fatigue

[Guest guest]

Thanks! I feel like a new person, although I do wish I felt more well.

That will come, I'm sure.

Keen

Re: fatigue

Keen -

I eat soooo many veggies and tons of salads. Also good with my

eggs/fish and lots of lamb. I cheated so much this summer and got

into the routine of eating more carbs and white sugar than I needed

to. Gained back about 5 lbs and feeling so tired again. I have

tried for 2 days now to go back on no sugar/white or any carbs

including fruit. Really tired today - probably from no sugar but

lately I just can't seem to get full or content. Does anyone else

go through that. What I am eating is not bad, it's just that I

never get satisfied. Is it because I am back craving things

again??? Will it subside if I can stay yeast free for a few days

and get back on track? Also - I have been eating quinoa instead of

brown rice lately - anyone have anything to say about that???

(quinoa - that is).

a

>

> If you are eating what you should and feeling ill, then it is most

likely die off that is making you feel ill.

>

> Keen

>

[Guest guest]

please think positive - has anyone read about Quantum Healing? If not I

strongly advise you to. It goes hand in hand with all of this. Good time

to ALWAYS think in positive terms! good stuff.

Re: fatigue

Keen -

I eat soooo many veggies and tons of salads. Also good with my

eggs/fish and lots of lamb. I cheated so much this summer and got

into the routine of eating more carbs and white sugar than I needed

to. Gained back about 5 lbs and feeling so tired again. I have

tried for 2 days now to go back on no sugar/white or any carbs

including fruit. Really tired today - probably from no sugar but

lately I just can't seem to get full or content. Does anyone else

go through that. What I am eating is not bad, it's just that I

never get satisfied. Is it because I am back craving things

again??? Will it subside if I can stay yeast free for a few days

and get back on track? Also - I have been eating quinoa instead of

brown rice lately - anyone have anything to say about that???

(quinoa - that is).

a

>

> If you are eating what you should and feeling ill, then it is most

likely die off that is making you feel ill.

>

> Keen

>

[Guest guest]

Being positive is good, and I do practice it (being needlessly negative

is pointless), but unrelenting positivity in the face of adversity can

be called by another name - denial. Or even insanity. Reality is a

good thing to face.

Keen

Re: fatigue

Keen -

I eat soooo many veggies and tons of salads. Also good with my

eggs/fish and lots of lamb. I cheated so much this summer and got

into the routine of eating more carbs and white sugar than I needed

to. Gained back about 5 lbs and feeling so tired again. I have

tried for 2 days now to go back on no sugar/white or any carbs

including fruit. Really tired today - probably from no sugar but

lately I just can't seem to get full or content. Does anyone else

go through that. What I am eating is not bad, it's just that I

never get satisfied. Is it because I am back craving things

again??? Will it subside if I can stay yeast free for a few days

and get back on track? Also - I have been eating quinoa instead of

brown rice lately - anyone have anything to say about that???

(quinoa - that is).

a

>

> If you are eating what you should and feeling ill, then it is most

likely die off that is making you feel ill.

>

> Keen

>

[Guest guest]

Absolutely! and I apologize that was not directed at you but a reminder

for all of us. It is easy to get pulled down and our choice of words at

times could be altered to emanate added positivity for our experience of

discovery. One interesting side reading I've done was the book on water

and its thoughtful meditation. Being as we, humans, are made up mostly

of water (okay candida sometimes it feels like) we should really

consider how the positive spin affects our healing and each drop of

water in our bodies. Just reminders. Again, not meant to be pointed at

anyone in particular. Cheers.

Re: fatigue

Keen -

I eat soooo many veggies and tons of salads. Also good with my

eggs/fish and lots of lamb. I cheated so much this summer and got

into the routine of eating more carbs and white sugar than I needed

to. Gained back about 5 lbs and feeling so tired again. I have

tried for 2 days now to go back on no sugar/white or any carbs

including fruit. Really tired today - probably from no sugar but

lately I just can't seem to get full or content. Does anyone else

go through that. What I am eating is not bad, it's just that I

never get satisfied. Is it because I am back craving things

again??? Will it subside if I can stay yeast free for a few days

and get back on track? Also - I have been eating quinoa instead of

brown rice lately - anyone have anything to say about that???

(quinoa - that is).

a

>

> If you are eating what you should and feeling ill, then it is most

likely die off that is making you feel ill.

