Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 If oc=Obesessive Compulsive, then I didn't find a low dose effective. I was on 20mg/day and my psychiatrist moved me up to 30 just a few days ago. So far I've seen no relief from my OCD, but it has helped my depression and mood in general. - > just started on lex four days ago. taking 10 mg/day. curious if > others have found this dose effective for mild oc...or if 20 mg/day > was better. other than feeling somewhat sleepy, i haven't noticed > much of a change yet. thx, --scot. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 7, 2003 Report Share Posted September 7, 2003 > just started on lex four days ago. taking 10 mg/day. curious if > others have found this dose effective for mild oc...or if 20 mg/day > was better. other than feeling somewhat sleepy, i haven't noticed > much of a change yet. thx, --scot. Hi, To me I think it hasn't been long enough to tell.Give it some more time. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 7, 2003 Report Share Posted September 7, 2003 > Hi, > To me I think it hasn't been long enough to tell.Give it some > more time. > How long is enough time ? I was on Celexa for over a year and have now been on lex fo ra week or so. How long do have have to have been on Lex for me to know whats what ? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 8, 2003 Report Share Posted September 8, 2003 > > > Hi, > > To me I think it hasn't been long enough to tell.Give it some > > more time. > > > > > How long is enough time ? > > I was on Celexa for over a year and have now been on lex fo ra week > or so. How long do have have to have been on Lex for me to know whats > what ? I think a good rule of thumb would probably be 4-6 weeks. At least this is what my Dr. says. For me, the biggest problem I'm facing with Lexapro is the sleepiness and the feeling of listlessness. It's a real toss up as to which is better...being sleepy and listless or hyper and panicky LOL. I guess, I'd rather be sleepy and listless than to have a full scale panic attack. I'm sticking with the 10 mg. until the end of the month. Good luck. sasha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 8, 2003 Report Share Posted September 8, 2003 And good luck to you ) ! > than to have a full scale panic attack. I'm sticking with the 10 mg. > until the end of the month. Good luck. > sasha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 10, 2003 Report Share Posted September 10, 2003 > just started on lex four days ago. taking 10 mg/day. curious if > others have found this dose effective for mild oc...or if 20 mg/day > was better. other than feeling somewhat sleepy, i haven't noticed > much of a change yet. thx, --scot. Hi Scot, I got started at 10, then 15, then 20. It took about four months to find noticeable relief from oc. Actually, I think my medical provider wanted me to go on 20 earlier, but I lied to him about how I was feeling on the 15 dose because I was starting to gain weight and didn't want to. I was a little underweight when I started seening him to begin with, so, when I'd been on the Lexipro long enough not to be so worried about a weight problem I didn't even have, I told him why I was saying I was doing better than I was, and he upped the dose to 20. 2 months later, I noticed the difference of not being ruled by my oc. I didn't even think I had the problem, even though the evaluation my doctor and psychiatrist said I did. -Lia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2006 Report Share Posted June 2, 2006 > Are dosing reccommendations outa whack too?? > > What exactly are lethal doses of these drugs and are people's weights > being taken into accout at all? > > Obviously the adult dosage is going to be and SHOULD BE different ie. > less, for a 120 lb woman who is 5 feet tall and a 200lb man who is 6 > feet tall, yet are these restrictions being put to doctors or is it > left to the doctor to decide the dosage? Are doctors even taking into > accout the height and weight of their patients when dosing????>> ** Weight plays little to no role in the dosing of these drugs. Age, especially with the elderly, plays more of a role, but P450 enzymes play the largest role. If a person has the appropriate enzymes to metabolize one of these drugs they will experience minimal adverse effects of which they are aware (many negative things are happening in the body when one is taking these drugs). If a person has too little or no enzymes of the specific type needed to metabolize a particular drug, a " normal " dose is going to remain in the system for a very long time and accumulate with each dose. A person will experience a number of adverse effects, sometimes bad enough to be life-threatening even after only one or two doses. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2006 Report Share Posted June 2, 2006 > Are dosing reccommendations outa whack too?? > > What exactly are lethal doses of these drugs and are people's weights > being taken into accout at all? > > Obviously the adult dosage is going to be and SHOULD BE different ie. > less, for a 120 lb woman who is 5 feet tall and a 200lb man who is 6 > feet tall, yet are these restrictions being put to doctors or is it > left to the doctor to decide the dosage? Are doctors even taking into > accout the height and weight of their patients when dosing????>> ** Weight plays little to no role in the dosing of these drugs. Age, especially with the elderly, plays more of a role, but P450 enzymes play the largest role. If a person has the appropriate enzymes to metabolize one of these drugs they will experience minimal adverse effects of which they are aware (many negative things are happening in the body when one is taking these drugs). If a person has too little or no enzymes of the specific type needed to metabolize a particular drug, a " normal " dose is going to remain in the system for a very long time and accumulate with each dose. A person will experience a number of adverse effects, sometimes bad enough to be life-threatening even after only one or two doses. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2006 Report Share Posted June 2, 2006 > Are dosing reccommendations outa whack too?? > > What exactly are lethal doses of these drugs and are people's weights > being taken into accout at all? > > Obviously the adult dosage is going to be and SHOULD BE different ie. > less, for a 120 lb woman who is 5 feet tall and a 200lb man who is 6 > feet tall, yet are these restrictions being put to doctors or is it > left to the doctor to decide the dosage? Are doctors even taking into > accout the height and weight of their patients when dosing????>> ** Weight plays little to no role in the dosing of these drugs. Age, especially with the elderly, plays more of a role, but P450 enzymes play the largest role. If a person has the appropriate enzymes to metabolize one of these drugs they will experience minimal adverse effects of which they are aware (many negative things are happening in the body when one is taking these drugs). If a person has too little or no enzymes of the specific type needed to metabolize a particular drug, a " normal " dose is going to remain in the system for a very long time and accumulate with each dose. A person will experience a number of adverse effects, sometimes bad enough to be life-threatening even after only one or two doses. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2006 Report Share Posted June 2, 2006 > Are dosing reccommendations outa whack too?? > > What exactly are lethal doses of these drugs and are people's weights > being taken into accout at all? > > Obviously the adult dosage is going to be and SHOULD BE different ie. > less, for a 120 lb woman who is 5 feet tall and a 200lb man who is 6 > feet tall, yet are these restrictions being put to doctors or is it > left to the doctor to decide the dosage? Are doctors even taking into > accout the height and weight of their patients when dosing????>> ** Weight plays little to no role in the dosing of these drugs. Age, especially with the elderly, plays more of a role, but P450 enzymes play the largest role. If a person has the appropriate enzymes to metabolize one of these drugs they will experience minimal adverse effects of which they are aware (many negative things are happening in the body when one is taking these drugs). If a person has too little or no enzymes of the specific type needed to metabolize a particular drug, a " normal " dose is going to remain in the system for a very long time and accumulate with each dose. A person will experience a number of adverse effects, sometimes bad enough to be life-threatening even after only one or two doses. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2006 Report Share Posted June 3, 2006 How many doctors check to see if their patients have these enzymes before writing a script? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2006 Report Share Posted June 3, 2006 How many doctors check to see if their patients have these enzymes before writing a script? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2006 Report Share Posted June 3, 2006 How many doctors check to see if their patients have these enzymes before writing a script? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2006 Report Share Posted June 3, 2006 How many doctors check to see if their patients have these enzymes before writing a script? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 > > > > > How many doctors check to see if their patients have these enzymes > before writing a script?>> ** A number of doctors are still unaware of P450 enzymes and the role they play in drug metabolism. Giver them a break; science has known about this only since the mid-1950's ;-) There are currently only 2 enzymes that can be somewhat reliably detected -- 2D6 and 2C19. I say " somewhat " because there are some polymorphic variations that go undetected. While 2D6 is the oxidative pathway for many SSRIs, the majority of psychotropic drugs also inhibit, induce, or are substrates of 3AY4. There is currently no reliable test for 3AY4. Many psychotropic drugs affect more than one of these enzymes (there several more enzymes, with many genetic polymorphisms to each of them, not mentioned here. The reality is that science has yet to identify all of these). Most insurance companies will not pay for these tests, referring to them as " experimental " . I have mixed feelings about testing for these. On one hand it has the potential to reduce the amount of people who experience extreme adverse reactions to some of the drugs (remember, we're limited in testing capabilities). On the other hand, it would give people a false sense of safety, which they should never have, about these drugs. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 > > > > > How many doctors check to see if their patients have these enzymes > before writing a script?>> ** A number of doctors are still unaware of P450 enzymes and the role they play in drug metabolism. Giver them a break; science has known about this only since the mid-1950's ;-) There are currently only 2 enzymes that can be somewhat reliably detected -- 2D6 and 2C19. I say " somewhat " because there are some polymorphic variations that go undetected. While 2D6 is the oxidative pathway for many SSRIs, the majority of psychotropic drugs also inhibit, induce, or are substrates of 3AY4. There is currently no reliable test for 3AY4. Many psychotropic drugs affect more than one of these enzymes (there several more enzymes, with many genetic polymorphisms to each of them, not mentioned here. The reality is that science has yet to identify all of these). Most insurance companies will not pay for these tests, referring to them as " experimental " . I have mixed feelings about testing for these. On one hand it has the potential to reduce the amount of people who experience extreme adverse reactions to some of the drugs (remember, we're limited in testing capabilities). On the other hand, it would give people a false sense of safety, which they should never have, about these drugs. