Re: Yeast Infection Help? Malarone ingredient details

[Guest guest]

Hey Lynne, I don't know it this helps but the ingredients and

contraindications don't sound too savory for me at all. I had to

remove one l because the mallorone info is only in german, but I

made sure they were the same products. There wasn't much on

malarone, so I used the medical information for the two active

ingredients.

Each MALARONE Tablet contains the active ingredients atovaquone 250

mg and proguanil hydrochloride 100 mg.

Each MALARONE Pediatric Tablet contains 62.5 mg atovaquone and 25 mg

proguanil hydrochloride.

The inactive ingredients are:

Poloxamer 188

Microcrystalline Cellulose

Low-substituted Hydroxypropyl Cellulose

Povidone K30

Sodium Starch Glycollate

Magnesium Stearate

hydroxypropyl methylcellulose

Titanium Dioxide

Red Iron Oxide

Polyethylene Glycol 8000 (a plastic)

Polyethylene Glycol 400 (a plastic "

______________About the Atovaquone____________

Description

Atovaquone (a-TOE-va-kwone) is used to treat and to prevent

Pneumocystis carinii (noo-moe-SISS-tis) pneumonia (PCP), a very

serious kind of pneumonia. This particular kind of pneumonia occurs

commonly in patients whose immune systems are not working normally,

such as cancer patients, transplant patients, and patients with

acquired immune deficiency syndrome (AIDS).

This medicine is available only with your doctor's prescription, in

the following dosage form:

Oral

Oral suspension (U.S.)

Tablets (Canada)

Before Receiving This Medicine

In deciding to use a medicine, the risks of taking the medicine must

be weighed against the good it will do. This is a decision you and

your doctor will make. For atovaquone, the following should be

considered:

Allergies--Tell your doctor if you have ever had any unusual or

allergic reaction to atovaquone. Also tell your health care

professional if you are allergic to any other substances, such as

foods, preservatives, or dyes.

Diet--Make certain your health care professional knows if you are on

any special diet. This medicine must be taken with balanced meals so

that it can work properly.

Pregnancy--Atovaquone has not been studied in pregnant women.

However, studies in rabbits have shown an increase in miscarriages

and other harmful effects in the mother and fetus. Before taking

this medicine, make sure your doctor knows if you are pregnant or if

you may become pregnant.

Breast-feeding--It is not known whether atovaquone passes into human

breast milk. However, it was found in the milk of rats. Be sure you

have discussed the risks and benefits of atovaquone with your

doctor.

Children--Atovaquone has been tested in a limited number of children

1 month of age to 13 years old. It is not known if this medicine

causes different side effects or problems in children than it does

in adults.

Older adults--Many medicines have not been studied specifically in

older people. Therefore, it may not be known whether they work

exactly the same way they do in younger adults or if they cause

different side effects or problems in older people. There is no

specific information comparing use of atovaquone in the elderly with

use in other age groups.

Other medicines--Although certain medicines should not be used

together at all, in other cases two different medicines may be used

together even if an interaction might occur. In these cases, your

doctor may want to change the dose, or other precautions may be

necessary. When you are taking atovaquone, it is especially

important that your health care professional know if you are taking

any of the following:

Rifampin (e.g., Rifadin)--Use of rifampin with atovaquone may

decrease the amount of atovaquone in the blood and keep it from

working properly

Other medical problems--The presence of other medical problems may

affect the use of atovaquone. Make sure you tell your doctor if you

have any other medical problems, especially:

Stomach or intestinal disorders--Atovaquone may not work properly in

patients with some kinds of stomach or intestinal problems

Proper Use of This Medicine

It is important that you take atovaquone with a balanced meal . This

is to make sure the medicine is fully absorbed into the body and

will work properly.

Atovaquone tablets may be crushed if necessary to make it easier to

swallow the tablets.

Because atovaquone tablets and oral suspension do not produce the

same amount of medicine in the blood, the tablets and the suspension

cannot be switched and used in place of each other .

For patients taking the oral liquid form of this medicine:

This medicine is to be taken by mouth. Use a specially marked

measuring spoon or other device to measure each dose accurately. The

average household teaspoon may not hold the right amount of liquid.

Do not use after the expiration date on the label since the medicine

may not work properly after that date. Check with your pharmacist if

you have any questions about this.

To help clear up your infection completely, keep taking your

medicine for the full time of treatment , even if you begin to feel

better after a few days. If you stop taking this medicine too soon,

your symptoms may return.

Atovaquone works best when there is a constant amount in the blood.

To help keep the amount constant, do not miss any doses .

