If you suffer from sore joints and muscles read this.

[Guest guest]

I have to take these supplements because of being on Statin Drugs. My older

family members and my wife started taking them 4 weeks ago and tell me no more

pain.

http://www.spacedoc.net/aging_mitochondrial_mutations

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Anti-oxidants found useful: Vitamin C, Vitamin E (tocotrienols), Coenzyme Q10,

Alpha-Lipoic Acid, N-acetyl cysteine, Carotenoids, Flavonoids, Proanthocyanidins

and Selenium.

Important Accessory Molecules: Vitamin B3 (niacin), Vitamin B6 (pyridoxine

hydrochloride), Vitamin B12 (cyanocobalamin), Vitamin B2 (riboflavin), Folic

Acid (folate), Vitamin D, Melatonin, Magnesium and Zinc

Phosphatidylcholine and related compounds

Glyconutrients

Probiotics

There is no way the average person can look at this list and formulate their

personal requirements for mitochondrial repair. Even medical professionals,

after a lifetime of experience, must work hard to convert these elements of

metabolism and anti-oxidation into a rational plan for help. I have taken on the

task of selecting a few from this list that most impress me with their potential

to help slow down or reverse the natural process of mitochondrial mutations.

Much research remains to be done to validate these premises.

1. CoQ10 - Coenzyme Q10 in our blood and tissue has been shown repeatedly to be

reduced in the elderly. The reason for this is now thoroughly understood - our

natural ability to synthesize CoQ10 falls off rapidly after the age of 50. Our

sole source comes from diet, known to be largely deficient in CoQ10.

2. Selenium - only in the past few years has the full spectrum of selenium's

role in health been revealed. Mooseman and Behl's review has done much to

illuminate its various roles in body function.

3. Glyconutrient supplements - No longer do we consider our sugars as just

simple fuel. The effects of these vital sugars on the resulting peptide

structure being created in the endoplasmic reticulum and companion piece, the

Golgi apparatus, may be significant.

4. Lecithin - Lecithin is a phospholipid found primarily in egg yolks and soy.

Of all the phospholipids, phosphatidylcholine is singularly the most important.

The powerful, even miraculous, reports of extensive studies over the past

several decades in the U.S. and in Europe have established a firm understanding

of its relationship to aging and diseases of old age.

5. Omega-3 (EPA, DHA). This one is easy. We all know about this powerful

antiinflammatory / antioxidant found in Fish or Krill oils.

6. Vitamin C, powdered. A powerful anti-oxidant.

7. Tocotrienol - The new and much improved form of vitamin E. Tocotrienols are

naturally occurring members of the Vitamin E family derived from the annatto

plant. For years they have been overshadowed by the better known tocopherols,

which long have made claim to the title, vitamin E.

8. Magnesium - The average American consumes only 40 percent of the recommended

daily allowance of magnesium. This has serious consequences, including death, in

many people. Magnesium activates 76 percent of the enzymes in the body and many

of these enzymes are in the mitochondrial energy equation.

9. L-carnitine - The adult form of carnitine palmitoyltransferase (CPT) II

deficiency has been labeled as the most common lipid myopathy in humans. This

autosomal recessively inherited disease may be even more prevalent than

generally believed due to under-recognition of the disorder.

10. Alpha Lipoic acid (ALA) -is a vital coenzyme in the mitochondria's Krebs

cycle for the production of cellular energy. In the late 1980s, researchers

first identified alpha-lipoic acid's powerful antioxidant role. Of special

interest was the unique beneficial effect of alpha lipoic acid on other

anti-oxidants.

11. Vitamin B2 and B3 - integral to the oxidative phosphorylation role as

companions to CoQ10.

Duane Graveline MD MPH

Former USAF Flight Surgeon

Former NASA Astronaut

Retired Family Doctor