Fiber & Redistribution

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This is a continuation of a tangent from the following discussion.

What happens to mercury released from last dose in round?

/message/277735

Since redistribution is such an important issue it would be valuable to find

additional ways to minimize it. The use of fiber at the end of rounds seems

quite interesting from some information in several papers.

>

> I've seen some info suggesting apple pectin is helpful for binding loose

metals. Since it doesn't have the high sulfur issues of chlorella/algins and

stays in the gut, we use it at the end of rounds. I theorize it might prevent

reabsorption of remaining toxic metals contained in the bile, but haven't seen

anything that specifically confirms that. These are some reports on pectin

though

>

> (http://www.springerlink.com/content/h274504752m30735/)

>

> (http://curezone.com/blogs/fm.asp?i=973732)

I brought up the topic after reading J. Rooney's 2007 paper that is in our

group's files section.

" The role of thiols, dithiols, nutritional factors and interacting ligands in

the toxicology of mercury "

http://f1.grp.fs.com/v1/oEeuSwoGA9DWpr3v_hP3mKjCHB8dyH-yWbJd1VuUIuHn5g6iIJ7\

UVHNZcWcBs4BVz4yZaHqstimzMVKYZ1MGSuooFPKsBKQd/Rooney2007.pdf

The following are a few quotes from p.152.

" in vitro studies have shown that wheat bran can effectively bind mercury and

other heavy metals "

" a 30% bran diet was seen to increase the rate of elimination of mercury from

the body and to reduce the level of mercury present in the brain "

" it is proposed that fibre in the diet interrupts the entero-hepatic

recirculation by binding the mercury and undergoing excretion, thus leading to

an increased rate of elimination of mercury. "

The page at curzone.com that pjthreeboys posted contains a couple of interesting

quotes.

" A special property of pectins is their ability to bind heavy metals by a

complexation mechanism. This is possible because pectins are negatively charged

polyelectrolytes and can bind positively charged heavy metal ions. The binding

affinity is very high for lead, followed by barium, cadmium and strontium and

decreases to earth alkali and alkali ions. With that low methoxyl pectins are an

antidote for heavy metal poisoning by an increased excretion in the stool and

with that a reduced resorption. But also heavy metals once resorpted are

excreted in the urine. "

" Pectins - naturally Binding and Excretion of heavy metals and their

radionuclides

This mechanism is based on oligogalacturonides degraded from pectin by

microorganisms in the colon and with that resorpable into the body. This

oligogalacturonides either catalyze an excretion reaction or bind itself heavy

metals resulting in an excretion via urine. The way of action is not clearly

understood up to now....

Medetopekt is a tablet consisting of a low methoxyl apple pectin with a special

improved binding capacity for heavy metals especially for lead ...

Medetopekt was tested against crude wheat fiber..... The results with crude

wheat fiber were not significant. Medetopekt reduced the lead concentration...

There was an article in Life Extension magazine last year on Modified Citrus

Pectin as an actual chelator. I was more interested in fiber's potential role in

reducing redistribution as proposed in J. Rooney's paper; however, If pectin is

less powerful than DMSA and DMPS as a chelator might a small dose still be

useful in 'mopping up' after a round of chelation?

http://www.lef.org/magazine/mag2009/mar2009_Modified-Citrus-Pectin-Fighting-Canc\

er-Metastasis-Heavy-Metal-Toxicities_01.htm

" In a study published in 2006, ... The investigators reported that significant

urinary excretion of arsenic, mercury, cadmium, and lead increased within one to

six days of MCP treatment. ... Essential minerals such as calcium, zinc, and

magnesium were not seen to increase in the urine analysis, indicating that MCP

treatment did not deplete these nutrients. "

However the last sentence above makes me nervous about the quality of the

research. I believe Andy has said that different metals come out over time.

For example, you might see arsinic come out after the mercury levels have been

significantly reduced.

This is more informaton on modified citrus pectin.

http://www.annieappleseedproject.org/modcitpechea.html

" Pectin is a soluble fiber effective at binding toxic and radioactive metals and

has been applied to environmental clean-up and detoxification in humans. Due to

its large molecular size, it is not readily absorbed and its actions are limited

to the gut. "

" Modified citrus pectin is a smaller molecular weight compound that can be

absorbed into the bloodstream. "

The quotes above help us to better understand the scope of the pectin's effects.

Unmodified pectin apparently only works in the gut. This would seem to have some

usefulness in reducing resorption.

I assume the modified pectin only works in the blood stream and does not cross

the blood-brain barrier. If it is indeed a less powerful chelator than ALA,

DMPS and DMSA might a combination of the pectins have a role in reducing

redistribution when used at the end of a round of ALA plus DMPS or DMSA?

Has Andy made any comments on the possible role of fiber/pectin, especially in

this limited role?

Joe

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