Re: autoantigen in treatment-resistant Lyme arthritis

[Guest guest]

That's the one! Thanks Sue, as always you are a fountain of terrific

information.

Hugs,

Marta

>From: sueted@...

>

>As requested by Marta:

>Title:

> Identification of LFA-1 as a candidate

> autoantigen in treatment-resistant Lyme

> arthritis

> Authors:

> Gross DM, Forsthuber T, Tary-Lehmann M,

> Etling C, Ito K, Nagy ZA, Field JA, Steere AC,

> Huber BT

> Source:

> Science 1998 Jul 31;281(5377):703-6

> Organization:

> Department of Pathology, Tufts University,

> Boston, MA 02111 USA.

>

>

>Abstract:

>Treatment-resistant Lyme arthritis is associated with immune

>reactivity to outer surface protein A (OspA) of Borrelia

>burgdorferi, the agent of Lyme disease, and the major

>histocompatibility complex class II allele DRB1*0401. The

>immunodominant epitope of OspA for T helper cells was identified.

>A homology search revealed a peptide from human leukocyte

>function-associated antigen-1 (hLFA-1) as a candidate

>autoantigen. Individuals with treatment-resistant Lyme arthritis, but

>not other forms of arthritis, generated responses to OspA,

>hLFA-1, and their highly related peptide epitopes. Identification of

>the initiating bacterial antigen and a cross-reactive autoantigen may

>provide a model for development of autoimmune disease.