>

> Keen

>

[Guest guest]

From what I went through the fatigue got allot better after week 14 , I had much more energy then . But of course that's when my blood work started to get all funky ,lol

Fatigue

This is the beginning of week number two where all I do is sleep and walk the dog. I've had 7 injections so far. Does anybody have any words of advice about the fatigue? This totally sucks and I can't imagine having to go through 41 more weeks of this.

[Guest guest]

When my fatigue started getting extreme I checked my bloodwork and sure enough, my hemoglobin was way down so my Dr gave me a shot for that which helped immensely. I am still tired but not enough to keep me from doing what I want to do.

On 10/22/06, <linda68082@...> wrote:

This is the beginning of week number two where all I do is sleep and walk the dog. I've had 7 injections so far. Does anybody have any words of advice about the fatigue? This totally sucks and I can't imagine having to go through 41 more weeks of this.

[Guest guest]

In a message dated 10/23/2006 6:41:29 PM Central Daylight Time, redjaxjm@... writes:

Make sure you are drinking that gallon of water,, it REALLY helps with the fatigue!

yeah cuz you have to get up every 5 minutes to pee...LOL..geri

[Guest guest]

Make sure you are drinking that gallon of water,, it REALLY helps with the fatigue! <linda68082@...> wrote: This is the beginning of week number two where all I do is sleep and walk the dog. I've had 7 injections so far. Does anybody have any words of advice about the fatigue? This totally sucks and I can't imagine having to go through 41 more weeks of this. Jackie

[Guest guest]

hahaha, I hadnt thought of that! mayb you are right,, but I DO know it helps! lolus4heavenbound@... wrote: In a message dated 10/23/2006 6:41:29 PM Central Daylight Time, redjaxjm writes: Make sure you are drinking that gallon of water,, it REALLY helps with the fatigue! yeah cuz you have to get up every 5 minutes to pee...LOL..geri Jackie

[Guest guest]

That would be the exercise part!

-- In Hepatitis C , us4heavenbound@... wrote:

>

>

>

> In a message dated 10/23/2006 6:41:29 PM Central Daylight Time,

> redjaxjm@... writes:

>

> Make sure you are drinking that gallon of water,, it REALLY helps

with the

> fatigue!

>

>

> yeah cuz you have to get up every 5 minutes to pee...LOL..geri

>

[Guest guest]

you need to get enough Armour, which means you cannot be treated to TSH. You

will not get well without iodine!!!

http://www.helpmythyroid.com

http://www.stopthethyroidmadness.com

Gracia

I am on Armour. I have hot/cold temperature extremes, shed hair like a

dog, fatigued. Is there any supplement/vitamin, alternative thryoid

medication. My mother, grandmother had this disease and they were

almost house bound unable to do anything. I am willing to hear any

suggestions or medical resources.Thanks

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[Guest guest]

> I recently increased my dosage from 15mg to 20 mg

> this seems to be working for me

>

> does anyone know how long it takes for the 20 mg take complete effect?

>

> I am feeling soooo tired

> fatigue

> like I did not have on 15

>

> common side effect when upping ?

> any chance this will go away ?

I also recently increased from 15 to 20 (from 10 originally).

It went so well from 10 to 15 (beginning of year) that in

April I went to the full 20. From 15 to 20 wasn't as easy

as 10 to 15. I think 20 is a lot for me and it's taking a

while for side effects to go away. For a while I was falling

asleep as soon as I got home from work and sleeping for an hour

or so- that after a good night's sleep. Now after 3 months

I don't feel that fatigued/sleepy. So hang in there and the

tiredness should go away before too long.

[Guest guest]

20mg GREATLY increased my fatigue. I had to go back to 10 mg.

I would think that with most dosage changes, if you're not feeling better in

the next 10 days or so, you might want to call your doc.

Hope this helps!

munraB munraB <munrab_mail@...> wrote:

Hi all

hope everyone is having a bearable day

I recently increased my dosage from 15mg to 20 mg

this seems to be working for me

does anyone know how long it takes for the 20 mg take complete effect?

I am feeling soooo tired

fatigue

like I did not have on 15

common side effect when upping ?

any chance this will go away ?

many thanks

---------------------------------

Sick sense of humor? Visit TV's Comedy with an Edge to see what's on,

when.

