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Mitochondrial Dysfunction

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Yes, it is basically the same. I was dx'd w/myopathy and joined a

Mito support group several years ago even though my dx was CFIDS+++

before I was dx'd with Lyme (at al) 2-3 years ago (sick since 1986).

In persons with mitochondrial disorders they are usually born with a

genetic defect in the mitochondria, but the mitochondria can also be

damaged and then the symptoms overlap. The new wave of research is

very good for both groups!

hth

Kendra

On 1/29/09, randydean3 <randydean3@...> wrote:

>

I am curious what is the difference between mitochondrial myopathy and

> the mitochondrial dysfunction they found in CFS patients?? I read a

> recent article about the ballplayer with mitochondrial myopathy, and

> sounds like the same symptoms. Thanks, Randy

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What is the good news research re: mito. dysfunction? I want to be

fixed. joyce jamkaye@...

> In persons with mitochondrial disorders they are usually born with a

> genetic defect in the mitochondria, but the mitochondria can also be

> damaged and then the symptoms overlap. The new wave of research is

> very good for both groups!

>

> hth

> Kendra

>

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I personally had a negative experience with Holtorf Medical Group.

First, much of their focus is on hormone supplementation to postpone

the effects of aging, which many medical practitioners would consider

at least fringe medicine and potentially reckless. This gives a bit

of indication of their general approach and concerned me that they may

be particularly profit driven rather than truly trying to help CFS

patients.

While I do believe in the idea that there are problems with infection,

mitochondrial function, and HPA axis, I don't believe that the doctor

I saw did a thoughtful evaluation of my eperience and condition (btw

it was not dr. Holtorf). Instead, it seemed cursory and formulaic. I

was thoroughly unimpressed with the questions he asked and the

simplistic way that he described the mechanisms behind CFS. I

honestly felt like he had read a two-page pamphlet (or the same info I

had read on the website) rather than studied and thought carefully

about CFS. I was honestly very close to writing a letter and asking

for my money back.

I can't say this is the same experience that you would have, but I

would not recommend anyone to go there.

>

> Does anyone know anything about Dr. Holtorf and the Holtorf Medical

Group.  Are they good?  Thanks

> Walter

>

>

>

>

>

>

>

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How were you diagnosed with a myopathy, and did they identify a specific one...?

> >

> I am curious what is the difference between mitochondrial myopathy and

> > the mitochondrial dysfunction they found in CFS patients?? I read a

> > recent article about the ballplayer with mitochondrial myopathy, and

> > sounds like the same symptoms. Thanks, Randy

>

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Be very careful with Holtorf. I went to him and I would not go back. A

number of Dr. Chia's patients have used him and after seeing Chia they

stopped going to him. Beforwarned.

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Thanks, , for your input on Holtorf ..... his website is so encouraging,

full of information and hope directed at us CFSers but it felt too good to be

true and you are the third person from LA who has warned me about him.  thanks. 

My appt with Chia is march 16 and i am very excited and hopeful. 

Walter

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  • 3 months later...
Guest guest

Dear Dr

The new ATP-testing article might sound fantastic at first sight but when you

consult experts (like I did - scientist of the mitochondria-lab at the local

uni), they're not so excited... They will need independent labs to confirm the

reproducability and more studies in bigger populations...

From: thefatigueclinic <thefatigueclinic@...>

Subject: Mitochondrial dysfunction

Date: Monday, May 4, 2009, 4:32 AM

Hi everyone

Ive just put a paper in the file section on mitochondrial dysfunction. The

biochemist Dr McClaren is doing fantastic work and finding out new

things.

It seems one of the most important is that in some people , especially the

sickest,there is a calcium-protein complex jamming up the mitochondria.

It sometimes is removed by magnesium but sometimes not. This is the greatest

challenge and hes looking at ideas on how to do this at this time.I think its

the major reason for non responders to any treatment

Best wishes

Dr Andy wright

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Guest guest

Dr. ,

Have you tried IV glutathione or glutathione precursors? What about Rich V.'s

treatment ideas?

Next question: Are you seeing this block in patients with borrelia and babesia,

mycoplasma, ehrlichia, bartonella? If so, do you treat the infections/parasites

first then the methylation cycle block, or do you find that the methylation

cycle block clears on its own when the infections and parasites are effectively

treated?

Do you consider that tick borne infections are some percentage of cfs cases,

and, if so, what percent?

a Carnes

>

> Hi everyone

> Ive just put a paper in the file section on mitochondrial dysfunction. The

biochemist Dr McClaren is doing fantastic work and finding out new

things.

