Guest guest Posted March 4, 2011 Report Share Posted March 4, 2011 The non-preserved liquid is refrigerated to keep down any bacterial or fungal growth. How long does liquid LDN last? http://ldn.proboards.com/index.cgi?board=links & action=display & thread=1468 Here is what Larry Frieders, LDN pharmacist. had to say: STABILITY OF NALTREXONE From: " Larry J. Frieders " <larry@t...> Date: Wed Mar 3, 2004 5:44 pmSubject: NOT 1 day... NOT 1 week...BUT a MONTH or MORE! Naltrexone is quite stable in water. I am quoting from Trissel's book, " Stability of Compounded Formulations " , Second Edition, page 266 " Stability-indicating HPLC analysis found less than 10% loss within 90 days ateither 4 degrees C or 25 degrees C; most samples exhibited noloss. .... The recommended shelf lives of 30 and 60 days stored at25 degrees C and 4 degrees C, respectively. " This is a reference book that every compounder OUGHT to have on hand. 4 degrees C is refrigeration and 25 degrees C is room temperature. We make a lot of naltrexone solutions for people who need to adjust their doses. The most popular strength is 1mg per ml. We supply a syringe with which the patient can measure the correct dose. It is bitter so it needs to be mixed with something (unless you have strong taste buds). Nobody has ever complained that it " stopped working " . Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora, IL 60506 630-859-0333 FAX 630-859-0114 What Larry has left out is that this is a compounded LDN, not home made. Big difference. Dr.Skip Once a drug passes from a solid to a liquid state, its shelf life can decrease dramatically. Therefore, do not make more than 50 ml of liquid Naltrexone at a time, store it in the refrigerator, and do not keep it for more than a month. The fresher the preparation, the better. Be sure to shake the liquid LDN well before using, and keep it from direct exposure to sunlight. Art My MS/LDN story/1988 - 2011 http://ldn.proboards.com/index.cgi?board=personal & action=display & thread=867 -- > > When you make up the LDN using a 50 mg tablet, dissolving it in 50 mg distilled water, must it be refrigerated? (Using 4.5mg daily) I'm kind of hoping it's not essential, because I've been keeping it in the bathroom, to give him just before bed, and that's handier than running down to the kitchen. > > Also, if he takes it just before bed, it ends up being around 8:50 - 9:00, somewhere thereabouts. Does that sound okay? > > Thank you! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 4, 2011 Report Share Posted March 4, 2011 LDN-day/night dosing controversy/research http://tinyurl.com/lgux5k -- Mechanisms involved in beneficial effect of LDN http://tinyurl.com/me85wb -- Changing time zones and LDN timing ??? http://preview.tinyurl.com/ohso7o -- Why I do Bihari dosing protocol over Zagon/Gilhooly http://tinyurl.com/l37lkk -- Taking LDN AM instead of PM ??????? http://tinyurl.com/yz4ajs8 -- LDN Taken Morning or Night? http://tinyurl.com/yho6g3l -- Why take LDN only once a day? http://ldn.proboards.com/index.cgi?board=forum & action=display & thread=1140 The LDN should only be given once per day and never be given before 9pm when we're off Daylight saving time(fall and winter) and never give LDN before 10pm during daylight saving time(spring and summer). This will ensure that the LDN is in the system during peak endorphin production time of between 2am and 4am(the most endorphins are produced during this time and it is very important to take advantage of this to stop disease progression). Never give LDN twice within 24 hours. Read the LDN website and read the Further Q and A page while there, it's an important page and understanding how LDN works and why we take LDN in this manner is vital. LDN should not be given any later than 3am. -- In regard to daytime dosing, of all the clinical trials of LDN conducted with humans, only one used daytime dosing--a German study with a group of MS patients. While about a third of the group did experience limited benefit, this is the comment made about the trial by Dr. Gluck, webmaster of http://ldninfo.org: Unfortunately, because of some early complaints of sleep disturbance, the principal investigator of this trial switched all of the study group to taking LDN at 9 am in the morning, a questionable dosage time. It is generally recognized that the most effective time to take LDN is at bedtime, between 9 pm and 3 am, due to the fact that the endorphins for each day are always produced at their peak rate in the pre-dawn hours. A 9 am dosage time, as was used in this trial, might conceivably suppress—rather than boost—a patient's immune system. Low Dose Naltrexone (LDN): The German MS Study http://www.webspawner.com/users/germanldnstudy/index.html Art My MS/LDN story/1988 - 2011 http://ldn.proboards.com/index.cgi?board=personal & action=display & thread=867 -- > > When you make up the LDN using a 50 mg tablet, dissolving it in 50 mg distilled water, must it be refrigerated? (Using 4.5mg daily) I'm kind of hoping it's not essential, because I've been keeping it in the bathroom, to give him just before bed, and that's handier than running down to the kitchen. > > Also, if he takes it just before bed, it ends up being around 8:50 - 9:00, somewhere thereabouts. Does that sound okay? > > Thank you! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 4, 2011 Report Share Posted March 4, 2011 LDN induces a sharp increase in pituitary and adrenal production of beta-endorphin and metenkephalin, respectively, in the pre-dawn(2am-4am) hours, when 90% of the day's manufacture of these hormones occur. Most studies have shown that low dose naltrexone induces a two to three-fold increase in production of metenkephalin overnight. LDN only stays in the system 4 to 5 hours. Taken too early, say 5pm you miss the peak endorphin production, taken at other times, like AM the endorphin boost may not be enough to halt your disease progression if your disease is chronic progressive. -- -- Here is a comment on the day/night LDN dosing by a very credible LDN Pharmacist, Skip Lenz...please read the entire comment as the two cycles he mentions pack different punch levels. I really hate to get involved with this question, and the he said,he said responses. Who is right, Zagon or Bihari, well they both are right. One has to look at the diurnal nature of endorphin secretion to understand HOW they are both right. You get your zenith peak during your normal sleep cycle. You get your penultimate peak during your wake cycle. Taking LDN prior to your zenith peak will give you more bang for your buck than prior to your wake cycle peak. Therefore you will get some increase taking LDN at times other than prior to bedtime but they will not be the most you can get. Now if you take it indiscriminately temporally, then depending of which peak is next in the cycle, you will get a fraction of the response you would get if taken at an appropriate time frame. This explains why both docs are right, for those taking it in the am, you get the PM peak to skew upwards, those taking the PM dose gets the am peak to skew upwards. Dr.Skip -- Art My MS/LDN story/1988 - 2011 http://ldn.proboards.com/index.cgi?board=personal & action=display & thread=867 -- > > When you make up the LDN using a 50 mg tablet, dissolving it in 50 mg distilled water, must it be refrigerated? (Using 4.5mg daily) I'm kind of hoping it's not essential, because I've been keeping it in the bathroom, to give him just before bed, and that's handier than running down to the kitchen. > > Also, if he takes it just before bed, it ends up being around 8:50 - 9:00, somewhere thereabouts. Does that sound okay? > > Thank you! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 4, 2011 Report Share Posted March 4, 2011 I put a bit of Xylitol in our LDN mixture to kill any bacteria or fungus. Two of us take the liquid nightly, so it doesn't last long. d >>>The non-preserved liquid is refrigerated to keep down any bacterial or fungal growth. Quote Link to comment Share on other sites More sharing options...
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