[Guest guest]

:-) it has passed :-) thank god

and all of you :-)

I hope everyone is having a good day

Rickye Pool <rickye.pool@...> wrote:

20mg GREATLY increased my fatigue. I had to go back to 10 mg.

I would think that with most dosage changes, if you're not feeling better in the

next 10 days or so, you might want to call your doc.

Hope this helps!

munraB munraB <munrab_mail@...> wrote:

Hi all

hope everyone is having a bearable day

I recently increased my dosage from 15mg to 20 mg

this seems to be working for me

does anyone know how long it takes for the 20 mg take complete effect?

I am feeling soooo tired

fatigue

like I did not have on 15

common side effect when upping ?

any chance this will go away ?

many thanks

---------------------------------

Sick sense of humor? Visit TV's Comedy with an Edge to see what's on,

when.

[Guest guest]

is 20 " a lot " ?

fisemicr <fisemicr@...> wrote:

> I recently increased my dosage from 15mg to 20 mg

> this seems to be working for me

>

> does anyone know how long it takes for the 20 mg take complete effect?

>

> I am feeling soooo tired

> fatigue

> like I did not have on 15

>

> common side effect when upping ?

> any chance this will go away ?

I also recently increased from 15 to 20 (from 10 originally).

It went so well from 10 to 15 (beginning of year) that in

April I went to the full 20. From 15 to 20 wasn't as easy

as 10 to 15. I think 20 is a lot for me and it's taking a

while for side effects to go away. For a while I was falling

asleep as soon as I got home from work and sleeping for an hour

or so- that after a good night's sleep. Now after 3 months

I don't feel that fatigued/sleepy. So hang in there and the

tiredness should go away before too long.

---------------------------------

Get the toolbar and be alerted to new email wherever you're surfing.

[Guest guest]

I am also on 20mg a day. My doctor just added 150mg of wellbutrin as well. I

cannot get over the fatigue / always tired no matter how much sleep I get, so

she thought the wellbutrin would help with that. Its been 5 days since adding

the Wellbutrin, still tired, but feel more stable.

munraB munraB <munrab_mail@...> wrote: is 20 " a lot " ?

fisemicr wrote:

> I recently increased my dosage from 15mg to 20 mg

> this seems to be working for me

>

> does anyone know how long it takes for the 20 mg take complete effect?

>

> I am feeling soooo tired

> fatigue

> like I did not have on 15

>

> common side effect when upping ?

> any chance this will go away ?

I also recently increased from 15 to 20 (from 10 originally).

It went so well from 10 to 15 (beginning of year) that in

April I went to the full 20. From 15 to 20 wasn't as easy

as 10 to 15. I think 20 is a lot for me and it's taking a

while for side effects to go away. For a while I was falling

asleep as soon as I got home from work and sleeping for an hour

or so- that after a good night's sleep. Now after 3 months

I don't feel that fatigued/sleepy. So hang in there and the

tiredness should go away before too long.

---------------------------------

Get the toolbar and be alerted to new email wherever you're surfing.

[Guest guest]

I was a 25-year runner, age class racer, and was just about your age when I had to give it up. My body still worked but the price I had to pay in fatigue made it obvious that running was now working against me.

I switched to walking. I know, for a runner it's boring at first but it does have its charms. Eight years later and walking is still my primary exercise. It bugs me when I miss a day but I have to admit that during pre- and post-TX periods, even walking can be too much. Like running, however,

one can always adjust the distance to fit the situation.

Would I rather be running? Hell, yes! But I've learned that this disease will make certain demands that can't be ignored. All one can do is try to understand what it will give you and make the most of it.

And since you're a runner, I'm willing to bet you're already following a healthy diet. As far as fighting fatigue, I don't know what to tell you. Often when it's not completely overpowering, I simply have to push myself through it. I'd like to get the cat to pick up some of the slack but she just ignores my suggestions.

Good luck,

Fred Hummel, 80, Arcata, CA;CLL/SLL dx 1.98;Fludara 2000;Fludara, Rituxan, Novantrone, Decadron, 2002;Rituxan, 2004;Rituxan, Chlorambucil, Prednisone, 2005, 2006;IvIG 12/06 5/07;Started RFC-Lite 7/07.