Dosing--The dose of atovaquone may be different for different

patients. Follow your doctor's orders or the directions on the

label . The following information includes only the average doses of

atovaquone. If your dose is different, do not change it unless your

doctor tells you to do so.

For treatment of Pneumocystis carinii pneumonia (PCP):

For oral suspension dosage form:

Adults and teenagers--750 milligrams (mg) taken with a meal two

times a day for twenty-one days.

Children--Use and dose must be determined by your doctor.

For tablet dosage form:

Adults and teenagers--750 mg taken with a meal three times a day for

twenty-one days.

Children--Use and dose must be determined by your doctor.

For prevention of Pneumocystis carinii pneumonia (PCP):

For oral suspension dosage form:

Adults and teenagers--1500 milligrams (mg) once a day with a meal.

Children--Use and dose must be determined by your doctor.

Missed dose--If you miss a dose of this medicine, take it as soon as

possible. This will help to keep a constant amount of medicine in

the blood. However, if it is almost time for your next dose, skip

the missed dose and go back to your regular dosing schedule. Do not

double doses.

Storage--To store this medicine:

Keep out of the reach of children.

Store away from heat and direct light.

Do not store in the bathroom, near the kitchen sink, or in other

damp places. Heat or moisture may cause the medicine to break down.

Do not keep outdated medicine or medicine no longer needed. Be sure

that any discarded medicine is out of the reach of children.

Do not freeze.

Precautions While Using This Medicine

If your symptoms do not improve within a few days, or if they become

worse, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted

effects. Although not all of these side effects may occur, if they

do occur they may need medical attention.

Check with your doctor immediately if any of the following side

effects occur:

More common

Fever; skin rash

Other side effects may occur that usually do not need medical

attention. These side effects may go away during treatment as your

body adjusts to the medicine. However, check with your doctor if any

of the following side effects continue or are bothersome:

More common

Cough; diarrhea; headache; nausea; trouble in sleeping; vomiting

Other side effects not listed above may also occur in some patients.

If you notice any other effects, check with your doctor.

Revised: 12/20/1999

Micromedex, Inc. Disclaimer

______________________For the proguanil information____________

Active Ingredients

Proguanil hydrochloride

Mechanism:

Proguanil is inactive and acts through the active metabolite

cycloguanil, which inhibits dihydrofolate reductase. The effect of

this action is to prevent schizogony and it's main effect is against

the developing primary schizonts.

Indications:

Prevention of malaria in combination with chloroquine in areas of

confirmed chloroquine resistance.

Contra-Indications:

Patients with severe renal failure.

Dosage:

Management of overdose:

Symptoms: Haematuria, renal irritation, epigastric discomfort and

vomiting.

Rx: Symptomatic and supportive.

Dose: (Ref: Paludrine P/I)

Best taken with water, after food at the same time each day

It is advisable to start treatment at least 24 hours before entering

and continuing for at least 4 - 6 weeks after leaving the area.

ADULTS:

200mg daily CHILDREN UNDER ONE YEAR:

25mg daily CHILDREN 1 - 4 YEARS:

50mg daily CHILDREN 5 - 8 YEARS:

100mg daily CHILDREN 9 - 14 YEARS:

150mg daily OVER 14 YEARS:

200mg daily

Side-Effects:

GIT intolerance ...which normally subsides.

Hair loss, skin reactions, mouth ulceration and inflammation of the

mouth.

Precautions:

Always take in conjunction with chloroquine.

Pregnancy:

Paludrine is excreted into breast milk but not in sufficient

quantities to confer any benefit.Seperate chemoprophylaxis is

required.

Porphyria:

Safe (TPS)

> Holy Sh*t!! I feel like I've been hit over the head with a sledge

hammer! I never made the connection before, but my problems started

in June after a trip to S.Africa/Botswana. I thought about

everything else it could possibly be EXCEPT I took a new

antimalarial called Mallarone. It's not an antibiotic but maybe it

has antibiotic properties to prevent malaria. I have similar

symptoms to yours: vaginal burning and irritation that does not

respond to anything. Did you take Mallarone too? Maybe this is a

common side-effect.

> PLEASE respond and tell me more info. I don't know about you but

this kind of freaks me out.

>

> Lynne

>

>

> >>Hello,

> >>In preperation for a trip to South Africa earlier this spring, I

had

> >>to take exttended antibioitcs to prevent malaria. I have been

> >>plagued with a vaginal yeast infection since, at least thats

what the

> >>doc says it is. No discharge, just itching and burning. It just

won't

> >>go away. Tried Monostat, Diflucan. I don't eat sugar, bake my

own

> >>bread, won't eat fast or processed foods, exercise 30-60 minutes

per

> >>day and eat a balanced diet.