> It seems one of the most important is that in some people , especially the

sickest,there is a calcium-protein complex jamming up the mitochondria.

> It sometimes is removed by magnesium but sometimes not. This is the greatest

challenge and hes looking at ideas on how to do this at this time.I think its

the major reason for non responders to any treatment

>

> Best wishes

> Dr Andy wright

>

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  • 2 weeks later...
Guest guest

Hi andy

This is very interesting. I read the paper by McLaren &

Myhill, but I didn't see anything on this idea of calcium protein jamming up the

mitochondria.

Can I ask where you got this from?

Thanks

L.

>

> Hi everyone

> Ive just put a paper in the file section on mitochondrial dysfunction. The

biochemist Dr McClaren is doing fantastic work and finding out new

things.

> It seems one of the most important is that in some people , especially the

sickest,there is a calcium-protein complex jamming up the mitochondria.

> It sometimes is removed by magnesium but sometimes not. This is the greatest

challenge and hes looking at ideas on how to do this at this time.I think its

the major reason for non responders to any treatment

>

> Best wishes

> Dr Andy wright

>

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  • 1 year later...

Andy has written that mitochondrial dysfunction is a red herring diagnosis for

toxicity. Mercury causes mitochondrial problems.

My youngest (now 3) had many signs of mitochondrial dysfunction since he was 1

including a bad vaccine reaction at 8 months. But I didn't do any spinal fluid

testing. As we chelate, he has improved in all areas. We did stop vaccinating

him and do give carnitine fumarate and CoQ-10 daily in addition to the usual

supplements.

Jo

>

> Does the A-C protocol work with children that have Mitochondrial Dysfunction?

I am just curious. We are still testing for stuff.

> Martha

>

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Yes.

Instead of doing the testing (which looks as if it can be very invasive and

testing), research the symptoms.  You will find that a large amount

of children on the spectrum fall within the category. I haven't found a

mainstream treatment for MD outside of using the ingredients in a mit-cocktail

that is discussed on this list.  

The more we chelate, the symptoms go away. i.e. brain fog and low muscle tone.

HTH,  S.

>

>From: healme42 <4usyoungs@...>

>

>Sent: Mon, October 18, 2010 12:49:38 AM

>Subject: [ ] Mitochondrial Dysfunction

>

> 

>Does the A-C protocol work with children that have Mitochondrial Dysfunction? I

>am just curious. We are still testing for stuff.

>Martha

>

>

>

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Jo,

Does he write about this in his book or on the discussion board? When he argued

with Dr. Boyd, the subject of ALA doing something in the mitochondria was

brought up numerous times (and boy am I confused, knowing nothing about any of

this), but it just brought up the mitochondrial dysfunction in my mind.

Do you use ALA or DMSA?

Thank you so much and congratulations on your son's improvement! That is

wonderful.

Martha

> >

> > Does the A-C protocol work with children that have Mitochondrial

Dysfunction? I am just curious. We are still testing for stuff.

> > Martha

> >

>

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The more I learn (and I stay up very late every night!) the more I realize I

don't know. My son has brain fog and low muscle tone. What is in the

mito-cocktail and do you need a dr's recommendation?

Martha

>

> Yes.

> Instead of doing the testing (which looks as if it can be very invasive and

> testing), research the symptoms.  You will find that a large amount

> of children on the spectrum fall within the category. I haven't found a

> mainstream treatment for MD outside of using the ingredients in a mit-cocktail

> that is discussed on this list.  

>

> The more we chelate, the symptoms go away. i.e. brain fog and low muscle tone.

>

> HTH,  S.

>

>

> >

> >From: healme42 <4usyoungs@...>

> >

> >Sent: Mon, October 18, 2010 12:49:38 AM

> >Subject: [ ] Mitochondrial Dysfunction

> >

> > 

> >Does the A-C protocol work with children that have Mitochondrial Dysfunction?

I

> >am just curious. We are still testing for stuff.

> >Martha

> >

> >

> >

>

>

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You can google MD symptoms and form a list of symptoms.  As long as you are

chelating, you are heading in the right direction.

http://www.answers.com/topic/mitochondrial-disorders

S.

[ ] Re: Mitochondrial Dysfunction

> >

> > < %40>

> > Date: Monday, October 18, 2010, 9:48 AM

> >

> >

> >

> >

> > Andy has written that mitochondrial dysfunction is a red herring diagnosis

> > for toxicity. Mercury causes mitochondrial problems.

