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Hi Lilian

Eur J Endocrinol. 2008 February ; 158(2): 217–221.

Free triiodothyronine plasma concentrations are positively

associated with insulin secretion in euthyroid individuals

Emilio Ortega, Juraj Koska, Nicola Pannacciulli, Joy C Bunt, and

Krakoff

Obesity and Diabetes Clinical Research Section, Department of Health

and Human Services, National

Institute of Diabetes and Digestive and Kidney, Diseases, National

Institutes of Health, 4212, North 16th

Street, Room 5–35, Phoenix, Arizona 85016, USA

also the original article:-

Thyroid hormone receptor TRbeta1 mediates Akt activation by T3 in

pancreatic beta cells

http://jme.endocrinology-journals.org/cgi/reprint/38/2/221.pdf

http://jme.endocrinology-journals.org/cgi/content/abstract/38/2/221

http://jme.endocrinology-journals.org/cgi/content/full/38/2/221

basically:~ there's a fast response to T3 in the pancreas and it

relates to insulin output....

whatever else it (T3) does, this one is clearly critical to all

functions where you need a fast and energetic response.

ie you can't wait for two hours before your FreeT3 increases.

best wishes

Bob

>

> Bob, or anyone else, can you please tell me what this means in

simple words which I can understand.

>

> http://www.medscape.com/medline/abstract/17293442

>

> Lilian

>

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Thanks Bob, not quite sure I still understand. Basically is T3 good for diabetes control?

Lilian

Eur J Endocrinol. 2008 February ; 158(2): 217-221.Free triiodothyronine plasma concentrations are positivelyassociated with insulin secretion in euthyroid individualsEmilio Ortega, Juraj Koska, Nicola Pannacciulli, Joy C Bunt, and KrakoffObesity and Diabetes Clinical Research Section, Department of Health and Human Services, NationalInstitute of Diabetes and Digestive and Kidney, Diseases, National Institutes of Health, 4212, North 16thStreet, Room 5-35, Phoenix, Arizona 85016, USAalso the original article:- Thyroid hormone receptor TRbeta1 mediates Akt activation by T3 in pancreatic beta cellshttp://jme.endocrinology-journals.org/cgi/reprint/38/2/221.pdfhttp://jme.endocrinology-journals.org/cgi/content/abstract/38/2/221http://jme.endocrinology-journals.org/cgi/content/full/38/2/221basically:~ there's a fast response to T3 in the pancreas and it relates to insulin output....whatever else it (T3) does, this one is clearly critical to all functions where you need a fast and energetic response. ie you can't wait for two hours before your FreeT3 increases.best wishesBob

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Hi Lilian,

It looks like it's (T3) critical to me.

I'm amazed at the apparent 'distance' between both diabetes and

hypothyroidism and likewise between hypercholesterolemia and

hypothyroidism, plus 'one or two' other worrying correspondences.

The recent paper by Panicker et al 2008, shows just how far there is

to go, in getting some of the treatment protocols amended.

I suspect they have had to go back to the drawing board and start

agin with some of these recent papers; practically, by the month

there is another paper that calls into question the entire 'story'

that we heard last year in Manchester.

best wishes

Bob

>

> Thanks Bob, not quite sure I still understand. Basically is T3

good for diabetes control?

>

> Lilian

>

> Eur J Endocrinol. 2008 February ; 158(2): 217-221.

>

> Free triiodothyronine plasma concentrations are positively

> associated with insulin secretion in euthyroid individuals

>

> Emilio Ortega, Juraj Koska, Nicola Pannacciulli, Joy C Bunt, and

> Krakoff

> Obesity and Diabetes Clinical Research Section, Department of

Health

> and Human Services, National

> Institute of Diabetes and Digestive and Kidney, Diseases,

National

> Institutes of Health, 4212, North 16th

> Street, Room 5-35, Phoenix, Arizona 85016, USA

>

> also the original article:-

> Thyroid hormone receptor TRbeta1 mediates Akt activation by T3 in

> pancreatic beta cells

>

> http://jme.endocrinology-journals.org/cgi/reprint/38/2/221.pdf

>

> http://jme.endocrinology-

journals.org/cgi/content/abstract/38/2/221

>

> http://jme.endocrinology-journals.org/cgi/content/full/38/2/221

>

>

> basically:~ there's a fast response to T3 in the pancreas and it

> relates to insulin output....

>

> whatever else it (T3) does, this one is clearly critical to all

> functions where you need a fast and energetic response.

>

> ie you can't wait for two hours before your FreeT3 increases.

>

>

> best wishes

> Bob

>

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