[Guest guest]

Fred H said it well in his post. I am 71 and play tennis (doubles) 3 to 4 days a week and try and get about 35 miles a week on my bike (however not in this hot weather we are having -90+ degrees each day) I was diagnosed with CLL in 2002.Nothing fights my fatigue like a 1 1/2 hour nap about 12.:30 pm. I just got up from my nap and feel energized to go the rest of the day.Good luck on your method.Gordonputt72putt <darlind@...> wrote: I am a 72 year old man, diagnosed with CLL

in August 04. Treated immediately as I was classed at Rai III. Always enjoyed running but got fatigued. I had fludarabine treatments for 3 months, several infections and blood transfusions. Rituxin treatment for 1 month. Now all accounts in normal range, however I fight fatigue alot of the time. Do others have fatigue and is there anything you do for this? I had a ct scan because of the fatigue but haven't received the results yet. Do others of you suffer fatigue and what do you do about it? Thanks G & J Doblergj628dobler@...ph 269-375-9229 fx 269-375-0607

[Guest guest]

Fatigue seems to be commonly associated with CLL, at least among those on the 'net who tell of their CLL. wayneallison evans <alliwile@...> wrote: i am in 0 stage but i am finding that any sort of knock to my bones is quite painful, is this something that is common in cll or am i just being paranoid, beacause as i am newly diagnosed i seem to blame everything on the disease, i am also tired all the time but my doc thinks this is not related because my wbc is 13.7. can anyone advise Messenger NEW - crystal clear PC to PC calling worldwide with voicemail

Be a better sports nut! Let your teams follow you with Mobile. Try it now.

[Guest guest]

Dear ,

I'm sorry you're feeling that way.

I know exactly what you mean. When I first had Lyme, I had to husband

my energy. So if I was able to prepare breakfast, that might be it for

the day.

Then as I improved, I fixed breakfast AND washed the dishes.

(Boy I remember - that was a big step!)

Don't know if you saw my post- I found CoQ-10 made a big difference

for my Lyme-fatigue.

Is there any possibility that you have adrenal exhaustion which is

what I have now?

Abx can cause it. If you think you do, I could post the diet and

supplements which have worked for me.

I am already feeling better than before, altho not yet 100 percent.

People have also found, and Buhner recommends, Siberian ginseng, which

I have not tried, altho I find any ginseng to be good for energy.

regards,

ellen

>

> Hi Betty and Ellen, could you let me know of anything to help with

> energy? I am so sick that I can only do 1 thing per day - clean kitchen

> (maybe), change bed (difficult), do a near-by errand (sometimes). The

> rest of the time I have to stay in bed. I feel terrible, have been sick

> 9 years, including 3 years Doxy & Zith abx.

>

> I'm on Buhner's protocol now. I would so love to get well! Thanks,

>

>

>

>

>

>

>

[Guest guest]

Sandy

you are NOT the only one not getting better on Rife--too bad you wont be able to

post that though!! Obviuously others with same experiences arent being allowed

to or else you wouldnt have said that!!!

Please try to post on all Rife groups and maybe others like you wont feel so

alone.

btw Rosner's " top ten " book states that Rife alone cant/wont heal--he is a bit

vague about what is best to use with it--but he admits at least his first

book(s) stating this were not entirely accurate--but as far as I recall, I

havent seen such admissions on any of his sites/blogs.or from an Rife-ites

either

try to search Rife on www.lymeneteurope.org for interesting an NON biased info

which may explain your failure to heal with it

Fatigue is a general sx common with a LOT of things: stress ( physical mental

and emotional); any/all illness infection etc, connective tissue, muscle and

metabolic disorders ( even diabetes)...

yes Lyme can cause fatigue and for a lot of reasons too: disruption of sleep,

changes in chemistry and metabolism, inability to exercise ( negative cycle of

less exercise, more fatigue loops), body using energy for immuno-fight, etc etc

" just " fatigue isnt criteria for any illness including Lyme--if you had or have

Lyme and fatigue is only sx left. maybe time and energy boosting will help (

nutrition, herbs, exercise?etc) some develop Chronic fatigue or even whats often

called CFIDs...you need to try to find the cause and experiment with treatments.

Id suggest a very well trained and credentialed health professional ( one with

alternatives knowledge).

good luck

Finette

[Guest guest]

I found the information on fatigue interesting. I have often wondered why I feel

so bad when my test are good. Now I kind of understand that there are other

factors that determine how tired I feel.

