Guest guest Posted February 13, 2011 Report Share Posted February 13, 2011 Before taking LDN twice daily, let the scientists determine whether this will IN THE FUTURE cause disease worsening. No one has yet determined whether twice a day LDN dosing could cause disease worsening in future years. If you do take LDN twice daily, do so at your own risk but do not blame LDN if your illness worsens in the future. You may feel better on twice a day LDN dosing but what is it really doing to your illness, is it helping the illness or possibly hurting it and won't show up until many years later, ?????? that only research will tell. Our LDN forum resident pharmacist describes night vs day LDN dosing best. Here is a comment on the day/night LDN dosing by a very credible LDN Pharmacist, Skip Lenz...please read the entire comment as the two cycles he mentions pack different punch levels. I really hate to get involved with this question, and the he said,he said responses. Who is right, Zagon or Bihari, well they both are right. One has to look at the diurnal nature of endorphin secretion to understand HOW they are both right. You get your zenith peak during your normal sleep cycle. You get your penultimate peak during your wake cycle. Taking LDN prior to your zenith peak will give you more bang for your buck than prior to your wake cycle peak. Therefore you will get some increase taking LDN at times other than prior to bedtime but they will not be the most you can get. Now if you take it indiscriminately temporally, then depending of which peak is next in the cycle, you will get a fraction of the response you would get if taken at an appropriate time frame. This explains why both docs are right, for those taking it in the am, you get the PM peak to skew upwards, those taking the PM dose gets the am peak to skew upwards. Dr.Skip posted by , LDN user over 7yrs for chronic progressive MS Quote Link to comment Share on other sites More sharing options...
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