular atrophy. Irrespective of the numerous and abundant benefits of TRT,

men never enjoy seeing their genitals shrinking! Testicular atrophy occurs

because the depressed LH level, secondary to the HPTA suppression TRT induces,

no longer supports them. It is well known that HCG—a Luteinizing Hormone (LH)

analog—will effectively, and dramatically, restore the testicles to previous

form and function. It accomplishes this due to shared moiety between the alpha

subunits of both hormones.

So, that satisfies an aesthetic consideration which should not be ignored. Now

let's delve into the pharmacodynamics of the TRT medications. For those

employing injectable

testosterone cypionate, the cypionate ester provides a 5-8 day half-life,

depending upon the specific metabolism, activity level, and overall health of

the patient. It is now well-established that appropriate TRT using IM injections

must be dosed at weekly intervals, in order to avoid seating the patient on a

hormonal, and emotional, roller coaster. Adding in some HCG toward the end of

the weekly " cycle " compensates for the drop in serum androgen levels by the

half-life of the cypionate ester. Certainly the body thrives on regularity, and

supplementing the TRT with endogenous testosterone production at just the right

time—without inappropriately raising androgen OR estrogen (more on that

later)—approximates the excellent performance stability of transdermal

testosterone delivery systems for those who, for whatever reason or reasons,

prefer test cyp.

But there's another metabolic reason to employ this protocol. The P450 Side

Chain Cleavage enzyme, which converts CHOL into pregnenolone at the initiation

of all three metabolic pathways CHOL serves as precursor (the sex hormones,

glucocorticoids and mineralcorticoids), is actively stimulated, or depressed, by

LH concentrations. It is intuitively consistent that during conditions of

lowered testosterone levels, commensurate increases in LH production would serve

to stimulate this conversion from CHOL into these pathways, thereby feeding more

raw material for increased hormone production. And vice versa. Thus the addition

of HCG (which also stimulates the P450scc enzyme) helps restore a more natural

balance of the hormones within this pathway in patients who are entirely, or

even partially, HPTA-suppressed.

http://healthfully.org/malehormones/id11.html

An interesting new way of increasing testosterone levels in men has been

achieved through the use of human chorionic gonadotropin (hCG). hCG is a hormone

that is able to bind to lutenizing hormone (LH) receptors with the same binding

affinity as LH. Administration of hCG can, therefore, mimic the same effect as

LH and increase testosterone production by stimulating Leydig cells in the

testicles. In men who still have a functional LH/testosterone control loop,

testosterone production with hCG is the most physiologic method and is not

associated with the testicular atrophy that can occasionally happen with direct

testosterone administration. The preferred method of administering hCG is to

give self-administered subcutaneous doses with a tiny insulin syringe twice

weekly. With normal aging, the testicles will at some point stop responding to

the LH and hCG signals. If testosterone levels do not rise in a patient

receiving hCG after 6 weeks, we know the " disconnect " between the testicles and

the pituitary gland has occurred and direct testosterone supplementation is the

preferred route

As far as I can see the only reason for taking hcg is to prevent testicular

atrophy

Question - Are there any studies showing that use of hcg reverses testicular

atrophy?

I mean if you're primary - why would you need hcg??