Chelation

[Guest guest]

When my wife was alive she tried:

Oral Chelating Formula with FDTA

From:

NutraLife Laboratories

(800) 644-6224

They do not have a web site.

She found the formula to be too strong and too sedating,

and she had to discontinue it. did not have CFS/FM.

***

Interesting Oral Chelation wars info:

http://www.oralchelation.com/nutralife/nutralife10.htm

Written by this competitor:

http://www.oralchelation.com/lgmch1.html

[Guest guest]

How does one get diagnosed with heavy metals. Can a regular blood test, done at the physicians office do this? I have a developmentally delayed daughter and would like more information.

[Guest guest]

Go to e-groups and join autism treatmentegroups . You can check the archives for a lot of useful information. Also, check for a research paper called, " Autism: A Unique Type of Mercury Poisoning " . It credits mercury poisoning with everything from severe autism to Tourette's and ADHD. I have two children who have been affected to some degree. If you have any more questions, please feel free to e-mail me privately.

Kathy liamm@...

Re: chelation

How does one get diagnosed with heavy metals. Can a regular blood test, done at the physicians office do this? I have a developmentally delayed daughter and would like more information. Subscription email: bowel cleanse-subscribeegroups

[Guest guest]

To answer your question, a blood test will not detect presence of heavy metals unless the exposure was recent (6 months or less). A hair analysis is the best way. Some doctors do provocational urine challenge tests, but this may not be safe for children as it could strain the kidneys.

Kathy

Re: chelation

How does one get diagnosed with heavy metals. Can a regular blood test, done at the physicians office do this? I have a developmentally delayed daughter and would like more information. Subscription email: bowel cleanse-subscribeegroups

[Guest guest]

Kathy,

I think the information you are getting on the Autism group at e-groups would be more appropriate in terms of the chelation therapy than what you will find on this group. The Autism group has professionals on it--Phd's, MD's and others who have alot of experience with chelating agents.

As you know, there are different chelating agents for different purposes. EDTA is not what most kids need when dealing with the various heavy metal toxicity issues. EDTA can chelate metals, but for metals such as arsenic and mercury, DMSA is preferred. Of course, you can try the oral chelators on your son, with the EDTA, but you chance not treating the heavy metal issue completely.

It is so important to remember that chelators take minerals out of the body--the good and the bad. So, the good have to be replaced regularly as well. That means a good multi-mineral supplement.

Patty

[Guest guest]

Kelation Plus is packed full of minerals to compensate for minerals being lost. Check with the company before you make your decision. It does remove heavy metals.

This brings to mind another question--how do you know the "chelator", which is weak at best in this formulation, isn't taking out the very minerals included in the product, grabbing practically nothing from your own body?

Patty

[Guest guest]

Kelation Plus is packed full of minerals to compensate for minerals being lost. Check with the company before you make your decision. It does remove heavy metals.

Re: chelation

Kathy,

I think the information you are getting on the Autism group at e-groups would be more appropriate in terms of the chelation therapy than what you will find on this group. The Autism group has professionals on it--Phd's, MD's and others who have alot of experience with chelating agents.

As you know, there are different chelating agents for different purposes. EDTA is not what most kids need when dealing with the various heavy metal toxicity issues. EDTA can chelate metals, but for metals such as arsenic and mercury, DMSA is preferred. Of course, you can try the oral chelators on your son, with the EDTA, but you chance not treating the heavy metal issue completely.

It is so important to remember that chelators take minerals out of the body--the good and the bad. So, the good have to be replaced regularly as well. That means a good multi-mineral supplement.

Patty Subscription email: bowel cleanse-subscribeegroups

[Guest guest]

I know from experience using it and the results the Dr.s of my clients found. They were amazed at the results their patients were getting and told them all to keep going. The best thing is to contact the manufacturer for assay reports. All I can do is give the results my husband and I got, and my clients got.

Sherry

Re: chelation

Kelation Plus is packed full of minerals to compensate for minerals being lost. Check with the company before you make your decision. It does remove heavy metals.

This brings to mind another question--how do you know the "chelator", which is weak at best in this formulation, isn't taking out the very minerals included in the product, grabbing practically nothing from your own body?

PattySubscription email: bowel cleanse-subscribeegroups

[Guest guest]

Chelation should not be attempted with ORAL or IV without monitoring by a

physician of some sort.

At 08:40 AM 02/19/2001 -0000, you wrote:

>Awhile back, someone asked about children's vitamins with chealting

>properties. According to my husband, a family doc(opposed to

>vaxxes), chelation is the process of removing heavy metals out of the

>bloodstream. This is usually done using IV therapy. I don't want

>this to sound like an ad for Golden Pride but as Directors involved

>in this company, I asked my husband about our Formula #1 which is the

>original oral chelator. It has been used with great results and not

>near as costly as IV treatments which may take many treatments. The

>reasoning behind the chealtion is the removal of such metals as

>mercury,aluminum,lead,iron,formadehyde...you get the picture. This

>should result in decreased blood pressure, decreased chances of

>hardening of the arteries and heart disease. My husband also stated

>that for some reason, calcium is removed and can be a problem for

>children but does not seem to be for adults. He was going to

>research to find why there was a discrepancy as we all need calcium,

>young and old alike. Unfortunately, he hasn't had the time yet. I

>just wanted to inform whoever that chealtion does not have to do with

>the absorption of the nutrients in a supplement so I doubt if you

>will find vitamins for your children with chelating ingredients.

>

>

>

>

>

>

--------------------------------------------------------

Sheri Nakken, R.N., MA

Vaccination Information & Choice Network, Nevada City CA & UK

530-478-1242 Voicemail

http://www.nccn.net/~wwithin/vaccine.htm

" All that is necessary for the triumph of evil is that good men ( &

women) do nothing " ...Edmund Burke

ANY INFO OBTAINED HERE NOT TO BE CONSTRUED AS MEDICAL OR LEGAL ADVICE. THE

DECISION TO VACCINATE IS YOURS AND YOURS ALONE.

Well Within's Earth Mysteries & Sacred Site Tours

http://www.nccn.net/~wwithin

International Tours, Homestudy Courses, ANTHRAX & OTHER Vaccine Dangers

Education, Homeopathic Education

CEU's for nurses, Books & Multi-Pure Water Filters

[Guest guest]

Laurie,

I was the one who asked. My cousin had just seen a enzyme therapist who said if your vitamins aren't chelated that they were not being properly absorbed. I've heard of the IV chelation for lowering lead levels.

L.Proud mom to Autumn 1-13-97 & Zoe 8-8-00

[Guest guest]

Does anyone know of any links about this? Sounds interesting.

Shanna Small

>From: " Laurie " <boldml@...>

>Reply-Vaccinations

>Vaccinations

>Subject: chelation

>Date: Mon, 19 Feb 2001 08:40:06 -0000

>

>Awhile back, someone asked about children's vitamins with chealting

>properties. According to my husband, a family doc(opposed to

>vaxxes), chelation is the process of removing heavy metals out of the

>bloodstream. This is usually done using IV therapy. I don't want

>this to sound like an ad for Golden Pride but as Directors involved

>in this company, I asked my husband about our Formula #1 which is the

>original oral chelator. It has been used with great results and not

>near as costly as IV treatments which may take many treatments. The

>reasoning behind the chealtion is the removal of such metals as

>mercury,aluminum,lead,iron,formadehyde...you get the picture. This

>should result in decreased blood pressure, decreased chances of

>hardening of the arteries and heart disease. My husband also stated

>that for some reason, calcium is removed and can be a problem for

>children but does not seem to be for adults. He was going to

>research to find why there was a discrepancy as we all need calcium,

>young and old alike. Unfortunately, he hasn't had the time yet. I

>just wanted to inform whoever that chealtion does not have to do with

>the absorption of the nutrients in a supplement so I doubt if you

>will find vitamins for your children with chelating ingredients.

>

_________________________________________________________________

Get your FREE download of MSN Explorer at http://explorer.msn.com

[Guest guest]

I don't know if there are any links but I can send you literature if you'd email me privately...boldml@...

Laurie>Bucyrus,OhioPlease visit us at our websitehttp://www.goldenprideweb.com/drmikeandlaurie for information on nutritional supplements,including the original oral chelator, skin care,weight loss(The Florida Diet),Herbs for Health,and home products

----- Original Message -----

From: Lashanna Small

: Re: chelation

Does anyone know of any links about this? Sounds interesting.Shanna Small>

[Guest guest]

In a message dated 06/29/2001 11:38:35 AM Central Daylight Time,

rr-jr@... writes:

<<

Apparently there are a few different ways to chelate. >>

/x/x/x/x/x/x/x/x/x/

A customer in my barber shop today told me that he and his wife go to Mexico

once or twice a year for " chelation treatments " which cost fifty dollars

each. He said it is for cleansing the blood and had never known it to have

anything to do with mercury, but he claims to feel " wonderful " and brags

about his wife, who, at 59, looks all of 30. I didn't get a chance to have

him describe the treatment, except to say it took less than an hour and

involved an IV. Is this similar to the kind of chelation I see mentioned

here on the board so often?

[Guest guest]

<<...I didn't get a chance to have him describe the treatment, except to say

it took less than an hour and involved an IV. Is this similar to the kind

of chelation I see mentioned here on the board so often? >>

Hi :

The type of chelation that was described to you was the IV variety and is

practiced in the U. S., but not for $50. Most physicians who practice it

recommend 4 or more chelation sessions, some as many as 20 depending on your

condition. A clinic just a short distance from me here in the Seattle area

that practices IV chelation has a web page on it at:

http://www.tahomaclinic.com/chelation.shtml

You will notice at that page that in the U. S. the FTC has restricted what

they can say about it. They used to be able to say that it clears the

arteries and does other things as well. In Mexico, they can still say that.

