pdf: Medication-induced mitochondrial damage and disease

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*/ Medication-induced mitochondrial damage and disease/*

Neustadt and Steve R. Pieczenik

Montana Integrative Medicine, Bozeman, MT, USA

Mol. Nutr. Food Res. 2008, 52, 780 -- 788

http://psychrights.org/research/Digest/NLPs/DrugsCauseMitochondrialDamage.pdf

Since the first mitochondrial dysfunction was described in the 1960s,

the medicine has advanced in

its understanding the role mitochondria play in health and disease.

Damage to mitochondria is now

understood to play a role in the pathogenesis of a wide range of

seemingly unrelated disorders such as

schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy,

migraine headaches, strokes,

neuropathic pain, Parkinson's disease, ataxia, transient ischemic

attack, cardiomyopathy, coronary

artery disease, chronic fatigue syndrome, fibromyalgia, retinitis

pigmentosa, diabetes, hepatitis C,

and primary biliary cirrhosis. Medications have now emerged as a major

cause of mitochondrial damage,

which may explain many adverse effects. All classes of psychotropic

drugs have been documented

to damage mitochondria, as have stain [sic: statin] medications,

analgesics such as acetaminophen, and

many others. While targeted nutrient therapies using antioxidants or

their prescursors (e.g., N-acetylcysteine)

hold promise for improving mitochondrial function, there are large gaps

in our knowledge.

The most rational approach is to understand the mechanisms underlying

mitochondrial damage for

specific medications and attempt to counteract their deleterious effects

with nutritional therapies.

This article reviews our basic understanding of how mitochondria

function and how medications damage

mitochondria to create their occasionally fatal adverse effects.*/

Thimerosal also/*

24 citations in Pubmed via:

thimerosal AND mitochond*