Re: DMSA rat study, lasting cognitive dysfunction

[Guest guest]

Hi,

" Succimer or apple juice (vehicle) was administered twice daily via oral gavage

from PND31 to PND52. The daily succimer dose was 50 mg/kg body weight/day during

the first week of chelation, followed by 25 mg/kg/day for the second and third

weeks, similar to the regimen used clinically (Rogan et al. 2001). "

Half life of DMSA was not respected.....

I'm sure others will elaborate if you haven't read the files section.

na

>

> I'm concerned about the use of DMSA due to this study that showed " lasting

cognitive and and affective dysunction " in rats treated with DMSA.

>

> In contrast, succimer treatment of rats not previously exposed to Pb produced

lasting and pervasive cognitive and affective dysfunction comparable in

magnitude to that produced by the higher Pb exposure regimen.

>

>

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F1\

0.1289%2Fehp.9263

>

>

> Does anyone have any explanation why DMSA could have caused this? I'm

concerned that over time these effects could be observes in humans as well with

continued use of this chelator.

>

> Maybe low-dose DMPS would be safer?

>

[Guest guest]

Not only that but it also seems to me that the dose was way too high... What

kind of " rats " weigh over a kg??? Or???

Isa

Enviado desde mi oficina móvil BlackBerry® de Telcel

[ ] Re: DMSA rat study, " lasting cognitive dysfunction "

Hi,

" Succimer or apple juice (vehicle) was administered twice daily via oral gavage

from PND31 to PND52. The daily succimer dose was 50 mg/kg body weight/day during

the first week of chelation, followed by 25 mg/kg/day for the second and third

weeks, similar to the regimen used clinically (Rogan et al. 2001). "

Half life of DMSA was not respected.....

I'm sure others will elaborate if you haven't read the files section.

na

>

> I'm concerned about the use of DMSA due to this study that showed " lasting

cognitive and and affective dysunction " in rats treated with DMSA.

>

> In contrast, succimer treatment of rats not previously exposed to Pb produced

lasting and pervasive cognitive and affective dysfunction comparable in

magnitude to that produced by the higher Pb exposure regimen.

>

>

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F1\

0.1289%2Fehp.9263

>

>

> Does anyone have any explanation why DMSA could have caused this? I'm

concerned that over time these effects could be observes in humans as well with

continued use of this chelator.

>

> Maybe low-dose DMPS would be safer?

>

[Guest guest]

I doubt test rats weigh much over a kilo, but I have seen some city rats that

were pretty darn big!

Karla

> >

> > I'm concerned about the use of DMSA due to this study that showed " lasting

cognitive and and affective dysunction " in rats treated with DMSA.

> >

> > In contrast, succimer treatment of rats not previously exposed to Pb

produced lasting and pervasive cognitive and affective dysfunction comparable in

magnitude to that produced by the higher Pb exposure regimen.

> >

> >

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F1\

0.1289%2Fehp.9263

> >

> >

> > Does anyone have any explanation why DMSA could have caused this? I'm

concerned that over time these effects could be observes in humans as well with

continued use of this chelator.

> >

> > Maybe low-dose DMPS would be safer?

> >

>

>

>

>

>

>

[Guest guest]

Yup. The joys of people playing gin rummy with pubmed abstracts.

I see the correct answer is below. The DMSA was given on a dangerous, harmful

and inappropriate schedule and not surprisingly that caused brain damage in the

rats.

It can do so in children, too, for example when given every 8 hours by DAN!

doctors practicing medicine without a clue.

At least they reported their experimental methods well enough we could figure

out what happened.

Andy

http://www.noamalgam.com/index.html

Amalgam Illness: Diagnosis and Treatment

http://www.noamalgam.com/hairtestbook.html

Hair Test Interpretation: Finding Hidden Toxicities

http://www.noamalgam.com/nourishinghope.html

Nourishing Hope for Autism: Nutrition Intervention for Healing Our Children

http://www.noamalgam.com/biologicaltreatments.html

Biological Treatments for Autism and PDD

> > >

> > > I'm concerned about the use of DMSA due to this study that showed " lasting

cognitive and and affective dysunction " in rats treated with DMSA.

> > >

> > > In contrast, succimer treatment of rats not previously exposed to Pb

produced lasting and pervasive cognitive and affective dysfunction comparable in

magnitude to that produced by the higher Pb exposure regimen.

> > >

> > >

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F1\

0.1289%2Fehp.9263

> > >

> > >

> > > Does anyone have any explanation why DMSA could have caused this? I'm

concerned that over time these effects could be observes in humans as well with

continued use of this chelator.

> > >

> > > Maybe low-dose DMPS would be safer?

> > >

> >

> >

> >

> >

> >

> >