Re: New Study shows Vaccinated monkeys have brain changes found in Autism

[Guest guest]

Thanks for bringing this up again - I was sent a rebuttal against this paper and

have asked a few times if anyone can help explain.

http://scienceblogs.com/insolence/2010/07/too_much_vaccineautism_monkey_business\

_f.php

I would love to offer a response but don't understand enough to refute. Thanks!

>

> In Case You Missed It.

>

>

> 2 posts in one:

>

> New Study Shows Vaccines Cause Brain Changes Found in Autism

>

>

<http://www.ageofautism.com/2010/07/new-study-shows-vaccines-cause-brain-changes\

-found-in-autism.html>

>

> By Dan Olmsted and Mark Blaxill

>

> Abnormal brain growth and function are features of autism, an increasingly

common developmental disorder that now affects 1 in 60 boys in the US. Now

researchers from the University of Pittsburgh and Thoughtful House Center for

Children in Austin, Texas, have found remarkably similar brain changes to those

seen in autism in infant monkeys receiving the vaccine schedule used in the

1990's that contained the mercury-based preservative thimerosal.

>

> The group's findings were published yesterday in the journal Acta

Neurobiologiae Experimentalis. They used scanning techniques that assessed both

brain growth and brain function in the same animals over time. The research team

was able to see differences in the way the brains of vaccinated and unvaccinated

animals developed. Scans were performed before and after the administration of

primary MMR and DTaP/Hib boosters that were given at the human equivalent of 12

months of age.

>

> Throughout the study period, vaccinated animals showed an increase in total

brain volume - a feature of the brain in many young children with autism - when

compared with unvaccinated animals. However, a specific part of the brain

associated with emotional responses that is thought to be important in autism,

the amygdala, did not show abnormalities until after the 12-month vaccines had

been given. In addition, after the 12-month vaccines only, the functional brain

scans showed significant differences between vaccinated and unvaccinated groups.

These functional scans looked at the activity of receptors for morphine-like

compounds (opioids) that may play a role in the brain of children affected by

autism. Vaccine administration was associated with an increase in opioid binding

activity in the amygdala compared with a decrease in the unvaccinated group.

>

> The results indicate that multiple vaccine exposures during the previous 3-4

months may have had a significant impact on brain growth and development in ways

that are consistent with the published data on autism. For the amygdala, the

novel findings of abnormal growth and function appear to be a function of more

recent vaccine exposures - the 12-month primary MMR vaccine and the DTaP and Hib

boosters.

>

> In an accompanying editorial Dr. Kris Turlejski, the Editor-in-Chief,

described the findings as " alarming " , " support[ing] the possibility that there

is a link between early immunization and the etiology of autism. "

>

> In the same primate model, the research team has already identified delayed

acquisition of vital brainstem reflexes in infants exposed to the

thimerosal-containi ng hepatitis B vaccine on the first day of life, compared

with unvaccinated animals. A larger, second phase study is currently underway to

see if these findings can be replicated.

>

> Dr. Wakefield, who is not a listed author but whose support in the

design of the study is acknowledged, said " I hope the model will not only

provide important insights into the origins of autism, but also ways of safely

testing possible new autism treatments and vaccines. "

>

> References:

>

> Hewitson, J. Lopresti, Carol Stott, N. Mason, and

Tomko. Influence of pediatric vaccines on amygdala growth and opioid ligand

binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp 2010. 70:

147-164

>

> Kris Turlejski. Focus on Autism Editorial Comment Acta Neurobiol Exp 2010. 70:

117-118

>

> -------------------------------

> 2)

> We Finally Get a Vaxxed v. Unvaxxed Study, Vaccinated Primates Have Brain

Changes Seen In Autism

>

>

<http://adventuresinautism.blogspot.com/2010/07/we-finally-get-vaxxed-v-unvaxxed\

-study.html>

>

> see above link for a link to the actual full study.

>

> We finally get a vaccinated v. unvaccinated study. No... no actual children

yet, but infant rhesus macaque monkeys.

>

>

>

> And no wonder main stream medicine doesn't want vaccine studies with an actual

baseline (completely unvaccinated), because the results are dramatic.