The type of chelation discussed on this list is " oral " chelation, achieving

the same results through supplements but without the IV process. Both are

controversial.

Jim B

[Guest guest]

to do the 24 hour urine test the DMSA being used may not give an accurate

result.

DMSA does not chelate mercury from the brain tissue (where it deposits

itself eventually).

ALA does that well.

DMSA is good for chelating mercury out of other body tissues which will be

excreted for the test.

if your chid haas not had recent exposure to mercury, it could potentially

be that the 24 hour urine test will not show his/her mercury load because it

has allready passed into the brain.

minna

[Guest guest]

Hi List,

Attached is an excellent article on Chelation.

A Comparative Study of Three Chelation Protocols.

Dear Friends:This is a long, but must read paper. More details on chelation, and a comparison of the three top methods of chelation by a man who has been there, done that. Warmly,Willis The Mobilization and Elimination of Systemic Heavy Metals in the Context of Biological Medicine.© Copyright 2001 by Ray O.M.D., LAc, USAIntroductionThis article focuses on the methods of mobilization, the pathways of elimination, and the difficulties that present themselves during heavy metal detoxification. I hear as many stories involving heavy metal chelators, about the devastating side effects as I do about the miraculous recoveries. What has become apparent is that the difference is due to the methodology of the attending physician, and not necessarily the choice of chelator. Those who practice Biological Medicine, Autonomic Resonance Testing (A.R.T.), the work of Dr. Y. Omura, and similar methods that rely on in-vivo testing for biological individuality and protocol, place the chelator into the context of their findings. Those who only prescribe the chelator as a drug, relying on in-vitro studies, usually do not have information relevant to the patient’s specific, individual requirements for the utilization of the chelator or the processing of the result. This latter ‘recipe’ approach can easily lead to side effects, and thus the present confusion about the relative effectiveness and safety of the available heavy metal chelators. For example, on the negative side, a patient related that her local ‘alternative’ doctor was administering two DMPS IV pushes per week to people who still had amalgams in their teeth with little or no supplement support and no prioritized case management, with the result that they were all feeling terrible. One woman’s health had been in a steady state of decline since her first push. Not only was she experiencing all of the side effects and complications mentioned below, but also she had a severe allergy to sulfur. No wonder we hear horror stories.Primary Chelation MethodsThis discussion is limited to the clinical use of three different types of independent laboratory proven effective heavy metal chelators, each with a different method of action, each providing a different exit route for the mobilized metals from the body. 1. Sulfhydryl (SH) Groups[1] (DMSA & DMPS) – via the bowel and urine.2. Peptidyl and Sulfhydryl (P-SH) Complexes, Clathration types, (See note[2] for product list.) – via the bowel.3. Mucopolysaccharide Ion Exchange Resin (MIER) NDF and NDF Plus[3] – via the urine.The following other methods will not be discussed for the following reasons: 1. I have no experience using EDTA and penicillamine. 2. Clay baths and far infrared saunas are of beneficial secondary support, but they do not directly impact the central nervous system (CNS). 3. The specific action of homeopathics, energy remedies and isopathics is very slow, they rely on the ability of the patient to react. (Most heavy metal toxic patients are no longer able to do so efficiently or completely.) Mercury appears to be an effective antidote or inhibitor of isopathic[4] and frequency information.[5] 4. Complex nutrient supplements sound effective, but heavy metal toxic patients have varying degrees of assimilation and utilization problems and multiple allergies. Many supplements these days actually contain heavy metals[6] and there is little to no independent laboratory proof as to their predictable effectiveness.Diagnosis – False Negatives and the Provocative ChallengeGiven that just about every person on this planet has some degree of heavy metal toxicity (from air pollution, amalgam fillings, dental offices, inoculations, fish, in utero exposure from the mother’s fillings, ground and water contamination)[7], the fact that the World Health Organization (WHO) acknowledges environmental pollution as the underlying cause of 80% of all chronic degenerative diseases,[8] that proof has been established as to the causative effect of heavy metals in neurological diseases including Alzheimer’s and MS,[9] that the FDA now warns women of childbearing age (all women above age 18) to not eat certain (heavy metal containing) fish,[10] and that there are at least 76 published functional and behavioral abnormalities associated with heavy metal toxicity,[11] the most serious and common mistake that can be made is a misdiagnosis (false negative) either at the beginning or end of therapy. The most serious problems associated with the exclusive use of independent labs for establishing heavy metal toxicity and monitoring the results of detoxification follow: Since we can only measure what the patient can eliminate, not the actual total body burden (as this would require multiple biopsies), any blockages in the pathways of ionization, assimilation, utilization or elimination can produce a false negative. Unprovoked lab tests of urine, stool or blood will not always reveal the body burden of metals. Hair analysis is certainly not reliable.[12] SH chelators provoke the elimination of soft tissue but not necessarily CNS burdens. P-SH chelators provoke predominantly via the bowel, so if you only analyze the urine you won’t find the correct level of heavy metal elimination. The MIER chelators take the metals out through the first urine following the dose, therefore a 24-hour urine test will give a diluted result, and a post challenge fecal elements test will show a decrease in metals. If the dose of any provocative agent is not strong enough to reach the deepest layers of the body burden, a false negative will occur. To determine if the patient has completed therapy, a megadose of a provocative chelator that does cross the blood brain barrier must be used. In addition, if there are any undetected or unresolved focal problems the patient may not respond to the provocative dose and a false negative will occur. ‘Healing Crisis’ – Side EffectsIt is the author’s continued experience that a ‘healing crisis’ means that more toxins are being pulled out of the tissue than the organs of elimination and the binding capacity of the chelator can cope with, causing the toxins to be redistributed in the body and to produce symptoms. If the choice of chelator, method of administration, dosage and metabolic support are correct, the patient only feels better. If the patient’s individual priorities and ability to utilize the protocol[13] have not been established the patient will feel, and be, worse. Depending on the size of the dose, massive amounts (up to a 750% increase from pre challenge levels) of toxic metals can be mobilized via the liver and dumped into the bowel and or kidney using either SH or P-SH chelators. Without proper drainage support, this can cause problems. If the patient is intolerant of or allergic to sulfur there will be additional complications. The Bowel: General Concerns Patients with dental amalgam fillings, especially those of long duration (5-30 years), and even those who have had them replaced with biocompatible materials, are known to suffer from the complications of dysbiosis, candidiasis, poor digestion, food allergies, compromised local immunity, Leaky Gut Syndrome (intestinal permeability), intestinal inflammation, impaired nerve function and diminished peristalsis causing constipation, and parasitic and bacterial infections. The mercury traveling into the gut with the saliva compromises the function of the Peyer’s patches, thus arresting the first line of immune defense. These conditions tend to persist during continued exposure from any source, after amalgam removal and at least until heavy metal detox is complete. Once the amalgams have been removed, the tissue burden of mercury can remain high for years to come, and the crippled bowels will not begin to return to full health until after most of the metals have been removed. During detox, the mobilized heavy metals can linger in the bowel for between 6 and 24 hours or more before evacuation takes place. The bowel of a healthy person may not be prone to free radical damage, but the damaged bowel of the metal toxic patient is at least an area for added concern and monitoring.Enzyme Mediated Resorption A central question is what percent of the mobilized metal is bound beyond the point of contact with surrounding tissue, and can the bond that holds it withstand the action of digestive enzymes in the bowel? A peptide (protein particle) molecule, when cleaved by a proteolytic enzyme, has its three-dimensional structure irreversibly altered, thus reversing any chelation effect it once had. The answer to this is a matter of degree. What is the current enzyme content of the patient’s digestive tract? How much of the bound metal will be released? Methyl Mercury FormationCandida albicans, E. Coli, oral Streptococci, and certain beneficial gut bacteria have the ability to methylate mercury into methyl mercury, the most noxious form of the toxin.[14] [15] [16] Most heavy metal toxic patients suffer from chronic candidiasis. Frequent bowel movements reduce the time of exposure of the mercury to the bowel flora. Intestinal Permeability and ResorptionSome of the mobilized metals may be unbound because the mobilizing and binding mechanisms of each chelator may have different degrees of efficiency depending on each patient’s current biochemistry. The longer the metals stay in the bowel, the more damage and inflammation they can cause. If the patient has Leaky Gut Syndrome or Inflammatory Bowel Disease, which most of these patients do, the increased permeability of the intestinal wall may provide little resistance to the resorption of these mobilized metals, which then travel back to where they came from—the brain, kidneys, liver, connective tissue, etc., or are deposited into previously healthy tissue. The problem with leaky gut and bowel inflammation in general, is that they are very difficult to treat while the metals are still present in that tissue and continuing to cause inflammation. (Observation: Selenium is said to bind mercury preventing resorption—WSL)Antibiotic Resistant BacteriaMercury is known to create antibiotic resistant bacteria, the plasmid responsible also being replicated and passed on to other bacteria.[17] The presence of mercury in the bowel could therefore contribute to the severity and duration of intestinal infections or Fields of Disturbance (metal and endotoxin pooling).The Kidney: General ConcernsAll heavy metals are nephrotoxic.[18] "Most heavy metals accumulate in segments of the proximal nephron because of transport or binding sites such as sulfhydryl (SH) groups."