Re: NIH Study: Succimer found ineffective for removing mercury

[Guest guest]

HA HA, it's like I knew it was coming, but I didn't know till it came.

>

> There are some questions on this study regarding methodology, outcomes,

> and relevance to autism but FYI.

>

> http://www.nih.gov/news/health/oct2010/niehs-22.htm

>

> DHHS, NIH News

> National Institute of Environmental Health Sciences (NIEHS)

> For Immediate Release Friday, October 22, 2010

> Contact: Robin Mackar, NIEHS 919-541-0073

>

> Succimer found ineffective for removing mercury

>

> Succimer, a drug used for treating lead poisoning, does not effectively

> remove mercury from the body, according to research supported by the

> National Institutes of Health. Some families have turned to succimer as

> an alternative therapy for treating autism.

>

> " Succimer is effective for treating children with lead poisoning, but it

> does not work very well for mercury, " said Walter Rogan, M.D., head of

> the Pediatric Epidemiology Group at the National Institute of

> Environmental Health Sciences (NIEHS), part of NIH, and an author on the

> paper that appears online in the Journal of Pediatrics.

>

> " Although it is not approved by the Food and Drug Administration to

> reduce mercury, succimer is reportedly being used for conditions like

> autism, in the belief that these conditions are caused, in part, by

> mercury poisoning, " Rogan stated. " Our new data offers little support

> for this practice. "

>

> Although researchers found that succimer lowered blood concentrations of

> mercury after one week, continued therapy for five months only slowed

> the rate at which the children accumulated mercury. The safety of higher

> doses and longer courses of treatment has not been studied.

>

> Most mercury exposure in the United States is from methylmercury, found

> in foods such as certain fish. Thimerosal, a preservative once more

> commonly used in vaccines, contains another form of mercury, called

> ethylmercury.

>

> To conduct the study, the researchers used samples and data from an

> earlier clinical trial, led by NIEHS, called the Treatment of

> Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

> blood lead in 2-year-old children with moderate to high blood lead

> concentrations.

>

> Using blood samples from 767 children who participated in the TLC trial,

> the researchers measured mercury concentration in the toddlers' blood

> samples collected before treatment began, one week after beginning

> treatment with succimer or placebo, and then again after three

> month-long courses of treatment. Mercury concentrations were similar in

> all children before treatment. Concentrations eventually increased in

> both groups, but more slowly in the children given succimer. Succimer

> had produced a 42 percent difference in blood lead, but only an 18

> percent difference in blood mercury.

>

> " Although succimer may slow the increase in blood mercury

> concentrations, such small changes seem unlikely to produce any clinical

> benefit, " Rogan said. He and his colleagues had reported in an earlier

> paper that succimer has few adverse side effects, mostly rashes, and an

> unexplained increase in injuries in children given succimer rather than

> placebo.

>

> The subjects of the study did not have unusually high blood mercury

> concentrations for African-American children and the study did not

> investigate where the mercury in the children came from.

>

> " This research fills a gap in the scientific literature that could not

> be addressed any other way. We were fortunate to have samples already

> collected from toddlers who had been treated with succimer for lead

> poisoning allowing us to help answer this important question, " said

> Birnbaum, Ph.D., director of NIEHS and the National Toxicology

> Program.

>

> Birnbaum noted NIH's commitment to supporting research that provides

> critically needed information that will help drive more prevention and

> treatment options for children with autism and other neurodevelopmental

> disorders.

>

> The study was supported by the NIEHS Intramural Research Program, the

> National Institute for Minority Health and Health Disparities at NIH,

> and the National Center for Environmental Health at the Centers for

> Disease Control and Prevention. The succimer, Chemet, and the placebo,

> were gifts from McNeil Laboratories, Fort Washington, Pa.

>

> The NIEHS supports research to understand the effects of the environment

> on human health and is part of NIH. For more information on

> environmental health topics, visit www.niehs.nih.gov. Subscribe to one

> or more of the NIEHS news lists

> (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

> NIEHS news, press releases, grant opportunities, training, events, and

> publications.

>

> The National Institutes of Health (NIH) — The Nation's Medical Research

> Agency — includes 27 Institutes and Centers and is a component of the

> U.S. Department of Health and Human Services. It is the primary federal

> agency for conducting and supporting basic, clinical and translational

> medical research, and it investigates the causes, treatments, and cures

> for both common and rare diseases. For more information about NIH and

> its programs, visit www.nih.gov.

>

> Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

> KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

> Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

> print. DOI:10.1016/j.jpeds.2010.08.036.