>

> The infant primates vaccinated according to the US vaccine schedule

(equivalent to their size/development rate, pre 2002 shots WITH full doses of

mercury) showed the same brain changes found in children with autism. The

amygdala, the fear and anxiety center, did not mature properly in the vaccinated

group, and those differences did not appear until AFTER the 12 month vaccines

were given.

>

> The abstract:

>

> Influence of pediatric vaccines on amygdala growth and opioid

> ligand binding in rhesus macaque infants: A pilot study

>

> Acta Neurobiol Exp 2010, 70: 147–164

> ©2010 by Polish Neuroscience Society - PTBUN, Nencki Institute of

Experimental Biology

>

> Hewitson1,2,*, J. Lopresti3, Carol Stott4, N. Mason3 and

Tomko1

>

> 1Department of Obstetrics and Gynecology, University of Pittsburgh School

of Medicine, Pittsburgh, PA, USA;

> 2Thoughtful House Center for Children, Austin, TX, USA; 3Department of

Radiology, University of Pittsburgh School of

> Medicine, Pittsburgh, PA, USA; 4Independent Chartered Scientist,

Cambridge, UK;

> *Email: lch1@...

>

> This longitudinal, case-control pilot study examined amygdala growth in

rhesus macaque infants receiving the complete US childhood vaccine schedule

(1994-1999). Longitudinal structural and functional neuroimaging was undertaken

to examine central effects of the vaccine regimen on the developing brain.

Vaccine-exposed and saline-injected control infants underwent MRI and PET

imaging at approximately 4 and 6 months of age, representing two specific

timeframes within the vaccination schedule. Volumetric analyses showed that

exposed animals did not undergo the maturational changes over time in amygdala

volume that was observed in unexposed animals. After controlling for left

amygdala volume, the binding of the opioid antagonist [11C]diprenorphine (DPN)

in exposed animals remained relatively constant over time, compared with

unexposed animals, in which a significant decrease in [11C]DPN binding occurred.

These results suggest that maturational changes in amygdala volume and the

binding capacity of [11C]DPN in the amygdala was significantly altered in infant

macaques receiving the vaccine schedule. The macaque infant is a relevant animal

model in which to investigate specific environmental exposures and

structural/functional neuroimaging during neurodevelopment.

>

> Key Words: rhesus macaques, Macaca mulatta, non-human primates, animal

model, neuroimaging, PET, MRI, amygdala, opioids, ethyl mercury, thimerosal,

neurotoxicity

>

>

> The full paper: Hewitson et. al.

>

> The editorial written by the editor of the journal, who says:

>

> An alarming finding is reported by Hewitson and coworkers showing that, in

infant monkeys that were immunized, the amygdala does not show the normal

pattern of maturation but is hypertrophied. Although these are only preliminary

data, given the well-known role of the amygdala in generation of fear and other

negative emotions, they support the possibility that there is a link between

early immunization and the etiology of autism.

>

>

> Mark Blaxill and Dan Olmsted's discussion of the paper: New Study Shows

Vaccines Cause Brain Changes Found in Autism

>

> It should be noted that in the spring of 2008, The American Academy of

Pediatrics was informed of this study. At the conclusion of the DAN conference

in Cherry Hill, NJ in April of 2008, Dr. Jerry Kartzinel personally discussed it

with Dr. Louis who was there representing the AAP. skirted the

issue, acting as if he was concerned with the cost of the study, and Kartzinel

replied that the study was fully funded and underway. was clearly not

comfortable with the discussion of the study, and changed the subject. In their

discussion of what had seen at the conference and how to proceed with

some sort of partnership between ARI and AAP, had already stated to

Kartzinel:

>

> " I'm concerned about immunization policy and how you protect

immunization. "

>

>

> To my knowledge, AAP never got back to anyone on their input into, or

involvement with, this primate study. Note that the study was not published by

Pediatrics, where it belongs, as it is AAP's journal and AAP is Pharma's main

vaccine distributor. I am sure they want this buried as deep as is possible.

>

> I am interested to see what AAP's public comment will be on this. If there is

one.

>

> AAP's (@ameracadpeds)twitter page can be found here:

http://twitter.com/ameracadpeds

>

> Feel free to call this post to their attention.