Right now I am taking B-12 shots and so far I seem to feel worse. I started out

taking them for 5 days and now I take one shot a week. If the blood work is okay

then I go to once a month. I finally gave myself the shot this week.

I just want to know if anyone can tell me when I will feel better? Right now I

just want to sleep all the time, my joints ache and my body hates me. My nails

are all breaking and splitting and my hair is falling out. I also have no

appetite at all.

To tired to eat,

the WV hillbilly

LOVE IS IN ALL THINGS AND IN ALL THINGS IS LOVE

[ ] Good days bad days

Clara, Bad days are the days when I just have no energy and I do little that

is taxing. Those days I will putter around and read or paint. Or sit and weed

the flowert garden. Good days are those days when I wake up and have energy!

Then I take advantage of it and rush around cleaning the house. I never get up

in the morning until I feel like it. My normal time for getting up is 10:00 am.

If I got up before that I would be worthless! The days of getting up by 8:00

are long gone. I had thought that after transplant I would have lots of

energy.but I don/t. But, then I also have fibromyalsia. ......perhaps you do

too. You should see an rheumytologist to see if you have arthritis, fibro, or

Sjogrens. Sjpogrens causes very dry eyes and mouth along with sore and tired

muscles. But, remember liver disease in itself causes fatigue! Just because

you may look fine you aren't...... .I know.most of us look healthy and people

don't realize we are REALLY

ill..You have to learn when to do what........ to what you can each day and be

happy you can do that much.

Deb, You are safe.don't worry about any of the radiation touching you. They

use a very small dose of radiation... ..otherwise it would kill the patient.

Feel free to hug her. " her chemo and radiation treatment next week and

thought I better ask if there are any precautions I need to take considering I

have PBC " Blessings, Joanne http://www.ahfmr.

ab.ca/publicatio ns/newsletter/ Summer06/ fatique.htm Fatigue and illness

Why do we feel tired when we're ill?

In many illnesses-such as cancer, multiple sclerosis, rheumatoid arthritis, and

liver disease-as well as infections, fatigue can be a major issue.

Brain function drives the fatigue in these diseases, even though all of them

occur outside of the brain, AHFMR Senior Scholar and Calgary hepatologist Dr.

Mark Swain points out.

" When we become sick with the flu or a bacterial infection, we feel tired, as

well as losing our appetite and so on, " explains Dr. Swain. " The body signals

the brain to produce these symptoms or behaviours. It's important for us to

conserve energy and not move around and do things-so we'll get over the illness

and get back to normal. Unfortunately, with a chronic disease, we don't get over

the illness. The stimuli to the brain keep happening. Our bodies try to adapt

but they never fully do so. "

Throughout his career as a physician and researcher, Dr. Swain has attempted to

improve the quality of life and health outcomes for people suffering from liver

disorders. More than 100 known forms of liver disease affect everyone from

infants to older adults. Liver damage can result from viruses, cancer,

autoimmune disorders, alcohol, drug use, toxins, and obesity.

Liver problems

Dr. Swain studies, diagnoses, and treats such liver problems as hepatitis,

cirrhosis, fatty liver disease, and liver cancer. He investigates the basic

mechanisms of liver inflammation and the changes in neurotransmission within the

brain that occur in the context of liver disease. He is especially fascinated by

the effects of liver damage on symptoms in liver disease, particularly fatigue.

Dr. Swain studies how the liver might signal the brain, with the end result that

the person feels tired.

Fatigue is the symptom most commonly mentioned by people with liver disease, but

its cause is a puzzle. Since fatigue is an unspecific symptom (in other words,

it can be caused by a variety of health problems), it is difficult to determine

whether it is caused by the liver disease or by something else, or by a

combination of factors. This is one reason why fatigue is difficult to study,

understand, and treat.

Peripheral fatigue

Many people with very severe liver disease suffer what is called peripheral

fatigue as a result of muscle atrophy. Patients with less severe disease often

experience fatigue not related to muscle deterioration: that is, fatigue that

comes from changes occurring within the brain. The severity of the fatigue in

these individuals does not relate to their liver function. This means that some

people who have severe liver damage may not feel tired at all, while others with

minimal liver damage may feel totally exhausted.

" Fatigue can be the main feature of many forms of liver disease, and can be

anywhere from mild and trivial to completely incapacitating, " explains Dr.