>

[Guest guest]

Something I believe Andy has said numerous times....not sure why people want to

reinvent the wheel. AlA for mercury, DMSA for lead, given every 3 hours (4 on

parents sleep schedule) 4 main supplements to be given.

>

> There are some questions on this study regarding methodology, outcomes,

> and relevance to autism but FYI.

>

> http://www.nih.gov/news/health/oct2010/niehs-22.htm

>

> DHHS, NIH News

> National Institute of Environmental Health Sciences (NIEHS)

> For Immediate Release Friday, October 22, 2010

> Contact: Robin Mackar, NIEHS 919-541-0073

>

> Succimer found ineffective for removing mercury

>

> Succimer, a drug used for treating lead poisoning, does not effectively

> remove mercury from the body, according to research supported by the

> National Institutes of Health. Some families have turned to succimer as

> an alternative therapy for treating autism.

>

> " Succimer is effective for treating children with lead poisoning, but it

> does not work very well for mercury, " said Walter Rogan, M.D., head of

> the Pediatric Epidemiology Group at the National Institute of

> Environmental Health Sciences (NIEHS), part of NIH, and an author on the

> paper that appears online in the Journal of Pediatrics.

>

> " Although it is not approved by the Food and Drug Administration to

> reduce mercury, succimer is reportedly being used for conditions like

> autism, in the belief that these conditions are caused, in part, by

> mercury poisoning, " Rogan stated. " Our new data offers little support

> for this practice. "

>

> Although researchers found that succimer lowered blood concentrations of

> mercury after one week, continued therapy for five months only slowed

> the rate at which the children accumulated mercury. The safety of higher

> doses and longer courses of treatment has not been studied.

>

> Most mercury exposure in the United States is from methylmercury, found

> in foods such as certain fish. Thimerosal, a preservative once more

> commonly used in vaccines, contains another form of mercury, called

> ethylmercury.

>

> To conduct the study, the researchers used samples and data from an

> earlier clinical trial, led by NIEHS, called the Treatment of

> Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

> blood lead in 2-year-old children with moderate to high blood lead

> concentrations.

>

> Using blood samples from 767 children who participated in the TLC trial,

> the researchers measured mercury concentration in the toddlers' blood

> samples collected before treatment began, one week after beginning

> treatment with succimer or placebo, and then again after three

> month-long courses of treatment. Mercury concentrations were similar in

> all children before treatment. Concentrations eventually increased in

> both groups, but more slowly in the children given succimer. Succimer

> had produced a 42 percent difference in blood lead, but only an 18

> percent difference in blood mercury.

>

> " Although succimer may slow the increase in blood mercury

> concentrations, such small changes seem unlikely to produce any clinical

> benefit, " Rogan said. He and his colleagues had reported in an earlier

> paper that succimer has few adverse side effects, mostly rashes, and an

> unexplained increase in injuries in children given succimer rather than

> placebo.

>

> The subjects of the study did not have unusually high blood mercury

> concentrations for African-American children and the study did not

> investigate where the mercury in the children came from.

>

> " This research fills a gap in the scientific literature that could not

> be addressed any other way. We were fortunate to have samples already

> collected from toddlers who had been treated with succimer for lead

> poisoning allowing us to help answer this important question, " said

> Birnbaum, Ph.D., director of NIEHS and the National Toxicology

> Program.

>

> Birnbaum noted NIH's commitment to supporting research that provides

> critically needed information that will help drive more prevention and

> treatment options for children with autism and other neurodevelopmental

> disorders.

>

> The study was supported by the NIEHS Intramural Research Program, the

> National Institute for Minority Health and Health Disparities at NIH,

> and the National Center for Environmental Health at the Centers for

> Disease Control and Prevention. The succimer, Chemet, and the placebo,

> were gifts from McNeil Laboratories, Fort Washington, Pa.

>

> The NIEHS supports research to understand the effects of the environment

> on human health and is part of NIH. For more information on

> environmental health topics, visit www.niehs.nih.gov. Subscribe to one

> or more of the NIEHS news lists

> (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

> NIEHS news, press releases, grant opportunities, training, events, and

> publications.

>

> The National Institutes of Health (NIH) — The Nation's Medical Research

> Agency — includes 27 Institutes and Centers and is a component of the

> U.S. Department of Health and Human Services. It is the primary federal

> agency for conducting and supporting basic, clinical and translational

> medical research, and it investigates the causes, treatments, and cures

> for both common and rare diseases. For more information about NIH and

> its programs, visit www.nih.gov.

>

> Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

> KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

> Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

> print. DOI:10.1016/j.jpeds.2010.08.036.