[19] If more metals are mobilized than are bound, or if the bound metals are released by the action of enzymes, kidney problems will occur. While using SH and P-SH chelators: vitamin C, kidney drainage remedies, coffee enemas, saunas, clay baths and additional water can be useful for kidney support. While using MIER chelators, megadoses of proteolytic enzymes on an empty stomach should be avoided on the day of the dose because the enzymes may enter the bloodstream and threaten the integrity of the chelation bond, thus exposing tissue, especially the kidney and bladder, to direct exposure.The Unattended Spiral Down – Elimination via the BowelIf the mobilized and bound (SH and P-SH chelators) mercury is released by the action of a protease, the candida and gut flora convert it to methyl mercury, which poisons the tissue (more inflammation and permeability), nerves (increased constipation), and Peyer’s patches (lowered immunity). Superbacteria are generated in the same moment that the intestinal immune system is compromised. The infections further contribute to the local inflammation and intestinal permeability, which then allows for an increased resorption of the mobilized metals. Mercury in the combined presence of other heavy metals is even more toxic[20]. SH groups have a binding affinity in the kidney, where metals can accumulate and cause further problems. A patient taking a provocation level dose of an SH or P-SH chelator without expert drainage support could be at risk of side effects. A substantially reduced dose might take a while to produce a side effect, but would also take a very long time to produce the desired beneficial results. I believe this unattended spiral down to be one of the main reasons why complete heavy metal detox is so difficult, if not impossible to achieve, when elimination occurs via the bowel and is not managed in the context of a Biological Medicine protocol. If all of these issues are not addressed according to the patient’s individual and prioritized needs, the outcome will be less than favorable. General PrecautionsPatients using SH and P-SH chelators have avoided most of the complications and side effects when support supplements and therapies were selected according to in-vivo testing. The options include: · Coffee enemas and fiber containing bowel cleansers · Large and frequent doses of activated charcoal · Strong and fast acting laxatives · MSM or garlic · Vitamin C (IV and oral) · Liver and kidney protective supplements are imperative. No proteolytic enzymes or pancreatic PMG can be given. Flora supplements may be problematic in some patients, especially on the day of the dose. Unpasteurized fermented foods and beers are to be avoided. No protein on the day of the dose; a low protein diet is advisable. If an attempt is made to kill the candida before the metals are gone, breaking the cell wall of the candida releases more metals into the gut because the candida cell wall binds to the metals. L-glutamine is of some benefit for intestinal permeability. However, not much can be done to correct intestinal permeability while the patient is still heavy metal toxic and thus at risk of reabsorbing a significant percentage of the mobilized metals. How do you know what combination of therapies or remedies, what form of what remedy at what dosage and frequency to give if you can’t find out what the patient requires and how they will respond, in-vivo, ahead of time?[21] Placing a patient on a ‘pre-fab’ protocol, even one that is extremely well thought out, has to miss some of their needs.Experience with SH Chelation (1994-1997)SH chelators mobilize the metals via both the urine and the bowel and there are two different types, DMSA and DMPS. DMSA never tested well with my patients so I never used it. (I later found out that the use of DMSA prior to treatment with DMPS could mobilize metals into the brain, making it very dangerous if used as the exclusive chelator.) At that time the only clearly effective choice was DMPS and I worked with an M.D. who administered it while I determined the Biological protocols. The general support required for the patient to tolerate two pushes per month with no side-effects, after all metals had been removed from the teeth, included both a supplementation and a spa detox protocol.Supplements included: MSM or garlic (sulfation), OxyOxc (laxative), Super Colon Glow (fiber with herbs), Immunocal whey (glutathione), Barley Grass (alkaline reserve, minerals, enzymes), activated charcoal (bowel protection), Solidago and Buccu (kidney drainage), LiverLife (kidney and liver support and drainage), Multi-Minerals (mineral replacement), zinc picolinate, and vitamin C. Additional remedies and therapies were required for Terrain balancing (diet and focal problems addressed) and for the patient’s specific condition. Spa Detox included: Two hours after the push the patient returned to the office and participated in: · An alternating hot and cold shower· A total of 7 minutes sweating in a Far Infrared Sauna (rigged with TDF plates and a full spectrum light bulb) while wiping off the sweat· 20 minutes in an ozonated body bag while lying on a powerful North pole magnetic sound table, doing a sound and light program to induce alpha waves· Went back into the sauna to sweat for an additional 3 minutes· Took a final shower. Then they were advised to go home and take a nap afterwards.The mainstay of drainage support was the coffee enema,[22] which the patient did at home, initially between 2 and 6 hours after the push and possibly several times thereafter. Frequency, volume and strength of the enemas were determined on an individual basis. Very acidic or sensitive patients used the ‘cold process’ method of preparing the organic coffee. They were instructed to not drink coffee during this time.All of the patients (~200) tolerated the therapy extremely well, however I now know that their metal levels were coming down comparatively slowly and that the CNS was not being addressed. SH chelation required a heroic effort on the part of the patient to avoid side effects.Experience with P-SH Chelation (1997-1999)P-SH chelation primarily mobilizes the metals via the bowel. At a huge oral dose of ½ ounce (15 ml or 113.6 sprays) every other day it was an improvement in speed, efficiency, and safety over DMPS. Fewer supplements were required, it did not take out beneficial minerals, and the Spa Detox was no longer necessary. It was eventually found, by others, to have the potential of causing side effects (hair loss, nausea, fatigue, achy joints, dizziness, exacerbation of acute infections, liver accumulation of metals) because they did not practice Biological Medicine or the equivalent and were not including it into the context of an individualized Biological Medicine protocol.Fecal Elements tests had not been performed during that time and no one was sure how the metals were coming out, if at all. However resonance testing provided the correct clues and remedies for a safe and effective detox—in hindsight—protect the bowel. Our patients never had any side effect equal to what they had previously experienced with DMPS in other offices. Extensive terrain analysis and resonance testing were performed on a weekly basis to guarantee this. Again, the mainstay of drainage support was the coffee enema, which the patient did at home, between 2 and 4 hours after the dose. Very acidic or sensitive patients used the ‘cold process’ method of preparing the organic coffee. Super Colon Glow, OxyOxc, MSM, activated charcoal, Barley Grass, and LiverLife tested most of the time. Kidney drainage was not as critical an issue. Additional remedies were required for Terrain balancing and the patient’s specific condition. After the cold vapor AFS (atomic fluorescence spectrometry) urine challenges (which I used at that time) went below 18 ppb, anti-parasite, anti-viral, anti-bacterial and anti-candida programs were prescribed when needed. Over the years it became apparent that addressing dysbiosis and infection before the metals were cleared did not produce a lasting result, and often times aggravated the detox process. All patients (~300) did extremely well, and it was found that patients who had completed their course of DMPS or DMSA could be provoked to excrete more metals, probably from the CNS, because DMPS does not cross the blood brain barrier and the P-SH complexes appear to. Experience with MIER Chelation (1999-2001)MIER chelation pulls 95% of the metals out through the urine, 80% of which come out quickly in the first urination following the oral dose,[23] and causes a steady decrease of the presence of fecal metals.[24] The risks associated with elimination via the bowel are therefore not a critical issue. MIER chelation has been shown to cross the blood-brain barrier within 5 and 20 minutes of the oral dose based on real-time EEG studies, and it is found to normalize brain wave activity. It can therefore be used as both a reliable provocative challenge and therapeutic chelator. It cleans and prepares the terrain for isopathic therapy as seen with phase contrast and Darkfield microscopy. High Resolution Imaging of dried blood shows it to reduce oxidative stress. The free radical sensitive kidney is protected because the binding effect is not subject to enzymatic degradation as in the GI tract (as long as the patient is not taking megadoses of oral proteolytic enzymes), and because the binding effect is not SH group dependent. I have to conclude from the laboratory evidence that this is the safest, fastest, most effective method; and clinically the least difficult to manage. At most, I have seen 5% of the mobilized metals come out via the bowel, and there is no evidence of the metals depositing in the kidney (improved creatinine/BUN ratio following 1 year of daily use at near maximum dose[25]). The dose is taken in 10 ounces of distilled water, and no sulfur containing foods or supplements, or proteolytic enzymes on an empty stomach, are taken on the day of the dose. Coffee enemas, saunas, clay baths, and supplements are not generally a must, but can certainly speed up the process. Ensuring one bowel movement per meal per day is always a good idea.Doctors are finding that much less supplementation is required during the course of MIER chelation, which tends to have a regulatory effect on both the terrain and the bowel (dysbiosis). I have found that using a MIER chelator exclusively at the beginning of therapy (with a patient whose priority is heavy metal toxicity) gives increased understanding and control of the case. A method of in-vivo ‘ingestion’ testing, that does not require muscle or point testing, has been devised to guarantee the efficiency and tolerance of the dose.[26]All patients (~400) are doing extremely well and the doctors using MIER chelation are saying that, "This is the direction heavy metal detox is going."Patients who have completed courses of both SH and P-SH chelation can be provoked to excrete additional heavy metals with MIER chelation. Lingering neurological symptoms in those same patients tend to subside or disappear.[27]Conclusion One can see that all three of the primary chelation methods discussed in this article can be used to advantage and without side effects if administered within the context of a Biological Medicine protocol.