Swain. " The thing that's most difficult is that there's no correlation between

the severity of the fatigue and the severity of the liver disease. Some people

will say, 'If I have cirrhosis, why do I feel so good?' Others will say, 'Why do

I feel so bad?' I think, inherently, some people are more tired than others

because of the different ways individuals adapt to the signals which their

bodies are sending to their brain. " Dr. Swain hopes that his research may

someday allow physicians to better target the treatment of fatigue as a symptom,

improving quality of life for patients with liver disease and possibly for those

with other chronic diseases as well.

Dr. Mark Swain is an AHFMR Senior Scholar and a professor in the Department of

Medicine at the University of Calgary. He receives funding from the Canadian

Institutes of Health Research (CIHR).

Selected publications

Swain MG. Fatigue in liver disease: pathophysiology and clinical management.

Canadian Journal of Gastroenterology 2006 Mar;20(3):181- 188.

Kerfoot SM, D'Mello C, Nguyen H, Ajuebor MN, Kubes P, Le T, Swain MG.

TNF-a-secreting monocytes are recruited into the brain of cholestatic mice.

Hepatology 2006 Jan;43(1):154- 162.

____________ _________ _________ _________ _________ _________ _

Fashion Design Education - Click Here!

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[Guest guest]

Very informative article! Thank you, for writing it for all of us,

who are sometimes discouraged of why we are so tired when our " tests " .

seem to look OK. Nevertheless we still have the problem and the

disease. Reading about it really helps!

Clara from OR

> [ ] Good days bad days

>

>

> Clara, Bad days are the days when I just have no energy and I do

little that is taxing. Those days I will putter around and read or

paint. Or sit and weed the flowert garden. Good days are those days

when I wake up and have energy! Then I take advantage of it and rush

around cleaning the house. I never get up in the morning until I feel

like it. My normal time for getting up is 10:00 am. If I got up

before that I would be worthless! The days of getting up by 8:00 are

long gone. I had thought that after transplant I would have lots of

energy.but I don/t. But, then I also have fibromyalsia. ......perhaps

you do too. You should see an rheumytologist to see if you have

arthritis, fibro, or Sjogrens. Sjpogrens causes very dry eyes and

mouth along with sore and tired muscles. But, remember liver disease

in itself causes fatigue! Just because you may look fine you

aren't...... .I know.most of us look healthy and people don't realize

we are REALLY

> ill..You have to learn when to do what........ to what you can each

day and be happy you can do that much.

Deb, You are safe.don't worry about any of the

radiation touching you. They use a very small dose of radiation...

...otherwise it would kill the patient. Feel free to hug her. " her

chemo and radiation treatment next week and thought I better ask if

there are any precautions I need to take considering I have PBC "

Blessings, Joanne

http://www.ahfmr. ab.ca/publicatio ns/newsletter/ Summer06/

fatique.htm Fatigue and illness

> Why do we feel tired when we're ill?

>

> In many illnesses-such as cancer, multiple sclerosis, rheumatoid

arthritis, and liver disease-as well as infections, fatigue can be a

major issue.

>

> Brain function drives the fatigue in these diseases, even though all

of them occur outside of the brain, AHFMR Senior Scholar and Calgary

hepatologist Dr. Mark Swain points out.

>

> " When we become sick with the flu or a bacterial infection, we feel

tired, as well as losing our appetite and so on, " explains Dr. Swain.

" The body signals the brain to produce these symptoms or behaviours.

It's important for us to conserve energy and not move around and do

things-so we'll get over the illness and get back to normal.

Unfortunately, with a chronic disease, we don't get over the illness.

The stimuli to the brain keep happening. Our bodies try to adapt but

they never fully do so. "

>

> Throughout his career as a physician and researcher, Dr. Swain has

attempted to improve the quality of life and health outcomes for

people suffering from liver disorders. More than 100 known forms of

liver disease affect everyone from infants to older adults. Liver

damage can result from viruses, cancer, autoimmune disorders, alcohol,

drug use, toxins, and obesity.

>

> Liver problems

> Dr. Swain studies, diagnoses, and treats such liver problems as

hepatitis, cirrhosis, fatty liver disease, and liver cancer. He

investigates the basic mechanisms of liver inflammation and the

changes in neurotransmission within the brain that occur in the

context of liver disease. He is especially fascinated by the effects

of liver damage on symptoms in liver disease, particularly fatigue.