>

[Guest guest]

Why not just take L-Carnosine? I never really looked into chelating drugs, but

it never really seemed all that necessary. In addition to working on a whole

range of minerals, it also increases Bile production (The Body uses Bad

Cholesterol in the production of bile. More bile produced means less cholesterol

reabsorbed so it effectively lowers Bad Cholesterol levels) and in one study was

shown to have immediate effects on the symptoms of Autism in high doses.

But then again, I don't know anything about these drugs or if they are more

effective.

From: ideals04 <ideals04@...>

Subject: [ ] Re: NIH Study: Succimer found ineffective for removing

mercury

Date: Tuesday, October 26, 2010, 1:43 AM

 

Something I believe Andy has said numerous times....not sure why people

want to reinvent the wheel. AlA for mercury, DMSA for lead, given every 3 hours

(4 on parents sleep schedule) 4 main supplements to be given.

>

> There are some questions on this study regarding methodology, outcomes,

> and relevance to autism but FYI.

>

> http://www.nih.gov/news/health/oct2010/niehs-22.htm

>

> DHHS, NIH News

> National Institute of Environmental Health Sciences (NIEHS)

> For Immediate Release Friday, October 22, 2010

> Contact: Robin Mackar, NIEHS 919-541-0073

>

> Succimer found ineffective for removing mercury

>

> Succimer, a drug used for treating lead poisoning, does not effectively

> remove mercury from the body, according to research supported by the

> National Institutes of Health. Some families have turned to succimer as

> an alternative therapy for treating autism.

>

> " Succimer is effective for treating children with lead poisoning, but it

> does not work very well for mercury, " said Walter Rogan, M.D., head of

> the Pediatric Epidemiology Group at the National Institute of

> Environmental Health Sciences (NIEHS), part of NIH, and an author on the

> paper that appears online in the Journal of Pediatrics.

>

> " Although it is not approved by the Food and Drug Administration to

> reduce mercury, succimer is reportedly being used for conditions like

> autism, in the belief that these conditions are caused, in part, by

> mercury poisoning, " Rogan stated. " Our new data offers little support

> for this practice. "

>

> Although researchers found that succimer lowered blood concentrations of

> mercury after one week, continued therapy for five months only slowed

> the rate at which the children accumulated mercury. The safety of higher

> doses and longer courses of treatment has not been studied.

>

> Most mercury exposure in the United States is from methylmercury, found

> in foods such as certain fish. Thimerosal, a preservative once more

> commonly used in vaccines, contains another form of mercury, called

> ethylmercury.

>

> To conduct the study, the researchers used samples and data from an

> earlier clinical trial, led by NIEHS, called the Treatment of

> Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

> blood lead in 2-year-old children with moderate to high blood lead

> concentrations.

>

> Using blood samples from 767 children who participated in the TLC trial,

> the researchers measured mercury concentration in the toddlers' blood

> samples collected before treatment began, one week after beginning

> treatment with succimer or placebo, and then again after three

> month-long courses of treatment. Mercury concentrations were similar in

> all children before treatment. Concentrations eventually increased in

> both groups, but more slowly in the children given succimer. Succimer

> had produced a 42 percent difference in blood lead, but only an 18

> percent difference in blood mercury.

>

> " Although succimer may slow the increase in blood mercury

> concentrations, such small changes seem unlikely to produce any clinical

> benefit, " Rogan said. He and his colleagues had reported in an earlier

> paper that succimer has few adverse side effects, mostly rashes, and an

> unexplained increase in injuries in children given succimer rather than

> placebo.

>

> The subjects of the study did not have unusually high blood mercury

> concentrations for African-American children and the study did not

> investigate where the mercury in the children came from.

>

> " This research fills a gap in the scientific literature that could not

> be addressed any other way. We were fortunate to have samples already

> collected from toddlers who had been treated with succimer for lead

> poisoning allowing us to help answer this important question, " said

> Birnbaum, Ph.D., director of NIEHS and the National Toxicology

> Program.

>

> Birnbaum noted NIH's commitment to supporting research that provides

> critically needed information that will help drive more prevention and

> treatment options for children with autism and other neurodevelopmental

> disorders.

>

> The study was supported by the NIEHS Intramural Research Program, the

> National Institute for Minority Health and Health Disparities at NIH,

> and the National Center for Environmental Health at the Centers for

> Disease Control and Prevention. The succimer, Chemet, and the placebo,

> were gifts from McNeil Laboratories, Fort Washington, Pa.

