Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Thanks for this info. I recently increased my doxy dose from 300- 400mg/day, and saw improvement, so then went up to 600mg/day, and that's making even more of a difference. It can be hard on an empty stomach, so I have to take it with some food, but then it's ok. I also increased my Tindamax to 500mg 3x/day and saw an improvement with that as well. Something else I'm doing is using metronidazole cream and Venex ointment topically...just about everywhere, esp. the scalp, and it makes me herx a lot, but they're also helping a lot. I've been taking artemesinin, but only 200mg 2x/day, so maybe I'll try increasing that dose, because it never seems to have much impact. Thanks again. Good info. Patti > > I am trying to come up with a reference list for myself and will be > happy to share with others if you would like. > > I've got a start. Please let me know if you know of others. Thank you. > Robin (see below) > > LYME BBB > > > MMS > > Allicin: The main agent--allicin--has a very small molecular weight > and can therefore penetrate the blood-brain barrier in order to > combat infections of the central nervous system, something that > conventional antibiotics are unable to do. > > http://huiliacuherbclinic.com/lymedisease.html > > Artemisinin: > > Artesunate is water soluble and may be the most active and the least > toxic, but it has the shortest life within the body. Artemether is > oil or lipid soluble and has the longest half-life. It also has the > most toxicity (but this is related to rather high dosages, which are > unnecessary. Its big advantage is that it can cross the blood-brain > barrier to reach cancers in the nervous system. Artemisinin is the > active parent compound of the plant. > It has an intermediate half-life, is very safe, and also can cross > the bloodbrain > barrier. The first two are slightly altered semi-synthetic > derivatives of artemisinin, the concentrated and purified active > agent. Dr. Singh reports that a combination of the forms may be the > very best treatment due to these different properties (based on a lab > experiment). Thus, he feels the best preparation will contain > artemisinin and artemether to provide a dose of 0.5-2 mg/Kg of each > form once daily before bed (away from any residual iron left in the > stomach from the evening meal). Dr. Hoang reports that 500 mg > twice daily of oral artemisinin by itself is the dosage he has been > using with great success. > > http://tst.kanker-actueel.nl/index.asp? blz=an_al.Artemisinin & nieuws=23 > > intravenous rocephin > > Minoclycline (high dose) (200 to 400 a day) > > Doxyclycline high dose (300 to 600 a day) > > > > http://info.lymebook.com/matthewgoss.html > > (Zithromax) may successfully accomplish blood-brain tissue barrier > penetration that is needed. > > http://www.wellsphere.com/healing---recovery-article/bells-palsy-of- > the-gut-and-other-gi-manifestations-of-lyme-and-associated- > diseases/20512 > > > > Metronidazole inhibits anaerobic bacteria and protozoa. The exact > mechanism is not understood, but it is believed that it interferes > with the synthesis of DNA. It penetrates all tissues including those > found in the CNS (no link) > > Possibility? because of low BBB threshold with lyme: > > The role of the newer macrolides in the treatment of Lyme > Disease needs further assessment. Erythromycin has been regarded > as ineffective, despite its good in vitro sensitivities. > Azithromycin has been reported to be less effective in the > treatment of early Lyme Disease than amoxicillin (21). Some > physicians use clarithromycin and azithromycin in higher dosages > and for longer periods of time, but there have been no reports of > greater success with these drugs than with the tetracyclines or > beta-lactams. In our experience, all macrolides are effective > when combined with a lysosomotropic agent, especially > hydroxychloroquine(see below)(10). > > > In evaluating the possible factors, it would appear that > antibiotics that can achieve intracellular concentrations and > activity are the most efficacious drugs. The results of studies in > Klempner's laboratory using a tissue culture model of borrelia > infection demonstrated that ceftriaxone was incapable of eradicating > intracellular organisms (17); similar experiments in Raoult's > laboratory using an endothelial cell model > demonstrated that tetracycline and erythromycin were effective, > but beta lactam antibiotics were not (3). These results are in line > with our experience that the tetracyclines and macrolides achieve the > greatest success. > > In contrast to beta lactams, antibiotics of the tetracycline and > macrolide classes are capable of good intracellular penetration. > Experience with the macrolide antibiotics has been disappointing, > however, when compared with > its in vitro activities against the Lyme borreliae, and with the > established efficacy of macrolides against other intracellular > parasites such as chlamydia, legionella, mycobacterium-avium > intracellulare, and toxoplasma. If, though, the Lyme borreliae reside > in intracellular vesicles that are acidic, the macrolides' activity > would be sharply decreased at the lower pH. > > This is in contrast to the tetracyclines, which are active at acid > pH; even > so, the activity of doxycycline was shown to be further increased by > increasing the pH. In a tissue culture model of ehrlichia infection, > the use of lysosomotropic agents such as amantidine, NH4Cl, and > chloroquine increased the killing of intracellular organisms by > doxycycline (22). > > Based on those studies, and the hypothesis that late Lyme Disease > symptoms are due to persisting intracellular infection, we have been > successfully treating patients using the combination of a macrolide > and hydroxychloroquine (10). > > As regards " CNS " disease, there is no evidence that ceftriaxone > is more successful than either the tetracyclines or the combination > of macrolide and hydroxychloroquine; if our presumption that the > pathogenesis of the disease involves the localization of the borrelia > to the endothelial cells of the blood vessels serving the nervous > system or to glial or neural > cells is correct, then one would not need to have a drug that can > cross the blood-brain barrier to be effective. Indeed, the > tetracyclines can cross the blood-brain