LDN and pain meds

[Guest guest]

I was wondering if vicodin or oxycodone will still work while on LDN? I have something wrong that's pushing on a nerve and I'm in extreme pain. I'm seeing 2 specialists this week but all I have been takings ibuprofin. I have pain pills but am afraid to take them! Please someone help me, I feel I'm going to go crazy!! Thanks!!!

[Guest guest]

I came across this some time ago, forgot about it and came across it again last night. I found the comments at the end of this site re LDN and pain fascinating. In order to get pain relief, some take quite high doses. Here’s an excerpt of the article:- Naltrexone~I have found that naltrexone is a remarkable medication for various pain conditions, and going through the steps of rational polypharmacy may be very rewarding for some patients though at times it may work all on its own. It has caused me to completely reassess how I approach the treatment of intractable pain – not just RSD or CRPS but arthritis, sciatica and various forms of mechanical pain. And it has led to further changes in the timing and dosing of naltrexone based upon the experiences patients have reported back to me over the years. It is hoped that further research will lead to better understanding of how naltrexone acts upon pain pathways. Surprisingly we already know quite a fair amount. And the link to this article is http://painsandiego.com/2010/03/03/rsd-complex-regional-pain-syndrome-a-case-report/ This Doctor too is fascinated with the effects LDN has on the TLRs:- Toll Like Receptors.Like all immune competent cells, glia have a myriad of receptors on their cell surface membranes. One of the more important are the Toll Like Receptors (TLRs) that are innate immune receptors in the CNS, discussed here. See image, below. TLRs “are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated….These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma…. [They] may contribute to susceptibility to severe neonatal inflammatory diseases, allergies, and autoimmune diseases.” Other studies have shown “Toll-like receptors (TLRs) are essential in the host defense against infections. They also have functional roles in tumor progression and their ligands affect tumor cell proliferation, anti-apoptosis and immune escape. The expression or up-regulation of TLRs has been detected in various tumor cells.” “Dysregulation of these signaling pathways has severe consequences, and causes many autoimmune diseases and chronic pathological inflammation.”~The Toll Like Receptors are not like other receptors. Not these snug little pockets where naltrexone binds. Instead the Toll Like Receptors are like an entire football field, with enormous nooks and crannies. Unlike other receptors, they have enormous interactions with many molecules and medications, e.g. naltrexone is a TLR4 inhibitor, an immune modulator, amitriptyline is a TLR4 inhibitor. And “Glial activation is now known to occur in response to opioids as well. Opioid-induced glial activation opposes opioid analgesia and enhances opioid tolerance, dependence, reward and respiratory depression.” That source is referenced here. Opioids create pain, not just the dread opioid induced hyperalgesia. Glia also contain cannabinoid receptors. Glia produce endogenous cannabinoids and they inactivate them.The link for the above is here http://painsandiego.com/2011/01/ Hope this helps. Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Lori VajgrtSent: 06 April 2011 01:54low dose naltrexone Subject: [low dose naltrexone] LDN and pain meds I was wondering if vicodin or oxycodone will still work while on LDN? I have something wrong that's pushing on a nerve and I'm in extreme pain. I'm seeing 2 specialists this week but all I have been takings ibuprofin. I have pain pills but am afraid to take them! Please someone help me, I feel I'm going to go crazy!! Thanks!!!

[Guest guest]

Lori, this is the link I meant to send re the pain etc., I had posted it on this board before http://painsandiego.com/2010/03/03/rsd-complex-regional-pain-syndrome-a-case-report/ Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Lori VajgrtSent: 06 April 2011 01:54low dose naltrexone Subject: [low dose naltrexone] LDN and pain meds I was wondering if vicodin or oxycodone will still work while on LDN? I have something wrong that's pushing on a nerve and I'm in extreme pain. I'm seeing 2 specialists this week but all I have been takings ibuprofin. I have pain pills but am afraid to take them! Please someone help me, I feel I'm going to go crazy!! Thanks!!!