>

> The NIEHS supports research to understand the effects of the environment

> on human health and is part of NIH. For more information on

> environmental health topics, visit www.niehs.nih.gov. Subscribe to one

> or more of the NIEHS news lists

> (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

> NIEHS news, press releases, grant opportunities, training, events, and

> publications.

>

> The National Institutes of Health (NIH) — The Nation's Medical Research

> Agency — includes 27 Institutes and Centers and is a component of the

> U.S. Department of Health and Human Services. It is the primary federal

> agency for conducting and supporting basic, clinical and translational

> medical research, and it investigates the causes, treatments, and cures

> for both common and rare diseases. For more information about NIH and

> its programs, visit www.nih.gov.

>

> Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

> KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

> Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

> print. DOI:10.1016/j.jpeds.2010.08.036.

>

[Guest guest]

L carnosine is not going to take the place of chelators like ALA or DmSa.

Carnosine is not going to make your child NT, no diets, no therapies, no ADHD,

if that's the goal AC chelation is the way, everything else is just a band aide.

>

> >

>

> > There are some questions on this study regarding methodology, outcomes,

>

> > and relevance to autism but FYI.

>

> >

>

> > http://www.nih.gov/news/health/oct2010/niehs-22.htm

>

> >

>

> > DHHS, NIH News

>

> > National Institute of Environmental Health Sciences (NIEHS)

>

> > For Immediate Release Friday, October 22, 2010

>

> > Contact: Robin Mackar, NIEHS 919-541-0073

>

> >

>

> > Succimer found ineffective for removing mercury

>

> >

>

> > Succimer, a drug used for treating lead poisoning, does not effectively

>

> > remove mercury from the body, according to research supported by the

>

> > National Institutes of Health. Some families have turned to succimer as

>

> > an alternative therapy for treating autism.

>

> >

>

> > " Succimer is effective for treating children with lead poisoning, but it

>

> > does not work very well for mercury, " said Walter Rogan, M.D., head of

>

> > the Pediatric Epidemiology Group at the National Institute of

>

> > Environmental Health Sciences (NIEHS), part of NIH, and an author on the

>

> > paper that appears online in the Journal of Pediatrics.

>

> >

>

> > " Although it is not approved by the Food and Drug Administration to

>

> > reduce mercury, succimer is reportedly being used for conditions like

>

> > autism, in the belief that these conditions are caused, in part, by

>

> > mercury poisoning, " Rogan stated. " Our new data offers little support

>

> > for this practice. "

>

> >

>

> > Although researchers found that succimer lowered blood concentrations of

>

> > mercury after one week, continued therapy for five months only slowed

>

> > the rate at which the children accumulated mercury. The safety of higher

>

> > doses and longer courses of treatment has not been studied.

>

> >

>

> > Most mercury exposure in the United States is from methylmercury, found

>

> > in foods such as certain fish. Thimerosal, a preservative once more

>

> > commonly used in vaccines, contains another form of mercury, called

>

> > ethylmercury.

>

> >

>

> > To conduct the study, the researchers used samples and data from an

>

> > earlier clinical trial, led by NIEHS, called the Treatment of

>

> > Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

>

> > blood lead in 2-year-old children with moderate to high blood lead

>

> > concentrations.

>

> >

>

> > Using blood samples from 767 children who participated in the TLC trial,

>

> > the researchers measured mercury concentration in the toddlers' blood

>

> > samples collected before treatment began, one week after beginning

>

> > treatment with succimer or placebo, and then again after three

>

> > month-long courses of treatment. Mercury concentrations were similar in

>

> > all children before treatment. Concentrations eventually increased in

>

> > both groups, but more slowly in the children given succimer. Succimer

>

> > had produced a 42 percent difference in blood lead, but only an 18

>

> > percent difference in blood mercury.

>

> >

>

> > " Although succimer may slow the increase in blood mercury

>

> > concentrations, such small changes seem unlikely to produce any clinical

>

> > benefit, " Rogan said. He and his colleagues had reported in an earlier

>

> > paper that succimer has few adverse side effects, mostly rashes, and an

>

> > unexplained increase in injuries in children given succimer rather than

>

> > placebo.

>

> >

>

> > The subjects of the study did not have unusually high blood mercury

>

> > concentrations for African-American children and the study did not

>

> > investigate where the mercury in the children came from.

>

> >

>

> > " This research fills a gap in the scientific literature that could not

>

> > be addressed any other way. We were fortunate to have samples already

>

> > collected from toddlers who had been treated with succimer for lead

>

> > poisoning allowing us to help answer this important question, " said

>

> > Birnbaum, Ph.D., director of NIEHS and the National Toxicology

>

> > Program.