barrier to some extent, and > were used when initially introduced into clinical medicine for the > treatment of meningitis, with some success. > > > Macrolide antibiotics do not cross the blood-brain barrier, but have > been > effective in treating other CNS infections (e.g., toxoplasmosis), and > in our experience have been effective in reversing the > neuropsychiatric symptoms and signs (eg SPECT scans) of Lyme Disease > (10). With regard to the issue of bactericidal vs bacteristatic > effects, any such effect in vivo has not been demonstrated. > > > Finally, there have been no reports showing any change in antibiotic > resistance patterns during the course of treatment. Ultimately, the > determination of efficacy of therapy depends on the clinical > response. > > clinical response. > > http://www.prohealth.com/library/showarticle.cfm?id=3579 & t=CFIDS_FM > > Lyme Disease and Autism > > Other neurogenic strains of Borrelia that cause Relapsing Fevers in > Africa can be deadly within mere weeks of entering the brain. While > Lyme disease may be a bit more subtle upon penetrating the brain, > its > silent and insidious invasion may be the reason that brain > involvement > can and is often be overlooked by physicians for months or even > years > in neurological Lyme patients. > Just as the spirochete that causes syphilis can remain active > within > the brain for decades in tertiary Syphilis, there is equal cause for > concern that the Lyme bacteria can also become a sequestered > unwelcome > interloper to the central nervous system. How does the Lyme bacteria > enter the brain when the blood brain barrier fights against foreign > invasion? > Once the Lyme spirochete enters the peripheral blood circulation > through an infected tick bite, the bacteria fights to escape the > confines of the blood vessel walls. The spirochete's motility allows > it to swim in the blood stream until it lodges a wiggling tip into a > endothelial cell junction, where it bores between endothelial cells > lining the capillaries and causes a specific inflammation and > irritation that causes the endothelial cells to release digestive > proteins that create holes within the capillary bed. > In 1989, experiments were done using umbilical cord vein to show > that Borrelia burgdorferi attaches tip first to endothelial cells > and > microscopic examination found holes near the areas of attachment. If > these vessels were within the heart or brain, it would be clear that > there is nothing to stop Borrelia and other blood stream components > from entering those sites. In the case of the brain, allowing > bacteria > and white blood cells access to the brain is setting up the brain > for > a series of events to occur which we can call neurocascade events. > This is where one event will trigger another, which in turn will > trigger another and so on until a small nonsymptomatic event becomes > noticeable. > To see if Borrelia burgdorferi truly breaks down the blood brain > barrier, several animal experiments were done. Since blood albumin > protein should not be in the cerebral spinal fluid (CSF), > researchers > tagged normal albumin with radioactive Iodine. In mice, hamsters, > and > dogs without infection the radioactive Iodine never penetrated into > the CSF of the normal control animals. But when the animals were > infected with Lyme disease, within mere hours the blood brain > barrier > became permeable and radioactive iodine was found within the CSF of > infected animals usually for about two weeks following initial > infection. This window of permeability certainly gives ample time > for > the Lyme bacteria to establish itself within the brain. Detailed > collection of CSF from recently bitten Lyme patients reveals that > sub > clinical infections of the CNS occurs often before the infection in > the body is even detected. > Before we talk about the neurotoxic effects of Borrelia > burgdorferi > within the brain, let's first look at some other neurocascade events > that occur in acute brain trauma and repeated brain trauma such as > in > sports accidents like soccer, football and boxing. Repeated > concussions in football players and boxers can cause a slow onset > of a > syndrome sometimes called Pugilistic Dementia, or Sports-Related > Encephalopathy. Common symptoms begin months to years after injury > occurs and usually includes: headaches, muscle twitches, tics, > sensitivity to bright lights and loud noises, inability to retrieve > words, loss of time, depression, suicidal thoughts. Later these > symptoms can progress to fatigue, lethargy, loss of interest, severe > depression, Parkinson-like tremors, loss of motor control, and > overall > slowness, and finally dementia. > An interesting comparison between Lyme encephalitis and Pugilistic > dementia besides sharing similar symptoms is that both patients can > have global-cerebral-atrophy years after their initial trauma. In > other words, the brain shrinks, and appears to have lost the ability > to properly repair damage that accumulates over many years. These > abnormal MRIs of the brains of boxers and Lyme patients may be > caused > by different mechanisms, but the end result can appear similar in > both > the symptoms and pathology of the two conditions. > > > http://findarticles.com/p/articles/mi_m0ISW/is_285/ai_n19170369/print? > tag=artBody;col1 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 Thank you, Patti. Interesting. Never hard of cream form... will add to my list! Thanks for the tip! Robin > > Thanks for this info. I recently increased my doxy dose from 300- > 400mg/day, and saw improvement, so then went up to 600mg/day, and > that's making even more of a difference. It can be hard on an empty > stomach, so I have to take it with some food, but then it's ok. > > I also increased my Tindamax to 500mg 3x/day and saw an improvement > with that as well. > > Something else I'm doing is using metronidazole cream and Venex > ointment topically...just about everywhere, esp. the scalp, and it > makes me herx a lot, but they're also helping a lot. > > I've been taking artemesinin, but only 200mg 2x/day, so maybe I'll > try increasing that dose, because it never seems to have much impact. > > Thanks again. Good info. > > Patti > Quote Link to comment Share on other sites More sharing options...
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