> >

> > My youngest (now 3) had many signs of mitochondrial dysfunction since he

> > was 1 including a bad vaccine reaction at 8 months. But I didn't do any

> > spinal fluid testing. As we chelate, he has improved in all areas. We did

> > stop vaccinating him and do give carnitine fumarate and CoQ-10 daily in

> > addition to the usual supplements.

> >

> > Jo

> >

> >

> > >

> > > Does the A-C protocol work with children that have Mitochondrial

> > Dysfunction? I am just curious. We are still testing for stuff.

> > > Martha

> > >

> >

> >

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Thanks .

Z

On Mon, Oct 18, 2010 at 4:32 PM, Strozier

<imyconsulting@...>wrote:

>

>

> You can google MD symptoms and form a list of symptoms. As long as you are

>

> chelating, you are heading in the right direction.

> http://www.answers.com/topic/mitochondrial-disorders

> S.

>

> [ ] Re: Mitochondrial Dysfunction

> > >

> > >

< %40>< %

> 40>

>

> > > Date: Monday, October 18, 2010, 9:48 AM

> > >

> > >

> > >

> > >

> > > Andy has written that mitochondrial dysfunction is a red herring

> diagnosis

> > > for toxicity. Mercury causes mitochondrial problems.

> > >

> > > My youngest (now 3) had many signs of mitochondrial dysfunction since

> he

> > > was 1 including a bad vaccine reaction at 8 months. But I didn't do any

> > > spinal fluid testing. As we chelate, he has improved in all areas. We

> did

> > > stop vaccinating him and do give carnitine fumarate and CoQ-10 daily in

> > > addition to the usual supplements.

> > >

> > > Jo

> > >

> > >

> > > >

> > > > Does the A-C protocol work with children that have Mitochondrial

> > > Dysfunction? I am just curious. We are still testing for stuff.

> > > > Martha

> > > >

> > >

> > >

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I am not aware of a balancing amino acid relationship like there is with lysine

and arginine. Carnitine comes from the diet (mainly meats) or is synthesized in

the body from lysine and methionine and that process requires vit C, B6, iron

and niacin. Carnitine deficiency can sometimes be a result of vit C deficiency.

Sorry I can't answer more of your question!

Jo

>

>

> From: detoxhealing <detoxhealing@...>

> Subject: [ ] Re: Mitochondrial Dysfunction

>

> Date: Tuesday, October 19, 2010, 11:38 AM

>

>

>  

>

>

>

>

> > > > > Hi Jo,

> > > > > Can I ask you why you chose carnitine fumarate (this form of

carnitin),

> > > and

> > > > > what tests did you do for your son's mito condition?

> > > > >

> > > > > Thanks in advance!

>

> We've used acetyl l-carnitine, l-carnitine and carnitine fumarate. He

tolerated them all, but I felt his muscle tone improved more with fumarate. I

also wanted one with less fillers for him so chose Pure Encapsulations. Here's

what their site says about them:

>

> l-Carnitine Fumarate:

> l-Carnitine fumarate promotes healthy fat metabolism, oxygenation of the heart

muscle, and enhances high intensity training much like l-carnitine-l-tartrate.

However, unlike most forms of carnitine, l-carnitine fumarate provides dual

support for energy production and cardiovascular function (7) in addition to

providing a stable form of carnitine. Fumarate is a key compound in the Krebs

cycle, which is the major energy-producing pathway preceding the electron

transport chain. This intimate connection with energy metabolism makes

l-carnitine fumarate an excellent supplement for enhanced muscle and fat

metabolism support.

>

> Acetyl-l-Carnitine:

> This acetylated form of l-carnitine is supportive of healthy mental and

cognitive function (8). The acetyl group is needed for acetylcholine synthesis,

a key neurotransmitter for healthy cognitive function, memory, and attention

(8-11). Several clinical trials have reported improved scoring on memory,

attention, verbal, and logic examinations in those volunteers receiving

acetyl-1-carnitine (9-11). Additionally, both the acetyl group and l-carnitine

help promote the generation of energy. The acetyl group can break off and form

acetyl CoA, important for most metabolic pathways in the body, mitochondrial

function, and cell membrane stability (8). Furthermore, investigators found the

supplement to be well tolerated (9-11).

>

> Personally I use Acetyl l-Carnitine when I take EFAs. It really helps me

absorb them better.

>

> Jo

>

>

>

>

>

>

>

>

>

>

>

>

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