A question that can now be asked, and answered with in-vivo testing, case history, or laboratory findings is: "What is the preferred and safest route of heavy metal elimination for this patient, at this moment?" With today’s health problems multiplying at the growth rate of modern technology, doctors have to be quick on their feet. It is not practical to wait 5 years or more for a traditionally approved solution, the eventual application of which still requires in-vivo testing if side effects are to be avoided. Armed with in-vivo testing methods and the paradigm of Biological Medicine, it is possible to determine a solution in a timely fashion without causing harm. The treatment of heavy metal toxicity is a clear example of how Biological Medicine can prevail over traditional methods of ‘recipe’ prescribing in producing positive clinical results.REFERENCES-----------------------------------------------------------------------------[1] Including DMPS and DMSA.[2] Including PCA, PC, PC-15, PC-30, PCA-Rx and Metal-Free.[3] Including NDF and NDF-Plus.[4] Unpublished peer group opinion: It has been observed by several Darkfield practitioners, including myself, that addressing acid/alkaline balance (Dr. Rau) as well as heavy metal/hydrocarbon toxicity (Dr. Harvey) are prerequisite to obtaining the expected beneficial therapeutic impact of isopathic therapy. [5] Unpublished peer group opinion, various: It has been theorized that this is caused by excess positive ion, free radical jamming of the bioelectric circuits causing distortion of the incoming frequency information and an inability to respond.[6] See the data sheets in the Spectrum Chemicals catalogue on USP grade minerals. Most are loaded with heavy metals.[7] See the pre and post challenge urine Toxic Element Clearance Profiles from Great Smokies Diagnostic Laboratories on a male, age 28, with perfect health at www.docray.com. [8] WHO 1974, Florence, Italy.[9] See www.altcorp.com/haleyresponds.htm [10] A 20/20 Investigation Jan. 12, 2001 — Pregnant women and women who may become pregnant should not eat shark, swordfish, king mackerel and tile fish because they could contain levels of mercury that could lead to brain damage in a developing fetus, the Food and Drug Administration said today. [11] Townsend Letter for Doctors, #213, April, 2001.[12] Clinical experience: I had a patient with 18 amalgams in his teeth and prostate cancer. At that time, 6 years ago, I was using hair analysis. The patient required proof of heavy metal toxicity before he would have his teeth fixed. The hair analysis showed zero mercury. The patient discontinued treatment and left with what he considered proof that I was a quack. I called the lab to inquire about their findings and they told me, "The metals don’t necessarily deposit in the hair."[13] See "The Low Battery Focus" by T. Ray, Explore, Vol. 10, #4, 2001. [14] "Transformations of Inorganic Mercury by Candida Albicans and Saccharomyces Cerevisiae," Applied and Environmental Microbiology, Jan 1991; 57:1:245-247; S Yannai; I Berdicevsky, L Duek; Dept. of Food Engineering and Biotechnology, and Unit of Microbiology, Faculty of Medicine, Technion-Israel Institute of Technology.[15] "The Methylization of Mercuric Chloride by Human Intestinal Bacteria," Experentia, 31:9; 1975; Sept 15, 1064-5; IR Rowland; P Grasso; MJ Davies; British Industrial Biological Research Association, Woodmansterne Road, Cashalton, Surrey, SM5 4DS, England.[16] Heintze, U. son, S., Derand, T. and Birkhed, D. Methylation of Mercury from Dental Amalgam and Mercuric Chloride by Oral Streptococci in-vitro. Scand. J. Dental Research 91(2) 150-152, 1983.[17] Gilbert, M.P.; & Summers, A.O., Plasmid, 1988, 20,127-36.[18] ibid.[19] Merc’s Manual, 16th Edition, p.1708.[20] See www.altcorp.com/haleyresponds.htm. [21] Professional courses in the field of Biological Medicine are advertised in and supported by Explore Magazine, and are offered by Drs. Klinghardt, Omura, Ulan and O.I.R.F. [22] See "Liver Detoxification with Coffee Enemas…", M. and C. Gerson, Townsend Letter, July, 2001, #216, p.45.[23] Post dose urine challenges verified repeatedly with the Schwermetall Test, InterPharma GmbH, and Great Smokies Diagnostic Laboratory. See www.docray.com for lab data.[24] Doctor’s Data Fecal Elements Test verification available to view at http://www.docray.com/ .[25] Lab report available to view at http://www.docray.com/. [26] Method available to view at http://www.docray.com/. [27] Case histories available to view at http://www.docray.com/. ©2001,

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:

I'd love to read the article, but unfortunately I can't get at it (sometimes

my id does that to me). Is there a website from which I could read the

article?

>From: " wakiza21- " <wakiza21@...>

>Date: Sun, 31 Mar 2002 15:18:58 -0500

>

>Hi List,

>Attached is an excellent article on Chelation.

>

><< Re_Chelation.htm >>

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Hi ,

The article on Chelation came from an EMail Message and because it was rather long I posted it as an attachment. Nevertheless it is a very good article and since you are interested I will Re-Post it in the normal format.

Re: [ ] Re: Chelation

[Guest guest]

Hi ,

Here is the article on Chelation.

A Comparative Study of Three Chelation Protocols.