>

> >

>

> > Birnbaum noted NIH's commitment to supporting research that provides

>

> > critically needed information that will help drive more prevention and

>

> > treatment options for children with autism and other neurodevelopmental

>

> > disorders.

>

> >

>

> > The study was supported by the NIEHS Intramural Research Program, the

>

> > National Institute for Minority Health and Health Disparities at NIH,

>

> > and the National Center for Environmental Health at the Centers for

>

> > Disease Control and Prevention. The succimer, Chemet, and the placebo,

>

> > were gifts from McNeil Laboratories, Fort Washington, Pa.

>

> >

>

> > The NIEHS supports research to understand the effects of the environment

>

> > on human health and is part of NIH. For more information on

>

> > environmental health topics, visit www.niehs.nih.gov. Subscribe to one

>

> > or more of the NIEHS news lists

>

> > (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

>

> > NIEHS news, press releases, grant opportunities, training, events, and

>

> > publications.

>

> >

>

> > The National Institutes of Health (NIH) †" The Nation's Medical Research

>

> > Agency †" includes 27 Institutes and Centers and is a component of the

>

> > U.S. Department of Health and Human Services. It is the primary federal

>

> > agency for conducting and supporting basic, clinical and translational

>

> > medical research, and it investigates the causes, treatments, and cures

>

> > for both common and rare diseases. For more information about NIH and

>

> > its programs, visit www.nih.gov.

>

> >

>

> > Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

>

> > KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

>

> > Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

>

> > print. DOI:10.1016/j.jpeds.2010.08.036.

>

> >

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

Well, I tried L-Carnosine after reading about it's benefits for Autism. I took 6

Grams of L-Carnosine in combination with 2 Grams of L-Theanine and I appeared to

have no symptoms at all for a few hours and people who knew me were very

surprised.... If the benefit of L-Carnosine is primarily in the chelating, then

if this is just a bandaid in comparison than the other stuff must be VERY

potent. What are the full names? Because I don't understand the abbreviations.

From: ideals04 <ideals04@...>

Subject: [ ] Re: NIH Study: Succimer found ineffective for removing

mercury

Date: Tuesday, October 26, 2010, 1:54 AM

 

L carnosine is not going to take the place of chelators like ALA or DmSa.

Carnosine is not going to make your child NT, no diets, no therapies, no ADHD,

if that's the goal AC chelation is the way, everything else is just a band aide.

>

> >

>

> > There are some questions on this study regarding methodology, outcomes,

>

> > and relevance to autism but FYI.

>

> >

>

> > http://www.nih.gov/news/health/oct2010/niehs-22.htm

>

> >

>

> > DHHS, NIH News

>

> > National Institute of Environmental Health Sciences (NIEHS)

>

> > For Immediate Release Friday, October 22, 2010

>

> > Contact: Robin Mackar, NIEHS 919-541-0073

>

> >

>

> > Succimer found ineffective for removing mercury

>

> >

>

> > Succimer, a drug used for treating lead poisoning, does not effectively

>

> > remove mercury from the body, according to research supported by the

>

> > National Institutes of Health. Some families have turned to succimer as

>

> > an alternative therapy for treating autism.

>

> >

>

> > " Succimer is effective for treating children with lead poisoning, but it

>

> > does not work very well for mercury, " said Walter Rogan, M.D., head of

>

> > the Pediatric Epidemiology Group at the National Institute of

>

> > Environmental Health Sciences (NIEHS), part of NIH, and an author on the

>

> > paper that appears online in the Journal of Pediatrics.

>

> >

>

> > " Although it is not approved by the Food and Drug Administration to

>

> > reduce mercury, succimer is reportedly being used for conditions like

>

> > autism, in the belief that these conditions are caused, in part, by

>

> > mercury poisoning, " Rogan stated. " Our new data offers little support

>

> > for this practice. "

>

> >

>

> > Although researchers found that succimer lowered blood concentrations of

>

> > mercury after one week, continued therapy for five months only slowed

>

> > the rate at which the children accumulated mercury. The safety of higher

>

> > doses and longer courses of treatment has not been studied.

>

> >

>

> > Most mercury exposure in the United States is from methylmercury, found

>

> > in foods such as certain fish. Thimerosal, a preservative once more

>

> > commonly used in vaccines, contains another form of mercury, called

>

> > ethylmercury.

>

> >

>

> > To conduct the study, the researchers used samples and data from an

>

> > earlier clinical trial, led by NIEHS, called the Treatment of

>

> > Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

>

> > blood lead in 2-year-old children with moderate to high blood lead

>

> > concentrations.