Dr. Swain studies how the liver might signal the brain, with the end

result that the person feels tired.

>

> Fatigue is the symptom most commonly mentioned by people with liver

disease, but its cause is a puzzle. Since fatigue is an unspecific

symptom (in other words, it can be caused by a variety of health

problems), it is difficult to determine whether it is caused by the

liver disease or by something else, or by a combination of factors.

This is one reason why fatigue is difficult to study, understand, and

treat.

>

> Peripheral fatigue

> Many people with very severe liver disease suffer what is called

peripheral fatigue as a result of muscle atrophy. Patients with less

severe disease often experience fatigue not related to muscle

deterioration: that is, fatigue that comes from changes occurring

within the brain. The severity of the fatigue in these individuals

does not relate to their liver function. This means that some people

who have severe liver damage may not feel tired at all, while others

with minimal liver damage may feel totally exhausted.

>

> " Fatigue can be the main feature of many forms of liver disease, and

can be anywhere from mild and trivial to completely incapacitating, "

explains Dr. Swain. " The thing that's most difficult is that there's

no correlation between the severity of the fatigue and the severity of

the liver disease. Some people will say, 'If I have cirrhosis, why do

I feel so good?' Others will say, 'Why do I feel so bad?' I think,

inherently, some people are more tired than others because of the

different ways individuals adapt to the signals which their bodies are

sending to their brain. " Dr. Swain hopes that his research may someday

allow physicians to better target the treatment of fatigue as a

symptom, improving quality of life for patients with liver disease and

possibly for those with other chronic diseases as well.

>

> Dr. Mark Swain is an AHFMR Senior Scholar and a professor in the

Department of Medicine at the University of Calgary. He receives

funding from the Canadian Institutes of Health Research (CIHR).

>

> Selected publications

>

> Swain MG. Fatigue in liver disease: pathophysiology and clinical

management. Canadian Journal of Gastroenterology 2006 Mar;20(3):181- 188.

>

> Kerfoot SM, D'Mello C, Nguyen H, Ajuebor MN, Kubes P, Le T, Swain

MG. TNF-a-secreting monocytes are recruited into the brain of

cholestatic mice. Hepatology 2006 Jan;43(1):154- 162.

>

> ____________ _________ _________ _________ _________ _________ _

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[Guest guest]

I am taking chlorella (4000 mg per day) and I drink a mixture called Greens Plus Daily Detox. For some reason it gives me energy and helps my digestion. A lot.The chlorella is like chlorophill, I think, and helps give you extra oxygen. Whatever, they work along with 2 gm of B12 every day.HelenFrom: hardcase125 <sheryl@...>Subject: Fatiguedominie Received: Tuesday, September 23, 2008, 1:40 PM

Just wondering what you all have found to be helpful for the extreme

fatigue from fibro. I have gotten the pain pretty much under control

but this fatigue is riduculous. Thanks for any suggestions. I am

already doing b-12 shots and Vit-d and multi-vitamins.

[Guest guest]

I was a HUGE skeptic of the different exotic juices that are out there, because they all seem to be sold in pyramid type schemes. So, I've passed on them even though I've had so many of my friends sing their praises. Well, I was in Akins health food store a few weeks ago with my husband - we haven't tried a whole lot of natural and vitamin supplement type treatments, but one of our neighbors had recommended something for his allergies. While we were there, I saw a whole shelf full of Mangosteen juice. It is expensive - the range for a 32 oz. bottle depending on the brand, was $17 to $26. I got the $17 stuff, still extremely skeptic but figured I'd try it since so many people had so many good things to say about it. I drink one oz. in the morning and one oz. in the evening, and I have had

more energy in the past couple weeks than I have had in the 2 years I've been suffering with Fibro. I know that different things work for different people, but for me, this was worth the money. I have only had one major fatigue "crash" in the past 2 weeks - and that was after over-exherting myself for a couple days (which I tend to do when I'm feeling overly good). AmityPosted by: "hardcase125"

sheryl@...

hardcase125

Tue Sep 23, 2008 6:40 am (PDT)

Just wondering what you all have found to be helpful for the extreme

fatigue from fibro. I have gotten the pain pretty much under control

but this fatigue is riduculous. Thanks for any suggestions. I am

already doing b-12 shots and Vit-d and multi-vitamins.