Dear Friends:This is a long, but must read paper. More details on chelation, and a comparison of the three top methods of chelation by a man who has been there, done that. Warmly,Willis The Mobilization and Elimination of Systemic Heavy Metals in the Context of Biological Medicine.© Copyright 2001 by Ray O.M.D., LAc, USAIntroductionThis article focuses on the methods of mobilization, the pathways of elimination, and the difficulties that present themselves during heavy metal detoxification. I hear as many stories involving heavy metal chelators, about the devastating side effects as I do about the miraculous recoveries. What has become apparent is that the difference is due to the methodology of the attending physician, and not necessarily the choice of chelator. Those who practice Biological Medicine, Autonomic Resonance Testing (A.R.T.), the work of Dr. Y. Omura, and similar methods that rely on in-vivo testing for biological individuality and protocol, place the chelator into the context of their findings. Those who only prescribe the chelator as a drug, relying on in-vitro studies, usually do not have information relevant to the patient’s specific, individual requirements for the utilization of the chelator or the processing of the result. This latter ‘recipe’ approach can easily lead to side effects, and thus the present confusion about the relative effectiveness and safety of the available heavy metal chelators. For example, on the negative side, a patient related that her local ‘alternative’ doctor was administering two DMPS IV pushes per week to people who still had amalgams in their teeth with little or no supplement support and no prioritized case management, with the result that they were all feeling terrible. One woman’s health had been in a steady state of decline since her first push. Not only was she experiencing all of the side effects and complications mentioned below, but also she had a severe allergy to sulfur. No wonder we hear horror stories.Primary Chelation MethodsThis discussion is limited to the clinical use of three different types of independent laboratory proven effective heavy metal chelators, each with a different method of action, each providing a different exit route for the mobilized metals from the body. 1. Sulfhydryl (SH) Groups[1] (DMSA & DMPS) – via the bowel and urine.2. Peptidyl and Sulfhydryl (P-SH) Complexes, Clathration types, (See note[2] for product list.) – via the bowel.3. Mucopolysaccharide Ion Exchange Resin (MIER) NDF and NDF Plus[3] – via the urine.The following other methods will not be discussed for the following reasons: 1. I have no experience using EDTA and penicillamine. 2. Clay baths and far infrared saunas are of beneficial secondary support, but they do not directly impact the central nervous system (CNS). 3. The specific action of homeopathics, energy remedies and isopathics is very slow, they rely on the ability of the patient to react. (Most heavy metal toxic patients are no longer able to do so efficiently or completely.) Mercury appears to be an effective antidote or inhibitor of isopathic[4] and frequency information.[5] 4. Complex nutrient supplements sound effective, but heavy metal toxic patients have varying degrees of assimilation and utilization problems and multiple allergies. Many supplements these days actually contain heavy metals[6] and there is little to no independent laboratory proof as to their predictable effectiveness.Diagnosis – False Negatives and the Provocative ChallengeGiven that just about every person on this planet has some degree of heavy metal toxicity (from air pollution, amalgam fillings, dental offices, inoculations, fish, in utero exposure from the mother’s fillings, ground and water contamination)[7], the fact that the World Health Organization (WHO) acknowledges environmental pollution as the underlying cause of 80% of all chronic degenerative diseases,[8] that proof has been established as to the causative effect of heavy metals in neurological diseases including Alzheimer’s and MS,[9] that the FDA now warns women of childbearing age (all women above age 18) to not eat certain (heavy metal containing) fish,[10] and that there are at least 76 published functional and behavioral abnormalities associated with heavy metal toxicity,[11] the most serious and common mistake that can be made is a misdiagnosis (false negative) either at the beginning or end of therapy. The most serious problems associated with the exclusive use of independent labs for establishing heavy metal toxicity and monitoring the results of detoxification follow: Since we can only measure what the patient can eliminate, not the actual total body burden (as this would require multiple biopsies), any blockages in the pathways of ionization, assimilation, utilization or elimination can produce a false negative. Unprovoked lab tests of urine, stool or blood will not always reveal the body burden of metals. Hair analysis is certainly not reliable.[12] SH chelators provoke the elimination of soft tissue but not necessarily CNS burdens. P-SH chelators provoke predominantly via the bowel, so if you only analyze the urine you won’t find the correct level of heavy metal elimination. The MIER chelators take the metals out through the first urine following the dose, therefore a 24-hour urine test will give a diluted result, and a post challenge fecal elements test will show a decrease in metals. If the dose of any provocative agent is not strong enough to reach the deepest layers of the body burden, a false negative will occur. To determine if the patient has completed therapy, a megadose of a provocative chelator that does cross the blood brain barrier must be used. In addition, if there are any undetected or unresolved focal problems the patient may not respond to the provocative dose and a false negative will occur. ‘Healing Crisis’ – Side EffectsIt is the author’s continued experience that a ‘healing crisis’ means that more toxins are being pulled out of the tissue than the organs of elimination and the binding capacity of the chelator can cope with, causing the toxins to be redistributed in the body and to produce symptoms. If the choice of chelator, method of administration, dosage and metabolic support are correct, the patient only feels better. If the patient’s individual priorities and ability to utilize the protocol[13] have not been established the patient will feel, and be, worse. Depending on the size of the dose, massive amounts (up to a 750% increase from pre challenge levels) of toxic metals can be mobilized via the liver and dumped into the bowel and or kidney using either SH or P-SH chelators. Without proper drainage support, this can cause problems. If the patient is intolerant of or allergic to sulfur there will be additional complications. The Bowel: General Concerns Patients with dental amalgam fillings, especially those of long duration (5-30 years), and even those who have had them replaced with biocompatible materials, are known to suffer from the complications of dysbiosis, candidiasis, poor digestion, food allergies, compromised local immunity, Leaky Gut Syndrome (intestinal permeability), intestinal inflammation, impaired nerve function and diminished peristalsis causing constipation, and parasitic and bacterial infections. The mercury traveling into the gut with the saliva compromises the function of the Peyer’s patches, thus arresting the first line of immune defense. These conditions tend to persist during continued exposure from any source, after amalgam removal and at least until heavy metal detox is complete. Once the amalgams have been removed, the tissue burden of mercury can remain high for years to come, and the crippled bowels will not begin to return to full health until after most of the metals have been removed. During detox, the mobilized heavy metals can linger in the bowel for between 6 and 24 hours or more before evacuation takes place. The bowel of a healthy person may not be prone to free radical damage, but the damaged bowel of the metal toxic patient is at least an area for added concern and monitoring.Enzyme Mediated Resorption A central question is what percent of the mobilized metal is bound beyond the point of contact with surrounding tissue, and can the bond that holds it withstand the action of digestive enzymes in the bowel? A peptide (protein particle) molecule, when cleaved by a proteolytic enzyme, has its three-dimensional structure irreversibly altered, thus reversing any chelation effect it once had. The answer to this is a matter of degree. What is the current enzyme content of the patient’s digestive tract? How much of the bound metal will be released? Methyl Mercury FormationCandida albicans, E. Coli, oral Streptococci, and certain beneficial gut bacteria have the ability to methylate mercury into methyl mercury, the most noxious form of the toxin.[14] [15] [16] Most heavy metal toxic patients suffer from chronic candidiasis. Frequent bowel movements reduce the time of exposure of the mercury to the bowel flora. Intestinal Permeability and ResorptionSome of the mobilized metals may be unbound because the mobilizing and binding mechanisms of each chelator may have different degrees of efficiency depending on each patient’s current biochemistry. The longer the metals stay in the bowel, the more damage and inflammation they can cause. If the patient has Leaky Gut Syndrome or Inflammatory Bowel Disease, which most of these patients do, the increased permeability of the intestinal wall may provide little resistance to the resorption of these mobilized metals, which then travel back to where they came from—the brain, kidneys, liver, connective tissue, etc., or are deposited into previously healthy tissue. The problem with leaky gut and bowel inflammation in general, is that they are very difficult to treat while the metals are still present in that tissue and continuing to cause inflammation. (Observation: Selenium is said to bind mercury preventing resorption—WSL)Antibiotic Resistant BacteriaMercury is known to create antibiotic resistant bacteria, the plasmid responsible also being replicated and passed on to other bacteria.[17] The presence of mercury in the bowel could therefore contribute to the severity and duration of intestinal infections or Fields of Disturbance (metal and endotoxin pooling).The Kidney: General ConcernsAll heavy metals are nephrotoxic.[18] "Most heavy metals accumulate in segments of the proximal nephron because of transport or binding sites such as sulfhydryl (SH) groups."[19] If more metals are mobilized than are bound, or if the bound metals are released by the action of enzymes, kidney problems will occur. While using SH and P-SH chelators: vitamin C, kidney drainage remedies, coffee enemas, saunas, clay baths and additional water can be useful for kidney support. While using MIER chelators, megadoses of proteolytic enzymes on an empty stomach should be avoided on the day of the dose because the enzymes may enter the bloodstream and threaten the integrity of the chelation bond, thus exposing tissue, especially the kidney and bladder, to direct exposure.The Unattended Spiral Down – Elimination via the BowelIf the mobilized and bound (SH and P-SH chelators) mercury is released by the action of a protease, the candida and gut flora convert it to methyl mercury, which poisons the tissue (more inflammation and permeability), nerves (increased constipation), and Peyer’s patches (lowered immunity). Superbacteria are generated in the same moment that the intestinal immune system is compromised. The infections further contribute to the local inflammation and intestinal permeability, which then allows for an increased resorption of the mobilized metals. Mercury in the combined presence of other heavy metals is even more toxic[20]. SH groups have a binding affinity in the kidney, where metals can accumulate and cause further problems. A patient taking a provocation level dose of an SH or P-SH chelator without expert drainage support could be at risk of side effects. A substantially reduced dose might take a while to produce a side effect, but would also take a very long time to produce the desired beneficial results. I believe this unattended spiral down to be one of the main reasons why complete heavy metal detox is so difficult, if not impossible to achieve, when elimination occurs via the bowel and is not managed in the context of a Biological Medicine protocol. If all of these issues are not addressed according to the patient’s individual and prioritized needs, the outcome will be less than favorable. General PrecautionsPatients using SH and P-SH chelators have avoided most of the complications and side effects when support supplements and therapies were selected according to in-vivo testing. The options include: · Coffee enemas and fiber containing bowel cleansers · Large and frequent doses of activated charcoal · Strong and fast acting laxatives · MSM or garlic · Vitamin C (IV and oral) · Liver and kidney protective supplements are imperative. No proteolytic enzymes or pancreatic PMG can be given. Flora supplements may be problematic in some patients, especially on the day of the dose. Unpasteurized fermented foods and beers are to be avoided. No protein on the day of the dose; a low protein diet is advisable. If an attempt is made to kill the candida before the metals are gone, breaking the cell wall of the candida releases more metals into the gut because the candida cell wall binds to the metals. L-glutamine is of some benefit for intestinal permeability. However, not much can be done to correct intestinal permeability while the patient is still heavy metal toxic and thus at risk of reabsorbing a significant percentage of the mobilized metals. How do you know what combination of therapies or remedies, what form of what remedy at what dosage and frequency to give if you can’t find out what the patient requires and how they will respond, in-vivo, ahead of time?[21] Placing a patient on a ‘pre-fab’ protocol, even one that is extremely well thought out, has to miss some of their needs.Experience with SH Chelation (1994-1997)SH chelators mobilize the metals via both the urine and the bowel and there are two different types, DMSA and DMPS. DMSA never tested well with my patients so I never used it. (I later found out that the use of DMSA prior to treatment with DMPS could mobilize metals into the brain, making it very dangerous if used as the exclusive chelator.) At that time the only clearly effective choice was DMPS and I worked with an M.D. who administered it while I determined the Biological protocols. The general support required for the patient to tolerate two pushes per month with no side-effects, after all metals had been removed from the teeth, included both a supplementation and a spa detox protocol.Supplements included: MSM or garlic (sulfation), OxyOxc (laxative), Super Colon Glow (fiber with herbs), Immunocal whey (glutathione), Barley Grass (alkaline reserve, minerals, enzymes), activated charcoal (bowel protection), Solidago and Buccu (kidney drainage), LiverLife (kidney and liver support and drainage), Multi-Minerals (mineral replacement), zinc picolinate, and vitamin C. Additional remedies and therapies were required for Terrain balancing (diet and focal problems addressed) and for the patient’s specific condition. Spa Detox included: Two hours after the push the patient returned to the office and participated in: · An alternating hot and cold shower· A total of 7 minutes sweating in a Far Infrared Sauna (rigged with TDF plates and a full spectrum light bulb) while wiping off the sweat· 20 minutes in an ozonated body bag while lying on a powerful North pole magnetic sound table, doing a sound and light program to induce alpha waves· Went back into the sauna to sweat for an additional 3 minutes· Took a final shower. Then they were advised to go home and take a nap afterwards.The mainstay of drainage support was the coffee enema,[22] which the patient did at home, initially between 2 and 6 hours after the push and possibly several times thereafter. Frequency, volume and strength of the enemas were determined on an individual basis. Very acidic or sensitive patients used the ‘cold process’ method of preparing the organic coffee. They were instructed to not drink coffee during this time.All of the patients (~200) tolerated the therapy extremely well, however I now know that their metal levels were coming down comparatively slowly and that the CNS was not being addressed. SH chelation required a heroic effort on the part of the patient to avoid side effects.Experience with P-SH Chelation (1997-1999)P-SH chelation primarily mobilizes the metals via the bowel. At a huge oral dose of ½ ounce (15 ml or 113.6 sprays) every other day it was an improvement in speed, efficiency, and safety over DMPS. Fewer supplements were required, it did not take out beneficial minerals, and the Spa Detox was no longer necessary. It was eventually found, by others, to have the potential of causing side effects (hair loss, nausea, fatigue, achy joints, dizziness, exacerbation of acute infections, liver accumulation of metals) because they did not practice Biological Medicine or the equivalent and were not including it into the context of an individualized Biological Medicine protocol.Fecal Elements tests had not been performed during that time and no one was sure how the metals were coming out, if at all. However resonance testing provided the correct clues and remedies for a safe and effective detox—in hindsight—protect the bowel. Our patients never had any side effect equal to what they had previously experienced with DMPS in other offices. Extensive terrain analysis and resonance testing were performed on a weekly basis to guarantee this. Again, the mainstay of drainage support was the coffee enema, which the patient did at home, between 2 and 4 hours after the dose. Very acidic or sensitive patients used the ‘cold process’ method of preparing the organic coffee. Super Colon Glow, OxyOxc, MSM, activated charcoal, Barley Grass, and LiverLife tested most of the time. Kidney drainage was not as critical an issue. Additional remedies were required for Terrain balancing and the patient’s specific condition. After the cold vapor AFS (atomic fluorescence spectrometry) urine challenges (which I used at that time) went below 18 ppb, anti-parasite, anti-viral, anti-bacterial and anti-candida programs were prescribed when needed. Over the years it became apparent that addressing dysbiosis and infection before the metals were cleared did not produce a lasting result, and often times aggravated the detox process. All patients (~300) did extremely well, and it was found that patients who had completed their course of DMPS or DMSA could be provoked to excrete more metals, probably from the CNS, because DMPS does not cross the blood brain barrier and the P-SH complexes appear to. Experience with MIER Chelation (1999-2001)MIER chelation pulls 95% of the metals out through the urine, 80% of which come out quickly in the first urination following the oral dose,[23] and causes a steady decrease of the presence of fecal metals.[24] The risks associated with elimination via the bowel are therefore not a critical issue. MIER chelation has been shown to cross the blood-brain barrier within 5 and 20 minutes of the oral dose based on real-time EEG studies, and it is found to normalize brain wave activity. It can therefore be used as both a reliable provocative challenge and therapeutic chelator. It cleans and prepares the terrain for isopathic therapy as seen with phase contrast and Darkfield microscopy. High Resolution Imaging of dried blood shows it to reduce oxidative stress. The free radical sensitive kidney is protected because the binding effect is not subject to enzymatic degradation as in the GI tract (as long as the patient is not taking megadoses of oral proteolytic enzymes), and because the binding effect is not SH group dependent. I have to conclude from the laboratory evidence that this is the safest, fastest, most effective method; and clinically the least difficult to manage. At most, I have seen 5% of the mobilized metals come out via the bowel, and there is no evidence of the metals depositing in the kidney (improved creatinine/BUN ratio following 1 year of daily use at near maximum dose[25]). The dose is taken in 10 ounces of distilled water, and no sulfur containing foods or supplements, or proteolytic enzymes on an empty stomach, are taken on the day of the dose. Coffee enemas, saunas, clay baths, and supplements are not generally a must, but can certainly speed up the process. Ensuring one bowel movement per meal per day is always a good idea.Doctors are finding that much less supplementation is required during the course of MIER chelation, which tends to have a regulatory effect on both the terrain and the bowel (dysbiosis). I have found that using a MIER chelator exclusively at the beginning of therapy (with a patient whose priority is heavy metal toxicity) gives increased understanding and control of the case. A method of in-vivo ‘ingestion’ testing, that does not require muscle or point testing, has been devised to guarantee the efficiency and tolerance of the dose.[26]All patients (~400) are doing extremely well and the doctors using MIER chelation are saying that, "This is the direction heavy metal detox is going."Patients who have completed courses of both SH and P-SH chelation can be provoked to excrete additional heavy metals with MIER chelation. Lingering neurological symptoms in those same patients tend to subside or disappear.[27]Conclusion One can see that all three of the primary chelation methods discussed in this article can be used to advantage and without side effects if administered within the context of a Biological Medicine protocol.

