More info about Pregnenelone.

[Guest guest]

First I know I have been saying it's not good for men to take progesterone. Dr.

says it's a femanizing hormone and can cause problems for men.

Well by accident I got progesterone cream 20 mgs been on it 2 weeks no problems.

I even feel better reading back on my logs. When I ordered this I thought I was

ordering Pregnenelone Cream 20 mgs.

So I had no idea I was taking the Prog. cream thinking it was Preg. cream.

Reading back in my logs I feel more clam and feel like having sex everyday. My

E2 levels did not change and it looks like it made me feel better.

So now I am thinking about using both.

The following is from a thread at Dr. 's and chilln posted the following

from this link.

http://www.musclechatroom.com/forum/showthread.php?t=15587

====================================================================

Quote:

Originally Posted by seekonk

Chilln, how does one know (by feel) if one is supplementing the right dose of TD

pregnenolone?

copied without modification from:

http://musclechatroom.com/forum/show...4 & postcount=12

TOO-LOW CORTISOL, TREAT VIA PREGNENOLONE

Dosing

After commencing pregnenolone supplementation, we don't initially determine

optimum pregnenolone supplementation from progesterone labs, we monitor

symptoms, as follows:

Here's what happens with optimum pregnenolone dosing:

1) ACTH initially too low, cortisol initially too low, symptoms of tiredness and

/ or brain fade.

2) Take optimum pregenolone.

3) Pregnenolone levels rise, neurotransmitter levels rise, cortisol levels rise.

4) Symptoms of tiredness / brain fade gradually replaced by alertness.

5) ACTH pulse levels become suppressed a little, not a problem.

6) Pregnenolone levels fall very slowly - at the rate of liver metabolization,

cortisol levels fall very slowly - at the rate of liver metabolization.

7) Due to extra neurotransmitters, and gradual reduction in cortisol, ACTH

levels gradually increase, maintaining natural pregnenolone production, keeping

pregnenolone at higher levels for around 4 to 6 hours.

8) Neurotransmitter boost finally runs out, ACTH falls low, cortisol falls low,

but for some this occurs as their body's requirement for neurotransmitters and

cortisol are reducing, so this person may not need to apply another dose of

pregnenolone.

###

Here's what happens with slightly too high pregnenolone dosing:

1) ACTH initially too low, cortisol initially too low, symptoms of tiredness and

/ or brain fade.

2) Take too much pregenolone, but not enough to completely replace all of your

pregnenolone

3) Pregnenolone levels rise, neurotransmitter levels rise, cortisol levels rise.

4) Symptoms of tiredness / brain fade gradually replaced by alertness.

5) Pregnenolone levels continue to rise, neurotransmitter levels continue to

rise, cortisol levels continue to rise.

6) ACTH pulse levels are suppressed back to initial too low levels (or even

lower).

7) ACTH suppression of natural pregnenolone means only supplementary

pregnenolone is providing nearly all pregnenolone, but it's not enough

pregnenolone, and so pregnenolone and cortisol levels return to " too low " within

one or two hours from initial application

8) Pregenenlone, neurotransmitters and cortisol stay too low, and symptoms of

tiredness / brain fade remain until the late afternoon / early evening when our

body's requirement for pregnenolone and cortisol matches our actual low levels

of these hormones.

###

Here's what happens with first-half-day pregnenolone replacement dosing (very

high dosing):

1) ACTH initially too low, cortisol initially too low, symptoms of tiredness and

/ or brain fade.

2) Take very high dose pregenolone.

3) Pregnenolone levels rise, neurotransmitter levels rise, cortisol levels rise.

4) Symptoms of tiredness / brain fade gradually replaced by alertness.

5) ACTH levels are suppressed almost completely, but it's not going to be a

problem.

6) Pregnenolone levels fall very slowly - at the rate of absorption and liver

metabolization, cortisol levels fall very slowly - at the rate of liver

metabolization.

7) ACTH remains suppressed, but there's so much transdermal pregnenolone, that

we don't need ACTH to trigger any natural pregnenolone synthesis.

8) After 6 to 8 hours, neurotransmitter boost finally runs out, ACTH,

pregnenolone, neurotransmitters and cortisol return to their original values

(low, but not completely suppressed). For some this occurs as their body's

requirement for neurotransmitters and cortisol are reducing, so this person may

not need to apply another dose of pregnenolone. Others will indeed need to

re-dose, but with a lot less pregnenolone since the second half of the day's

pregnenolone requirement is a lot less than the first half of the day.

##

After optimizing transdermal pregnenolone dosages based on symptoms, then

remeasure eiher serum pregnenolone or serum progesterone to record new baseline

levels. We do this to be able to revisit this same level in the future, in case

we start having to introduce other hormone supps, which may feedback on

pregnenolone and progesterone, such as HCG.

..

__________________

Warning:

A) Slow excreters have pooly functioning livers. They must monitor hormone

levels very carefully, to ensure their dosages are low enough to prevent

accumulation of hormones to the point where levels become excessive, or even

toxic, after several days or weeks of supplementation.

Fast excreters have excessive liver enzyme activity. These people require

relatively high and frequent doses of hormones, and the cost of hormone

supplementation, for these people, is relatively high.