>

[Guest guest]

don't waste your time responding to idiocy, I say! That guy is arrogant and

heartless.

Plus he basically ridicules everyone and everything I hold dear, somewhere on

that site.

I scanned it for exactly 2.5 minutes while it downloaded and couldn't take any

more.

Hardly scientific writing ( " anti-vaccine loons " appears multiple times) and not

worthy of anyone's time.

best,

> >

> > In Case You Missed It.

> >

> >

> > 2 posts in one:

> >

> > New Study Shows Vaccines Cause Brain Changes Found in Autism

> >

> >

<http://www.ageofautism.com/2010/07/new-study-shows-vaccines-cause-brain-changes\

-found-in-autism.html>

> >

> > By Dan Olmsted and Mark Blaxill

> >

> > Abnormal brain growth and function are features of autism, an increasingly

common developmental disorder that now affects 1 in 60 boys in the US. Now

researchers from the University of Pittsburgh and Thoughtful House Center for

Children in Austin, Texas, have found remarkably similar brain changes to those

seen in autism in infant monkeys receiving the vaccine schedule used in the

1990's that contained the mercury-based preservative thimerosal.

> >

> > The group's findings were published yesterday in the journal Acta

Neurobiologiae Experimentalis. They used scanning techniques that assessed both

brain growth and brain function in the same animals over time. The research team

was able to see differences in the way the brains of vaccinated and unvaccinated

animals developed. Scans were performed before and after the administration of

primary MMR and DTaP/Hib boosters that were given at the human equivalent of 12

months of age.

> >

> > Throughout the study period, vaccinated animals showed an increase in total

brain volume - a feature of the brain in many young children with autism - when

compared with unvaccinated animals. However, a specific part of the brain

associated with emotional responses that is thought to be important in autism,

the amygdala, did not show abnormalities until after the 12-month vaccines had

been given. In addition, after the 12-month vaccines only, the functional brain

scans showed significant differences between vaccinated and unvaccinated groups.

These functional scans looked at the activity of receptors for morphine-like

compounds (opioids) that may play a role in the brain of children affected by

autism. Vaccine administration was associated with an increase in opioid binding

activity in the amygdala compared with a decrease in the unvaccinated group.

> >

> > The results indicate that multiple vaccine exposures during the previous 3-4

months may have had a significant impact on brain growth and development in ways

that are consistent with the published data on autism. For the amygdala, the

novel findings of abnormal growth and function appear to be a function of more

recent vaccine exposures - the 12-month primary MMR vaccine and the DTaP and Hib

boosters.

> >

> > In an accompanying editorial Dr. Kris Turlejski, the Editor-in-Chief,

described the findings as " alarming " , " support[ing] the possibility that there

is a link between early immunization and the etiology of autism. "

> >

> > In the same primate model, the research team has already identified delayed

acquisition of vital brainstem reflexes in infants exposed to the

thimerosal-containi ng hepatitis B vaccine on the first day of life, compared

with unvaccinated animals. A larger, second phase study is currently underway to

see if these findings can be replicated.

> >

> > Dr. Wakefield, who is not a listed author but whose support in the

design of the study is acknowledged, said " I hope the model will not only

provide important insights into the origins of autism, but also ways of safely

testing possible new autism treatments and vaccines. "

> >

> > References:

> >

> > Hewitson, J. Lopresti, Carol Stott, N. Mason, and

Tomko. Influence of pediatric vaccines on amygdala growth and opioid ligand

binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp 2010. 70:

147-164

> >

> > Kris Turlejski. Focus on Autism Editorial Comment Acta Neurobiol Exp 2010.

70: 117-118

> >

> > -------------------------------

> > 2)

> > We Finally Get a Vaxxed v. Unvaxxed Study, Vaccinated Primates Have Brain

Changes Seen In Autism

> >

> >

<http://adventuresinautism.blogspot.com/2010/07/we-finally-get-vaxxed-v-unvaxxed\

-study.html>

> >

> > see above link for a link to the actual full study.

> >

> > We finally get a vaccinated v. unvaccinated study. No... no actual children

yet, but infant rhesus macaque monkeys.

> >

> >

> >

> > And no wonder main stream medicine doesn't want vaccine studies with an

actual baseline (completely unvaccinated), because the results are dramatic.