A question that can now be asked, and answered with in-vivo testing, case history, or laboratory findings is: "What is the preferred and safest route of heavy metal elimination for this patient, at this moment?" With today’s health problems multiplying at the growth rate of modern technology, doctors have to be quick on their feet. It is not practical to wait 5 years or more for a traditionally approved solution, the eventual application of which still requires in-vivo testing if side effects are to be avoided. Armed with in-vivo testing methods and the paradigm of Biological Medicine, it is possible to determine a solution in a timely fashion without causing harm. The treatment of heavy metal toxicity is a clear example of how Biological Medicine can prevail over traditional methods of ‘recipe’ prescribing in producing positive clinical results.REFERENCES-----------------------------------------------------------------------------[1] Including DMPS and DMSA.[2] Including PCA, PC, PC-15, PC-30, PCA-Rx and Metal-Free.[3] Including NDF and NDF-Plus.[4] Unpublished peer group opinion: It has been observed by several Darkfield practitioners, including myself, that addressing acid/alkaline balance (Dr. Rau) as well as heavy metal/hydrocarbon toxicity (Dr. Harvey) are prerequisite to obtaining the expected beneficial therapeutic impact of isopathic therapy. [5] Unpublished peer group opinion, various: It has been theorized that this is caused by excess positive ion, free radical jamming of the bioelectric circuits causing distortion of the incoming frequency information and an inability to respond.[6] See the data sheets in the Spectrum Chemicals catalogue on USP grade minerals. Most are loaded with heavy metals.[7] See the pre and post challenge urine Toxic Element Clearance Profiles from Great Smokies Diagnostic Laboratories on a male, age 28, with perfect health at www.docray.com. [8] WHO 1974, Florence, Italy.[9] See www.altcorp.com/haleyresponds.htm [10] A 20/20 Investigation Jan. 12, 2001 — Pregnant women and women who may become pregnant should not eat shark, swordfish, king mackerel and tile fish because they could contain levels of mercury that could lead to brain damage in a developing fetus, the Food and Drug Administration said today. [11] Townsend Letter for Doctors, #213, April, 2001.[12] Clinical experience: I had a patient with 18 amalgams in his teeth and prostate cancer. At that time, 6 years ago, I was using hair analysis. The patient required proof of heavy metal toxicity before he would have his teeth fixed. The hair analysis showed zero mercury. The patient discontinued treatment and left with what he considered proof that I was a quack. I called the lab to inquire about their findings and they told me, "The metals don’t necessarily deposit in the hair."[13] See "The Low Battery Focus" by T. Ray, Explore, Vol. 10, #4, 2001. [14] "Transformations of Inorganic Mercury by Candida Albicans and Saccharomyces Cerevisiae," Applied and Environmental Microbiology, Jan 1991; 57:1:245-247; S Yannai; I Berdicevsky, L Duek; Dept. of Food Engineering and Biotechnology, and Unit of Microbiology, Faculty of Medicine, Technion-Israel Institute of Technology.[15] "The Methylization of Mercuric Chloride by Human Intestinal Bacteria," Experentia, 31:9; 1975; Sept 15, 1064-5; IR Rowland; P Grasso; MJ Davies; British Industrial Biological Research Association, Woodmansterne Road, Cashalton, Surrey, SM5 4DS, England.[16] Heintze, U. son, S., Derand, T. and Birkhed, D. Methylation of Mercury from Dental Amalgam and Mercuric Chloride by Oral Streptococci in-vitro. Scand. J. Dental Research 91(2) 150-152, 1983.[17] Gilbert, M.P.; & Summers, A.O., Plasmid, 1988, 20,127-36.[18] ibid.[19] Merc’s Manual, 16th Edition, p.1708.[20] See www.altcorp.com/haleyresponds.htm. [21] Professional courses in the field of Biological Medicine are advertised in and supported by Explore Magazine, and are offered by Drs. Klinghardt, Omura, Ulan and O.I.R.F. [22] See "Liver Detoxification with Coffee Enemas…", M. and C. Gerson, Townsend Letter, July, 2001, #216, p.45.[23] Post dose urine challenges verified repeatedly with the Schwermetall Test, InterPharma GmbH, and Great Smokies Diagnostic Laboratory. See www.docray.com for lab data.[24] Doctor’s Data Fecal Elements Test verification available to view at http://www.docray.com/ .[25] Lab report available to view at http://www.docray.com/. [26] Method available to view at http://www.docray.com/. [27] Case histories available to view at http://www.docray.com/. ©2001,

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Thank you. As you said, it was a good article.

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How is he on the DMSA and OFF, this is your clue.

Kathy

Re: [ ] Chelation

> In a message dated 6/7/2003 2:35:13 AM Eastern Standard Time,

> kblanco@... writes:

>

> > Do not follow the DAN protocol, chelate every 3-4 hours around the

clock,

> > not every 8, or the child will become worse.

> > Kathy

> >

>

> This is not true. My child has been following the DAN for over two years

on

> the 8 hour protocol and is doing great.

>

>

>

>

[Guest guest]

This from Andy Cutler-

First, in discussing the DAN! protocol I do have to note that it

started with a few of the early DAN! doctors following the protocol as

laid out in my book Amalgam Illness: Diagnosis and Treatment. They

got excellent results with this. However, they also spent a lot of

time arguing with parents about the need to get up at night because

the doc's weren't all that convinced it was necessary (for the most

part they had not chelated people before or had used protocols that

don't require the patient to get up).

Based on the excellent response achived early on with this every 3-4

hour low dose protocol, DAN! decided to use a DMSA and ALA protocol.

