Guest guest Posted May 12, 1999 Report Share Posted May 12, 1999 In a message dated 5/12/1999 4:59:32 PM Eastern Daylight Time, SCSullivan@... writes: << Are mepron and Plaquinel in the same family of drugs? Are they antimalarial drugs? >> : I know Plaquenil is an antimalarial drug.....not familiar with mepron. Mona Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 1999 Report Share Posted May 13, 1999 , While I have heard that the LP will not necessarily show Lyme, other conclusions can be drawn from the testing. Yet, below is a study that shows how it is not effective for the dx of Lyme. Neuroborreliosis: Comparison of PCR, Culture, and a Bioassay Detection of Active Infection in Nonhuman Primates with Lyme. Ideally a diagnosis of infection of the central nervous system (CNS) is made by culture of the etiologic pathogen, but Borrelia burgdorferi, the causative agent of Lyme neuroborreliosis (LNB), is rarely cultured from the cerebrospinal fluid (CSF). PCR and measurement of specific antibody in the CSF also have their limitations. The role of available assays for LNB has not been studied carefully in a comparative investigation. There is a need to assess the reliability of assays and to increase the ability to document active infection in the CNS. The recent development of the nonhuman primate (NHP) model of LNB allowed us to address this need in a faithful model of human LNB. In this study we compared the abilities of PCR and culture to detect the presence of spirochetes in the CSF and brain tissue of infected NHPs and related these measures of infection to the development of anti-B. burgdorferi antibody. We also tested a bioassay, the mouse infectivity test (MIT), in this model. Fourteen of 16 CSFs from four NHPs were positive by at least one of these techniques. Detection of spirochetes in the CSF by PCR, the MIT, and culture was inversely related to the concomitant presence of anti-B. burgdorferi antibody intrathecally. The performance of any particular test was associated with the strength of the host immune response. In early CNS infection, when anti-B. burgdorferi antibody had not yet appeared, or in immunocompromised hosts, the MIT compared favorably to culture and PCR for infected NHPs; antibody in the CSF was the most useful assay for immunocompetent NHPs. R. Pachner, Wei-Fen Zhang, Henry Schaefer, Schaefer, and Tim O'Neill. Journal of Clinical Microbiology, November 1998;36:3243-3247. >From: SCSullivan@... > >>Also, I finally caved in and told my LLMD and neurologist that I would have a >lumbar puncture -- I've been able to hold them off for 2 years. Needless to >say, I am very, very nervous about this procedure. I meet with the neuro on >Monday to discuss the procedure, and I'm scheduled for the LP on Weds >morning. I think I'm looking for reassurance from the list that it is worth >going thru this horrible test. Is it really more accurate than the blood >tests? >Thanks for any insight you can provide, > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 1999 Report Share Posted May 13, 1999 Hi I just read your post about the Lumbar Puncture. My personal opinion is to stay away from it. The test is no more conclusive than the regular blood tests and this was brought up at the lyme conference in April. I had one done 6 years ago and I could not move for over two weeks. I was in the worst pain in my back and the headaches are unbearabel. I mean the worst headaches ever imagineable. I was flat on my back in pain for two weeks on percocet. Couldn't even sit up to eat because of the headaches. the results were also negative and I was denied treatment from the dr. who preformed it. Had to find another doc to treat me three weeks later although the tap did show a white blood cell in the fluid which shouldn't be there. I urge you to re-think this. The doc who I had promised me IV treatment regardless of the lresults and then told me no after. I had to have a back MRI because of my back pain too. It is unessacery unless your doc trult speculates that yu have menengitis or something else tht can be definitifly proven by a spinal tap. Ihope you are feeling better -Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 1999 Report Share Posted May 13, 1999 In a message dated 5/12/99 4:07:39 PM, WISHXXX@... writes: <<<< Are mepron and Plaquinel in the same family of drugs? Are they antimalarial drugs? >>>> Hi susan, Mepron is an anti protazoan. i think babesia is some form of protozoa (piroplasm) but i am not sure.feel better-Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 1999 Report Share Posted May 14, 1999 , I had a spinal tap before my diagnosis. It was neg. My doc told me that , if you have had antiiotics prior to these test...they most likely be neg......Now I have a spot on my lower spine that aches continuously from it. Dr. B. told me I never should haven put through that....However it was before I found a lyme literate doc......Hugs [Lyme-aid] Abx combo question >From: SCSullivan@... > >Hi everyone, >I know a lot of you are on combinations of Biaxin and either Mepron or >Plaquinel (sp?). Are mepron and Plaquinel in the same family of drugs? Are >they antimalarial drugs? > >Also, I finally caved in and told my LLMD and neurologist that I would have a >lumbar puncture -- I've been able to hold them off for 2 years. Needless to >say, I am very, very nervous about this procedure. I meet with the neuro on >Monday to discuss the procedure, and I'm scheduled for the LP on Weds >morning. I think I'm looking for reassurance from the list that it is worth >going thru this horrible test. Is it really more accurate than the blood >tests? >Thanks for any insight you can provide, > > >------------------------------------------------------------------------ >ONElist: where real people with real interests get connected. > >Join a new list today! >------------------------------------------------------------------------ >Please send privately messages unrelated to lyme. >/archives.cgi/ >/archives.cgi/Lyme-Docs >Email: -subscribeonelist >You may substitute " unsubscribe " , " digest " , or " normal " for >the word " subscribe " ( " normal " is the opposite of " digest " ) > Quote Link to comment Share on other sites More sharing options...
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