> >>Now I am taking Centrum multi vit, vit c, b complex at dr's

> >>suggestion. I take two acodophilis (spelling!) pills per day. Am

> >>rinsing internally with a yougurt wash 2x per day, because it is

> >>soothing. No help. Even tried inserting garlic, and although

that

> >>eased itching, it didn'y help long term. Doc says be patient.

But can

> >>anyone give me any suggestions, please?

> >>Thank you!

> >>

> >>

> >>

> >>

[Guest guest]

Thanks ! I don't think that this info is for what I was taking because I

did some research on it before I took it and I don't remember reading any of

this! I will call my Dr. that prescribed it for me tomorrow and find out the

exact spelling.

Lynne

>Hey Lynne, I don't know it this helps but the ingredients and

>contraindications don't sound too savory for me at all. I had to

>remove one l because the mallorone info is only in german, but I

>made sure they were the same products. There wasn't much on

>malarone, so I used the medical information for the two active

>ingredients.

>

>Each MALARONE Tablet contains the active ingredients atovaquone 250

>mg and proguanil hydrochloride 100 mg.

>Each MALARONE Pediatric Tablet contains 62.5 mg atovaquone and 25 mg

>proguanil hydrochloride.

>

>The inactive ingredients are:

>Poloxamer 188

>Microcrystalline Cellulose

>Low-substituted Hydroxypropyl Cellulose

>Povidone K30

>Sodium Starch Glycollate

>Magnesium Stearate

> hydroxypropyl methylcellulose

>Titanium Dioxide

>Red Iron Oxide

>Polyethylene Glycol 8000 (a plastic)

>Polyethylene Glycol 400 (a plastic "

>______________About the Atovaquone____________

>

>Description

>Atovaquone (a-TOE-va-kwone) is used to treat and to prevent

>Pneumocystis carinii (noo-moe-SISS-tis) pneumonia (PCP), a very

>serious kind of pneumonia. This particular kind of pneumonia occurs

>commonly in patients whose immune systems are not working normally,

>such as cancer patients, transplant patients, and patients with

>acquired immune deficiency syndrome (AIDS).

>

>This medicine is available only with your doctor's prescription, in

>the following dosage form:

>

>Oral

>Oral suspension (U.S.)

>Tablets (Canada)

>

>

>

>Before Receiving This Medicine

>In deciding to use a medicine, the risks of taking the medicine must

>be weighed against the good it will do. This is a decision you and

>your doctor will make. For atovaquone, the following should be

>considered:

>

>Allergies--Tell your doctor if you have ever had any unusual or

>allergic reaction to atovaquone. Also tell your health care

>professional if you are allergic to any other substances, such as

>foods, preservatives, or dyes.

>

>Diet--Make certain your health care professional knows if you are on

>any special diet. This medicine must be taken with balanced meals so

>that it can work properly.

>

>Pregnancy--Atovaquone has not been studied in pregnant women.

>However, studies in rabbits have shown an increase in miscarriages

>and other harmful effects in the mother and fetus. Before taking

>this medicine, make sure your doctor knows if you are pregnant or if

>you may become pregnant.

>

>Breast-feeding--It is not known whether atovaquone passes into human

>breast milk. However, it was found in the milk of rats. Be sure you

>have discussed the risks and benefits of atovaquone with your

>doctor.

>

>Children--Atovaquone has been tested in a limited number of children

>1 month of age to 13 years old. It is not known if this medicine

>causes different side effects or problems in children than it does

>in adults.

>

>Older adults--Many medicines have not been studied specifically in

>older people. Therefore, it may not be known whether they work

>exactly the same way they do in younger adults or if they cause

>different side effects or problems in older people. There is no

>specific information comparing use of atovaquone in the elderly with

>use in other age groups.

>

>Other medicines--Although certain medicines should not be used

>together at all, in other cases two different medicines may be used

>together even if an interaction might occur. In these cases, your

>doctor may want to change the dose, or other precautions may be

>necessary. When you are taking atovaquone, it is especially

>important that your health care professional know if you are taking

>any of the following:

>

>Rifampin (e.g., Rifadin)--Use of rifampin with atovaquone may

>decrease the amount of atovaquone in the blood and keep it from

>working properly

>Other medical problems--The presence of other medical problems may

>affect the use of atovaquone. Make sure you tell your doctor if you

>have any other medical problems, especially:

>

>Stomach or intestinal disorders--Atovaquone may not work properly in

>patients with some kinds of stomach or intestinal problems

>

>

>Proper Use of This Medicine

>It is important that you take atovaquone with a balanced meal . This

>is to make sure the medicine is fully absorbed into the body and

>will work properly.