However, based on the fact that nobody at the relevant meeting

understood any pharmacokinetics so they weren't able to figure out why

3-4 hour dosing was a crucial part of the protocol, they decided it

would make no difference to dose every 8 hours so they arbitrarily

changed the protocol. They also arbitrarily decided that since one

textbook talks about using 10 mg/kg of DMSA every 8 hours and they

didn't understand why there was any reason to use less, they would

also arbitrarily change the dosage because more must be better, and

using a higher dose must speed things up a lot.

So the existing DAN! protocol was made up by a room full of doctors

who had never used it clinically and didn't understand what the

important differences were between it and the protoccol they had heard

was successful. Basically, they were arrogant enough in their

ignorance to believe that their (lack of) understanding was adequate

to change the protocol willy-nilly and still have it work fine without

even doing a trial of the new protocol on people, or animals, before

endorsing it.

This is the same combination of arrogance and ignorance that leads

most current pediatricians to continue injecting children with the

thimerosal preserved vaccines they have in the stockroom rather than

take the economic loss of throwing them away, because the doc's don't

see how the thimerosal could hurt the kids and are certain they know

everything important there is to know about the subject. This

unfortunately is part of the medical culture and is not unique to the

mainstream or alternative medicine communities.

So, after that DAN! meeting, a new, randomly modified and untested

protocol was emitted. As is easily verified in the polls section of

this list and in its archives, what actually happened is that a lot of

kids who had been getting better on the every 4 hour protocol were

switcched to the every 8 hour protocol and started to get worse again.

Once the parents realized that the doc's had gone off the deep end and

switched back to the 3-4 hour protocol, their kids resumed improving.

While informal, this is a " controlled crossover study, " which is among

the most powerful evidence doctors claim to believe in. It provided

conclusive proof that the lower dose 3-4 hour protocol is dramatically

superior to the DAN! 8 hour, high dose protocol. Like the mainstream,

however, DAN! has ignored those results that don't agree with its

position.

In fact, when using the 3-4 hour protocol, the early DAN! doctors were

reporting dramatic, rapid improvements in their patients. Since

switching to the 8 hour protocol they are reporting rough going, some

improvement in perhaps 60% of patients, and are getting really

interested in using other interventions (like MT promoter) in place of

chelation.

I believe that the reports of the DAN! doctors actually are correct.

Dramatic progress in most cases on 3-4 hour chelation, rough going

with modest progress on 8 hour chelation. I believe these are in fact

the rule. They are consistent with reports on this list, with what I

have heard from many adults, with what one would expect from basic

pharmacologic and pharmacokinetic considerations, and with how things

felt when I was very toxic and chelated a few different random ways at

first before I figured out what I was doing.

The difference in administration frequency between the DAN! protocol

(every 8-12 hours for ALA, every 8 for DMSA) and the " Andy " protocol

(every 4 hours or more often for DMSA, every 3 hours or more often for

ALA with occasional 4 hour use) are pretty straightforward to explain.

First, chelating agents serve two functions. They mobilize toxic

metals. They also bind toxic metals. They do NOT " hold on tight " and

do NOT bind irreversibly. They pick up and drop the metals often.

Thus, you need to maintain a rough balance between mobilization and

binding so that the chelators grab most of the free toxic metals

rather than letting them grab back on to the body. In order to do

this, you need to keep the blood level of chelating agents reasonably

constant. This is done by giving them roughly a half life apart, so

that blood levels don't fluctuate by more than a factor of 2. The

half life of DMSA (directly measured in human children) is 2.5 to 3.5

hours. The kinetics of ALA are much more complicated but are

adequately described as a half life of 1.5 to 2.5 hours. The peaks

get smeared out over a 2 hour period due to it taking about 2 hours

for the stuff to slowly be absorbed when it is given by mouth.

EXACTLY how long you can wait between doses varies from individual to

individual and I have determined my numbers based on the experience of

a lot of people who have done it this way. They are theoretically

sound and empirically verified. While I can't really tell you exactly

why ALA is best every 3 hours or whether DMSA could be stretched to 5

and still be OK, I can tell you with great certainty that 8 hours is

way beyond the bounds of reason.

Now please note that everyone is different. Everyone is a unique

individual. This is just as true biochemically as socially. Thus

while there is perfect certainty that the above applies to any large

group of people, and is best for most people in that group, any given

individual may need to do it differently and in any large group there

will be a few who do better on something other than the " one size fits

all " average protocol. This leads to the following conditions which I

believe any responsible person would adhere to:

1. Try the " best " approach on everyone, no matter what. Just try it.

2. If some particular person repeatedly does poorly on the " best "

approach and well on something else, respect their individual needs

and do what works for them.

Please also note something else covered under " everyone is different. "

Not all autistic children have mercury (or a related heavy metal) as

the root cause of their condition. Good diagnosis is needed. Any

doctor who chelates ALL of the children who come in the door isn't

doing it right. The first step is make some attempt to figure out

WHAT is wrong, and direct treatment at that. If treatment is not

leading to the expected progress, go back to the diagnostic step. A

diagnosis is only an opinion as to what is going on. Opinions can be

wrong.

As to dosing differences between the " Andy " and DAN! protocols, the

important factor is that increasing the dose increases side effects

rapidly, but does not increase metal removal much. Doubling the

amount of DMSA or ALA in a dose more than doubles side effects.

However, it speeds up metal removal by less than 33%. Once you are

using enough chelator to get some response and have some side effects

there really is no reason to push things. You can double your dose

and go from noticeable side effects to a horrendous, intolerable

experience and make it so you can get through a given amount of metal

in 3 months instead of 4. Also, as the side effects increase, your

ability to chelate frequently will decrease so sticking to a lower

dose and doing it routinely every weekend or every other weekend will

in practice get your kid cleared of metal faster than using a very

high dose and spending weeks or months putting your kid back together

after each cycle. This is clearest in the discussions regarding all

the yeast problems kids have with chelation that are in the archives.

Summarizing the dosage and administration differences:

8 vs 3-4 hour dosing. Why dose more often? It is necessary for most

children if they are going to get better. This is supported by the

fact that DAN! doctors were reporting dramatic progress when doing it

this way and no longer are now that they use 8 hour dosing.

1500 mg/day versus 350 mg/day. Why use more DMSA/ALA? There is no

real need to use a lot, since it makes the kid dramatically more

uncomfortable without really speeding things up much.

Let me work the arithmetic on this one and you will quickly see what I

mean about dosing. The relevant formulae are in the appendix to my

book Amalgam Illness: Diagnosis and Treatment (described at

www.noamalgam.com).

Each 500 mg dose of DMSA removes (500/50)^0.409 = 2.56 times as much

metal as each 50 mg dose.

3 500 mg doses daily remove 7.69 units of metal.

7 50 mg doses daily remove 7.00 units of metal.

The difference in metal removed by DMSA between the DAN! high dose

protocol and the Andy low dose protocol is 10% in this case. If you

use 100 mg DMSA every 4 hours versus 500 mg every 8 hours the lower

dose protocol actually removes 21% MORE metal than the higher dose

protocol.

Similarly for lipoic acid, the arithmetic is:

Three 100 mg doses remove 5.29 units of metal, while seven 25 mg doses

remove 7.00 units of metal. Again, the " lower dose " protocol actually

removes more metal in a 24 hour period.

The really important thing to keep in mind is some further human

biochemistry as far as heavy metals are concerned. That is, why is it

such a bad idea to let the metals bounce around by just giving

chelator randomly? Don't the metals come out eventually no matter how

you do it?

The real issue is that the metals do NOT sit where they are until they

come out. Chelators ccan move them all over the body. The most

damaging place they can be is in the brain, and the next most damaging

is in the liver. A lot of the metal that is sitting quietly in a

muscle, bone, kidney, or ligament and not really causing much damage

there can be moved INTO the brain and liver if it gets stirred up and

there isn't chelator around to keep it company until it is excreted.

So improper chelation with too long an interval between doses actually

can make people MORE poisoned by INCREASING the amount of toxic metal

in the brain and liver even though the total amount in their body does

decline. This has been observed innumerable times with adults for

many years, and DAN! has now experimentally demonstrated that it

works just the same way in children. With proper chelation everything

gets BETTER from the start. With improper chelation some things get

WORSE. Then it takes LONGER for those to get better than if proper

chelation had been used all along.

I hope this rather long post clarifies the differences between the

DAN! and Andy chelation approaches, and explains why I think it is

important to do it one way instead of another.

What I hope you will consider the " take home lesson " here is to just

try it both ways a couple of times if you are considering the DAN!

protoccol or if your doctor insists

Re: [ ] Chelation

> In a message dated 6/7/2003 2:35:13 AM Eastern Standard Time,

> kblanco@... writes:

>

> > Do not follow the DAN protocol, chelate every 3-4 hours around the

clock,

> > not every 8, or the child will become worse.

> > Kathy

> >

>

> This is not true. My child has been following the DAN for over two years

on

> the 8 hour protocol and is doing great.

>

>

>

>

[Guest guest]

In a message dated 6/7/2003 2:35:13 AM Eastern Standard Time,

kblanco@... writes:

> Do not follow the DAN protocol, chelate every 3-4 hours around the clock,

> not every 8, or the child will become worse.

> Kathy

>

This is not true. My child has been following the DAN for over two years on

the 8 hour protocol and is doing great.

[Guest guest]

How does one figure out if a child is a candidate for chelation -- or not?