> >

> > The infant primates vaccinated according to the US vaccine schedule

(equivalent to their size/development rate, pre 2002 shots WITH full doses of

mercury) showed the same brain changes found in children with autism. The

amygdala, the fear and anxiety center, did not mature properly in the vaccinated

group, and those differences did not appear until AFTER the 12 month vaccines

were given.

> >

> > The abstract:

> >

> > Influence of pediatric vaccines on amygdala growth and opioid

> > ligand binding in rhesus macaque infants: A pilot study

> >

> > Acta Neurobiol Exp 2010, 70: 147–164

> > ©2010 by Polish Neuroscience Society - PTBUN, Nencki Institute of

Experimental Biology

> >

> > Hewitson1,2,*, J. Lopresti3, Carol Stott4, N. Mason3

and Tomko1

> >

> > 1Department of Obstetrics and Gynecology, University of Pittsburgh

School of Medicine, Pittsburgh, PA, USA;

> > 2Thoughtful House Center for Children, Austin, TX, USA; 3Department of

Radiology, University of Pittsburgh School of

> > Medicine, Pittsburgh, PA, USA; 4Independent Chartered Scientist,

Cambridge, UK;

> > *Email: lch1@

> >

> > This longitudinal, case-control pilot study examined amygdala growth in

rhesus macaque infants receiving the complete US childhood vaccine schedule

(1994-1999). Longitudinal structural and functional neuroimaging was undertaken

to examine central effects of the vaccine regimen on the developing brain.

Vaccine-exposed and saline-injected control infants underwent MRI and PET

imaging at approximately 4 and 6 months of age, representing two specific

timeframes within the vaccination schedule. Volumetric analyses showed that

exposed animals did not undergo the maturational changes over time in amygdala

volume that was observed in unexposed animals. After controlling for left

amygdala volume, the binding of the opioid antagonist [11C]diprenorphine (DPN)

in exposed animals remained relatively constant over time, compared with

unexposed animals, in which a significant decrease in [11C]DPN binding occurred.

These results suggest that maturational changes in amygdala volume and the

binding capacity of [11C]DPN in the amygdala was significantly altered in infant

macaques receiving the vaccine schedule. The macaque infant is a relevant animal

model in which to investigate specific environmental exposures and

structural/functional neuroimaging during neurodevelopment.

> >

> > Key Words: rhesus macaques, Macaca mulatta, non-human primates, animal

model, neuroimaging, PET, MRI, amygdala, opioids, ethyl mercury, thimerosal,

neurotoxicity

> >

> >

> > The full paper: Hewitson et. al.

> >

> > The editorial written by the editor of the journal, who says:

> >

> > An alarming finding is reported by Hewitson and coworkers showing that,

in infant monkeys that were immunized, the amygdala does not show the normal

pattern of maturation but is hypertrophied. Although these are only preliminary

data, given the well-known role of the amygdala in generation of fear and other

negative emotions, they support the possibility that there is a link between

early immunization and the etiology of autism.

> >

> >

> > Mark Blaxill and Dan Olmsted's discussion of the paper: New Study Shows

Vaccines Cause Brain Changes Found in Autism

> >

> > It should be noted that in the spring of 2008, The American Academy of

Pediatrics was informed of this study. At the conclusion of the DAN conference

in Cherry Hill, NJ in April of 2008, Dr. Jerry Kartzinel personally discussed it

with Dr. Louis who was there representing the AAP. skirted the

issue, acting as if he was concerned with the cost of the study, and Kartzinel

replied that the study was fully funded and underway. was clearly not

comfortable with the discussion of the study, and changed the subject. In their

discussion of what had seen at the conference and how to proceed with

some sort of partnership between ARI and AAP, had already stated to

Kartzinel:

> >

> > " I'm concerned about immunization policy and how you protect

immunization. "

> >

> >

> > To my knowledge, AAP never got back to anyone on their input into, or

involvement with, this primate study. Note that the study was not published by

Pediatrics, where it belongs, as it is AAP's journal and AAP is Pharma's main

vaccine distributor. I am sure they want this buried as deep as is possible.

> >

> > I am interested to see what AAP's public comment will be on this. If there

is one.