>

>Atovaquone tablets may be crushed if necessary to make it easier to

>swallow the tablets.

>

>Because atovaquone tablets and oral suspension do not produce the

>same amount of medicine in the blood, the tablets and the suspension

>cannot be switched and used in place of each other .

>

>For patients taking the oral liquid form of this medicine:

>

>This medicine is to be taken by mouth. Use a specially marked

>measuring spoon or other device to measure each dose accurately. The

>average household teaspoon may not hold the right amount of liquid.

>Do not use after the expiration date on the label since the medicine

>may not work properly after that date. Check with your pharmacist if

>you have any questions about this.

>

>To help clear up your infection completely, keep taking your

>medicine for the full time of treatment , even if you begin to feel

>better after a few days. If you stop taking this medicine too soon,

>your symptoms may return.

>

>Atovaquone works best when there is a constant amount in the blood.

>To help keep the amount constant, do not miss any doses .

>

>Dosing--The dose of atovaquone may be different for different

>patients. Follow your doctor's orders or the directions on the

>label . The following information includes only the average doses of

>atovaquone. If your dose is different, do not change it unless your

>doctor tells you to do so.

>

>For treatment of Pneumocystis carinii pneumonia (PCP):

>For oral suspension dosage form:

>Adults and teenagers--750 milligrams (mg) taken with a meal two

>times a day for twenty-one days.

>Children--Use and dose must be determined by your doctor.

>For tablet dosage form:

>Adults and teenagers--750 mg taken with a meal three times a day for

>twenty-one days.

>Children--Use and dose must be determined by your doctor.

>For prevention of Pneumocystis carinii pneumonia (PCP):

>For oral suspension dosage form:

>Adults and teenagers--1500 milligrams (mg) once a day with a meal.

>Children--Use and dose must be determined by your doctor.

>Missed dose--If you miss a dose of this medicine, take it as soon as

>possible. This will help to keep a constant amount of medicine in

>the blood. However, if it is almost time for your next dose, skip

>the missed dose and go back to your regular dosing schedule. Do not

>double doses.

>

>Storage--To store this medicine:

>

>Keep out of the reach of children.

>Store away from heat and direct light.

>Do not store in the bathroom, near the kitchen sink, or in other

>damp places. Heat or moisture may cause the medicine to break down.

>Do not keep outdated medicine or medicine no longer needed. Be sure

>that any discarded medicine is out of the reach of children.

>Do not freeze.

>

>

>Precautions While Using This Medicine

>If your symptoms do not improve within a few days, or if they become

>worse, check with your doctor.

>

>

>

>Side Effects of This Medicine

>Along with its needed effects, a medicine may cause some unwanted

>effects. Although not all of these side effects may occur, if they

>do occur they may need medical attention.

>

>Check with your doctor immediately if any of the following side

>effects occur:

>

>More common

>

>Fever; skin rash

>

>Other side effects may occur that usually do not need medical

>attention. These side effects may go away during treatment as your

>body adjusts to the medicine. However, check with your doctor if any

>of the following side effects continue or are bothersome:

>

>More common

>

>Cough; diarrhea; headache; nausea; trouble in sleeping; vomiting

>

>Other side effects not listed above may also occur in some patients.

>If you notice any other effects, check with your doctor.

>

>

>

>Revised: 12/20/1999

>Micromedex, Inc. Disclaimer

>

>

>______________________For the proguanil information____________

>

>Active Ingredients

>

>Proguanil hydrochloride

>

>Mechanism:

>

>

>Proguanil is inactive and acts through the active metabolite

>cycloguanil, which inhibits dihydrofolate reductase. The effect of

>this action is to prevent schizogony and it's main effect is against

>the developing primary schizonts.

>

>Indications:

>

>

>Prevention of malaria in combination with chloroquine in areas of

>confirmed chloroquine resistance.

>

>Contra-Indications:

>

>

>Patients with severe renal failure.

>

>Dosage:

>

>

>Management of overdose:

>Symptoms: Haematuria, renal irritation, epigastric discomfort and

>vomiting.

>Rx: Symptomatic and supportive.

>Dose: (Ref: Paludrine P/I)

>Best taken with water, after food at the same time each day

>It is advisable to start treatment at least 24 hours before entering

>and continuing for at least 4 - 6 weeks after leaving the area.