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 > > > > > How many doctors check to see if their patients have these enzymes > before writing a script?>> ** A number of doctors are still unaware of P450 enzymes and the role they play in drug metabolism. Giver them a break; science has known about this only since the mid-1950's ;-) There are currently only 2 enzymes that can be somewhat reliably detected -- 2D6 and 2C19. I say " somewhat " because there are some polymorphic variations that go undetected. While 2D6 is the oxidative pathway for many SSRIs, the majority of psychotropic drugs also inhibit, induce, or are substrates of 3AY4. There is currently no reliable test for 3AY4. Many psychotropic drugs affect more than one of these enzymes (there several more enzymes, with many genetic polymorphisms to each of them, not mentioned here. The reality is that science has yet to identify all of these). Most insurance companies will not pay for these tests, referring to them as " experimental " . I have mixed feelings about testing for these. On one hand it has the potential to reduce the amount of people who experience extreme adverse reactions to some of the drugs (remember, we're limited in testing capabilities). On the other hand, it would give people a false sense of safety, which they should never have, about these drugs. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 > > > > > How many doctors check to see if their patients have these enzymes > before writing a script?>> ** A number of doctors are still unaware of P450 enzymes and the role they play in drug metabolism. Giver them a break; science has known about this only since the mid-1950's ;-) There are currently only 2 enzymes that can be somewhat reliably detected -- 2D6 and 2C19. I say " somewhat " because there are some polymorphic variations that go undetected. While 2D6 is the oxidative pathway for many SSRIs, the majority of psychotropic drugs also inhibit, induce, or are substrates of 3AY4. There is currently no reliable test for 3AY4. Many psychotropic drugs affect more than one of these enzymes (there several more enzymes, with many genetic polymorphisms to each of them, not mentioned here. The reality is that science has yet to identify all of these). Most insurance companies will not pay for these tests, referring to them as " experimental " . I have mixed feelings about testing for these. On one hand it has the potential to reduce the amount of people who experience extreme adverse reactions to some of the drugs (remember, we're limited in testing capabilities). On the other hand, it would give people a false sense of safety, which they should never have, about these drugs. Regards, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 I agree; feeling crappy and acting weird is enough reason for me not to use them. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 I agree; feeling crappy and acting weird is enough reason for me not to use them. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 I agree; feeling crappy and acting weird is enough reason for me not to use them. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2006 Report Share Posted June 4, 2006 I agree; feeling crappy and acting weird is enough reason for me not to use them. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 5, 2006 Report Share Posted June 5, 2006 I remember reading this in earlier posts a couple of years ago. Thanks, , for reminding us of this factor. Has there been any more said about the possibility that there is an increased incidence people of Native American and Asian origins lacking these P450 enzymes, as I seem to remember reading? Terry " ...There are certain things in our nation and in the world about which I am proud to be maladjusted and about which I hope all men of good-will will be maladjusted...Through such maladjustment, I believe that we will be able to emerge from the bleak and desolate midnight of man's inhumanity to man into the bright and glittering daybreak of freedom and justice. " - Dr. Luther King, Jr. - December 18, 1963 __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 5, 2006 Report Share Posted June 5, 2006 I remember reading this in earlier posts a couple of years ago. Thanks, , for reminding us of this factor. Has there been any more said about the possibility that there is an increased incidence people of Native American and Asian origins lacking these P450 enzymes, as I seem to remember reading? Terry " ...There are certain things in our nation and in the world about which I am proud to be maladjusted and about which I hope all men of good-will will be maladjusted...Through such maladjustment, I believe that we will be able to emerge from the bleak and desolate midnight of man's inhumanity to man into the bright and glittering daybreak of freedom and justice. " - Dr. Luther King, Jr. - December 18, 1963 __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 5, 2006 Report Share Posted June 5, 2006 I remember reading this in earlier posts a couple of years ago. Thanks, , for reminding us of this factor. Has there been any more said about the possibility that there is an increased incidence people of Native American and Asian origins lacking these P450 enzymes, as I seem to remember reading? Terry " ...There are certain things in our nation and in the world about which I am proud to be maladjusted and about which I hope all men of good-will will be maladjusted...Through such maladjustment, I believe that we will be able to emerge from the bleak and desolate midnight of man's inhumanity to man into the bright and glittering daybreak of freedom and justice. " - Dr. Luther King, Jr. - December 18, 1963 __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.