Fw: [ ] Chelation

This from Andy Cutler-

First, in discussing the DAN! protocol I do have to note that it

started with a few of the early DAN! doctors following the protocol as

laid out in my book Amalgam Illness: Diagnosis and Treatment. They

got excellent results with this. However, they also spent a lot of

time arguing with parents about the need to get up at night because

the doc's weren't all that convinced it was necessary (for the most

part they had not chelated people before or had used protocols that

don't require the patient to get up).

Based on the excellent response achived early on with this every 3-4

hour low dose protocol, DAN! decided to use a DMSA and ALA protocol.

However, based on the fact that nobody at the relevant meeting

understood any pharmacokinetics so they weren't able to figure out why

3-4 hour dosing was a crucial part of the protocol, they decided it

would make no difference to dose every 8 hours so they arbitrarily

changed the protocol. They also arbitrarily decided that since one

textbook talks about using 10 mg/kg of DMSA every 8 hours and they

didn't understand why there was any reason to use less, they would

also arbitrarily change the dosage because more must be better, and

using a higher dose must speed things up a lot.

So the existing DAN! protocol was made up by a room full of doctors

who had never used it clinically and didn't understand what the

important differences were between it and the protoccol they had heard

was successful. Basically, they were arrogant enough in their

ignorance to believe that their (lack of) understanding was adequate

to change the protocol willy-nilly and still have it work fine without

even doing a trial of the new protocol on people, or animals, before

endorsing it.

This is the same combination of arrogance and ignorance that leads

most current pediatricians to continue injecting children with the

thimerosal preserved vaccines they have in the stockroom rather than

take the economic loss of throwing them away, because the doc's don't

see how the thimerosal could hurt the kids and are certain they know

everything important there is to know about the subject. This

unfortunately is part of the medical culture and is not unique to the

mainstream or alternative medicine communities.

So, after that DAN! meeting, a new, randomly modified and untested

protocol was emitted. As is easily verified in the polls section of

this list and in its archives, what actually happened is that a lot of

kids who had been getting better on the every 4 hour protocol were

switcched to the every 8 hour protocol and started to get worse again.

Once the parents realized that the doc's had gone off the deep end and

switched back to the 3-4 hour protocol, their kids resumed improving.

While informal, this is a " controlled crossover study, " which is among

the most powerful evidence doctors claim to believe in. It provided

conclusive proof that the lower dose 3-4 hour protocol is dramatically

superior to the DAN! 8 hour, high dose protocol. Like the mainstream,

however, DAN! has ignored those results that don't agree with its

position.

In fact, when using the 3-4 hour protocol, the early DAN! doctors were

reporting dramatic, rapid improvements in their patients. Since

switching to the 8 hour protocol they are reporting rough going, some

improvement in perhaps 60% of patients, and are getting really

interested in using other interventions (like MT promoter) in place of

chelation.

I believe that the reports of the DAN! doctors actually are correct.

Dramatic progress in most cases on 3-4 hour chelation, rough going

with modest progress on 8 hour chelation. I believe these are in fact

the rule. They are consistent with reports on this list, with what I

have heard from many adults, with what one would expect from basic

pharmacologic and pharmacokinetic considerations, and with how things

felt when I was very toxic and chelated a few different random ways at

first before I figured out what I was doing.

The difference in administration frequency between the DAN! protocol

(every 8-12 hours for ALA, every 8 for DMSA) and the " Andy " protocol

(every 4 hours or more often for DMSA, every 3 hours or more often for

ALA with occasional 4 hour use) are pretty straightforward to explain.

First, chelating agents serve two functions. They mobilize toxic

metals. They also bind toxic metals. They do NOT " hold on tight " and

do NOT bind irreversibly. They pick up and drop the metals often.

Thus, you need to maintain a rough balance between mobilization and

binding so that the chelators grab most of the free toxic metals

rather than letting them grab back on to the body. In order to do

this, you need to keep the blood level of chelating agents reasonably

constant. This is done by giving them roughly a half life apart, so

that blood levels don't fluctuate by more than a factor of 2. The

half life of DMSA (directly measured in human children) is 2.5 to 3.5

hours. The kinetics of ALA are much more complicated but are

adequately described as a half life of 1.5 to 2.5 hours. The peaks

get smeared out over a 2 hour period due to it taking about 2 hours

for the stuff to slowly be absorbed when it is given by mouth.

EXACTLY how long you can wait between doses varies from individual to

individual and I have determined my numbers based on the experience of

a lot of people who have done it this way. They are theoretically

sound and empirically verified. While I can't really tell you exactly

why ALA is best every 3 hours or whether DMSA could be stretched to 5

and still be OK, I can tell you with great certainty that 8 hours is

way beyond the bounds of reason.

Now please note that everyone is different. Everyone is a unique

individual. This is just as true biochemically as socially. Thus

while there is perfect certainty that the above applies to any large

group of people, and is best for most people in that group, any given

individual may need to do it differently and in any large group there

will be a few who do better on something other than the " one size fits

all " average protocol. This leads to the following conditions which I

believe any responsible person would adhere to:

1. Try the " best " approach on everyone, no matter what. Just try it.

2. If some particular person repeatedly does poorly on the " best "

approach and well on something else, respect their individual needs

and do what works for them.

Please also note something else covered under " everyone is different. "

Not all autistic children have mercury (or a related heavy metal) as

the root cause of their condition. Good diagnosis is needed. Any

doctor who chelates ALL of the children who come in the door isn't

doing it right. The first step is make some attempt to figure out

WHAT is wrong, and direct treatment at that. If treatment is not

leading to the expected progress, go back to the diagnostic step. A

diagnosis is only an opinion as to what is going on. Opinions can be

wrong.

As to dosing differences between the " Andy " and DAN! protocols, the

important factor is that increasing the dose increases side effects

rapidly, but does not increase metal removal much. Doubling the

amount of DMSA or ALA in a dose more than doubles side effects.

However, it speeds up metal removal by less than 33%. Once you are

using enough chelator to get some response and have some side effects

there really is no reason to push things. You can double your dose

and go from noticeable side effects to a horrendous, intolerable

experience and make it so you can get through a given amount of metal

in 3 months instead of 4. Also, as the side effects increase, your

ability to chelate frequently will decrease so sticking to a lower

dose and doing it routinely every weekend or every other weekend will

in practice get your kid cleared of metal faster than using a very

high dose and spending weeks or months putting your kid back together

after each cycle. This is clearest in the discussions regarding all

the yeast problems kids have with chelation that are in the archives.

Summarizing the dosage and administration differences:

8 vs 3-4 hour dosing. Why dose more often? It is necessary for most

children if they are going to get better. This is supported by the

fact that DAN! doctors were reporting dramatic progress when doing it

this way and no longer are now that they use 8 hour dosing.

1500 mg/day versus 350 mg/day. Why use more DMSA/ALA? There is no

real need to use a lot, since it makes the kid dramatically more

uncomfortable without really speeding things up much.

Let me work the arithmetic on this one and you will quickly see what I

mean about dosing. The relevant formulae are in the appendix to my

book Amalgam Illness: Diagnosis and Treatment (described at

www.noamalgam.com).

Each 500 mg dose of DMSA removes (500/50)^0.409 = 2.56 times as much

metal as each 50 mg dose.

3 500 mg doses daily remove 7.69 units of metal.

7 50 mg doses daily remove 7.00 units of metal.

The difference in metal removed by DMSA between the DAN! high dose

protocol and the Andy low dose protocol is 10% in this case. If you

use 100 mg DMSA every 4 hours versus 500 mg every 8 hours the lower

dose protocol actually removes 21% MORE metal than the higher dose

protocol.

Similarly for lipoic acid, the arithmetic is:

Three 100 mg doses remove 5.29 units of metal, while seven 25 mg doses

remove 7.00 units of metal. Again, the " lower dose " protocol actually

removes more metal in a 24 hour period.

The really important thing to keep in mind is some further human

biochemistry as far as heavy metals are concerned. That is, why is it

such a bad idea to let the metals bounce around by just giving

chelator randomly? Don't the metals come out eventually no matter how

you do it?

The real issue is that the metals do NOT sit where they are until they

come out. Chelators ccan move them all over the body. The most

damaging place they can be is in the brain, and the next most damaging

is in the liver. A lot of the metal that is sitting quietly in a

muscle, bone, kidney, or ligament and not really causing much damage

there can be moved INTO the brain and liver if it gets stirred up and

there isn't chelator around to keep it company until it is excreted.

So improper chelation with too long an interval between doses actually

can make people MORE poisoned by INCREASING the amount of toxic metal

in the brain and liver even though the total amount in their body does

decline. This has been observed innumerable times with adults for

many years, and DAN! has now experimentally demonstrated that it

works just the same way in children. With proper chelation everything

gets BETTER from the start. With improper chelation some things get

WORSE. Then it takes LONGER for those to get better than if proper

chelation had been used all along.

I hope this rather long post clarifies the differences between the

DAN! and Andy chelation approaches, and explains why I think it is

important to do it one way instead of another.

What I hope you will consider the " take home lesson " here is to just

try it both ways a couple of times if you are considering the DAN!

protoccol or if your doctor insists

Re: [ ] Chelation

> In a message dated 6/7/2003 2:35:13 AM Eastern Standard Time,

> kblanco@... writes:

>

> > Do not follow the DAN protocol, chelate every 3-4 hours around the

clock,

> > not every 8, or the child will become worse.

> > Kathy

> >

>

> This is not true. My child has been following the DAN for over two

years

on

> the 8 hour protocol and is doing great.

>

>

>

>

[Guest guest]

Ali,

Thanks. I will save the links for future reference.

Sue