(No subject)

[Guest guest]

" orozcomaria39 " wrote:

" Hello

In response to your message re: Ambien and Ativan. In the LDN.org, there is a

Warning for people taking narcotics, while taking LDN, you shouldn't take any

narcotic medication or relaxing pill. Read below

Cautionary warnings:

Because LDN blocks opioid receptors throughout the body for three or four hours,

people using medicine that is an opioid agonist, i.e. narcotic medication —

such as Ultram (tramadol), morphine, Percocet, Duragesic patch or

codeine-containing medication — should not take LDN until such medicine is

completely out of one's system. Patients who have become dependant on daily use

of narcotic-containing pain medication may require 10 days to 2 weeks of slowly

weaning off of such drugs entirely (while first substituting full doses of

non-narcotic pain medications) before being able to begin LDN safely. "

I had an email discussion off-line from this group about the issue of taking

Tramadol while on LDN - I've been taking Tramadol for pain relief for over 3

years because chronic over-use of Ibuprofen was destroying my digestive system.

Below is some info I culled from Wikipedia on the pharmacology of how Tramadol,

Naltrexone, and it's sister drug Naloxone act in the brain - Tramadol primarily

is a μ-opioid receptor agonist, while Naltrexone and Naloxone work on the μ-,

δ-, and κ-opioid receptors:

" The analgesic action of tramadol has yet to be fully understood, but it is

believed to work through modulation of serotonin and norepinephrine in addition

to its mild agonism of the μ-opioid receptor. The contribution of non-opioid

activity is demonstrated by the fact that the analgesic effect of tramadol is

not fully antagonised by the μ-opioid receptor antagonist naloxone.

Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade

of those receptors often produces rapid onset of withdrawal symptoms. Naloxone

also has an antagonist action, though with a lower affinity, at κ- and

δ-opioid receptors.

Naltrexone and its active metabolite 6-β-naltrexol are competitive antagonists

at μ- and κ-opioid receptors, and to a lesser extent at δ-opioid receptors. "

Before I started taking LDN my doctor warned me that Tramadol may become less

effective and/or interact with the LDN in other undesirable ways, and told me

not to take any after 5:00 pm to help avoid any problems. Tramadol is

metabolized in about 4 hours, my plan was to take my 3 mg LDN dose at 11:00 pm

every night, but to be on the safe side I decided to completely eliminate my

late afternoon/early evening dose, but that I would continue to take my morning

dose as usual.

The results? No problems that I can definitely tie to a Tramadol/LDN link, most

likely due to the difference in how Tramadol works in the brain as opposed to

other opiates (see above Wiki explanation). I don't even consider Tramadol to be

in the narcotic/opiate catergory at all because it's so chemically different in

molecular terms and method of action, and the FDA agrees - it's not a

" controlled substance " like Percocet, for instance.

I posted to the group my experience was about how horrible the first few days on

LDN were, but thank god the worst appears to be over: I finally had a totally

" normal " night of sleep last night, albeit with a bunch of very vivid dreams.

Went to bed at midnight, slept straight thru to 8-8:30 am, then dozed to 11:00

am before I finally dragged my butt out of bed. I spent about 5 hours working in

my basement workshop yesterday afternoon, I'm a bit tired and sore today, but

otherwise okay.

Of course my experience with Tramadol and LDN should not be taken as an " all

clear " for everyone else, as I've posted before everyone has their own unique

physiology, so what's okay for me may not be okay for you.

________________________________________________________________________________\

____

Need Mail bonding?

Go to the Q & A for great tips from Answers users.

http://answers./dir/?link=list & sid=396546091