RE: Baclofen blocks opioid receptors - Dr Skip in particular any comments please?

[Guest guest]

This is a very good question , thanks for bringing it to everyone’s attention. I know you shouldn’t take Baclofen if you are taking DLPA:- Baclofen -- Phenylalanine may reduce absorption of baclofen (Lioresal), a medication used to relieve muscle spasms. Avoid taking Baclofen with a meal, especially one that is high in protein, or with phenylalanine supplements.Thanks to for reminding me of the link http://www.umm.edu/altmed/articles/phenylalanine-000318.htm Should you hear any more I would be grateful if you would share it. I have asked Dr Bob Lawrence for his opinion. Regards, Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of CSent: 13 April 2011 16:16LDN ListSubject: [low dose naltrexone] Baclofen blocks opioid receptors - Dr Skip in particular any comments please? Hi,I had this forwarded to me by a friend in the US who takes LDN and runs a group for people who take or are contemplating taking LDN for our disease (PLS = primary lateral sclerosis, a form of motor neurone disease and little brother to ALS). " Hi ,This apparently has been known for some time. The link below was a study done by the National Institute of Health in the USA and was done in 2002-3, but the theory they present is at least a decade old.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC293465/Perhaps LDB (low dose baclofen) would be just as good as LDN? Makes me wonder how LDN can work for people who take baclofen.Any comments or insight would be appreciated.Lyn " If indeed Baclofen blocks opioid receptors it makes me also wonder given LDN is only to be taken once per day/night whether people also taking Baclofen are sabotaging the benefits of LDN. I'm therefore very interested in comments from people much more knowledgeable than myself, particularly people like Dr Skip. Many people with PLS take Baclofen as one of the primary symptoms is spasticity.Cheers,

[Guest guest]

, I asked my partner about this and he doesn’t think baclofen would interfere with LDN as baclofen works on the GABA receptors and therefore might not effect the mu opioid receptors which LDN blocks at all. Will let you know Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: jaynelcrocker [mailto:jaynelcrocker@...] Sent: 13 April 2011 21:27'covo@...'; 'LDN List'Subject: RE: [low dose naltrexone] Baclofen blocks opioid receptors - Dr Skip in particular any comments please? This is a very good question , thanks for bringing it to everyone’s attention. I know you shouldn’t take Baclofen if you are taking DLPA:- Baclofen -- Phenylalanine may reduce absorption of baclofen (Lioresal), a medication used to relieve muscle spasms. Avoid taking Baclofen with a meal, especially one that is high in protein, or with phenylalanine supplements.Thanks to for reminding me of the link http://www.umm.edu/altmed/articles/phenylalanine-000318.htm Should you hear any more I would be grateful if you would share it. I have asked Dr Bob Lawrence for his opinion. Regards, Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of CSent: 13 April 2011 16:16LDN ListSubject: [low dose naltrexone] Baclofen blocks opioid receptors - Dr Skip in particular any comments please? Hi,I had this forwarded to me by a friend in the US who takes LDN and runs a group for people who take or are contemplating taking LDN for our disease (PLS = primary lateral sclerosis, a form of motor neurone disease and little brother to ALS). " Hi ,This apparently has been known for some time. The link below was a study done by the National Institute of Health in the USA and was done in 2002-3, but the theory they present is at least a decade old.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC293465/Perhaps LDB (low dose baclofen) would be just as good as LDN? Makes me wonder how LDN can work for people who take baclofen.Any comments or insight would be appreciated.Lyn " If indeed Baclofen blocks opioid receptors it makes me also wonder given LDN is only to be taken once per day/night whether people also taking Baclofen are sabotaging the benefits of LDN. I'm therefore very interested in comments from people much more knowledgeable than myself, particularly people like Dr Skip. Many people with PLS take Baclofen as one of the primary symptoms is spasticity.Cheers,

[Guest guest]

From Dr Zagon:- Dear Jayne: The baclofen blocking opioid receptors - another urban legend. Baclofen has been explored as a means of lessening withdrawal, but it is related to GABA receptors as you state.Dr. ZagonJayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of CSent: 13 April 2011 16:16LDN ListSubject: [low dose naltrexone] Baclofen blocks opioid receptors - Dr Skip in particular any comments please? Hi,I had this forwarded to me by a friend in the US who takes LDN and runs a group for people who take or are contemplating taking LDN for our disease (PLS = primary lateral sclerosis, a form of motor neurone disease and little brother to ALS). " Hi ,This apparently has been known for some time. The link below was a study done by the National Institute of Health in the USA and was done in 2002-3, but the theory they present is at least a decade old.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC293465/Perhaps LDB (low dose baclofen) would be just as good as LDN? Makes me wonder how LDN can work for people who take baclofen.Any comments or insight would be appreciated.Lyn " If indeed Baclofen blocks opioid receptors it makes me also wonder given LDN is only to be taken once per day/night whether people also taking Baclofen are sabotaging the benefits of LDN. I'm therefore very interested in comments from people much more knowledgeable than myself, particularly people like Dr Skip. Many people with PLS take Baclofen as one of the primary symptoms is spasticity.Cheers,

[Guest guest]

Thanks Jayne.

On 14/04/2011 19:42, jaynelcrocker wrote:

From Dr Zagon:-

Dear Jayne:

The baclofen blocking opioid receptors - another urban

legend. Baclofen has been explored as a means of lessening

withdrawal, but it is related to GABA receptors as you state.

Dr. Zagon