> >

> > AAP's (@ameracadpeds)twitter page can be found here:

http://twitter.com/ameracadpeds

> >

> > Feel free to call this post to their attention.

> >

>

[Guest guest]

Give me a break.

> >

> > In Case You Missed It.

> >

> >

> > 2 posts in one:

> >

> > New Study Shows Vaccines Cause Brain Changes Found in Autism

> >

> >

<http://www.ageofautism.com/2010/07/new-study-shows-vaccines-cause-brain-changes\

-found-in-autism.html>

> >

> > By Dan Olmsted and Mark Blaxill

> >

> > Abnormal brain growth and function are features of autism, an increasingly

common developmental disorder that now affects 1 in 60 boys in the US. Now

researchers from the University of Pittsburgh and Thoughtful House Center for

Children in Austin, Texas, have found remarkably similar brain changes to those

seen in autism in infant monkeys receiving the vaccine schedule used in the

1990's that contained the mercury-based preservative thimerosal.

> >

> > The group's findings were published yesterday in the journal Acta

Neurobiologiae Experimentalis. They used scanning techniques that assessed both

brain growth and brain function in the same animals over time. The research team

was able to see differences in the way the brains of vaccinated and unvaccinated

animals developed. Scans were performed before and after the administration of

primary MMR and DTaP/Hib boosters that were given at the human equivalent of 12

months of age.

> >

> > Throughout the study period, vaccinated animals showed an increase in total

brain volume - a feature of the brain in many young children with autism - when

compared with unvaccinated animals. However, a specific part of the brain

associated with emotional responses that is thought to be important in autism,

the amygdala, did not show abnormalities until after the 12-month vaccines had

been given. In addition, after the 12-month vaccines only, the functional brain

scans showed significant differences between vaccinated and unvaccinated groups.

These functional scans looked at the activity of receptors for morphine-like

compounds (opioids) that may play a role in the brain of children affected by

autism. Vaccine administration was associated with an increase in opioid binding

activity in the amygdala compared with a decrease in the unvaccinated group.

> >

> > The results indicate that multiple vaccine exposures during the previous 3-4

months may have had a significant impact on brain growth and development in ways

that are consistent with the published data on autism. For the amygdala, the

novel findings of abnormal growth and function appear to be a function of more

recent vaccine exposures - the 12-month primary MMR vaccine and the DTaP and Hib

boosters.

> >

> > In an accompanying editorial Dr. Kris Turlejski, the Editor-in-Chief,

described the findings as " alarming " , " support[ing] the possibility that there

is a link between early immunization and the etiology of autism. "

> >

> > In the same primate model, the research team has already identified delayed

acquisition of vital brainstem reflexes in infants exposed to the

thimerosal-containi ng hepatitis B vaccine on the first day of life, compared

with unvaccinated animals. A larger, second phase study is currently underway to

see if these findings can be replicated.

> >

> > Dr. Wakefield, who is not a listed author but whose support in the

design of the study is acknowledged, said " I hope the model will not only

provide important insights into the origins of autism, but also ways of safely

testing possible new autism treatments and vaccines. "

> >

> > References:

> >

> > Hewitson, J. Lopresti, Carol Stott, N. Mason, and

Tomko. Influence of pediatric vaccines on amygdala growth and opioid ligand

binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp 2010. 70:

147-164

> >

> > Kris Turlejski. Focus on Autism Editorial Comment Acta Neurobiol Exp 2010.

70: 117-118

> >

> > -------------------------------

> > 2)

> > We Finally Get a Vaxxed v. Unvaxxed Study, Vaccinated Primates Have Brain

Changes Seen In Autism

> >

> >

<http://adventuresinautism.blogspot.com/2010/07/we-finally-get-vaxxed-v-unvaxxed\

-study.html>

> >

> > see above link for a link to the actual full study.

> >

> > We finally get a vaccinated v. unvaccinated study. No... no actual children

yet, but infant rhesus macaque monkeys.

> >

> >

> >

> > And no wonder main stream medicine doesn't want vaccine studies with an

actual baseline (completely unvaccinated), because the results are dramatic.