>

> >

>

> > Using blood samples from 767 children who participated in the TLC trial,

>

> > the researchers measured mercury concentration in the toddlers' blood

>

> > samples collected before treatment began, one week after beginning

>

> > treatment with succimer or placebo, and then again after three

>

> > month-long courses of treatment. Mercury concentrations were similar in

>

> > all children before treatment. Concentrations eventually increased in

>

> > both groups, but more slowly in the children given succimer. Succimer

>

> > had produced a 42 percent difference in blood lead, but only an 18

>

> > percent difference in blood mercury.

>

> >

>

> > " Although succimer may slow the increase in blood mercury

>

> > concentrations, such small changes seem unlikely to produce any clinical

>

> > benefit, " Rogan said. He and his colleagues had reported in an earlier

>

> > paper that succimer has few adverse side effects, mostly rashes, and an

>

> > unexplained increase in injuries in children given succimer rather than

>

> > placebo.

>

> >

>

> > The subjects of the study did not have unusually high blood mercury

>

> > concentrations for African-American children and the study did not

>

> > investigate where the mercury in the children came from.

>

> >

>

> > " This research fills a gap in the scientific literature that could not

>

> > be addressed any other way. We were fortunate to have samples already

>

> > collected from toddlers who had been treated with succimer for lead

>

> > poisoning allowing us to help answer this important question, " said

>

> > Birnbaum, Ph.D., director of NIEHS and the National Toxicology

>

> > Program.

>

> >

>

> > Birnbaum noted NIH's commitment to supporting research that provides

>

> > critically needed information that will help drive more prevention and

>

> > treatment options for children with autism and other neurodevelopmental

>

> > disorders.

>

> >

>

> > The study was supported by the NIEHS Intramural Research Program, the

>

> > National Institute for Minority Health and Health Disparities at NIH,

>

> > and the National Center for Environmental Health at the Centers for

>

> > Disease Control and Prevention. The succimer, Chemet, and the placebo,

>

> > were gifts from McNeil Laboratories, Fort Washington, Pa.

>

> >

>

> > The NIEHS supports research to understand the effects of the environment

>

> > on human health and is part of NIH. For more information on

>

> > environmental health topics, visit www.niehs.nih.gov. Subscribe to one

>

> > or more of the NIEHS news lists

>

> > (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

>

> > NIEHS news, press releases, grant opportunities, training, events, and

>

> > publications.

>

> >

>

> > The National Institutes of Health (NIH) †" The Nation's Medical Research

>

> > Agency †" includes 27 Institutes and Centers and is a component of the

>

> > U.S. Department of Health and Human Services. It is the primary federal

>

> > agency for conducting and supporting basic, clinical and translational

>

> > medical research, and it investigates the causes, treatments, and cures

>

> > for both common and rare diseases. For more information about NIH and

>

> > its programs, visit www.nih.gov.

>

> >

>

> > Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

>

> > KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

>

> > Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

>

> > print. DOI:10.1016/j.jpeds.2010.08.036.

>

> >

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

Well, not exactly. His protocol for mercury detoxification includes the use of

DMSA alone for body burden or along with ALA for both body and brain elimination

of mercury. Although he is clear that DMSA is not needed because ALA alone can

do the job.

> >

> > There are some questions on this study regarding methodology, outcomes,

> > and relevance to autism but FYI.

> >

> > http://www.nih.gov/news/health/oct2010/niehs-22.htm

> >

> > DHHS, NIH News

> > National Institute of Environmental Health Sciences (NIEHS)

> > For Immediate Release Friday, October 22, 2010

> > Contact: Robin Mackar, NIEHS 919-541-0073

> >

> > Succimer found ineffective for removing mercury

> >

> > Succimer, a drug used for treating lead poisoning, does not effectively

> > remove mercury from the body, according to research supported by the

> > National Institutes of Health. Some families have turned to succimer as

> > an alternative therapy for treating autism.

> >

> > " Succimer is effective for treating children with lead poisoning, but it

> > does not work very well for mercury, " said Walter Rogan, M.D., head of

> > the Pediatric Epidemiology Group at the National Institute of

> > Environmental Health Sciences (NIEHS), part of NIH, and an author on the

> > paper that appears online in the Journal of Pediatrics.

> >

> > " Although it is not approved by the Food and Drug Administration to

> > reduce mercury, succimer is reportedly being used for conditions like

> > autism, in the belief that these conditions are caused, in part, by

> > mercury poisoning, " Rogan stated. " Our new data offers little support

> > for this practice. "

> >

> > Although researchers found that succimer lowered blood concentrations of

> > mercury after one week, continued therapy for five months only slowed

> > the rate at which the children accumulated mercury. The safety of higher

> > doses and longer courses of treatment has not been studied.