>ADULTS:

>200mg daily CHILDREN UNDER ONE YEAR:

>25mg daily CHILDREN 1 - 4 YEARS:

>50mg daily CHILDREN 5 - 8 YEARS:

>100mg daily CHILDREN 9 - 14 YEARS:

>150mg daily OVER 14 YEARS:

>200mg daily

>

>Side-Effects:

>

>

>GIT intolerance ...which normally subsides.

>Hair loss, skin reactions, mouth ulceration and inflammation of the

>mouth.

>

>Precautions:

>

>

>Always take in conjunction with chloroquine.

>

>Pregnancy:

>

>

>Paludrine is excreted into breast milk but not in sufficient

>quantities to confer any benefit.Seperate chemoprophylaxis is

>required.

>

>Porphyria:

>

>

>Safe (TPS)

>

>

>

>

>

>> Holy Sh*t!! I feel like I've been hit over the head with a sledge

>hammer! I never made the connection before, but my problems started

>in June after a trip to S.Africa/Botswana. I thought about

>everything else it could possibly be EXCEPT I took a new

>antimalarial called Mallarone. It's not an antibiotic but maybe it

>has antibiotic properties to prevent malaria. I have similar

>symptoms to yours: vaginal burning and irritation that does not

>respond to anything. Did you take Mallarone too? Maybe this is a

>common side-effect.

>> PLEASE respond and tell me more info. I don't know about you but

>this kind of freaks me out.

>>

>> Lynne

>>

>>

>> >>Hello,

>> >>In preperation for a trip to South Africa earlier this spring, I

>had

>> >>to take exttended antibioitcs to prevent malaria. I have been

>> >>plagued with a vaginal yeast infection since, at least thats

>what the

>> >>doc says it is. No discharge, just itching and burning. It just

>won't

>> >>go away. Tried Monostat, Diflucan. I don't eat sugar, bake my

>own

>> >>bread, won't eat fast or processed foods, exercise 30-60 minutes

>per

>> >>day and eat a balanced diet.

>> >>Now I am taking Centrum multi vit, vit c, b complex at dr's

>> >>suggestion. I take two acodophilis (spelling!) pills per day. Am

>> >>rinsing internally with a yougurt wash 2x per day, because it is

>> >>soothing. No help. Even tried inserting garlic, and although

>that

>> >>eased itching, it didn'y help long term. Doc says be patient.

>But can

>> >>anyone give me any suggestions, please?

>> >>Thank you!

>> >>

>> >>

>> >>

>> >>

[Guest guest]

Lynne, I couldn't really find any info for the product except for

the ingredients and that those with kidney problems shouldn't take

it. I added the infor for the two separate active ingredients

because there was more info in medline for them. I just checked

them out because they were for malaria. Don't want to cause undue

alarm. You certainly don't need that!

Anyway, I remember the fen-phen problem with combining drugs for

super activity and thought maybe this could be a similar problem.

> >> Holy Sh*t!! I feel like I've been hit over the head with a

sledge

> >hammer! I never made the connection before, but my problems

started

> >in June after a trip to S.Africa/Botswana. I thought about

> >everything else it could possibly be EXCEPT I took a new

> >antimalarial called Mallarone. It's not an antibiotic but maybe

it

> >has antibiotic properties to prevent malaria. I have similar

> >symptoms to yours: vaginal burning and irritation that does not

> >respond to anything. Did you take Mallarone too? Maybe this is a

> >common side-effect.

> >> PLEASE respond and tell me more info. I don't know about you

but

> >this kind of freaks me out.

> >>

> >> Lynne

> >>

> >>

> >> >>Hello,

> >> >>In preperation for a trip to South Africa earlier this

spring, I

> >had

> >> >>to take exttended antibioitcs to prevent malaria. I have

been

> >> >>plagued with a vaginal yeast infection since, at least thats

> >what the

> >> >>doc says it is. No discharge, just itching and burning. It

just

> >won't

> >> >>go away. Tried Monostat, Diflucan. I don't eat sugar, bake

my

> >own

> >> >>bread, won't eat fast or processed foods, exercise 30-60

minutes

> >per

> >> >>day and eat a balanced diet.

> >> >>Now I am taking Centrum multi vit, vit c, b complex at dr's

> >> >>suggestion. I take two acodophilis (spelling!) pills per day.

Am

> >> >>rinsing internally with a yougurt wash 2x per day, because it

is

> >> >>soothing. No help. Even tried inserting garlic, and although

> >that

> >> >>eased itching, it didn'y help long term. Doc says be patient.

> >But can

> >> >>anyone give me any suggestions, please?

> >> >>Thank you!

> >> >>

> >> >>

> >> >>

> >> >>