> >

> > The infant primates vaccinated according to the US vaccine schedule

(equivalent to their size/development rate, pre 2002 shots WITH full doses of

mercury) showed the same brain changes found in children with autism. The

amygdala, the fear and anxiety center, did not mature properly in the vaccinated

group, and those differences did not appear until AFTER the 12 month vaccines

were given.

> >

> > The abstract:

> >

> > Influence of pediatric vaccines on amygdala growth and opioid

> > ligand binding in rhesus macaque infants: A pilot study

> >

> > Acta Neurobiol Exp 2010, 70: 147–164

> > ©2010 by Polish Neuroscience Society - PTBUN, Nencki Institute of

Experimental Biology

> >

> > Hewitson1,2,*, J. Lopresti3, Carol Stott4, N. Mason3

and Tomko1

> >

> > 1Department of Obstetrics and Gynecology, University of Pittsburgh

School of Medicine, Pittsburgh, PA, USA;

> > 2Thoughtful House Center for Children, Austin, TX, USA; 3Department of

Radiology, University of Pittsburgh School of

> > Medicine, Pittsburgh, PA, USA; 4Independent Chartered Scientist,

Cambridge, UK;

> > *Email: lch1@

> >

> > This longitudinal, case-control pilot study examined amygdala growth in

rhesus macaque infants receiving the complete US childhood vaccine schedule

(1994-1999). Longitudinal structural and functional neuroimaging was undertaken

to examine central effects of the vaccine regimen on the developing brain.

Vaccine-exposed and saline-injected control infants underwent MRI and PET

imaging at approximately 4 and 6 months of age, representing two specific

timeframes within the vaccination schedule. Volumetric analyses showed that

exposed animals did not undergo the maturational changes over time in amygdala

volume that was observed in unexposed animals. After controlling for left

amygdala volume, the binding of the opioid antagonist [11C]diprenorphine (DPN)

in exposed animals remained relatively constant over time, compared with

unexposed animals, in which a significant decrease in [11C]DPN binding occurred.

These results suggest that maturational changes in amygdala volume and the

binding capacity of [11C]DPN in the amygdala was significantly altered in infant

macaques receiving the vaccine schedule. The macaque infant is a relevant animal

model in which to investigate specific environmental exposures and

structural/functional neuroimaging during neurodevelopment.

> >

> > Key Words: rhesus macaques, Macaca mulatta, non-human primates, animal

model, neuroimaging, PET, MRI, amygdala, opioids, ethyl mercury, thimerosal,

neurotoxicity

> >

> >

> > The full paper: Hewitson et. al.

> >

> > The editorial written by the editor of the journal, who says:

> >

> > An alarming finding is reported by Hewitson and coworkers showing that,

in infant monkeys that were immunized, the amygdala does not show the normal

pattern of maturation but is hypertrophied. Although these are only preliminary

data, given the well-known role of the amygdala in generation of fear and other

negative emotions, they support the possibility that there is a link between

early immunization and the etiology of autism.

> >

> >

> > Mark Blaxill and Dan Olmsted's discussion of the paper: New Study Shows

Vaccines Cause Brain Changes Found in Autism

> >

> > It should be noted that in the spring of 2008, The American Academy of

Pediatrics was informed of this study. At the conclusion of the DAN conference

in Cherry Hill, NJ in April of 2008, Dr. Jerry Kartzinel personally discussed it

with Dr. Louis who was there representing the AAP. skirted the

issue, acting as if he was concerned with the cost of the study, and Kartzinel

replied that the study was fully funded and underway. was clearly not

comfortable with the discussion of the study, and changed the subject. In their

discussion of what had seen at the conference and how to proceed with

some sort of partnership between ARI and AAP, had already stated to

Kartzinel:

> >

> > " I'm concerned about immunization policy and how you protect

immunization. "

> >

> >

> > To my knowledge, AAP never got back to anyone on their input into, or

involvement with, this primate study. Note that the study was not published by

Pediatrics, where it belongs, as it is AAP's journal and AAP is Pharma's main

vaccine distributor. I am sure they want this buried as deep as is possible.

> >

> > I am interested to see what AAP's public comment will be on this. If there

is one.

> >

> > AAP's (@ameracadpeds)twitter page can be found here:

http://twitter.com/ameracadpeds

> >

> > Feel free to call this post to their attention.

> >

>