> >

> > Most mercury exposure in the United States is from methylmercury, found

> > in foods such as certain fish. Thimerosal, a preservative once more

> > commonly used in vaccines, contains another form of mercury, called

> > ethylmercury.

> >

> > To conduct the study, the researchers used samples and data from an

> > earlier clinical trial, led by NIEHS, called the Treatment of

> > Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

> > blood lead in 2-year-old children with moderate to high blood lead

> > concentrations.

> >

> > Using blood samples from 767 children who participated in the TLC trial,

> > the researchers measured mercury concentration in the toddlers' blood

> > samples collected before treatment began, one week after beginning

> > treatment with succimer or placebo, and then again after three

> > month-long courses of treatment. Mercury concentrations were similar in

> > all children before treatment. Concentrations eventually increased in

> > both groups, but more slowly in the children given succimer. Succimer

> > had produced a 42 percent difference in blood lead, but only an 18

> > percent difference in blood mercury.

> >

> > " Although succimer may slow the increase in blood mercury

> > concentrations, such small changes seem unlikely to produce any clinical

> > benefit, " Rogan said. He and his colleagues had reported in an earlier

> > paper that succimer has few adverse side effects, mostly rashes, and an

> > unexplained increase in injuries in children given succimer rather than

> > placebo.

> >

> > The subjects of the study did not have unusually high blood mercury

> > concentrations for African-American children and the study did not

> > investigate where the mercury in the children came from.

> >

> > " This research fills a gap in the scientific literature that could not

> > be addressed any other way. We were fortunate to have samples already

> > collected from toddlers who had been treated with succimer for lead

> > poisoning allowing us to help answer this important question, " said

> > Birnbaum, Ph.D., director of NIEHS and the National Toxicology

> > Program.

> >

> > Birnbaum noted NIH's commitment to supporting research that provides

> > critically needed information that will help drive more prevention and

> > treatment options for children with autism and other neurodevelopmental

> > disorders.

> >

> > The study was supported by the NIEHS Intramural Research Program, the

> > National Institute for Minority Health and Health Disparities at NIH,

> > and the National Center for Environmental Health at the Centers for

> > Disease Control and Prevention. The succimer, Chemet, and the placebo,

> > were gifts from McNeil Laboratories, Fort Washington, Pa.

> >

> > The NIEHS supports research to understand the effects of the environment

> > on human health and is part of NIH. For more information on

> > environmental health topics, visit www.niehs.nih.gov. Subscribe to one

> > or more of the NIEHS news lists

> > (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

> > NIEHS news, press releases, grant opportunities, training, events, and

> > publications.

> >

> > The National Institutes of Health (NIH) — The Nation's Medical Research

> > Agency — includes 27 Institutes and Centers and is a component of the

> > U.S. Department of Health and Human Services. It is the primary federal

> > agency for conducting and supporting basic, clinical and translational

> > medical research, and it investigates the causes, treatments, and cures

> > for both common and rare diseases. For more information about NIH and

> > its programs, visit www.nih.gov.

> >

> > Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

> > KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

> > Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

> > print. DOI:10.1016/j.jpeds.2010.08.036.

> >

>

[Guest guest]

This trial had severe flaws in the dosing protocol - very large doses of DMSA

(400mg+) were given to children once a day continuously for nearly a month along

with some minerals (including iron and copper which Andy does not recommend) but

without specific antioxidant support. I really feel sorry for the kids

participating in this study.

Unfortunately there will be some people who glance at the headline and wrongly

conclude that DMSA is not a useful chelator.

Jo

> >

> > >

> > > There are some questions on this study regarding methodology, outcomes,

> > > and relevance to autism but FYI.

> > >

> > > http://www.nih.gov/news/health/oct2010/niehs-22.htm

> > >

> > > DHHS, NIH News

> > > National Institute of Environmental Health Sciences (NIEHS)

> > > For Immediate Release Friday, October 22, 2010

> > > Contact: Robin Mackar, NIEHS 919-541-0073

> > >

> > > Succimer found ineffective for removing mercury

> > >

> > > Succimer, a drug used for treating lead poisoning, does not effectively

> > > remove mercury from the body, according to research supported by the

> > > National Institutes of Health. Some families have turned to succimer as

> > > an alternative therapy for treating autism.

