Guest guest Posted March 20, 2006 Report Share Posted March 20, 2006 Sherry wrote: > Does anyone know if the thyroid can affect a person's IgG lab number? ... Sure, if the IgG is excessively attaching to thyroid hormones. That takes T4 and T3 out of circulation while reducing overall IgG levels. This is one situation in which TSH is not effective for preliminary screening. You need to measure Free T3 or Free T4 to know if these are interacting abnormally. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 20, 2006 Report Share Posted March 20, 2006 So Chuck if I understand you, The IgG number can be directly affected by Free T3/T4? My daughter is popping up with abnormally low (but not rediculously low) total IgG. She also tested VERY low on immunity to all of the pneumonioccocus germs. This kid is the healthiest sick kid you would ever meet. She looks like the perfect example of health. But, something is wrong because she is so tired and forgetful. And, she gets walking pneumonia every single winter. Many times she finally kicks this on her own, so it can't be solely a genetic immunity. With tons of athletic conditioning she only has 80-90% of lung function after inhalers. I will have to press this issue harder. Her doctor has always minimized her health issues because she looks so good. It was an allergist that tested for the immunity, which should have been caught 12 years ago. > > Does anyone know if the thyroid can affect a person's IgG lab number? ... > > Sure, if the IgG is excessively attaching to thyroid hormones. That > takes T4 and T3 out of circulation while reducing overall IgG levels. > This is one situation in which TSH is not effective for preliminary > screening. You need to measure Free T3 or Free T4 to know if these are > interacting abnormally. > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 20, 2006 Report Share Posted March 20, 2006 Sherry, You wrote: > So Chuck if I understand you, The IgG number can be directly > affected by Free T3/T4? ... Most of the T4 and T3 in your system is tied up by either globulin or albumin. The little bit that is left is the Free fraction. If too much is tied up, then both thyroid and immunoglobulin will be down. However, IgG usually refers to a specific type of antibody, one that usually appears late in an infection. If you are telling me that IgG type _antibodies_ are going down, that is a good indication. If you mean immunoglobulin in general in going down, that could be different. IgG antibodies are indeed a type that attacks the thyroid hormones, particularly in the thryoglobulin complex. So, do you mean antibodies or globulin? Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2006 Report Share Posted March 21, 2006 Total IgG antibodies is what I was told. - (IgG antibodies are considered the most important antibodies for fighting bacterial and viral infections.) I didn't realize there was another IgG. Yes, I was referring to antibodies. My daughters total IgG antibody number is low, and even dropped a little. So are you saying even the antibody version binds with T3 and T4? I'm just trying to understand the dynamics and what could cause variances. Thanks for all the help Chuck!! Sherry > > > So Chuck if I understand you, The IgG number can be directly > > affected by Free T3/T4? ... > > Most of the T4 and T3 in your system is tied up by either globulin or > albumin. The little bit that is left is the Free fraction. If too much > is tied up, then both thyroid and immunoglobulin will be down. > > However, IgG usually refers to a specific type of antibody, one that > usually appears late in an infection. If you are telling me that IgG > type _antibodies_ are going down, that is a good indication. If you mean > immunoglobulin in general in going down, that could be different. IgG > antibodies are indeed a type that attacks the thyroid hormones, > particularly in the thryoglobulin complex. > > So, do you mean antibodies or globulin? > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2006 Report Share Posted March 21, 2006 Sherry, You wrote: > ... Yes, I was referring to > antibodies. My daughters total IgG antibody number is low, and even > dropped a little. So are you saying even the antibody version binds > with T3 and T4? ... Actually there are five different classes of immunoglobulins, which are a subset of the globulins. The fact that her IgG antibodies are low is good news. That means her system is NOT mounting a defense against an infection, nor is it mistakenly attacking globulin bound thyroid hormones. There are more specific antibodies that identify Hashimoto's, but I think if IgG antibodies are low, that includes the specific ones and rules out Hashi's. I could be wrong about that, though. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2006 Report Share Posted March 21, 2006 Thanks for all the follow up Chuck. I geuss we can rule out the thyroid in this one. Bummer. For everyone thinking hashis stinks, in this case the fix for it is so much better than that for low immunity. And, I say that as someone who deals with the ups/downs of Hashis. It's no fun but it could be worse. Sherry -- In hypothyroidism , Chuck B <gumboyaya@...> wrote: > Actually there are five different classes of immunoglobulins, which are a subset of the globulins. The fact that her IgG antibodies are low is good news. That means her system is NOT mounting a defense against an infection, nor is it mistakenly attacking globulin bound thyroid hormones. There are more specific antibodies that identify Hashimoto's, but I think if IgG antibodies are low, that includes the specific ones and rules out Hashi's. I could be wrong about that, though. > Chuck > Quote Link to comment Share on other sites More sharing options...
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