Has metallothionein's failure to properly metabolize - been discredited?

[Guest guest]

Hello,

Anyone here familiar with Dr. Walsh and co's research on a metal metabolism

disorder associated with a/the metallothionein protein failing to regulate to

excrete heavy metal as it should contributing to heavy metal poisoning, as an

alternative theory on what's going on with some if not many people with autism?

I haven't heard where that theory/science has gone from when I was first

acquainted with it a few years ago. I'll assume that whole thing has been

discredited by mainstream *alternative* medicine where I don't hear anything

from us on it.. (basically). I'm not hearing about that from mainstream medicine

either, from the mass media sources I normally follow I mean.

I'm not hearing much about that anywhere these days. Maybe it's a gonner.. . And

it sounded so plausible (and promising)

Mike Glavic

[Guest guest]

According to this paper, metallothionein binds to many metals but in normal

circumstances only significantly to zinc, copper and cadmium.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156612/

And this one says that metallothionein levels are normal in autistic kids.

http://tinyurl.com/2clsnvy

If copper or cadmium is an issue with your child, I think that boosting

metallothionein levels with zinc is probably a safe intervention.

>

> Hello,

>

> Anyone here familiar with Dr. Walsh and co's research on a metal metabolism

disorder associated with a/the metallothionein protein failing to regulate to

excrete heavy metal as it should contributing to heavy metal poisoning, as an

alternative theory on what's going on with some if not many people with autism?

[Guest guest]

So much for that whole thing so far.. . Thanks.

Mike

> >

> > Hello,

> >

> > Anyone here familiar with Dr. Walsh and co's research on a metal metabolism

disorder associated with a/the metallothionein protein failing to regulate to

excrete heavy metal as it should contributing to heavy metal poisoning, as an

alternative theory on what's going on with some if not many people with autism?

>

[Guest guest]

The study linked at the bottom of this article seems to indicate as much,

(especially as related to autism, and in more specifically answering my

question) but metallothionein does seem to have its prospects, (for heavy metal

detox, etc.) and I'm not so sure we've heard the last on it, but, maybe from me

on the matter.. .

http://www.answers.com/topic/metallothionein

Mike

> > >

> > > Hello,

> > >

> > > Anyone here familiar with Dr. Walsh and co's research on a metal

metabolism disorder associated with a/the metallothionein protein failing to

regulate to excrete heavy metal as it should contributing to heavy metal

poisoning, as an alternative theory on what's going on with some if not many

people with autism?

> >

>

[Guest guest]

I've never heard of boosting metallothionein levels with zinc. I suppose it

might be something to try, (but in our situation zinc doesn't seem to directly

evidence any benefits) but there isn't even a consensus on these boards on how

to measure for metal toxicity, it seems

Our DAN goes with a urine test but hasn't found anything really out of the

ordinary with that. The most striking thing our blood tests indicate is that

our son uses iron faster than we give it to him, or he doesn't absorb it

properly, despite being on a GFCF diet and getting heavy iron supplementation.

I realized that the study you directed me to was the same one I found after the

fact, but nothing promising through the grapevine it would seem.. . Thanks again

on that matter

Some of us are all over the map with chelation it seems. Some seem quite content

with ALA and dealing with corresponding yeast and supplementing with what

trial-and-error seems to provide in that respect of directly observable

evidence.

I kind of like Dana's way, (on that, and for value) though it seems most folks

here lean more to Andy Cutler's more intense and invasive methods (that might

also accomodate Dana's approach) A blood and urine analysis by our DAN doesn't

take us in that direction (the more intense approach) and he seems OK with ALA,

though he still hasn't got a handle on why our son seems so low in iron despite

the heavy supplementing we are doing to try to balance that situation.

I won't blame metallothionein for over-reacting with our son's iron condition,

though I'm not so sure we understand all there is to that.

Here's for trying.

Mike

> >

> > Hello,

> >

> > Anyone here familiar with Dr. Walsh and co's research on a metal metabolism

disorder associated with a/the metallothionein protein failing to regulate to

excrete heavy metal as it should contributing to heavy metal poisoning, as an

alternative theory on what's going on with some if not many people with autism?

>

[Guest guest]

Zinc is prescribed by physicians to remove excess copper from s Disease

patients. It induces intracellular levels of metallothionein. Google s

Disease, zinc and cooper for more information.

I think that this intervention is like any other. Our kids differ in the number

of vaccines and the environmental assaults. They also differ in the types of

biomedical interventions, when they began, how aggressive they were, etc. Others

have ongoing gut issues while others seem to have parasites, viruses and yeast.

Finally some kids eat a healthy diet and others a restrictive one. It's like a a

rubics cube. There are so many variables. What is an issue for one is not an

issue for another. What works for one who seemingly has the same issue, doesn't

work for another.

Are your son's zinc levels normal?

You've probably already know this, but vitamin C helps iron absorption. Ascorbic

acid would probably work better than other forms.

>

> I've never heard of boosting metallothionein levels with zinc. I suppose it

might be something to try, (but in our situation zinc doesn't seem to directly

evidence any benefits) but there isn't even a consensus on these boards on how

to measure for metal toxicity, it seems

>

> Our DAN goes with a urine test but hasn't found anything really out of the

ordinary with that. The most striking thing our blood tests indicate is that

our son uses iron faster than we give it to him, or he doesn't absorb it

properly, despite being on a GFCF diet and getting heavy iron supplementation.