> > >

> > > " Succimer is effective for treating children with lead poisoning, but it

> > > does not work very well for mercury, " said Walter Rogan, M.D., head of

> > > the Pediatric Epidemiology Group at the National Institute of

> > > Environmental Health Sciences (NIEHS), part of NIH, and an author on the

> > > paper that appears online in the Journal of Pediatrics.

> > >

> > > " Although it is not approved by the Food and Drug Administration to

> > > reduce mercury, succimer is reportedly being used for conditions like

> > > autism, in the belief that these conditions are caused, in part, by

> > > mercury poisoning, " Rogan stated. " Our new data offers little support

> > > for this practice. "

> > >

> > > Although researchers found that succimer lowered blood concentrations of

> > > mercury after one week, continued therapy for five months only slowed

> > > the rate at which the children accumulated mercury. The safety of higher

> > > doses and longer courses of treatment has not been studied.

> > >

> > > Most mercury exposure in the United States is from methylmercury, found

> > > in foods such as certain fish. Thimerosal, a preservative once more

> > > commonly used in vaccines, contains another form of mercury, called

> > > ethylmercury.

> > >

> > > To conduct the study, the researchers used samples and data from an

> > > earlier clinical trial, led by NIEHS, called the Treatment of

> > > Lead-exposed Children (TLC) trial. In the TLC study, succimer lowered

> > > blood lead in 2-year-old children with moderate to high blood lead

> > > concentrations.

> > >

> > > Using blood samples from 767 children who participated in the TLC trial,

> > > the researchers measured mercury concentration in the toddlers' blood

> > > samples collected before treatment began, one week after beginning

> > > treatment with succimer or placebo, and then again after three

> > > month-long courses of treatment. Mercury concentrations were similar in

> > > all children before treatment. Concentrations eventually increased in

> > > both groups, but more slowly in the children given succimer. Succimer

> > > had produced a 42 percent difference in blood lead, but only an 18

> > > percent difference in blood mercury.

> > >

> > > " Although succimer may slow the increase in blood mercury

> > > concentrations, such small changes seem unlikely to produce any clinical

> > > benefit, " Rogan said. He and his colleagues had reported in an earlier

> > > paper that succimer has few adverse side effects, mostly rashes, and an

> > > unexplained increase in injuries in children given succimer rather than

> > > placebo.

> > >

> > > The subjects of the study did not have unusually high blood mercury

> > > concentrations for African-American children and the study did not

> > > investigate where the mercury in the children came from.

> > >

> > > " This research fills a gap in the scientific literature that could not

> > > be addressed any other way. We were fortunate to have samples already

> > > collected from toddlers who had been treated with succimer for lead

> > > poisoning allowing us to help answer this important question, " said

> > > Birnbaum, Ph.D., director of NIEHS and the National Toxicology

> > > Program.

> > >

> > > Birnbaum noted NIH's commitment to supporting research that provides

> > > critically needed information that will help drive more prevention and

> > > treatment options for children with autism and other neurodevelopmental

> > > disorders.

> > >

> > > The study was supported by the NIEHS Intramural Research Program, the

> > > National Institute for Minority Health and Health Disparities at NIH,

> > > and the National Center for Environmental Health at the Centers for

> > > Disease Control and Prevention. The succimer, Chemet, and the placebo,

> > > were gifts from McNeil Laboratories, Fort Washington, Pa.

> > >

> > > The NIEHS supports research to understand the effects of the environment

> > > on human health and is part of NIH. For more information on

> > > environmental health topics, visit www.niehs.nih.gov. Subscribe to one

> > > or more of the NIEHS news lists

> > > (www.niehs.nih.gov/news/releases/newslist/index.cfm) to stay current on

> > > NIEHS news, press releases, grant opportunities, training, events, and

> > > publications.

> > >

> > > The National Institutes of Health (NIH) — The Nation's Medical Research

> > > Agency — includes 27 Institutes and Centers and is a component of the

> > > U.S. Department of Health and Human Services. It is the primary federal

> > > agency for conducting and supporting basic, clinical and translational

> > > medical research, and it investigates the causes, treatments, and cures

> > > for both common and rare diseases. For more information about NIH and

> > > its programs, visit www.nih.gov.

> > >

> > > Reference: Cao Y, Chen A, RL, Radcliffe J, Dietrich KN, Caldwell

> > > KL, et al. 2010. Efficacy of Succimer Chelation of Mercury at Background

> > > Exposures in Toddlers: A Randomized Trial. J Pediatr. Epub ahead of

> > > print. DOI:10.1016/j.jpeds.2010.08.036.

> > >

> >

>